20 results on '"Kuhn, Tilman"'
Search Results
2. Big data and data-related abuses of market power
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Kuhn, Tilman, primary, O’Shaughnessy, Kristen, additional, Pesch, Tobias, additional, Phillips, Jaclyn, additional, and Sokol, D. Daniel, additional
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- 2023
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3. Sustainable Diets and Cancer: a Systematic Review
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Karavasiloglou, Nena, Pannen, Sarah T., Jochem, Carmen, Kuhn, Tilman, and Rohrmann, Sabine
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- 2022
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4. Adherence to a healthful plant-based diet and risk of chronic kidney disease among individuals with diabetes: A prospective cohort study
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Thompson, Alysha S., primary, Tresserra-Rimbau, Anna, additional, Jennings, Amy, additional, Bondonno, Nicola P., additional, Candussi, Catharina J., additional, O'Neill, Joshua K., additional, Hill, Claire, additional, Gaggl, Martina, additional, Cassidy, Aedin, additional, and Kuhn, Tilman, additional
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- 2024
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5. Health aspects of vegan diets among children and adolescents: a systematic review and meta-analyses
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Kuhn, Tilman, primary, Koller, Alina, additional, Rohrmann, Sabine, additional, Wakolbinger, Maria, additional, Gojda, Jan, additional, Selinger, Eliska, additional, Cahova, Monika, additional, Svetnicka, Martin, additional, Schlesinger, Sabrina, additional, Haider, Sandra, additional, and Keller, Jeffrey, additional
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- 2023
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6. High prevalence of iodine deficiency among vegan compared to vegetarian and omnivore children in the Czech Republic: cross sectional study
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Světnička, Martin, primary, Heniková, Marina, additional, Selinger, Eliška, additional, Ouřadová, Anna, additional, Potočková, Jana, additional, Kuhn, Tilman, additional, Gojda, Jan, additional, and El-Lababidi, Eva, additional
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- 2023
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7. Prediagnostic serum calcium concentrations and risk of colorectal cancer development in 2 large European prospective cohorts
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Karavasiloglou, Nena, Hughes, David J., Murphy, Neil, Schomburg, Lutz, Sun, Qian, Seher, Vartiter, Rohrmann, Sabine, Weiderpass, Elisabete, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Mahamat-Saleh, Yahya, Kaaks, Rudolf, Kuhn, Tilman, Schulze, Matthias B., Tumino, Rosario, Panico, Salvatore, Masala, Giovanna, Pala, Valeria, Sacerdote, Carlotta, Derksen, Jeroen W G, Skeie, Guri, Hjartåker, Anette, Lasheras, Cristina, Agudo, Antonio, Sánchez, Maria-José, Chirlaque, Maria-Dolores, Ardanaz, Eva, Amiano, Pilar, van Guelpen, Bethany, Gylling, Björn, Bradbury, Kathryn E., Papier, Keren, Freisling, Heinz, Aglago, Elom K., Cross, Amanda J., Riboli, Elio, Aune, Dagfinn, Gunter, Marc J., Jenab, Mazda, Karavasiloglou, Nena, Hughes, David J., Murphy, Neil, Schomburg, Lutz, Sun, Qian, Seher, Vartiter, Rohrmann, Sabine, Weiderpass, Elisabete, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Mahamat-Saleh, Yahya, Kaaks, Rudolf, Kuhn, Tilman, Schulze, Matthias B., Tumino, Rosario, Panico, Salvatore, Masala, Giovanna, Pala, Valeria, Sacerdote, Carlotta, Derksen, Jeroen W G, Skeie, Guri, Hjartåker, Anette, Lasheras, Cristina, Agudo, Antonio, Sánchez, Maria-José, Chirlaque, Maria-Dolores, Ardanaz, Eva, Amiano, Pilar, van Guelpen, Bethany, Gylling, Björn, Bradbury, Kathryn E., Papier, Keren, Freisling, Heinz, Aglago, Elom K., Cross, Amanda J., Riboli, Elio, Aune, Dagfinn, Gunter, Marc J., and Jenab, Mazda
- Abstract
