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838 results on '"Krumholz, Harlan M."'

1. Heart Failure Epidemiology and Outcomes Statistics: A Report of the Heart Failure Society of America

Author

Bozkurt, Biykem, Ahmad, Tariq, Alexander, Kevin M, Baker, William L, Bosak, Kelly, Breathett, Khadijah, Fonarow, Gregg C, Heidenreich, Paul, Ho, Jennifer E, Hsich, Eileen, Ibrahim, Nasrien E, Jones, Lenette M, Khan, Sadiya S, Khazanie, Prateeti, Koelling, Todd, Krumholz, Harlan M, Khush, Kiran K, Lee, Christopher, Morris, Alanna A, Page, Robert L, Pandey, Ambarish, Piano, Mariann R, Stehlik, Josef, Stevenson, Lynne Warner, Teerlink, John R, Vaduganathan, Muthiah, Ziaeian, Boback, and Members, Writing Committee

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Humans, Heart Failure, Hospitalization, Prevalence, Incidence, Writing Committee Members, Heart failure, epidemiology, incidence, mortality, outcomes, prevalence, Cardiorespiratory Medicine and Haematology, Nursing, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Published
2023

4. Distinguishing features of long COVID identified through immune profiling

Author

Klein, Jon, Wood, Jamie, Jaycox, Jillian R., Dhodapkar, Rahul M., Lu, Peiwen, Gehlhausen, Jeff R., Tabachnikova, Alexandra, Greene, Kerrie, Tabacof, Laura, Malik, Amyn A., Silva Monteiro, Valter, Silva, Julio, Kamath, Kathy, Zhang, Minlu, Dhal, Abhilash, Ott, Isabel M., Valle, Gabrielee, Peña-Hernández, Mario, Mao, Tianyang, Bhattacharjee, Bornali, Takahashi, Takehiro, Lucas, Carolina, Song, Eric, McCarthy, Dayna, Breyman, Erica, Tosto-Mancuso, Jenna, Dai, Yile, Perotti, Emily, Akduman, Koray, Tzeng, Tiffany J., Xu, Lan, Geraghty, Anna C., Monje, Michelle, Yildirim, Inci, Shon, John, Medzhitov, Ruslan, Lutchmansingh, Denyse, Possick, Jennifer D., Kaminski, Naftali, Omer, Saad B., Krumholz, Harlan M., Guan, Leying, Dela Cruz, Charles S., van Dijk, David, Ring, Aaron M., Putrino, David, and Iwasaki, Akiko

Published
2023
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6. Gene Sequencing Identifies Perturbation in Nitric Oxide Signaling as a Nonlipid Molecular Subtype of Coronary Artery Disease

Author

Khera, Amit V, Wang, Minxian, Chaffin, Mark, Emdin, Connor A, Samani, Nilesh J, Schunkert, Heribert, Watkins, Hugh, McPherson, Ruth, Erdmann, Jeanette, Elosua, Roberto, Boerwinkle, Eric, Ardissino, Diego, Butterworth, Adam S, Di Angelantonio, Emanuele, Naheed, Aliya, Danesh, John, Chowdhury, Rajiv, Krumholz, Harlan M, Sheu, Wayne H-H, Rich, Stephen S, Rotter, Jerome I, Chen, Yii-der Ida, Gabriel, Stacey, Lander, Eric S, Saleheen, Danish, and Kathiresan, Sekar

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Heart Disease - Coronary Heart Disease, Genetics, Prevention, Cardiovascular, Atherosclerosis, Heart Disease, Aetiology, 2.1 Biological and endogenous factors, Good Health and Well Being, Humans, Coronary Artery Disease, Polymorphism, Genetic, Nitric Oxide, Cholesterol, Hypercholesterolemia, atherosclerosis, coronary artery disease, genetic association studies, nitric oxide synthase type III, precision medicine, Medical Biotechnology, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

