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Your search keyword '"Lee, Keun-Joong"' showing total 4 results
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4 results on '"Lee, Keun-Joong"'

1. Discovery of Insulin Receptor Partial Agonists MK-5160 and MK-1092 as Novel Basal Insulins with Potential to Improve Therapeutic Index

Author

Pissarnitski, Dmitri A., primary, Kekec, Ahmet, additional, Yan, Lin, additional, Zhu, Yuping, additional, Feng, Danqing D., additional, Huo, Pei, additional, Madsen-Duggan, Christina, additional, Moyes, Christopher R., additional, Nargund, Ravi P., additional, Kelly, Terri, additional, Zhang, Xiaoping, additional, Carballo-Jane, Ester, additional, Gorski, Judith, additional, Zafian, Peter, additional, Qatanani, Mo, additional, Kaarsholm, Niels, additional, Meng, Fanyu, additional, Jia, Xiujuan, additional, Lee, Keun-Joong, additional, Wang, Weixun, additional, Xu, Sherrie, additional, Hohn, Michael J., additional, Iammarino, Michael J., additional, McCoy, Mark A., additional, Okoh, Grace A., additional, Liang, Yingkai, additional, Hollingsworth, Scott A., additional, Erion, Mark D., additional, Kelley, David E., additional, Garbaccio, Robert M., additional, Zhang, Amy, additional, Mu, James, additional, and Lin, Songnian, additional

Published
2022
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2. Development of ProTx-II Analogues as Highly Selective Peptide Blockers of Nav1.7 for the Treatment of Pain

Author

Adams, Gregory L., primary, Pall, Parul S., additional, Grauer, Steven M., additional, Zhou, Xiaoping, additional, Ballard, Jeanine E., additional, Vavrek, Marissa, additional, Kraus, Richard L., additional, Morissette, Pierre, additional, Li, Nianyu, additional, Colarusso, Stefania, additional, Bianchi, Elisabetta, additional, Palani, Anandan, additional, Klein, Rebecca, additional, John, Christopher T., additional, Wang, Deping, additional, Tudor, Matthew, additional, Nolting, Andrew F., additional, Biba, Mirlinda, additional, Nowak, Timothy, additional, Makarov, Alexey A., additional, Reibarkh, Mikhail, additional, Buevich, Alexei V., additional, Zhong, Wendy, additional, Regalado, Erik L., additional, Wang, Xiao, additional, Gao, Qi, additional, Shahripour, Aurash, additional, Zhu, Yuping, additional, de Simone, Daniele, additional, Frattarelli, Tommaso, additional, Pasquini, Nicolo’ Maria, additional, Magotti, Paola, additional, Iaccarino, Roberto, additional, Li, Yuxing, additional, Solly, Kelli, additional, Lee, Keun-Joong, additional, Wang, Weixun, additional, Chen, Feifei, additional, Zeng, Haoyu, additional, Wang, Jixin, additional, Regan, Hilary, additional, Amin, Rupesh P., additional, Regan, Christopher P., additional, Burgey, Christopher S., additional, Henze, Darrell A., additional, Sun, Chengzao, additional, and Tellers, David M., additional

Published
2021
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3. Vaccine Hyporesponse Induced by Individual Antibiotic Treatment in Mice and Non-Human Primates Is Diminished upon Recovery of the Gut Microbiome

Author

Swaminathan, Gokul, primary, Citron, Michael, additional, Xiao, Jianying, additional, Norton, James E., additional, Reens, Abigail L., additional, Topçuoğlu, Begüm D., additional, Maritz, Julia M., additional, Lee, Keun-Joong, additional, Freed, Daniel C., additional, Weber, Teresa M., additional, White, Cory H., additional, Kadam, Mahika, additional, Spofford, Erin, additional, Bryant-Hall, Erin, additional, Salituro, Gino, additional, Kommineni, Sushma, additional, Liang, Xue, additional, Danilchanka, Olga, additional, Fontenot, Jane A., additional, Woelk, Christopher H., additional, Gutierrez, Dario A., additional, Hazuda, Daria J., additional, and Hannigan, Geoffrey D., additional

Published
2021
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4. Development of ProTx-II Analogues as Highly Selective Peptide Blockers of Na v 1.7 for the Treatment of Pain.

Author

Adams GL, Pall PS, Grauer SM, Zhou X, Ballard JE, Vavrek M, Kraus RL, Morissette P, Li N, Colarusso S, Bianchi E, Palani A, Klein R, John CT, Wang D, Tudor M, Nolting AF, Biba M, Nowak T, Makarov AA, Reibarkh M, Buevich AV, Zhong W, Regalado EL, Wang X, Gao Q, Shahripour A, Zhu Y, de Simone D, Frattarelli T, Pasquini NM, Magotti P, Iaccarino R, Li Y, Solly K, Lee KJ, Wang W, Chen F, Zeng H, Wang J, Regan H, Amin RP, Regan CP, Burgey CS, Henze DA, Sun C, and Tellers DM

Subjects
Animals, Cell Degranulation drug effects, Cystine chemistry, Drug Design, Hot Temperature, Mast Cells drug effects, Models, Molecular, Pain Measurement drug effects, Rats, Spider Venoms pharmacology, NAV1.7 Voltage-Gated Sodium Channel drug effects, Pain drug therapy, Sodium Channel Blockers chemical synthesis, Sodium Channel Blockers pharmacology, Spider Venoms chemical synthesis
Abstract

Inhibitor cystine knot peptides, derived from venom, have evolved to block ion channel function but are often toxic when dosed at pharmacologically relevant levels in vivo . The article describes the design of analogues of ProTx-II that safely display systemic in vivo blocking of Na v 1.7, resulting in a latency of response to thermal stimuli in rodents. The new designs achieve a better in vivo profile by improving ion channel selectivity and limiting the ability of the peptides to cause mast cell degranulation. The design rationale, structural modeling, in vitro profiles, and rat tail flick outcomes are disclosed and discussed.

Published
2022
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