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5. Evaluation of aggregate stability methods for soil health

Author

Rieke, Elizabeth L., Bagnall, Dianna K., Morgan, Cristine L.S., Flynn, Kade D., Howe, Julie A., Greub, Kelsey L.H., Mac Bean, G., Cappellazzi, Shannon B., Cope, Michael, Liptzin, Daniel, Norris, Charlotte E., Tracy, Paul W., Aberle, Ezra, Ashworth, Amanda, Bañuelos Tavarez, Oscar, Bary, Andy I., Baumhardt, R.L., Borbón Gracia, Alberto, Brainard, Daniel C., Brennan, Jameson R., Briones Reyes, Dolores, Bruhjell, Darren, Carlyle, Cameron N., Crawford, James J.W., Creech, Cody F., Culman, Steve W., Deen, Bill, Dell, Curtis J., Derner, Justin D., Ducey, Thomas F., Duiker, Sjoerd W., Dyck, Miles F., Ellert, Benjamin H., Entz, Martin H., Espinosa Solorio, Avelino, Fonte, Steven J., Fonteyne, Simon, Fortuna, Ann-Marie, Foster, Jamie L., Fultz, Lisa M., Gamble, Audrey V., Geddes, Charles M., Griffin-LaHue, Deirdre, Grove, John H., Hamilton, Stephen K., Hao, Xiying, Hayden, Zachary D., Honsdorf, Nora, Ippolito, James A., Johnson, Gregg A., Kautz, Mark A., Kitchen, Newell R., Kumar, Sandeep, Kurtz, Kirsten S.M., Larney, Francis J., Lewis, Katie L., Liebman, Matt, Lopez Ramirez, Antonio, Machado, Stephen, Maharjan, Bijesh, Martinez Gamiño, Miguel Angel, May, William E., McClaran, Mitchel P., McDaniel, Marshall D., Millar, Neville, Mitchell, Jeffrey P., Moore, Amber D., Moore, Philip A., Jr., Mora Gutiérrez, Manuel, Nelson, Kelly A., Omondi, Emmanuel C., Osborne, Shannon L., Osorio Alcalá, Leodegario, Owens, Phillip, Pena-Yewtukhiw, Eugenia M., Poffenbarger, Hanna J., Ponce Lira, Brenda, Reeve, Jennifer R., Reinbott, Timothy M., Reiter, Mark S., Ritchey, Edwin L., Roozeboom, Kraig L., Rui, Yichao, Sadeghpour, Amir, Sainju, Upendra M., Sanford, Gregg R., Schillinger, William F., Schindelbeck, Robert R., Schipanski, Meagan E., Schlegel, Alan J., Scow, Kate M., Sherrod, Lucretia A., Shober, Amy L, Sidhu, Sudeep S., Solís Moya, Ernesto, St. Luce, Mervin, Strock, Jeffrey S., Suyker, Andrew E., Sykes, Virginia R., Tao, Haiying, Trujillo Campos, Alberto, Van Eerd, Laura L., van Es, Harold M., Verhulst, Nele, Vyn, Tony J., Wang, Yutao, Watts, Dexter B., Wright, David L., Zhang, Tiequan, and Honeycutt, C. Wayne

Published
2022
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6. The role of future-oriented affect in engagement with genomic testing results

Author

Gillman, Arielle S., Iles, Irina A., Klein, William M. P., Biesecker, Barbara B., Lewis, Katie L., Biesecker, Leslie G., and Ferrer, Rebecca A.

Subjects
Affect (Psychology) -- Health aspects -- Evaluation, Genetic screening -- Psychological aspects -- Health aspects, Psychology and mental health
Abstract

Future-oriented emotions such as anticipatory affect (i.e., current affect experienced regarding a potential future outcome) and anticipated affect (i.e., expectations about potential future affect), are uniquely associated with health decision-making (e.g., electing to receive results of genomic testing). This study investigated the degree to which negative anticipated and anticipatory emotions predict health decision making over time, and whether such emotions predict social, emotional, and behavioral responses to anticipated information (e.g., genomic testing results). 461 participants (M age = 63.9, SD = 5.61, 46% female) in a genomic sequencing cohort who elected to receive genomic sequencing (carrier) results were included in the current study. Anticipated and anticipatory affect about sequencing results were assessed at baseline. Psychological and behavioral responses to sequencing results, including participants' reported anxiety, decisional conflict, and distress about sequencing results, whether they shared results with family members, and their intentions to continue learning results in the future, were collected immediately, one month, and/or six months after receiving results. More negative anticipated and anticipatory affect at baseline was significantly and independently associated with lower intentions to continue learning results in the future, as well as higher levels of anxiety and uncertainty at multiple time points after receiving results. Anticipated negative affect was also associated with greater decisional conflict, and anticipatory negative affect was also associated with greater distress after receiving results. Future-oriented emotions may play an important role in decisions that unfold over time, with implications for genomic testing, behavioral medicine, and health decision-making broadly., Author(s): Arielle S. Gillman [sup.1] , Irina A. Iles [sup.2] , William M. P. Klein [sup.2] , Barbara B. Biesecker [sup.3] , Katie L. Lewis [sup.4] , Leslie G. Biesecker [...]