BACKGROUND: Higher dietary calcium consumption is associated with lower colorectal cancer (CRC) risk. However, little data are available on the association between circulating calcium concentrations and CRC risk. OBJECTIVES: To explore the association between circulating calcium concentrations and CRC risk using data from 2 large European prospective cohort studies. METHODS: Conditional logistic regression models were used to calculate multivariable-adjusted ORs and 95% CIs in case-control studies nested within the European Prospective Investigation into Cancer and Nutrition (EPIC; n-cases = 947, n-controls = 947) and the UK Biobank (UK-BB; n-cases = 2759, n-controls = 12,021) cohorts. RESULTS: In EPIC, nonalbumin-adjusted total serum calcium (a proxy of free calcium) was not associated with CRC (OR: 0.94; 95% CI: 0.85, 1.03; modeled as continuous variable, per 1 mg/dL increase), colon cancer (OR: 0.93; 95% CI: 0.82, 1.05) or rectal cancer (OR: 1.01; 95% CI: 0.84, 1.20) risk in the multivariable adjusted model. In the UK-BB, serum ionized calcium (free calcium, most active form) was inversely associated with the risk of CRC (OR: 0.85; 95% CI: 0.76, 0.95; per 1 mg/dL) and colon cancer (OR: 0.78; 95% CI: 0.68, 0.90), but not rectal cancer (OR: 1.02; 95% CI: 0.83, 1.24) in multivariable adjusted models. Meta-analysis of EPIC and UK-BB CRC risk estimates showed an inverse risk association for CRC in the multivariable adjusted model (OR: 0.90; 95%CI: 0.84, 0.97). In analyses by quintiles, in both cohorts, higher levels of serum calcium were associated with reduced CRC risk (EPIC: ORQ5vs.Q1: 0.69; 95% CI: 0.47, 1.00; P-trend = 0.03; UK-BB: ORQ5vs.Q1: 0.82; 95% CI: 0.72, 0.94; P-trend < 0.01). Analyses by anatomical subsite showed an inverse cancer risk association in the colon (EPIC: ORQ5vs.Q1: 0.63, 95% CI: 0.39, 1.02; P-trend = 0.05; UK-BB: ORQ5vs.Q1: 0.75; 95% CI: 0.64, 0.88; P-trend < 0.01) but not the rectum. CONCLUSIONS: In UK-BB, higher serum ionized calcium
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- 2023
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8. Prediagnostic serum calcium concentrations and risk of colorectal cancer development in 2 large European prospective cohorts
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Epi Kanker Team B, Cancer, Karavasiloglou, Nena, Hughes, David J, Murphy, Neil, Schomburg, Lutz, Sun, Qian, Seher, Vartiter, Rohrmann, Sabine, Weiderpass, Elisabete, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Mahamat-Saleh, Yahya, Kaaks, Rudolf, Kuhn, Tilman, Schulze, Matthias B, Tumino, Rosario, Panico, Salvatore, Masala, Giovanna, Pala, Valeria, Sacerdote, Carlotta, Derksen, Jeroen W G, Skeie, Guri, Hjartåker, Anette, Lasheras, Cristina, Agudo, Antonio, Sánchez, Maria-José, Chirlaque, Maria-Dolores, Ardanaz, Eva, Amiano, Pilar, Van Guelpen, Bethany, Gylling, Björn, Bradbury, Kathryn E, Papier, Keren, Freisling, Heinz, Aglago, Elom K, Cross, Amanda J, Riboli, Elio, Aune, Dagfinn, Gunter, Marc J, Jenab, Mazda, Epi Kanker Team B, Cancer, Karavasiloglou, Nena, Hughes, David J, Murphy, Neil, Schomburg, Lutz, Sun, Qian, Seher, Vartiter, Rohrmann, Sabine, Weiderpass, Elisabete, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Mahamat-Saleh, Yahya, Kaaks, Rudolf, Kuhn, Tilman, Schulze, Matthias B, Tumino, Rosario, Panico, Salvatore, Masala, Giovanna, Pala, Valeria, Sacerdote, Carlotta, Derksen, Jeroen W G, Skeie, Guri, Hjartåker, Anette, Lasheras, Cristina, Agudo, Antonio, Sánchez, Maria-José, Chirlaque, Maria-Dolores, Ardanaz, Eva, Amiano, Pilar, Van Guelpen, Bethany, Gylling, Björn, Bradbury, Kathryn E, Papier, Keren, Freisling, Heinz, Aglago, Elom K, Cross, Amanda J, Riboli, Elio, Aune, Dagfinn, Gunter, Marc J, and Jenab, Mazda
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- 2023
9. Health aspects of vegan diets among children and adolescents: a systematic review and meta-analyses
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Koller, Alina, Rohrmann, Sabine; https://orcid.org/0000-0002-2215-1200, Wakolbinger, Maria, Gojda, Jan, Selinger, Eliska, Cahova, Monika, Světnička, Martin, Haider, Sandra, Schlesinger, Sabrina, Kuhn, Tilman; https://orcid.org/0000-0001-7702-317X, Keller, Jeffrey W; https://orcid.org/0000-0003-3286-4105, Koller, Alina, Rohrmann, Sabine; https://orcid.org/0000-0002-2215-1200, Wakolbinger, Maria, Gojda, Jan, Selinger, Eliska, Cahova, Monika, Světnička, Martin, Haider, Sandra, Schlesinger, Sabrina, Kuhn, Tilman; https://orcid.org/0000-0001-7702-317X, and Keller, Jeffrey W; https://orcid.org/0000-0003-3286-4105
