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The Kulagangri Dome is located at the eastern part of the Himalayan metallogenic belt. Based on the 1 :50 000 mineral geological mapping and sparse surface engineering, the Gabo pegmatite-type lithium deposit was firstly found at the eastern part of the Kulagangri Dome. Ore-bearing spodumene pegmatite dikes are generally hosted by the marble in the middle unit of the dome, with length ranging from 1 m to 1 200 m, and width ranging from 0. 8 m to 40 m. The main lithium containing minerals in the spodumene pegmatite are spodumene, elbaite and lepidolite. At present, two main Li mineralization zones are controlled by 5 surface engineering. The mineralization zone I is about 2 km long, and includes 2 main orebodies (K1 and K2). The mineralization zone II is about 700 m long, and include one main orebody (K3). The K1 orebody is about 1 200 m long and 5 ~ 40 m thick, with an average thickness of about 20 m. The K2 and K3 orebodies occur as the large lenticular shape, with strike extension >100~600 m and thickness 15~50 m. The total thickness of K2 orebody is 45. 3 m. The average grade of Li2O, Rb2O and BeO is 1.11%, 0.064% and 0.047%, respectively. The newly discovered Gabo lithium deposit is dominated by Li, Be and Rb, associated with Nb, Ta, Cs, W and Sn. Based on the geological survey results, the Gabo lithium deposit is large in scale, and showing considerable potential for further prospecting in the area. The discovery of Gabo lithium deposit is another breakthrough in the exploration of rare metals in the Himalayan metallogenic belt, which is of great significant role in further understanding of the tectono-magmatic evolution and rare metal mineralization in the Cenozoic Himalaya, and further enriching the theory of collisional orogenesis and mineralization in the southern Qinghai-Tibet Plateau. [ABSTRACT FROM AUTHOR]

Background Few safety and effectiveness results have been published regarding the administration of tenofovir alafenamide fumarate (TAF) during pregnancy for the prevention of mother-to-child transmission (MTCT) of hepatitis B virus (HBV). Methods In this multicenter prospective observational study, pregnant women with HBV DNA levels higher than 200 000 IU/mL who received TAF or tenofovir disoproxil fumarate (TDF) from gestational weeks 24–35 to delivery were 1:1 enrolled and followed until postpartum month 6. Infants received immunoprophylaxis. The primary endpoint was the safety of mothers and infants. The secondary endpoint was the hepatitis B surface antigen (HBsAg)-positive rate at 7 months for infants. Results In total, 116 and 116 mothers were enrolled, and 117 and 116 infants were born, in the TAF and TDF groups, respectively. TAF was well tolerated during a mean treatment duration of 11.0 weeks. The most common maternal adverse event was nausea (19.0%). One (0.9%), 3 (2.6%), and 9 (7.8%) mothers had abnormal alanine aminotransferase levels at delivery and at postpartum months 3 and 6, respectively. The TDF group had safety profiles that were comparable to those of the TAF group. No infants had birth defects in either group. The infants' physical and neurological development at birth and at 7 months in the TAF group were comparable with those in the TDF group. The HBsAg positive rate was 0% at 7 months in all 233 infants. Conclusions Antiviral prophylaxis with TAF was determined to be generally safe for both mothers and infants and reduced the MTCT rate to 0%. [ABSTRACT FROM AUTHOR]

Acute kidney injury (AKI) is a major complication following liver transplantation (LT), which utilizes grafts from donors after cardiac death (DCD). We developed a machine-learning-based model to predict AKI, using data from 894 LT recipients (January 2015-March 2021), split into training and testing sets. Five machine learning algorithms were employed to construct the prediction models using 17 clinical variables. The performance of the models was assessed by the area under the receiver operating characteristic curve (AUC), accuracy, F1-score, sensitivity and specificity. The best-performing model was further validated in an independent cohort of 195 LT recipients who received DCD grafts between April 2021 and December 2021. The Shapley additive explanations method was utilized to elucidate the predictions and identify the most crucial features. The gradient boosting machine (GBM) model demonstrated the highest AUC (0.76, 95% CI: 0.70-0.82), F1-score (0.73, 95% CI: 0.66-0.79) and sensitivity (0.74, 95% CI: 0.66-0.80) in the testing set and a comparable AUC (0.75, 95% CI: 0.67-0.81) in the validation set. The GBM model identified high preoperative indirect bilirubin, low intraoperative urine output, prolonged anesthesia duration, low preoperative platelet count and graft steatosis graded NASH Clinical Research Network 1 and above as the top five important features for predicting AKI following LT using DCD grafts. The GBM model is a reliable and interpretable tool for predicting AKI in recipients of LT using DCD grafts. This model can assist clinicians in identifying patients at high risk and providing timely interventions to prevent or mitigate AKI., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Liu, Wang, Xu, Wang, Lai, Li and Meng.)