Published
2022
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7. Case report: Deep sequencing and long-read genome sequencing refine prior genetic analyses in families with apparent gonadal mosaicism in PIK3CD-related activated PI3K delta syndrome.

Author

Orellana, Halyn, Jia Yan, Paul, Alex, Mari Tokita, Yan Ding, Ghosh, Rajarshi, Lewis, Katie L., Davis, Jamal, Leila, Jodarski, Colleen, Similuk, Morgan, Saucier, Nermina, Zhanyang Zhu, Yihe Wang, Sitao Wu, Ruggieri, Jason, Su, Helen C., Uzel, Gulbu, Nahas, Shareef, and Cooper, Megan

Abstract

Gonadal and gonosomal mosaicism describe phenomena in which a seemingly healthy individual carries a genetic variant in a subset of their gonadal tissue or gonadal and somatic tissue(s), respectively, with risk of transmitting the variant to their offspring. In families with one or more affected offspring, occurrence of the same apparently de novo variants can be an indicator of mosaicism in either parent. Panel-based deep sequencing has the capacity to detect low-level mosaic variants with coverage exceeding the typical limit of detection provided by current, readily available sequencing techniques. In this study, we report three families with more than one affected offspring with either confirmed or apparent parental gonosomal or gonadal mosaicism for PIK3CD pathogenic variants. Data from targeted deep sequencing was suggestive of low-level maternal gonosomal mosaicism in Family 1. Through this approach we did not detect pathogenic variants in PIK3CD from parental samples in Family 2 and Family 3. We conclude that mosaicism was likely confined to the maternal gonads in Family 2. Subsequent long-read genome sequencing in Family 3 showed that the paternal chromosome harbored the pathogenic variant in PIK3CD in both affected children, consistent with paternal gonadal mosaicism. Detection of parental mosaic variants enables accurate risk assessment, informs reproductive decision-making, and provides helpful context to inform clinical management in families with PIK3CD pathogenic variants. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Dyadic concordance and associations of beliefs with intentions to learn carrier results from genomic sequencing

Author

Huelsnitz, Chloe O., Turbitt, Erin, Taber, Jennifer M., Lewis, Katie L., Biesecker, Leslie G., Biesecker, Barbara B., and Klein, William M. P.

Subjects
Interpersonal relations -- Psychological aspects -- Health aspects, Couples -- Behavior -- Health aspects, Information-seeking behavior -- Health aspects -- Social aspects, Health behavior -- Social aspects, Genetic screening -- Social aspects, Psychology and mental health
Abstract

Although romantic couple concordance has been demonstrated across a wide array of health behaviors, little research has examined dyadic concordance in health beliefs. This study examined the extent to which cohabitating romantic dyads' attitudes and beliefs coincide (i.e., dyadic concordance) in addition to how well they predict intentions to learn genomic sequencing results. The actor-partner interdependence model was applied to cross-sectional data from 81 dyads in an exome sequencing study who were surveyed about their risk perceptions, worry, information avoidance, attitudes, and intentions toward learning carrier results. Information avoidance tendencies were positively correlated between partners, but there was low concordance on other beliefs. Individuals' attitudes and information avoidance predicted their own intentions to learn results. Additionally, partners' information avoidance tendencies predicted their partner's intentions to learn results. Future research should explore mechanisms through which one's partner's information avoidance may affect one's own intentions and behaviors., Author(s): Chloe O. Huelsnitz [sup.1] , Erin Turbitt [sup.2] , Jennifer M. Taber [sup.3] , Katie L. Lewis [sup.4] , Leslie G. Biesecker [sup.4] , Barbara B. Biesecker [sup.5] , [...]

Published
2021
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11. An evaluation of nitrogen indicators for soil health in long‐term agricultural experiments