- Abstract
Health effects of vegan diets among children and adolescents are a controversial public health topic. Thus, the aim of the present systematic review is to evaluate a broad range of health outcomes among vegan children and adolescents aged 0 to 18 years. 18 studies met the inclusion criteria (17 cross-sectional, 1 RCT). Meta-analyses showed lower protein, calcium, vitamin B2, saturated fatty acid, and cholesterol intakes, and lower ferritin, HDL and LDL levels as well as height in vegan compared to omnivorous children/adolescents. Higher intakes of carbohydrates, polyunsaturated fatty acids, fiber, folate, vitamins C and E, magnesium, iron, and potassium were observed in vegans. Blood levels of vitamin B12 were higher among vegan children due to supplement use. Single study results suggested further differences between vegan and non-vegan children, such as lower bone mineral content or urinary iodine among vegan children. Risk of Bias was rated as high or very high in 7 out of 18 studies. The certainty of evidence for the meta-analyses was low (n = 2) or very low (n = 46). Overall, the available evidence points to both risks and benefits associated with a vegan diet among children, although more and better designed studies are needed.
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- 2023
10. Association of Healthful Plant-based Diet Adherence With Risk of Mortality and Major Chronic Diseases Among Adults in the UK
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Thompson, Alysha S, Tresserra-Rimbau, Anna, Karavasiloglou, Nena; https://orcid.org/0000-0001-5284-6612, Jennings, Amy, Cantwell, Marie, Hill, Claire, Perez-Cornago, Aurora, Bondonno, Nicola P, Murphy, Neil, Rohrmann, Sabine; https://orcid.org/0000-0002-2215-1200, Cassidy, Aedin, Kuhn, Tilman; https://orcid.org/0000-0001-7702-317X, Thompson, Alysha S, Tresserra-Rimbau, Anna, Karavasiloglou, Nena; https://orcid.org/0000-0001-5284-6612, Jennings, Amy, Cantwell, Marie, Hill, Claire, Perez-Cornago, Aurora, Bondonno, Nicola P, Murphy, Neil, Rohrmann, Sabine; https://orcid.org/0000-0002-2215-1200, Cassidy, Aedin, and Kuhn, Tilman; https://orcid.org/0000-0001-7702-317X
- Abstract
IMPORTANCE Plant-based diets have gained popularity for both environmental and health reasons, but a comprehensive assessment of their quality in relation to risk of mortality and major chronic diseases is lacking. OBJECTIVE To examine whether healthful vs unhealthful plant-based dietary patterns are associated with mortality and major chronic diseases among UK adults. DESIGN, SETTING, AND PARTICIPANTS This prospective cohort study used data from adults in the UK Biobank, a large-scale population-based study. Participants were recruited between 2006 and 2010 and followed up using record linkage data until 2021; follow-up for different outcomes ranged between 10.6 and 12.2 years. Data analysis was conducted from November 2021 to October 2022. EXPOSURES Adherence to a healthful vs unhealthful plant-based diet index (hPDI vs uPDI) derived from 24-hour dietary assessments. MAIN OUTCOMES AND MEASURES The main outcomes were hazard ratios (HRs) and 95% CIs of mortality (overall and cause specific), cardiovascular disease (CVD [total, myocardial infarction, ischemic stroke, and hemorrhagic stroke]), cancer (total, breast, prostate, and colorectal), and fracture (total, vertebrae, and hip) across quartiles of hPDI and uPDI adherence. RESULTS This study included 126 394 UK Biobank participants. They had a mean (SD) age of 56.1 (7.8) years; 70 618 (55.9%) were women. The majority of participants (115 371 [91.3%]) were White. Greater adherence to the hPDI was associated with lower risks of total mortality, cancer, and CVD, with HRs (95% CIs) of 0.84 (0.78-0.91), 0.93 (0.88-0.99), and 0.92 (0.86-0.99), respectively, for participants in the highest hPDI quartile compared with the lowest. The hPDI was also associated with lower risks of myocardial infarction and ischemic stroke, with HRs (95% CIs) of 0.86 (0.78-0.95) and 0.84 (0.71-0.99), respectively. By contrast, higher uPDI scores were associated with higher risks of mortality, CVD, and cancer. The associations observed did not
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- 2023
