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Anorexia nervosa (AN) is characterized by low body weight, disturbed eating, body image disturbance, anxiety, and interoceptive dysfunction. However, the neural processes underlying these dysfunctions in AN are unclear. This investigation combined an interoceptive pharmacological probe, the peripheral beta-adrenergic agonist isoproterenol, with resting state functional magnetic resonance imaging (rsfMRI) to examine whether individuals with AN relative to healthy comparisons (HC) show dysregulated neural coupling in central autonomic network brain regions.