Author

Liptzin, Daniel, primary, Rieke, Elizabeth L., additional, Cappellazzi, Shannon B., additional, Bean, G. Mac, additional, Cope, Michael, additional, Greub, Kelsey L. H., additional, Norris, Charlotte E., additional, Tracy, Paul W., additional, Aberle, Ezra, additional, Ashworth, Amanda, additional, Tavarez, Oscar Bañuelos, additional, Bary, Andy I., additional, Baumhardt, R. L., additional, Gracia, Alberto Borbón, additional, Brainard, Daniel C., additional, Brennan, Jameson R., additional, Reyes, Dolores Briones, additional, Bruhjell, Darren, additional, Carlyle, Cameron N., additional, Crawford, James J. W., additional, Creech, Cody F., additional, Culman, Steve W., additional, Deen, Bill, additional, Dell, Curtis J., additional, Derner, Justin D., additional, Ducey, Thomas F., additional, Duiker, Sjoerd W., additional, Dungan, Robert S., additional, Dyck, Miles F., additional, Ellert, Benjamin H., additional, Entz, Martin H., additional, Solorio, Avelino Espinosa, additional, Fonte, Steven J., additional, Fonteyne, Simon, additional, Fortuna, Ann‐Marie, additional, Foster, Jamie L., additional, Fultz, Lisa M., additional, Gamble, Audrey V., additional, Geddes, Charles M., additional, Griffin‐LaHue, Deirdre, additional, Grove, John H., additional, Hamilton, Stephen K., additional, Hao, Xiying, additional, Hayden, Zachary D., additional, Honsdorf, Nora, additional, Howe, Julie A., additional, Ippolito, James A., additional, Johnson, Gregg A., additional, Kautz, Mark A., additional, Kitchen, Newell R., additional, Kumar, Sandeep, additional, Kurtz, Kirsten S. M., additional, Larney, Francis J., additional, Lewis, Katie L., additional, Liebman, Matt, additional, Ramirez, Antonio Lopez, additional, Machado, Stephen, additional, Maharjan, Bijesh, additional, Gamiño, Miguel Angel Martinez, additional, May, William E., additional, McClaran, Mitchel P., additional, McDaniel, Marshall D., additional, Millar, Neville, additional, Mitchell, Jeffrey P., additional, Moore, Amber D., additional, Moore, Philip A., additional, Gutiérrez, Manuel Mora, additional, Nelson, Kelly A., additional, Omondi, Emmanuel C., additional, Osborne, Shannon L., additional, Alcalá, Leodegario Osorio, additional, Owens, Phillip, additional, Pena‐Yewtukhiw, Eugenia M., additional, Poffenbarger, Hanna J., additional, Lira, Brenda Ponce, additional, Reeve, Jennifer R., additional, Reinbott, Timothy M., additional, Reiter, Mark S., additional, Ritchey, Edwin L., additional, Roozeboom, Kraig L., additional, Rui, Yichao, additional, Sadeghpour, Amir, additional, Sainju, Upendra M., additional, Sanford, Gregg R., additional, Schillinger, William F., additional, Schindelbeck, Robert R., additional, Schipanski, Meagan E., additional, Schlegel, Alan J., additional, Scow, Kate M., additional, Sherrod, Lucretia A., additional, Shober, Amy L, additional, Sidhu, Sudeep S., additional, Moya, Ernesto Solís, additional, Luce, Mervin St., additional, Strock, Jeffrey S., additional, Suyker, Andrew E., additional, Sykes, Virginia R., additional, Tao, Haiying, additional, Campos, Alberto Trujillo, additional, Van Eerd, Laura L., additional, van Es, Harold M, additional, Verhulst, Nele, additional, Vyn, Tony J., additional, Wang, Yutao, additional, Watts, Dexter B., additional, Wright, David L., additional, Zhang, Tiequan, additional, Morgan, Cristine L. S., additional, and Honeycutt, C. Wayne, additional

Published
2023
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21. LBMON114 Enrichment Of Rare Sequence Variants In Genes That Communicate Metabolic Signals To The GnRH System In Hypothalamic Amenorrhea

Author

Brown, Ethan, primary, Shekhar, Skand, additional, Delaney, Angela, additional, Burkholder, Adam B, additional, Plummer, Lacey, additional, Mericq, Veronica, additional, Merino, Paulina M, additional, Quinton, Richard, additional, Lewis, Katie L, additional, Shaw, Natalie D, additional, Welt, Corrine K, additional, Martin, Kathryn A, additional, Seminara, Stephanie B, additional, Biesecker, Leslie G, additional, Motsinger-Reif, Alison, additional, House, John S, additional, and Hall, Janet, additional

Published
2022
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22. An evaluation of carbon indicators of soil health in long-term agricultural experiments