11. Prediagnostic serum calcium concentrations and risk of colorectal cancer development in 2 large European prospective cohorts
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Karavasiloglou, Nena; https://orcid.org/0000-0001-5284-6612, Hughes, David J, Murphy, Neil, Schomburg, Lutz, Sun, Qian, Seher, Vartiter, Rohrmann, Sabine, Weiderpass, Elisabete, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Mahamat-Saleh, Yahya, Kaaks, Rudolf, Kuhn, Tilman, Schulze, Matthias B, Tumino, Rosario, Panico, Salvatore, Masala, Giovanna, Pala, Valeria, Sacerdote, Carlotta, Derksen, Jeroen W G, Skeie, Guri, Hjartåker, Anette, Lasheras, Cristina, Agudo, Antonio, Sánchez, Maria-José, Chirlaque, Maria-Dolores, Ardanaz, Eva, et al, Karavasiloglou, Nena; https://orcid.org/0000-0001-5284-6612, Hughes, David J, Murphy, Neil, Schomburg, Lutz, Sun, Qian, Seher, Vartiter, Rohrmann, Sabine, Weiderpass, Elisabete, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Mahamat-Saleh, Yahya, Kaaks, Rudolf, Kuhn, Tilman, Schulze, Matthias B, Tumino, Rosario, Panico, Salvatore, Masala, Giovanna, Pala, Valeria, Sacerdote, Carlotta, Derksen, Jeroen W G, Skeie, Guri, Hjartåker, Anette, Lasheras, Cristina, Agudo, Antonio, Sánchez, Maria-José, Chirlaque, Maria-Dolores, Ardanaz, Eva, and et al
- Abstract
BACKGROUND: Higher dietary calcium consumption is associated with lower colorectal cancer (CRC) risk. However, little data are available on the association between circulating calcium concentrations and CRC risk. OBJECTIVES: To explore the association between circulating calcium concentrations and CRC risk using data from 2 large European prospective cohort studies. METHODS: Conditional logistic regression models were used to calculate multivariable-adjusted ORs and 95% CIs in case-control studies nested within the European Prospective Investigation into Cancer and Nutrition (EPIC; n-cases = 947, n-controls = 947) and the UK Biobank (UK-BB; n-cases = 2759, n-controls = 12,021) cohorts. RESULTS: In EPIC, nonalbumin-adjusted total serum calcium (a proxy of free calcium) was not associated with CRC (OR: 0.94; 95% CI: 0.85, 1.03; modeled as continuous variable, per 1 mg/dL increase), colon cancer (OR: 0.93; 95% CI: 0.82, 1.05) or rectal cancer (OR: 1.01; 95% CI: 0.84, 1.20) risk in the multivariable adjusted model. In the UK-BB, serum ionized calcium (free calcium, most active form) was inversely associated with the risk of CRC (OR: 0.85; 95% CI: 0.76, 0.95; per 1 mg/dL) and colon cancer (OR: 0.78; 95% CI: 0.68, 0.90), but not rectal cancer (OR: 1.02; 95% CI: 0.83, 1.24) in multivariable adjusted models. Meta-analysis of EPIC and UK-BB CRC risk estimates showed an inverse risk association for CRC in the multivariable adjusted model (OR: 0.90; 95%CI: 0.84, 0.97). In analyses by quintiles, in both cohorts, higher levels of serum calcium were associated with reduced CRC risk (EPIC: OR$_{Q5vs.Q1}$: 0.69; 95% CI: 0.47, 1.00; P-trend = 0.03; UK-BB: OR$_{Q5vs.Q1}$: 0.82; 95% CI: 0.72, 0.94; P-trend < 0.01). Analyses by anatomical subsite showed an inverse cancer risk association in the colon (EPIC: OR$_{Q5vs.Q1}$: 0.63, 95% CI: 0.39, 1.02; P-trend = 0.05; UK-BB: OR$_{Q5vs.Q1}$: 0.75; 95% CI: 0.64, 0.88; P-trend < 0.01) but not the rectum. CONCLUSIONS: In UK-BB, higher serum io
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- 2023
12. How prevalent is a cancer-protective lifestyle? Adherence to the 2018 World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations in Switzerland
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Karavasiloglou, Nena; https://orcid.org/0000-0001-5284-6612, Pestoni, Giulia; https://orcid.org/0000-0002-5933-7439, Pannen, Sarah Theresa, Schönenberger, Katja Angela; https://orcid.org/0000-0002-2122-4746, Kuhn, Tilman, Rohrmann, Sabine; https://orcid.org/0000-0002-2215-1200, Karavasiloglou, Nena; https://orcid.org/0000-0001-5284-6612, Pestoni, Giulia; https://orcid.org/0000-0002-5933-7439, Pannen, Sarah Theresa, Schönenberger, Katja Angela; https://orcid.org/0000-0002-2122-4746, Kuhn, Tilman, and Rohrmann, Sabine; https://orcid.org/0000-0002-2215-1200
- Abstract