BackgroundA key goal of precision medicine is to disaggregate common, complex diseases into discrete molecular subtypes. Rare coding variants in the low-density lipoprotein receptor gene (LDLR) are identified in 1% to 2% of coronary artery disease (CAD) patients, defining a molecular subtype with risk driven by hypercholesterolemia.MethodsTo search for additional subtypes, we compared the frequency of rare, predicted loss-of-function and damaging missense variants aggregated within a given gene in 41 081 CAD cases versus 217 115 controls.ResultsRare variants in LDLR were most strongly associated with CAD, present in 1% of cases and associated with 4.4-fold increased CAD risk. A second subtype was characterized by variants in endothelial nitric oxide synthase gene (NOS3), a key enzyme regulating vascular tone, endothelial function, and platelet aggregation. A rare predicted loss-of-function or damaging missense variants in NOS3 was present in 0.6% of cases and associated with 2.42-fold increased risk of CAD (95% CI, 1.80-3.26; P=5.50×10-9). These variants were associated with higher systolic blood pressure (+3.25 mm Hg; [95% CI, 1.86-4.65]; P=5.00×10-6) and increased risk of hypertension (adjusted odds ratio 1.31; [95% CI, 1.14-1.51]; P=2.00×10-4) but not circulating cholesterol concentrations, suggesting that, beyond lipid pathways, nitric oxide synthesis is a key nonlipid driver of CAD risk.ConclusionsBeyond LDLR, we identified an additional nonlipid molecular subtype of CAD characterized by rare variants in the NOS3 gene.

Published
2022

7. Large-scale evidence generation and evaluation across a network of databases for type 2 diabetes mellitus (LEGEND-T2DM): a protocol for a series of multinational, real-world comparative cardiovascular effectiveness and safety studies

Author

Khera, Rohan, Schuemie, Martijn J, Lu, Yuan, Ostropolets, Anna, Chen, RuiJun, Hripcsak, George, Ryan, Patrick B, Krumholz, Harlan M, and Suchard, Marc A

Subjects
Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Patient Safety, Clinical Research, Comparative Effectiveness Research, Diabetes, Cardiovascular, Generic health relevance, Metabolic and endocrine, Good Health and Well Being, Adult, Diabetes Mellitus, Type 2, Dipeptidyl-Peptidase IV Inhibitors, Humans, Hypoglycemic Agents, Reproducibility of Results, Sodium-Glucose Transporter 2 Inhibitors, Sulfonylurea Compounds, Health informatics, DIABETES & ENDOCRINOLOGY, Cardiology, Clinical Sciences, Public Health and Health Services, Other Medical and Health Sciences, Biomedical and clinical sciences, Health sciences, Psychology
Abstract

IntroductionTherapeutic options for type 2 diabetes mellitus (T2DM) have expanded over the last decade with the emergence of cardioprotective novel agents, but without such data for older drugs, leaving a critical gap in our understanding of the relative effects of T2DM agents on cardiovascular risk.Methods and analysisThe large-scale evidence generations across a network of databases for T2DM (LEGEND-T2DM) initiative is a series of systematic, large-scale, multinational, real-world comparative cardiovascular effectiveness and safety studies of all four major second-line anti-hyperglycaemic agents, including sodium-glucose co-transporter-2 inhibitor, glucagon-like peptide-1 receptor agonist, dipeptidyl peptidase-4 inhibitor and sulfonylureas. LEGEND-T2DM will leverage the Observational Health Data Sciences and Informatics (OHDSI) community that provides access to a global network of administrative claims and electronic health record data sources, representing 190 million patients in the USA and about 50 million internationally. LEGEND-T2DM will identify all adult, patients with T2DM who newly initiate a traditionally second-line T2DM agent. Using an active comparator, new-user cohort design, LEGEND-T2DM will execute all pairwise class-versus-class and drug-versus-drug comparisons in each data source, producing extensive study diagnostics that assess reliability and generalisability through cohort balance and equipoise to examine the relative risk of cardiovascular and safety outcomes. The primary cardiovascular outcomes include a composite of major adverse cardiovascular events and a series of safety outcomes. The study will pursue data-driven, large-scale propensity adjustment for measured confounding, a large set of negative control outcome experiments to address unmeasured and systematic bias.Ethics and disseminationThe study ensures data safety through a federated analytic approach and follows research best practices, including prespecification and full disclosure of results. LEGEND-T2DM is dedicated to open science and transparency and will publicly share all analytic code from reproducible cohort definitions through turn-key software, enabling other research groups to leverage our methods, data and results to verify and extend our findings.