Author

Liptzin, Daniel, primary, Norris, Charlotte E., additional, Cappellazzi, Shannon B., additional, Bean, G. Mac, additional, Cope, Michael, additional, Greub, Kelsey L.H., additional, Rieke, Elizabeth L., additional, Tracy, Paul W., additional, Aberle, Ezra, additional, Ashworth, Amanda, additional, Bañuelos Tavarez, Oscar, additional, Bary, Andy I., additional, Baumhardt, R.L., additional, Borbón Gracia, Alberto, additional, Brainard, Daniel C., additional, Brennan, Jameson R., additional, Briones Reyes, Dolores, additional, Bruhjell, Darren, additional, Carlyle, Cameron N., additional, Crawford, James J.W., additional, Creech, Cody F., additional, Culman, Steve W., additional, Deen, Bill, additional, Dell, Curtis J., additional, Derner, Justin D., additional, Ducey, Thomas F., additional, Duiker, Sjoerd W., additional, Dyck, Miles F., additional, Ellert, Benjamin H., additional, Entz, Martin H., additional, Espinosa Solorio, Avelino, additional, Fonte, Steven J., additional, Fonteyne, Simon, additional, Fortuna, Ann-Marie, additional, Foster, Jamie L., additional, Fultz, Lisa M., additional, Gamble, Audrey V., additional, Geddes, Charles M., additional, Griffin-LaHue, Deirdre, additional, Grove, John H., additional, Hamilton, Stephen K., additional, Hao, Xiying, additional, Hayden, Zachary D., additional, Honsdorf, Nora, additional, Howe, Julie A., additional, Ippolito, James A., additional, Johnson, Gregg A., additional, Kautz, Mark A., additional, Kitchen, Newell R., additional, Kumar, Sandeep, additional, Kurtz, Kirsten S.M., additional, Larney, Francis J., additional, Lewis, Katie L., additional, Liebman, Matt, additional, Lopez Ramirez, Antonio, additional, Machado, Stephen, additional, Maharjan, Bijesh, additional, Martinez Gamiño, Miguel Angel, additional, May, William E., additional, McClaran, Mitchel P., additional, McDaniel, Marshall D., additional, Millar, Neville, additional, Mitchell, Jeffrey P., additional, Moore, Amber D., additional, Moore, Philip A., additional, Mora Gutiérrez, Manuel, additional, Nelson, Kelly A., additional, Omondi, Emmanuel C., additional, Osborne, Shannon L., additional, Osorio Alcalá, Leodegario, additional, Owens, Philip, additional, Pena-Yewtukhiw, Eugenia M., additional, Poffenbarger, Hanna J., additional, Ponce Lira, Brenda, additional, Reeve, Jennifer R., additional, Reinbott, Timothy M., additional, Reiter, Mark S., additional, Ritchey, Edwin L., additional, Roozeboom, Kraig L., additional, Rui, Yichao, additional, Sadeghpour, Amir, additional, Sainju, Upendra M., additional, Sanford, Gregg R., additional, Schillinger, William F., additional, Schindelbeck, Robert R., additional, Schipanski, Meagan E., additional, Schlegel, Alan J., additional, Scow, Kate M., additional, Sherrod, Lucretia A., additional, Shober, Amy L., additional, Sidhu, Sudeep S., additional, Solís Moya, Ernesto, additional, St Luce, Mervin, additional, Strock, Jeffrey S., additional, Suyker, Andrew E., additional, Sykes, Virginia R., additional, Tao, Haiying, additional, Trujillo Campos, Alberto, additional, Van Eerd, Laura L., additional, van Es, Harold, additional, Verhulst, Nele, additional, Vyn, Tony J., additional, Wang, Yutao, additional, Watts, Dexter B., additional, Wright, David L., additional, Zhang, Tiequan, additional, Morgan, Cristine L.S., additional, and Honeycutt, C. Wayne, additional

Published
2022
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23. Selecting soil hydraulic properties as indicators of soil health: Measurement response to management and site characteristics

Author

Bagnall, Dianna K., primary, Morgan, Cristine L. S., additional, Bean, G. Mac, additional, Liptzin, Daniel, additional, Cappellazzi, Shannon B., additional, Cope, Michael, additional, Greub, Kelsey L. H., additional, Rieke, Elizabeth L., additional, Norris, Charlotte E., additional, Tracy, Paul W., additional, Aberle, Ezra, additional, Ashworth, Amanda, additional, Tavarez, Oscar Bañuelos, additional, Bary, Andy I., additional, Baumhardt, R. L., additional, Gracia, Alberto Borbón, additional, Brainard, Daniel C., additional, Brennan, Jameson R., additional, Reyes, Dolores Briones, additional, Bruhjell, Darren, additional, Carlyle, Cameron N., additional, Crawford, James J. W., additional, Creech, Cody F., additional, Culman, Steve W., additional, Deen, Bill, additional, Dell, Curtis J., additional, Derner, Justin D., additional, Ducey, Thomas F., additional, Duiker, Sjoerd W., additional, Dyck, Miles F., additional, Ellert, Benjamin H., additional, Entz, Martin H., additional, Solorio, Avelino Espinosa, additional, Fonte, Steven J., additional, Fonteyne, Simon, additional, Fortuna, Ann‐Marie, additional, Foster, Jamie L., additional, Fultz, Lisa M., additional, Gamble, Audrey V., additional, Geddes, Charles M., additional, Griffin‐LaHue, Deirdre, additional, Grove, John H., additional, Hamilton, Stephen K., additional, Hao, Xiying, additional, Hayden, Zachary D., additional, Honsdorf, Nora, additional, Howe, Julie A., additional, Ippolito, James A., additional, Johnson, Gregg A., additional, Kautz, Mark A., additional, Kitchen, Newell R., additional, Kumar, Sandeep, additional, Kurtz, Kirsten S. M., additional, Larney, Francis J., additional, Lewis, Katie L., additional, Liebman, Matt, additional, Ramirez, Antonio Lopez, additional, Machado, Stephen, additional, Maharjan, Bijesh, additional, Gamiño, Miguel Angel Martinez, additional, May, William E., additional, McClaran, Mitchel P., additional, McDaniel, Marshall D., additional, Millar, Neville, additional, Mitchell, Jeffrey P., additional, Moore, Amber D., additional, Moore, Philip A., additional, Gutiérrez, Manuel Mora, additional, Nelson, Kelly A., additional, Omondi, Emmanuel C., additional, Osborne, Shannon L., additional, Alcalá, Leodegario Osorio, additional, Owens, Philip, additional, Pena‐Yewtukhiw, Eugenia M., additional, Poffenbarger, Hanna J., additional, Lira, Brenda Ponce, additional, Reeve, Jennifer R., additional, Reinbott, Timothy M., additional, Reiter, Mark S., additional, Ritchey, Edwin L., additional, Roozeboom, Kraig L., additional, Rui, Yichao, additional, Sadeghpour, Amir, additional, Sainju, Upendra M., additional, Sanford, Gregg R., additional, Schillinger, William F., additional, Schindelbeck, Robert R., additional, Schipanski, Meagan E., additional, Schlegel, Alan J., additional, Scow, Kate M., additional, Sherrod, Lucretia A., additional, Shober, Amy L., additional, Sidhu, Sudeep S., additional, Moya, Ernesto Solís, additional, St. Luce, Mervin, additional, Strock, Jeffrey S., additional, Suyker, Andrew E., additional, Sykes, Virginia R., additional, Tao, Haiying, additional, Campos, Alberto Trujillo, additional, Van Eerd, Laura L., additional, van Es, Harold M., additional, Verhulst, Nele, additional, Vyn, Tony J., additional, Wang, Yutao, additional, Watts, Dexter B., additional, Wright, David L., additional, Zhang, Tiequan, additional, and Honeycutt, C. Wayne, additional