Population monitoring of lifestyle behaviours that are crucial as risk and protective factors for major chronic diseases is vital for the identification of priority areas for public health. In this study, we aimed to investigate the prevalence of adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) cancer prevention recommendations in Switzerland, overall and by selected sociodemographic and lifestyle characteristics. Data from the population-based, cross-sectional survey menuCH were used. We constructed a score reflecting adherence to the 2018 WCRF/AICR cancer prevention recommendations. Multinomial logistic regression models were fitted to investigate the association of sociodemographic and lifestyle characteristics with the level of adherence to the WCRF/AICR cancer prevention recommendations. The least frequently met cancer prevention recommendations were the ones on fibre intake (met by 13·7 %), red and processed meat (25·4 %), and ultra-processed food (33·3 %) consumption, while the recommendation on physical activity was met by almost 80 %. Women and individuals with tertiary education were more likely to have a score of ≥ 5 (as a reflection of adherence to the cancer prevention recommendations), compared with men or those who completed secondary education, respectively. Current smokers were less likely to have a score of ≥ 5, compared with never smokers. A high proportion of the population in Switzerland was found to not adhere closely to the WCRF/AICR cancer prevention recommendations. Differences were detected based on sociodemographic characteristics. Education and policy actions are needed to facilitate the adoption of a cancer-protective lifestyle.
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- 2023
13. How prevalent is a cancer-protective lifestyle? Adherence to the 2018 World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations in Switzerland.
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Karavasiloglou, Nena, Pestoni, Giulia, Pannen, Sarah Theresa, Schönenberger, Katja Angela, Kuhn, Tilman, and Rohrmann, Sabine
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TUMOR prevention ,LIFESTYLES ,CROSS-sectional method ,RISK assessment ,SOCIOECONOMIC factors ,RESEARCH funding ,DESCRIPTIVE statistics ,TUMORS ,LOGISTIC regression analysis - Abstract
Population monitoring of lifestyle behaviours that are crucial as risk and protective factors for major chronic diseases is vital for the identification of priority areas for public health. In this study, we aimed to investigate the prevalence of adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) cancer prevention recommendations in Switzerland, overall and by selected sociodemographic and lifestyle characteristics. Data from the population-based, cross-sectional survey menuCH were used. We constructed a score reflecting adherence to the 2018 WCRF/AICR cancer prevention recommendations. Multinomial logistic regression models were fitted to investigate the association of sociodemographic and lifestyle characteristics with the level of adherence to the WCRF/AICR cancer prevention recommendations. The least frequently met cancer prevention recommendations were the ones on fibre intake (met by 13·7 %), red and processed meat (25·4 %), and ultra-processed food (33·3 %) consumption, while the recommendation on physical activity was met by almost 80 %. Women and individuals with tertiary education were more likely to have a score of ≥ 5 (as a reflection of adherence to the cancer prevention recommendations), compared with men or those who completed secondary education, respectively. Current smokers were less likely to have a score of ≥ 5, compared with never smokers. A high proportion of the population in Switzerland was found to not adhere closely to the WCRF/AICR cancer prevention recommendations. Differences were detected based on sociodemographic characteristics. Education and policy actions are needed to facilitate the adoption of a cancer-protective lifestyle. [ABSTRACT FROM AUTHOR]
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- 2023
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14. Estimating the Level of Asymptomatic COVID-19 Infections in Northern Ireland in 2020
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Hall, Peter A., Kiss, Gabor, Kuhn, Tilman, Moutari, Salissou, Patterson, Ellen, and Smith, Emily
