1. Renal Artery Variations in Patients With Mild-to-Moderate Hypertension From the RADIANCE-HTN SOLO Trial
- Author
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Felix Mahfoud, Terry Levy, Ajay J. Kirtane, Marc Sapoval, Jeremy Sayer, Andreas M. Loening, Leslie Coleman, Ronald J. Zagoria, Ajay N. Jain, Anthony Mathur, Yale Wang, Meital Horesh-Bar, Joost Daemen, Philipp Lurz, Suhail Dohad, Kintur Sanghvi, David Craig, Michel Azizi, Abbott Northwestern Hospital, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Queen Mary University of London (QMUL), Cedars-Sinai Medical Center, Université Paris Descartes - Paris 5 (UPD5), CIC - HEGP (CIC 1418), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPC), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), CArdiovasculaire Rénal Transplantation nEurovasculaire [Paris] (DMU CARTE), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Saarland University Hospital (UKS), Leipzig University, Royal Bournemouth Hospital, University of California [San Francisco] (UCSF), University of California, Stanford University, Columbia University Medical Center (CUMC), Columbia University [New York], and Cardiology
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medicine.medical_specialty ,[SDV]Life Sciences [q-bio] ,Blood Pressure ,Fibromuscular dysplasia ,Kidney ,Imaging ,Renal Artery ,medicine.artery ,medicine ,Humans ,Sympathectomy ,Renal artery ,Antihypertensive Agents ,Denervation ,medicine.diagnostic_test ,business.industry ,Ultrasound ,Angiography ,General Medicine ,medicine.disease ,Clinical trial ,Stenosis ,medicine.anatomical_structure ,Hypertension ,Renal denervation ,Radiology ,Cardiology and Cardiovascular Medicine ,business - Abstract
International audience; Purpose: To assess the variability of renal artery (RA) anatomy and presence of RA-pathology in patients with mild-to-moderate hypertension enrolled in the RADIANCE-HTN SOLO trial.Background: RADIANCE-HTN SOLO was a multicenter, international, blinded, randomized, sham-controlled trial evaluating ultrasound-based endovascular renal denervation (RDN) in patients with mild-to-moderate hypertension while off antihypertensive medications.Methods: Eligible subjects had pre-randomization renal CT- or MR- angiography (CTA, MRA) to confirm anatomic suitability and to define RA ablation sites. All images were sent for independent review for evaluation of RA anatomy and other vascular pathology.Results: A total of 324 patients underwent RA imaging (282 CTA and 42 MRA). Of those, 178 had simple anatomy with a single left and single right RA with mean diameters of 5.4 ± 0.9 and 5.1 ± 0.8 mm and mean lengths of 40.0 ± 12.9 and 52.0 ± 13.1 mm, respectively. Twenty-seven patients (8.3%) had unilateral or bilateral dual RAs with mean diameters of 4.0 ± 0.9 mm on the left and 3.9 ± 0.9 mm on the right. Forty percent (129/324) of patients had at least 1 accessory RA, with mean accessory diameters of 2.4 ± 0.8 mm on the left and 2.3 ± 0.8 mm on the right. Twenty-eight patients (8.6%) had at least 1 short (
- Published
- 2022