Published
2022
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24. Future-oriented Emotions and Decisions to Receive Genomic Testing Results Among U.S. Adults of African Ancestry.

Author

Gillman, Arielle S, Iles, Irina A, Klein, William M P, Biesecker, Barbara B, Lewis, Katie L, Biesecker, Leslie G, and Ferrer, Rebecca A

Subjects
BEHAVIORAL medicine, EMOTIONS, BEHAVIORAL research, AFFECT (Psychology), BEHAVIORAL sciences
Abstract

Background: Future-oriented emotions are associated with consequential health decision-making, including genomic testing decisions. However, little is known about the relative role of various future-oriented emotions in such decisions. Moreover, most research on predictors of decision making regarding genomic testing is conducted with white participants.Purpose: This study examined the role of future-oriented emotions in decisions to receive genomic testing results in U.S. individuals of African descent.Methods: We analyzed cross-sectional survey data from a genomic sequencing cohort (N = 408). All participants identified as African, African-American, or Afro-Caribbean (Mage = 56.3, 74.7% female). Participants completed measures assessing anticipatory affect (worry about genetic testing results), anticipated distress (feeling devastated if genetic testing showed an increased risk for fatal disease), and anticipated regret (regretting a decision not to learn results). Outcomes were intentions for learning actionable, nonactionable, and carrier results.Results: Anticipated regret was robustly positively associated with intentions to receive actionable (b = 0.28, p < .001), nonactionable (b = 0.39, p < .001), and carrier (b = 0.30, p < .001) results. Anticipated distress was negatively associated with intentions to receive nonactionable results only (b = -0.16, p < .01). Anticipatory negative affect (worry) was not associated with intentions. At higher levels of anticipated regret, anticipated distress was less strongly associated with intentions to receive nonactionable results (b = 0.14, p = .02).Conclusions: Our results highlight the role of future-oriented emotions in genomic testing among participants who are typically underrepresented in genomic testing studies and behavioral medicine broadly. Future work should examine whether interventions targeting future-oriented emotions such as anticipated regret may have clinically meaningful effects in genetic counseling in similar cohorts. [ABSTRACT FROM AUTHOR]

Published
2023
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25. Linking soil microbial community structure to potential carbon mineralization: A continental scale assessment of reduced tillage