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SDG 3 - Good Health and Well-being ,General Medicine - Abstract
The identification and understanding of COVID-19 potential routes of transmission are fundamental to informing policies and strategies to successfully control the outbreak. Various studies highlighted asymptomatic infections as one of the silent drivers of the epidemic. An accurate estimation of the asymptomatic cases and the understanding of their contribution to the spread of the disease could enhance the effectiveness of current control strategies, mainly based on the symptom onset, to curb transmission. We investigate the dynamics of the COVID-19 epidemic in Northern Ireland during the period 1st March 25th to December 2020 to estimate the proportion of the asymptomatic infections in the country. We extended our previous model to include the stage of the asymptomatic infection, and we implement the corresponding deterministic model using a publicly available dataset. We partition the data into 11 sets over the period of study and fit the model parameters on the consecutive intervals using the cumulative number of confirmed positive cases for each interval. Moreover, we assess numerically the impacts of uncertainty in testing and we provide estimates of the reproduction numbers using the fitted parameters. We found that the proportion of asymptomatically infectious subpopulations, in Northern Ireland during the period of study, ranged between 5% and 25% of exposed individuals. Also, the estimate of the basic reproduction number, R0, is 3.3089. The lower and upper estimates for herd immunity are (0.6181, 0.7243) suggesting that around 70% of the population of Northern Ireland should acquire immunity via infection or vaccination, which is in line with estimates reported in other studies.
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- 2022
15. How prevalent is a cancer-protective lifestyle? Adherence to the 2018 World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations in Switzerland
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Karavasiloglou, Nena, primary, Pestoni, Giulia, additional, Pannen, Sarah Theresa, additional, Schönenberger, Katja Angela, additional, Kuhn, Tilman, additional, and Rohrmann, Sabine, additional
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- 2022
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16. Prediagnostic serum calcium concentrations and risk of colorectal cancer development in 2 large European prospective cohorts
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Karavasiloglou, Nena, primary, Hughes, David J., additional, Murphy, Neil, additional, Schomburg, Lutz, additional, Sun, Qian, additional, Seher, Vartiter, additional, Rohrmann, Sabine, additional, Weiderpass, Elisabete, additional, Tjønneland, Anne, additional, Olsen, Anja, additional, Overvad, Kim, additional, Boutron-Ruault, Marie-Christine, additional, Mancini, Francesca Romana, additional, Mahamat-Saleh, Yahya, additional, Kaaks, Rudolf, additional, Kuhn, Tilman, additional, Schulze, Matthias B., additional, Tumino, Rosario, additional, Panico, Salvatore, additional, Masala, Giovanna, additional, Pala, Valeria, additional, Sacerdote, Carlotta, additional, Derksen, Jeroen W.G., additional, Skeie, Guri, additional, Hjartåker, Anette, additional, Lasheras, Cristina, additional, Agudo, Antonio, additional, Sánchez, Maria-José, additional, Chirlaque, Maria-Dolores, additional, Ardanaz, Eva, additional, Amiano, Pilar, additional, Van Guelpen, Bethany, additional, Gylling, Björn, additional, Bradbury, Kathryn E., additional, Papier, Keren, additional, Freisling, Heinz, additional, Aglago, Elom K., additional, Cross, Amanda J., additional, Riboli, Elio, additional, Aune, Dagfinn, additional, Gunter, Marc J., additional, and Jenab, Mazda, additional
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- 2022
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17. Sustainable Diets and Cancer: a Systematic Review
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Karavasiloglou, Nena; https://orcid.org/0000-0001-5284-6612, Pannen, Sarah T; https://orcid.org/0000-0003-1806-6043, Jochem, Carmen, Kuhn, Tilman; https://orcid.org/0000-0001-7702-317X, Rohrmann, Sabine; https://orcid.org/0000-0002-2215-1200, Karavasiloglou, Nena; https://orcid.org/0000-0001-5284-6612, Pannen, Sarah T; https://orcid.org/0000-0003-1806-6043, Jochem, Carmen, Kuhn, Tilman; https://orcid.org/0000-0001-7702-317X, and Rohrmann, Sabine; https://orcid.org/0000-0002-2215-1200
