Search

The simultaneous detection of multiple stimuli, such as pressure and temperature, has long been a persistent challenge for developing electronic skin (e‐skin) to emulate the functionality of human skin. Meanwhile, the demand for integrated power supply units is an additional pressing concern to achieve its lightweightness and flexibility. Herein, we propose a self‐powered dual temperature–pressure (SPDM) sensor, which utilizes a compressible ionic gel electrolyte driven by the potential difference between MXene and Al electrodes. The SPDM sensor exhibits a rapid and timely response to changes in pressure‐induced deformation, while exhibiting a slow and hysteretic response to temperature variations. These distinct response characteristics enable the differentiation of current signals generated by different stimuli through machine learning, resulting in an impressive accuracy rate of 99.1%. Furthermore, the developed SPDM sensor exhibits a wide pressure detection range of 0–800 kPa and a broad temperature detection range of 5–75°C, encompassing the environmental conditions encountered in daily human life. The dual‐mode coupled strategy by machine learning provides an effective approach for temperature and pressure detection and discrimination, showcasing its potential applications in wearable electronics, intelligent robots, human–machine interactions, and so on. [ABSTRACT FROM AUTHOR]

For fixing the parametric design problem of blasting with water-coupled medium and improving the rock breaking quality, efforts should be made to quantify and examine the blasthole pressure and the explosive crack growth length in the scenario of blasting with water-coupled medium. The water medium was treated as an ideal fluid on the precondition that its flow velocity and internal energy would change continuously with time. Under the elastic wave theory and combining the propagation law of shock wave in water and rock or rock-like medium, the pressure, velocity, and other parameters in relation to shock wave at the interface between explosive and water, in the water medium, and in the peripheral medium after the occurrence of transmission and reflection at the interface between water and hole wall, were subject to theoretical calculations. As a result, the equation for the peak blasthole pressure in the scenarios of explosive and hole wall medium parameters was derived. Further considering the weakening effect of sparse wave on shock wave and the effect of multiple reflections superimposed on shock wave by the hole wall medium, the equation for the attenuation of blasthole pressure as a function of the time constant T was obtained. Next, the prediction model for crack length in the scenario of blasting with water-coupled medium was constructed by the aforementioned equation for calculation of blasthole pressure in the scenario of blasting and according to the model for explosive gas-driven one-dimensional crack growth. Finally, the blasthole pressure and one-dimensional crack length applicable to the explosive and hole wall medium parameter with decoupled coefficients of 1.33, 1.67, 2.00, 2.67, and 3.33 at a given time point were examined by combining the derived equations for theoretical calculations and numerical simulations. Results showed that in the scenario of blasting with water-coupled medium, the blasthole pressure would reduce as the decoupled coefficient η increases, and it is significantly influenced by η, up to 25% even above 50%. Similarly, the crack length would reduce as the decoupled coefficient η increases, but it is slightly influenced by η, only at 15% or so in general. [ABSTRACT FROM AUTHOR]

Psoriasis is a common immune‐mediated inflammatory skin disease, caused by disturbed interactions between keratinocytes and immune cells. Chinese medicine shows potential clinical application for its treatment. Liquiritin is a flavone compound extracted from licorice and shows potential antitussive, antioxidant and antiinflammatory effects, and therefore may have potential as a psoriasis therapeutic. The aim of this work was to examine the possible roles that liquiritin may have in treating psoriasis. HaCaT cells were stimulated by TNF‐α with or without liquiritin, harvested for analysis by western blots and RT‐qPCR, and the cellular supernatants were collected and analyzed by ELISA for cytokines. In addition, 4 groups of mice were examined: Normal, Vehicle, LQ‐L and LQ‐H. The mice were sacrificed after 6 days and analyzed using IHC, ELISA, RT‐qPCR and flow cytometry. The results showed that liquiritin could significantly inhibit the progression of psoriasis both in vitro and in vivo. Liquiritin strongly suppressed the proliferation of HaCaT keratinocytes but did not affect cell viability. Moreover, liquiritin alleviated imiquimod‐induced psoriasis‐like skin inflammation and accumulation of Th17 cells and DCs in vivo. In TNF‐α‐induced HaCaT keratinocytes, both protein and mRNA expression levels of inflammatory cytokines were sharply decreased. In imiquimod‐induced mice, the activation of NF‐κB and AP‐1 was reduced after treatment with liquiritin. Collectively, our results show that liquiritin might act as a pivotal regulator of psoriasis via modulating NF‐κB and AP‐1 signal pathways. [ABSTRACT FROM AUTHOR]