Author

Rieke, Elizabeth L., primary, Cappellazzi, Shannon B., additional, Cope, Michael, additional, Liptzin, Daniel, additional, Mac Bean, G., additional, Greub, Kelsey L.H., additional, Norris, Charlotte E., additional, Tracy, Paul W., additional, Aberle, Ezra, additional, Ashworth, Amanda, additional, Bañuelos Tavarez, Oscar, additional, Bary, Andy I., additional, Baumhardt, R.L., additional, Borbón Gracia, Alberto, additional, Brainard, Daniel C., additional, Brennan, Jameson R., additional, Briones Reyes, Dolores, additional, Bruhjell, Darren, additional, Carlyle, Cameron N., additional, Crawford, James J.W., additional, Creech, Cody F., additional, Culman, Steve W., additional, Deen, Bill, additional, Dell, Curtis J., additional, Derner, Justin D., additional, Ducey, Thomas F., additional, Duiker, Sjoerd W., additional, Dyck, Miles F., additional, Ellert, Benjamin H., additional, Espinosa Solorio, Avelino, additional, Fonte, Steven J., additional, Fonteyne, Simon, additional, Fortuna, Ann-Marie, additional, Foster, Jamie L., additional, Fultz, Lisa M., additional, Gamble, Audrey V., additional, Geddes, Charles M., additional, Griffin-LaHue, Deirdre, additional, Grove, John H., additional, Hamilton, Stephen K., additional, Hao, Xiying, additional, Hayden, Zachary D., additional, Honsdorf, Nora, additional, Howe, Julie A., additional, Ippolito, James A., additional, Johnson, Gregg A., additional, Kautz, Mark A., additional, Kitchen, Newell R., additional, Kumar, Sandeep, additional, Kurtz, Kirsten S.M., additional, Larney, Francis J., additional, Lewis, Katie L., additional, Liebman, Matt, additional, Lopez Ramirez, Antonio, additional, Machado, Stephen, additional, Maharjan, Bijesh, additional, Martinez Gamiño, Miguel Angel, additional, May, William E., additional, McClaran, Mitchel P., additional, McDaniel, Marshall D., additional, Millar, Neville, additional, Mitchell, Jeffrey P., additional, Moore, Amber D., additional, Moore, Philip A., additional, Mora Gutiérrez, Manuel, additional, Nelson, Kelly A., additional, Omondi, Emmanuel C., additional, Osborne, Shannon L., additional, Osorio Alcalá, Leodegario, additional, Owens, Philip, additional, Pena-Yewtukhiw, Eugenia M., additional, Poffenbarger, Hanna J., additional, Ponce Lira, Brenda, additional, Reeve, Jennifer R., additional, Reinbott, Timothy M., additional, Reiter, Mark S., additional, Ritchey, Edwin L., additional, Roozeboom, Kraig L., additional, Rui, Yichao, additional, Sadeghpour, Amir, additional, Sainju, Upendra M., additional, Sanford, Gregg R., additional, Schillinger, William F., additional, Schindelbeck, Robert R., additional, Schipanski, Meagan E., additional, Schlegel, Alan J., additional, Scow, Kate M., additional, Sherrod, Lucretia A., additional, Shober, Amy L., additional, Sidhu, Sudeep S., additional, Solís Moya, Ernesto, additional, St Luce, Mervin, additional, Strock, Jeffrey S., additional, Suyker, Andrew E., additional, Sykes, Virginia R., additional, Tao, Haiying, additional, Trujillo Campos, Alberto, additional, Van Eerd, Laura L., additional, Verhulst, Nele, additional, Vyn, Tony J., additional, Wang, Yutao, additional, Watts, Dexter B., additional, William, Bryan B., additional, Wright, David L., additional, Zhang, Tiequan, additional, Morgan, Cristine L.S., additional, and Honeycutt, C. Wayne, additional

Published
2022
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27. Evaluation of Aggregate Stability Methods for Soil Health

Author

Rieke, Elizabeth L., primary, Bagnall, Dianna K., additional, Morgan, Cristine L.S., additional, Flynn, Kade D., additional, Howe, Julie A., additional, Greub, Kelsey L.H., additional, Bean, Gregory M., additional, Cappellazzi, Shannon B., additional, Cope, Michael, additional, Liptzin, Daniel, additional, Norris, Charlotte E., additional, Tracy, Paul W., additional, Aberle, Ezra, additional, Ashworth, Amanda, additional, Bañuelos Tavarez, Oscar, additional, Bary, Andy, additional, Baumhardt, R. L., additional, Borbón Gracia, Alberto, additional, Brainard, Daniel C., additional, Brennan, Jameson R., additional, Briones Reyes, Dolores, additional, Bruhjell, Daniel, additional, Carlyle, Cameron N., additional, Crawford, James J.W., additional, Creech, Cody F., additional, Culman, Steve W., additional, Deen, Bill, additional, Dell, Curtis J., additional, Derner, Justin D., additional, Ducey, Thomas F., additional, Duiker, Sjoerd W., additional, Dyck, Miles F., additional, Ellert, Benjamin H., additional, Entz, Martin H., additional, Espinosa Solorio, Avelino, additional, Fonte, Steven J., additional, Fonteyne, Simon, additional, Fortuna, Ann-Marie, additional, Foster, Jamie L., additional, Fultz, Lisa M., additional, Gamble, Audrey V., additional, Geddes, Charles M., additional, Griffin-LaHue, Deirdre, additional, Grove, John, additional, Hamilton, Stephen K., additional, Hao, Xiying, additional, Hayden, Zachary D., additional, Honsdorf, Nora, additional, Ippolito, James A., additional, Johnson, Gregg A., additional, Kautz, Mark A., additional, Kitchen, Newell R., additional, Kumar, Sandeep, additional, Kurtz, Kirsten S.M., additional, Larney, Francis J., additional, Lewis, Katie L., additional, Liebman, Matt, additional, Lopez Ramirez, Antonio, additional, Machado, Stephen, additional, Maharjan, Bijesh, additional, Martinez Gamiño, Miguel Angel, additional, May, William E., additional, McClaran, Mitchel P., additional, McDaniel, Marshall D., additional, Millar, Neville, additional, Mitchell, Jeffrey P., additional, Moore, Amber D., additional, Moore Jr., Philip A., additional, Mora Gutiérrez, Manuel, additional, Nelson, Kelly A., additional, Omondi, Emmanuel C., additional, Osborne, Shannon L., additional, Osorio Alcalá, Leodegario, additional, Owens, Phillip, additional, Pena-Yewtukhiw, Eugenia, additional, Poffenbarger, Hanna J., additional, Ponce Lira, Brenda, additional, Reeve, Jennifer R., additional, Reinbott, Timothy R., additional, Reiter, Mark S., additional, Ritchey, Edwin L., additional, Roozeboom, Kraig L., additional, Rui, Yichao, additional, Sadeghpour, Amir, additional, Sanju, Upendra M., additional, Sanford, Gregg R., additional, Schillinger, William F., additional, Schindelbeck, Robert R., additional, Schipanski, Meagan E., additional, Schlegel, Alan J., additional, Scow, Kate, additional, Sherrod, Lucretia A., additional, Shober, Amy L., additional, Sidhu, Sudeep S., additional, Solís Moya, Ernesto, additional, St. Luce, Mervin, additional, Strock, Jeffrey S., additional, Suyker, Andrew E., additional, Sykes, Virginia R., additional, Tao, Haiying, additional, Trujillo Campos, Alberto, additional, Van Eerd, Laura L., additional, van Es, Harold M., additional, Verhulst, Nele, additional, Vyn, Tony J., additional, Wang, Yutao, additional, Watts, Dexter B., additional, Wright, David L., additional, Zhang, Tiequan, additional, and Honeycutt, C. Wayne, additional

