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Herein, we present an innovative and atom‐efficient synthesis of trimethine cyanines (Cy3) using formaldehyde (FA) as a single‐carbon reagent. The widespread application of Cy3 dyes in bioimaging and genomics/proteomics is often limited by synthetic routes plagued by low atom economy and substantial side‐product formation. Through systematic investigation, we have developed a practical and efficient synthetic pathway for both symmetrical and unsymmetrical Cy3 derivatives, significantly minimizing resource utilization. Notably, this approach yields water as the by‐product, in alignment with sustainable chemistry principles. Moreover, the efficient one‐pot synthesis facilitates the detection of intracellular FA levels, utilizing the fluorescence signal of Cy3 in live cells. It is also possible to detect endogenous FA in the intestinal tissues. We observed a significant decrease in FA in the small intestine of inflammatory bowel disease (IBD) mice as compared to healthy mice. This methodological advancement not only enhances the scope of fluorescent dye synthesis but also contributes to sustainable practices within chemical manufacturing, offering a significant leap forward in the development of environmentally friendly synthetic strategies. [ABSTRACT FROM AUTHOR]

Background: Subjective cognitive decline (SCD) can be considered as the preclinical manifestation of Alzheimer's disease. The objective of this study was to examine whether there would be differences of the clinical correlates due to evidence of subtle cognitive imparment (SCI) in inividuals with SCD. Method: One‐hundred‐and‐fifty‐five individuals with SCD (mean age: 68.18 ± 8.09 years) were included in this study. The participants underwent clinical assessments and completed detailed neuropsychological tests. The functional assessment was performed by the Korean Instrumental Activities of Daily Living (IADL) scale. Memory complaints were assessed using the Prospective and Retrospective Memory Questionnaire (PRMQ) consisting of 16 items that describe everyday memory failure. Result: SCD individuals with SCI (n = 20) had lower Mini‐Mental State Examination scores and showed lower performances in the neuropsychological tests than the SCD only group (n = 135). In addition, the SCI group had worse IADL performance than the SCD only group. There were no differenes in depressive symptoms and PRMQ scores between two groups. Conclusion: In SCD individuals, SCI was associated with subtle IADL deficits, but not with the severity of self‐reported memory complaints, compared to the SCD only group. These results suggest that functional assesments would be helpful for the clinical evaluation of individuals with SCD. [ABSTRACT FROM AUTHOR]