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Your search keyword '"Kundu, Kunal"' showing total 4 results
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4 results on '"Kundu, Kunal"'

1. Intratumoral dendritic cell–CD4+ T helper cell niches enable CD8+ T cell differentiation following PD-1 blockade in hepatocellular carcinoma

Author

Magen, Assaf, Hamon, Pauline, Fiaschi, Nathalie, Soong, Brian Y., Park, Matthew D., Mattiuz, Raphaël, Humblin, Etienne, Troncoso, Leanna, D’souza, Darwin, Dawson, Travis, Kim, Joel, Hamel, Steven, Buckup, Mark, Chang, Christie, Tabachnikova, Alexandra, Schwartz, Hara, Malissen, Nausicaa, Lavin, Yonit, Soares-Schanoski, Alessandra, Giotti, Bruno, Hegde, Samarth, Ioannou, Giorgio, Gonzalez-Kozlova, Edgar, Hennequin, Clotilde, Le Berichel, Jessica, Zhao, Zhen, Ward, Stephen C., Fiel, Isabel, Kou, Baijun, Dobosz, Michael, Li, Lianjie, Adler, Christina, Ni, Min, Wei, Yi, Wang, Wei, Atwal, Gurinder S., Kundu, Kunal, Cygan, Kamil J., Tsankov, Alexander M., Rahman, Adeeb, Price, Colles, Fernandez, Nicolas, He, Jiang, Gupta, Namita T., Kim-Schulze, Seunghee, Gnjatic, Sacha, Kenigsberg, Ephraim, Deering, Raquel P., Schwartz, Myron, Marron, Thomas U., Thurston, Gavin, Kamphorst, Alice O., and Merad, Miriam

Published
2023
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2. 690 Correlates of poor response to neoadjuvant anti-PD-1 therapy in hepatocellular carcinoma (HCC) include WNT pathway activation and loss of HLA expression

Author

Kundu, Kunal, primary, Fiaschi, Nathalie, additional, Wang, Wei, additional, Kou, Baijun, additional, Magen, Assaf, additional, Hamon, Pauline, additional, Gnjatic, Sacha, additional, Schwartz, Myron, additional, Kamphorst, Alice, additional, Marron, Thomas, additional, Merad, Miriam, additional, Guo, Chunguang, additional, Thurston, Gavin, additional, Gupta, Namita, additional, and Cygan, Kamil, additional

Published
2022
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3. Intratumoral mregDC and CXCL13 T helper niches enable local differentiation of CD8 T cells following PD-1 blockade

Author

Magen, Assaf, primary, Hamon, Pauline, additional, Fiaschi, Nathalie, additional, Troncoso, Leanna, additional, Humblin, Etienne, additional, D’souza, Darwin, additional, Dawson, Travis, additional, Park, Matthew D., additional, Kim, Joel, additional, Hamel, Steven, additional, Buckup, Mark, additional, Chang, Christie, additional, Tabachnikova, Alexandra, additional, Schwartz, Hara, additional, Malissen, Nausicaa, additional, Lavin, Yonit, additional, Soares-Schanoski, Alessandra, additional, Giotti, Bruno, additional, Hegde, Samarth, additional, Mattiuz, Raphaël, additional, Hennequin, Clotilde, additional, Berichel, Jessica Le, additional, Zhao, Zhen, additional, Ward, Stephen, additional, Fiel, Isabel, additional, Price, Colles, additional, Fernandez, Nicolas, additional, He, Jiang, additional, Kou, Baijun, additional, Dobosz, Michael, additional, Li, Lianjie, additional, Adler, Christina, additional, Ni, Min, additional, Wei, Yi, additional, Wang, Wei, additional, Gupta, Namita T., additional, Kundu, Kunal, additional, Cygan, Kamil, additional, Deering, Raquel P., additional, Tsankov, Alex, additional, Kim-Schulze, Seunghee, additional, Gnjatic, Sacha, additional, Kenigsberg, Ephraim, additional, Schwartz, Myron, additional, Marron, Thomas U., additional, Thurston, Gavin, additional, Kamphorst, Alice O., additional, and Merad, Miriam, additional

Published
2022
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4. Intratumoral dendritic cell–CD4+T helper cell niches enable CD8+T cell differentiation following PD-1 blockade in hepatocellular carcinoma

Author

Magen, Assaf, Hamon, Pauline, Fiaschi, Nathalie, Soong, Brian Y., Park, Matthew D., Mattiuz, Raphaël, Humblin, Etienne, Troncoso, Leanna, D’souza, Darwin, Dawson, Travis, Kim, Joel, Hamel, Steven, Buckup, Mark, Chang, Christie, Tabachnikova, Alexandra, Schwartz, Hara, Malissen, Nausicaa, Lavin, Yonit, Soares-Schanoski, Alessandra, Giotti, Bruno, Hegde, Samarth, Ioannou, Giorgio, Gonzalez-Kozlova, Edgar, Hennequin, Clotilde, Le Berichel, Jessica, Zhao, Zhen, Ward, Stephen C., Fiel, Isabel, Kou, Baijun, Dobosz, Michael, Li, Lianjie, Adler, Christina, Ni, Min, Wei, Yi, Wang, Wei, Atwal, Gurinder S., Kundu, Kunal, Cygan, Kamil J., Tsankov, Alexander M., Rahman, Adeeb, Price, Colles, Fernandez, Nicolas, He, Jiang, Gupta, Namita T., Kim-Schulze, Seunghee, Gnjatic, Sacha, Kenigsberg, Ephraim, Deering, Raquel P., Schwartz, Myron, Marron, Thomas U., Thurston, Gavin, Kamphorst, Alice O., and Merad, Miriam

Abstract

Despite no apparent defects in T cell priming and recruitment to tumors, a large subset of T cell rich tumors fail to respond to immune checkpoint blockade (ICB). We leveraged a neoadjuvant anti-PD-1 trial in patients with hepatocellular carcinoma (HCC), as well as additional samples collected from patients treated off-label, to explore correlates of response to ICB within T cell-rich tumors. We show that ICB response correlated with the clonal expansion of intratumoral CXCL13+CH25H+IL-21+PD-1+CD4+T helper cells (“CXCL13+TH”) and Granzyme K+PD-1+effector-like CD8+T cells, whereas terminally exhausted CD39hiTOXhiPD-1hiCD8+T cells dominated in nonresponders. CD4+and CD8+T cell clones that expanded post-treatment were found in pretreatment biopsies. Notably, PD-1+TCF-1+(Progenitor-exhausted) CD8+T cells shared clones mainly with effector-like cells in responders or terminally exhausted cells in nonresponders, suggesting that local CD8+T cell differentiation occurs upon ICB. We found that these Progenitor CD8+T cells interact with CXCL13+THwithin cellular triads around dendritic cells enriched in maturation and regulatory molecules, or “mregDC”. These results suggest that discrete intratumoral niches that include mregDC and CXCL13+THcontrol the differentiation of tumor-specific Progenitor exhasuted CD8+T cells following ICB.

Published
2023
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