Published
2022
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33. Preferences for and acceptability of receiving pharmacogenomic results by mail: A focus group study with a primarily African‐American cohort.

Author

Chan, Priscilla A., Lewis, Katie L., Biesecker, Barbara B., Erby, Lori H., Fasaye, Grace‐Ann, Epps, Sandra, Biesecker, Leslie G., and Turbitt, Erin

Abstract

Although genetic counseling is traditionally done through in‐person, one‐on‐one visits, workforce shortages call for efficient result return mechanisms. Studies have shown that telephone and in‐person return of cancer genetic results are equivalent for patient outcomes. Few studies have been conducted with other modes, result types or racially diverse participants. This study explored participants' perspectives on receiving pharmacogenomic results by mail. Two experienced moderators facilitated six focus groups with 49 individuals who self‐identified primarily as African‐American and consented to participate in a genome sequencing cohort study. Participants were given a hypothetical pharmacogenomic result report (positive for c.521T>C in SLCO1B1). An accompanying letter explained that the result was associated with statin intolerance along with a recommendation to share it with one's doctor and immediate relatives. Participants reacted to the idea of receiving this type of result by mail, discussing whether the letter's information was sufficient and what they predicted they would do with the result. Two researchers coded the focus group transcripts and identified themes. Many participants thought that it was appropriate to receive the result through the mail, but some suggested a phone call alerting the recipient to the letter. Others emphasized that although a letter was acceptable for disclosing pharmacogenomic results, it would be insufficient for what they perceived as life‐threatening results. Most participants found the content sufficient. Some participants suggested resources about statin intolerance and warning signs be added. Most claimed they would share the result with their doctor, yet few participants offered they would share the result with their relatives. This exploratory study advances the evidence that African‐American research participants are receptive to return of certain genetic results by approaches that do not involve direct contact with a genetic counselor and intend to share results with providers. ClinSeq: A Large‐Scale Medical Sequencing Clinical Research Pilot Study (NCT00410241). [ABSTRACT FROM AUTHOR]

Published
2021
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34. Hidden fractions: Another look at micronutrient and sodium partitioning in modern cotton cultivars.

Author

Pabuayon, Irish Lorraine B., Lewis, Katie L., and Ritchie, Glen L.

Subjects
*COTTON, *CULTIVARS, *SODIUM, *DEFICIENCY diseases, *NUTRITIONAL status, *TRACE elements
Abstract

Cotton (Gossypium hirsutum L.) productivity and nutritional status depend on the uptake and allocation of both macro‐ and micronutrients. Micronutrient deficiencies or toxicities reduce yields and must be corrected to achieve optimal yields. There is evidence that macronutrient uptake and partitioning have changed in modern cultivars, and it is therefore important to know whether a similar change has occurred with micronutrient uptake or partitioning. Total uptake and partitioning of essential micronutrients (boron, B; iron, Fe; manganese, Mn; zinc, Zn; and copper, Cu) and of sodium (Na) in different tissues of modern cultivars (FiberMax 958, FM 958; and Deltapine 1646, DP 1646) and a 1990s cultivar (Paymaster HS26, PM HS26) were determined in 2018 and 2019 at New Deal, TX. These were compared to results obtained in studies conducted 30 yr ago. The total seasonal uptake of Cu and Zn increased, whereas the total seasonal uptake of Fe and Mn decreased in modern cultivars. Newer cultivars FM 958 and DP 1646 partitioned greater percentage of Zn and Cu to the developing bolls compared to PM HS26. Iron and Mn were mostly retained in the leaves throughout the crop's life cycle. Sodium accumulated in nonphotosynthetic tissues likely as a salt‐tolerance mechanism of cotton. However, when Na availability is far more than required for normal plant growth, Na is redistributed and accumulated into transpiring leaves. This study offers additional insights for making effective fertilizer management decisions for newer cultivars and possible problems due to excess trace elements in the soil and irrigation supply. Core Ideas: Micronutrient uptake patterns have changed after 30 yr of progressive cotton breeding.Newer cotton cultivars partitioned more Zn and Cu into the bolls than older ones.Sodium accumulation in tissues change depending on its availability in soil and irrigation. [ABSTRACT FROM AUTHOR]

Published
2021
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35. The PrU: development and validation of a measure to assess personal utility of genomic results

Author

Turbitt, Erin, Kohler, Jennefer N., Angelo, Frank, Miller, Ilana M., Lewis, Katie L., Goddard, Katrina Ab, Wilfond, Benjamin S., Biesecker, Barbara B., and Leo, Michael C.