Published
2022

17. Study protocol for the Innovative Support for Patients with SARS-COV-2 Infections Registry (INSPIRE): A longitudinal study of the medium and long-term sequelae of SARS-CoV-2 infection

Author

O’Laughlin, Kelli N, Thompson, Matthew, Hota, Bala, Gottlieb, Michael, Plumb, Ian D, Chang, Anna Marie, Wisk, Lauren E, Hall, Aron J, Wang, Ralph C, Spatz, Erica S, Stephens, Kari A, Huebinger, Ryan M, McDonald, Samuel A, Venkatesh, Arjun, Gentile, Nikki, Slovis, Benjamin H, Hill, Mandy, Saydah, Sharon, Idris, Ahamed H, Rodriguez, Robert, Krumholz, Harlan M, Elmore, Joann G, Weinstein, Robert A, and Nichol, Graham

Subjects
Patient Safety, HIV/AIDS, Clinical Trials and Supportive Activities, Prevention, Emerging Infectious Diseases, Vaccine Related, Biodefense, Infectious Diseases, Clinical Research, Lung, Pneumonia, Cancer, Infection, Good Health and Well Being, Adolescent, Adult, Aged, Aged, 80 and over, COVID-19, Case-Control Studies, Cohort Studies, Female, Humans, Longitudinal Studies, Male, Middle Aged, Palliative Care, Patient Reported Outcome Measures, Prognosis, Registries, SARS-CoV-2, Social Determinants of Health, Therapies, Investigational, Time Factors, Young Adult, INSPIRE Investigators, General Science & Technology
Abstract

BackgroundReports on medium and long-term sequelae of SARS-CoV-2 infections largely lack quantification of incidence and relative risk. We describe the rationale and methods of the Innovative Support for Patients with SARS-CoV-2 Registry (INSPIRE) that combines patient-reported outcomes with data from digital health records to understand predictors and impacts of SARS-CoV-2 infection.MethodsINSPIRE is a prospective, multicenter, longitudinal study of individuals with symptoms of SARS-CoV-2 infection in eight regions across the US. Adults are eligible for enrollment if they are fluent in English or Spanish, reported symptoms suggestive of acute SARS-CoV-2 infection, and if they are within 42 days of having a SARS-CoV-2 viral test (i.e., nucleic acid amplification test or antigen test), regardless of test results. Recruitment occurs in-person, by phone or email, and through online advertisement. A secure online platform is used to facilitate the collation of consent-related materials, digital health records, and responses to self-administered surveys. Participants are followed for up to 18 months, with patient-reported outcomes collected every three months via survey and linked to concurrent digital health data; follow-up includes no in-person involvement. Our planned enrollment is 4,800 participants, including 2,400 SARS-CoV-2 positive and 2,400 SARS-CoV-2 negative participants (as a concurrent comparison group). These data will allow assessment of longitudinal outcomes from SARS-CoV-2 infection and comparison of the relative risk of outcomes in individuals with and without infection. Patient-reported outcomes include self-reported health function and status, as well as clinical outcomes including health system encounters and new diagnoses.ResultsParticipating sites obtained institutional review board approval. Enrollment and follow-up are ongoing.ConclusionsThis study will characterize medium and long-term sequelae of SARS-CoV-2 infection among a diverse population, predictors of sequelae, and their relative risk compared to persons with similar symptomatology but without SARS-CoV-2 infection. These data may inform clinical interventions for individuals with sequelae of SARS-CoV-2 infection.