- Abstract
PURPOSE OF REVIEW This review aimed to investigate the association of sustainable diets in relation to cancer risk, cancer recurrence, and cancer-specific mortality in adults. RECENT FINDINGS More than 500 articles were initially identified. Nine articles were eligible for inclusion, presenting data from 8 prospective cohort studies, conducted in Europe and the USA. The sustainability indicators investigated were greenhouse gas emissions, food biodiversity, land use, exposure to pesticides or organic food consumption, and the EAT-Lancet diet. One study reported a sustainability index that combined multiple sustainability indicators. A modest inverse association between higher adherence to sustainable diets and cancer incidence or cancer mortality was observed in most studies. While sustainable diets may decrease cancer risk or mortality, the reviewed studies were heterogeneous regarding sustainability indicators and cancer outcomes. A common definition of dietary sustainability would facilitate better generalization of future research findings. Also, studies among non-western populations are needed.
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- 2022
18. Factors associated with serum ferritin levels and iron excess: results from the EPIC-EurGast study
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Universitat Rovira i Virgili, Iglesias-Vazquez, Lucia; Arija, Victoria; Aranda, Nuria; Aglago, Elom K.; Cross, Amanda J.; Schulze, Matthias B.; Quintana Pacheco, Daniel; Kuhn, Tilman; Weiderpass, Elisabete; Tumino, Rosario; Redondo-Sanchez, Daniel; de Magistris, Maria Santucci; Palli, Domenico; Ardanaz, Eva; Laouali, Nasser; Sonestedt, Emily; Drake, Isabel; Rizzolo, Lucia; Santiuste, Carmen; Sacerdote, Carlotta; Quiros, Ramon; Amiano, Pilar; Agudo, Antonio; Jakszyn, Paula, Universitat Rovira i Virgili, and Iglesias-Vazquez, Lucia; Arija, Victoria; Aranda, Nuria; Aglago, Elom K.; Cross, Amanda J.; Schulze, Matthias B.; Quintana Pacheco, Daniel; Kuhn, Tilman; Weiderpass, Elisabete; Tumino, Rosario; Redondo-Sanchez, Daniel; de Magistris, Maria Santucci; Palli, Domenico; Ardanaz, Eva; Laouali, Nasser; Sonestedt, Emily; Drake, Isabel; Rizzolo, Lucia; Santiuste, Carmen; Sacerdote, Carlotta; Quiros, Ramon; Amiano, Pilar; Agudo, Antonio; Jakszyn, Paula
- Abstract
Purpose Excess iron is involved in the development of non-communicable diseases such as cancer, type 2 diabetes and cardiovascular conditions. We aimed to describe the prevalence of excess iron and its determinants in healthy European adults. Methods Sociodemographic, lifestyle, iron status, dietary information, and HFE genotyping were obtained from controls from the nested case-control study EPIC-EurGast study. High sensitivity C-reactive protein (hsCRP) was measured to address possible systemic inflammation. Descriptive and multivariate analyses were used to assess iron status and its determinants. Results Out of the 828 participants (median age: 58.7 years), 43% were females. Median serum ferritin and prevalence of excess iron were 143.7 mu g/L and 35.2% in males, respectively, and 77 mu g/L and 20% in females, both increasing with latitude across Europe. Prevalence of HFE C282Y mutation was significantly higher in Northern and Central Europe (similar to 11%) than in the South (5%). Overweight/obesity, age, and daily alcohol and heme iron intake were independent determinants for iron status, with sex differences even after excluding participants with hsCRP > 5 mg/L. Obese males showed a greater consumption of alcohol, total and red meat, and heme iron, compared with those normal weight. Conclusion Obesity, higher alcohol and heme iron consumption were the main risk factors for excess iron in males while only age was associated with iron overload in females. Weight control and promoting healthy lifestyle may help prevent iron overload, especially in obese people. Further research is needed to clarify determinants of excess iron in the healthy adult population, helping to reduce the associated comorbidities.