Abstract

People report experiencing value from learning genomic results even in the absence of clinically actionable information. Such personal utility has emerged as a key concept in genomic medicine. The lack of a validated patient-reported outcome measure of personal utility has impeded the ability to assess this concept among those receiving genomic results and evaluate the patient-perceived value of genomics. We aimed to construct and psychometrically evaluate a scale to measure personal utility of genomic results – the PrU.

Published
2022
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36. Psychological state at the time of psychiatric genetic counseling impacts patient empowerment: A pre-post analysis.

Author

Moses RG, Jodarski C, Setzer M, Lewis KL, Yan J, Byers S, Yavi M, Ballard ED, Walkiewicz M, Zarate CA Jr, Austin JC, and Similuk M

Abstract

Psychiatric genetic counseling (GC) has been associated with patient-reported increases in empowerment (perceived control, emotional regulation, and hope). We sought to evaluate the extent to which patients' psychological state at the time of GC is related to changes in empowerment. Participants with a history of major depressive disorder and/or bipolar disorder that had been refractory to treatment underwent psychiatric GC remotely from 2022 to 2023. GC was performed by four genetic counselors and included discussion of perceived causes of illness, multifactorial inheritance, and protective factors. Empowerment, depression, and anxiety were measured immediately prior to GC via online survey by the GCOS-16, PHQ-9, and GAD-7, respectively. Empowerment was re-assessed 2 weeks later. In total, 66/161 (41.0%) invited individuals completed both the baseline and follow-up surveys. Participants completing both surveys were 54.6% female, 84.8% white, and ranged in age from 22 to 78 years (mean = 54.8 years). Overall, a significant change in mean empowerment was not observed (p = 0.38); however, there were moderating effects by baseline psychological state. A multiple linear regression model incorporating PHQ-9, GAD-7 and baseline GCOS-16 score predicted change in empowerment with a large effect (F = 5.49, R 2  = 0.21, p < 0.01). A higher score on the PHQ-9 was associated with decreases in empowerment from pre to post GC. Higher scores on the GAD-7 and lower baseline GCOS-16 scores were associated with increases in empowerment. Further, two-way ANOVA was conducted to assess change in empowerment between subgroups based on the level of anxiety and depression. Those with low depression and high anxiety reported significant increases in empowerment (F = 6.64, p = 0.01). These findings suggest that psychiatric GC may be especially helpful to individuals experiencing anxiety and low baseline empowerment. Alternative approaches may be needed to best meet the needs of those experiencing significant depression., (© 2024 The Author(s). Journal of Genetic Counseling published by Wiley Periodicals LLC on behalf of National Society of Genetic Counselors. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.)

Published
2024
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37. Examining access to care in clinical genomic research and medicine: Experiences from the CSER Consortium.

Author

Gutierrez AM, Robinson JO, Outram SM, Smith HS, Kraft SA, Donohue KE, Biesecker BB, Brothers KB, Chen F, Hailu B, Hindorff LA, Hoban H, Hsu RL, Knight SJ, Koenig BA, Lewis KL, Lich KH, O'Daniel JM, Okuyama S, Tomlinson GE, Waltz M, Wilfond BS, Ackerman SL, and Majumder MA

Abstract

Introduction: Ensuring equitable access to health care is a widely agreed-upon goal in medicine, yet access to care is a multidimensional concept that is difficult to measure. Although frameworks exist to evaluate access to care generally, the concept of "access to genomic medicine" is largely unexplored and a clear framework for studying and addressing major dimensions is lacking., Methods: Comprised of seven clinical genomic research projects, the Clinical Sequencing Evidence-Generating Research consortium (CSER) presented opportunities to examine access to genomic medicine across diverse contexts. CSER emphasized engaging historically underrepresented and/or underserved populations. We used descriptive analysis of CSER participant survey data and qualitative case studies to explore anticipated and encountered access barriers and interventions to address them., Results: CSER's enrolled population was largely lower income and racially and ethnically diverse, with many Spanish-preferring individuals. In surveys, less than a fifth (18.7%) of participants reported experiencing barriers to care. However, CSER project case studies revealed a more nuanced picture that highlighted the blurred boundary between access to genomic research and clinical care. Drawing on insights from CSER, we build on an existing framework to characterize the concept and dimensions of access to genomic medicine along with associated measures and improvement strategies., Conclusions: Our findings support adopting a broad conceptualization of access to care encompassing multiple dimensions, using mixed methods to study access issues, and investing in innovative improvement strategies. This conceptualization may inform clinical translation of other cutting-edge technologies and contribute to the promotion of equitable, effective, and efficient access to genomic medicine., Competing Interests: The authors declare no conflict of interest., (© The Association for Clinical and Translational Science 2021.)

Published
2021
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