Published
2022

19. When Direct Oral Anticoagulants Should Not Be Standard Treatment: JACC State-of-the-Art Review

Author

Bejjani, Antoine, Khairani, Candrika D., Assi, Ali, Piazza, Gregory, Sadeghipour, Parham, Talasaz, Azita H., Fanikos, John, Connors, Jean M., Siegal, Deborah M., Barnes, Geoffrey D., Martin, Karlyn A., Angiolillo, Dominick J., Kleindorfer, Dawn, Monreal, Manuel, Jimenez, David, Middeldorp, Saskia, Elkind, Mitchell S.V., Ruff, Christian T., Goldhaber, Samuel Z., Krumholz, Harlan M., Mehran, Roxana, Cushman, Mary, Eikelboom, John W., Lip, Gregory Y.H., Weitz, Jeffrey I., Lopes, Renato D., and Bikdeli, Behnood

Published
2024
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20. Long COVID Characteristics and Experience: A Descriptive Study From the Yale LISTEN Research Cohort

Author

Sawano, Mitsuaki, Wu, Yilun, Shah, Rishi M., Zhou, Tianna, Arun, Adith S., Khosla, Pavan, Kaleem, Shayaan, Vashist, Anushree, Bhattacharjee, Bornali, Ding, Qinglan, Lu, Yuan, Caraballo, César, Warner, Frederick, Huang, Chenxi, Herrin, Jeph, Putrino, David, Michelsen, Teresa, Fisher, Liza, Adinig, Cynthia, Iwasaki, Akiko, and Krumholz, Harlan M.

Published
2024
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21. The PAX LC Trial: A Decentralized, Phase 2, Randomized, Double-Blind Study of Nirmatrelvir/Ritonavir Compared with Placebo/Ritonavir for Long COVID

Author

Krumholz, Harlan M., Sawano, Mitsuaki, Bhattacharjee, Bornali, Caraballo, César, Khera, Rohan, Li, Shu-Xia, Herrin, Jeph, Coppi, Andreas, Holub, Julie, Henriquez, Yashira, Johnson, Maria A., Goddard, Theresa B., Rocco, Erica, Hummel, Amy C., AL Mouslmani, Mohammad, Putrino, David F., Carr, Kevin D., Carvajal-Gonzalez, Santos, Charnas, Lawrence, De Jesus, Magdia, Ziegler, Frank W., III, and Iwasaki, Akiko

Published
2024
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22. Association of STEMI regionalization of care with de facto NSTEMI regionalization

Author

Montoy, Juan Carlos C, Shen, Yu-Chu, Krumholz, Harlan M, and Hsia, Renee Y

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Heart Disease, Heart Disease - Coronary Heart Disease, Patient Safety, Cardiovascular, Hospital Planning, Humans, Non-ST Elevated Myocardial Infarction, Percutaneous Coronary Intervention, ST Elevation Myocardial Infarction, Cardiorespiratory Medicine and Haematology, Public Health and Health Services, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

The regionalization of care for ST elevation myocardial infarction (STEMI) may unintentionally concentrate patients with non-ST elevation myocardial infarction (NSTEMI) into percutaneous coronary intervention (PCI) capable hospitals. This could lead to benefits such as increased access to PCI-capable hospitals, but could cause harms such as crowding in some hospitals with decreased patient volume and revenue in others. We set out to assess whether STEMI regionalization programs concentrated patients with NSTEMI at STEMI-receiving hospitals.

Published
2021

23. Comparative First-Line Effectiveness and Safety of ACE (Angiotensin-Converting Enzyme) Inhibitors and Angiotensin Receptor Blockers: A Multinational Cohort Study.