- Published
- 2022
19. Big Data and Data-Related Abuses of Market Power
- Author
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Kuhn, Tilman, primary, O'Shaughnessy, Kristen, additional, Pesch, Tobias, additional, Phillips, Jaclyn, additional, and Sokol, D. Daniel, additional
- Published
- 2022
- Full Text
- View/download PDF
20. Prediagnostic serum calcium concentrations and risk of colorectal cancer development in 2 large European prospective cohorts.
- Author
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Karavasiloglou N, Hughes DJ, Murphy N, Schomburg L, Sun Q, Seher V, Rohrmann S, Weiderpass E, Tjønneland A, Olsen A, Overvad K, Boutron-Ruault MC, Mancini FR, Mahamat-Saleh Y, Kaaks R, Kuhn T, Schulze MB, Tumino R, Panico S, Masala G, Pala V, Sacerdote C, Derksen JWG, Skeie G, Hjartåker A, Lasheras C, Agudo A, Sánchez MJ, Chirlaque MD, Ardanaz E, Amiano P, Van Guelpen B, Gylling B, Bradbury KE, Papier K, Freisling H, Aglago EK, Cross AJ, Riboli E, Aune D, Gunter MJ, and Jenab M
- Subjects
- Humans, Prospective Studies, Calcium, Nutritional Status, Case-Control Studies, Risk Factors, Europe epidemiology, Colorectal Neoplasms epidemiology, Colorectal Neoplasms etiology, Colonic Neoplasms
- Abstract
Background: Higher dietary calcium consumption is associated with lower colorectal cancer (CRC) risk. However, little data are available on the association between circulating calcium concentrations and CRC risk., Objectives: To explore the association between circulating calcium concentrations and CRC risk using data from 2 large European prospective cohort studies., Methods: Conditional logistic regression models were used to calculate multivariable-adjusted ORs and 95% CIs in case-control studies nested within the European Prospective Investigation into Cancer and Nutrition (EPIC; n-cases = 947, n-controls = 947) and the UK Biobank (UK-BB; n-cases = 2759, n-controls = 12,021) cohorts., Results: In EPIC, nonalbumin-adjusted total serum calcium (a proxy of free calcium) was not associated with CRC (OR: 0.94; 95% CI: 0.85, 1.03; modeled as continuous variable, per 1 mg/dL increase), colon cancer (OR: 0.93; 95% CI: 0.82, 1.05) or rectal cancer (OR: 1.01; 95% CI: 0.84, 1.20) risk in the multivariable adjusted model. In the UK-BB, serum ionized calcium (free calcium, most active form) was inversely associated with the risk of CRC (OR: 0.85; 95% CI: 0.76, 0.95; per 1 mg/dL) and colon cancer (OR: 0.78; 95% CI: 0.68, 0.90), but not rectal cancer (OR: 1.02; 95% CI: 0.83, 1.24) in multivariable adjusted models. Meta-analysis of EPIC and UK-BB CRC risk estimates showed an inverse risk association for CRC in the multivariable adjusted model (OR: 0.90; 95%CI: 0.84, 0.97). In analyses by quintiles, in both cohorts, higher levels of serum calcium were associated with reduced CRC risk (EPIC: OR
Q5vs.Q1 : 0.69; 95% CI: 0.47, 1.00; P-trend = 0.03; UK-BB: ORQ5vs.Q1 : 0.82; 95% CI: 0.72, 0.94; P-trend < 0.01). Analyses by anatomical subsite showed an inverse cancer risk association in the colon (EPIC: ORQ5vs.Q1 : 0.63, 95% CI: 0.39, 1.02; P-trend = 0.05; UK-BB: ORQ5vs.Q1 : 0.75; 95% CI: 0.64, 0.88; P-trend < 0.01) but not the rectum., Conclusions: In UK-BB, higher serum ionized calcium levels were inversely associated with CRC, but the risk was restricted to the colon. Total serum calcium showed a null association in EPIC. Additional prospective studies in other populations are needed to better investigate these associations., (Copyright © 2022. Published by Elsevier Inc.)- Published
- 2023
- Full Text
- View/download PDF
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