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Cognitive appraisal theory predicts that emotions affect participation decisions around risky collective action. However, little existing research has attempted to parse out the mechanisms by which this process occurs. We build a global game of regime change and discuss the effects that fear may have on participation through pessimism about the state of the world, other players’ willingness to participate, and risk aversion. We test the behavioral effects of fear in this game by conducting 32 sessions of an experiment in two labs where participants are randomly assigned to an emotion induction procedure. In some rounds of the game, potential mechanisms are shut down to identify their contribution to the overall effect of fear. Our results show that in this context, fear does not affect willingness to participate. This finding highlights the importance of context, including integral versus incidental emotions and the size of the stakes, in shaping effect of emotions on behavior.

State repression and protest are common in modern authoritarian and hybrid regimes, yet individual responses to these events are not well understood. This article draws on unique panel data from the months spanning Zimbabwe’s 2018 election, which we view as a moment of uncertainty for most Zimbabwean citizens. Using a difference-in-difference estimator, we estimate change in individual protest intentions following exposure to repression and dissent and we assess three individual-level mechanisms hypothesized to drive responses. We find evidence that exposure to local repression and dissent are mobilizing among opposition supporters and nonpartisans. Analysis of potential mechanisms suggests that the effects of exposure to dissent may be driven by information updating, whereas relational and emotional mechanisms seem to drive backlash against repression, despite increased perceptions of risk. We find no evidence of counter-mobilization by ruling party supporters, and little effect of exposure to contentious events over social media.

How does exposure to criminal violence shape attitudes towards justice and the rule of law? Citizens care about crime prevention and procedural legality, yet they also value punishing perpetrators for the harm they have done. We argue that anger induced by exposure to criminal violence increases the demand for retribution and harsh punishments, even at the expense of the rule of law. We test this theory using one observational and two experimental studies from an original survey of 1,200 individuals in Western Mexico, a region affected by organized criminal violence and vigilantism. First, we first show that exposure to violence is correlated with increased anger and support for punitive justice, including vigilante actions. Second, across our two experiments, we show that citizens are more supportive of harsh punishments and place less value on their legality in response to morally outrageous crimes. Third, we find that the innocence of the victim, rather than the severity of the crime, is what triggers outrage and punitiveness. This suggests that citizens may support extreme levels of violence as long as they perceive that its targets are criminals. Finally, we show that outrageous forms of violence against civilians can lead individuals to prioritize harsh punishment regardless of its legality. When criminal actors target perceived innocents with common crimes like extortion, there is greater support for harsh, vigilante action. These patterns provide a bottom-up explanation for harsh justice.

Large numbers of people living under authoritarian governments participate in pro-opposition politics despite sometimes significant risks. Increasing amounts of this political participation are taking place and being organized online. Do emotions play a causal role in inducing pro-opposition participation in authoritarian regimes? Can emotions that mobilize participation be spread via social media? Through an experiment carried out by an opposition party in Zimbabwe, I test whether campaign appeals to opposition supporters’ emotions affect their level of political participation in online pro-opposition discussions. I find that across two different issue areas, randomly assigned anger appeals increase participation on average by 0.4 standard deviations more than enthusiasm appeals with the same informational content. In real terms, this represents between 30% and 170% more participation in the groups assigned to the anger appeals across four different measures of participation. There is little evidence that these effects are stronger in areas with less poverty or that have historically been affected by more violence, or when coupled with messages emphasizing personal power. These results suggest that anger appeals that highlight economic grievances can be an important force for mobilizing online political participation in repressive environments.

Purpose: The clinical utility of next-generation sequencing (NGS) in breast cancer has not been demonstrated. We hypothesized that we could perform NGS of a new biopsy from patients with metastatic triple-negative breast cancer (TNBC) in a clinically actionable timeframe.Experimental Design: We planned to enroll 40 patients onto a prospective study, Individualized Molecular Analyses Guide Efforts (IMAGE), to evaluate the feasibility of obtaining a new biopsy of a metastatic site, perform NGS (FoundationOne), and convene a molecular tumor board to formulate treatment recommendations within 28 days. We collected blood at baseline and at time of restaging to assess cell-free circulating plasma tumor DNA (ptDNA).Results: We enrolled 26 women with metastatic TNBC who had received ≥1 line of prior chemotherapy, and 20 (77%) underwent NGS of a metastatic site biopsy. Twelve (60%) evaluable patients received treatment recommendations within 28 days of consent. The study closed after 20 patients underwent NGS, based on protocol-specified interim futility analysis. Three patients went on to receive genomically directed therapies. Twenty-four of 26 patients had genetic alterations successfully detected in ptDNA. Among 5 patients, 4 mutations found in tumor tissues were not identified in blood, and 4 mutations found in blood were not found in corresponding tumors. In 9 patients, NGS of follow-up blood samples showed 100% concordance with baseline blood samples.Conclusions: This study demonstrates challenges of performing NGS on prospective tissue biopsies in patients with metastatic TNBC within 28 days, while also highlighting the potential use of blood as a more time-efficient and less invasive method of mutational assessment. Clin Cancer Res; 23(2); 379–86. ©2016 AACR.