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The current study met its primary end-point which suggests the feasibility of high-dose MTX plus cytarabine in elderly PCNSL patients, and the positive role of additive rituximab. While the backbone treatment for young patients consist of high-dose methotrexate (MTX) and cytarabine, their feasibility has not been widely tested in the elderly. [Extracted from the article]

Real-world data about the efficacy of pembrolizumab in R/R ENKTL patients are limited. Multivariate analysis indicated that ECOG PS was the only significant predictor of PFS after pembrolizumab treatment (hazard ratio, 5.33; 95% confidence interval, 1.09-26.1; I P i =.039) Overall, 14 (58.3%) patients experienced adverse events (AEs), with fatigue ( I n i = 7, 29.1%) being the most common Eight patients (33.3%) developed G3-4 AEs, the most frequent of which was neutropenia (4,16.7%) B Conclusion: b Pembrolizumab could be a therapeutic approach for the control of R/R ENKTL. B Background: b Extranodal natural killer T-cell lymphoma (ENKTL) is an aggressive malignancy with a dismal prognosis. [Extracted from the article]

Objective: To evaluate risk factors for hospital-acquired infection (HAI) in patients during the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic, including historical and concurrent cohorts., Design: Retrospective cohort., Setting: Three Missouri hospitals, data from 1 st January 2017 to 30 th September 2020., Participants: Patients aged ≥18 years and admitted for ≥48 h., Methods: Univariate and multi-variate Cox proportional hazards models incorporating the competing risk of death were used to determine risk factors for HAI. A-priori sensitivity analyses were performed to assess the robustness of the urine-, blood- and respiratory-culture-based HAI definition., Results: The cohort included 254,792 admissions, with 7147 (2.8%) HAIs (1661 blood, 3407 urine, 2626 respiratory). Patients with SARS-CoV-2 had increased risk of HAI (adjusted hazards ratio 1.65, 95% confidence interval 1.38-1.96), and SARS-CoV-2 infection was one of the strongest risk factors for development of HAI. Other risk factors for HAI included certain admitting services, chronic comorbidities, intensive care unit stay during index admission, extremes of body mass index, hospital, and selected medications. Factors associated with lower risk of HAI included year of admission (declined over the course of the study), admitting service and medications. Risk factors for HAI were similar in sensitivity analyses restricted to patients with diagnostic codes for pneumonia/upper respiratory infection and urinary tract infection., Conclusions: SARS-CoV-2 was associated with significantly increased risk of HAI., (Copyright © 2022 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.)