Author

Chen, RuiJun, Suchard, Marc A, Krumholz, Harlan M, Schuemie, Martijn J, Shea, Steven, Duke, Jon, Pratt, Nicole, Reich, Christian G, Madigan, David, You, Seng Chan, Ryan, Patrick B, and Hripcsak, George

Subjects
Humans, Hypertension, Antihypertensive Agents, Angiotensin-Converting Enzyme Inhibitors, Treatment Outcome, Retrospective Studies, Adolescent, Adult, Aged, Aged, 80 and over, Middle Aged, Child, Child, Preschool, Infant, Female, Male, Young Adult, Angiotensin Receptor Antagonists, angiotensin receptor, angiotensin receptor blocker, cardiovascular outcomes, hypertension, safety, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Public Health and Health Services, Cardiovascular System & Hematology
Abstract

[Figure: see text].

Published
2021

25. Short- and longer-term all-cause mortality among SARS-CoV-2- infected individuals and the pull-forward phenomenon in Qatar: a national cohort study

Author

Chemaitelly, Hiam, Faust, Jeremy Samuel, Krumholz, Harlan M., Ayoub, Houssein H., Tang, Patrick, Coyle, Peter, Yassine, Hadi M., Al Thani, Asmaa A., Al-Khatib, Hebah A., Hasan, Mohammad R., Al-Kanaani, Zaina, Al-Kuwari, Einas, Jeremijenko, Andrew, Kaleeckal, Anvar Hassan, Latif, Ali Nizar, Shaik, Riyazuddin Mohammad, Abdul-Rahim, Hanan F., Nasrallah, Gheyath K., Al-Kuwari, Mohamed Ghaith, Butt, Adeel A., Al-Romaihi, Hamad Eid, Al-Thani, Mohamed H., Al-Khal, Abdullatif, Bertollini, Roberto, and Abu-Raddad, Laith J.

Published
2023
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27. Association of Neighborhood-Level Marginalization With Health Care Use and Clinical Outcomes Following Hospital Discharge in Patients Who Underwent Coronary Catheterization for Acute Myocardial Infarction in a Single-Payer Health Care System

Author

Akioyamen, Leo E., Abdel-Qadir, Husam, Han, Lu, Sud, Maneesh, Mistry, Nikhil, Alter, David A., Atzema, Clare L., Austin, Peter C., Bhatia, R. Sacha, Booth, Gillian L., Dhalla, Irfan, Ha, Andrew C.T., Jackevicius, Cynthia A., Kapral, Moira K., Krumholz, Harlan M., Lee, Douglas S., McNaughton, Candace D., Roifman, Idan, Schull, Michael J., Sivaswamy, Atul, Tu, Karen, Udell, Jacob A., Wijeysundera, Harindra C., and Ko, Dennis T.

Published
2023
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31. Abstract 17709: ICD-10 Codes Have Low Sensitivity and Suboptimal Positive Predictive Value for Identifying Cases of Pulmonary Embolism With Cor Pulmonale in Electronic Healthcare Records

Author

Bejjani, Antoine, Khairani, Candrika D, Lo, Ying-Chih, Jimenez, David, Barco, Stefano, Mahajan, Shiwani, Caraballo, Cesar, Secemsky, Eric A, Klok, Erik, Hunsaker, Andetta, Aghayev, Ayaz, Muriel, Alfonso, Hussain, Mohamad A, Appah-Sampong, Abena, MOJIBIAN, HAMID, Lu, Yuan, Lin, Zhenqiu, Aneja, Sanjay, Khera, Rohan, Goldhaber, Samuel, Zhou, Li, Monreal, Manuel, Piazza, Gregory, Krumholz, Harlan M, and Bikdeli, Behnood

Published
2023
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32. Abstract 17700: Double Trouble With Identification of Isolated Sub-Segmental Pulmonary Embolism Using ICD-10 Discharge Diagnosis Codes: The PE-EHR+ Study

Author

Bejjani, Antoine, Khairani, Candrika D, Lo, Ying-Chih, Jimenez, David, Barco, Stefano, Mahajan, Shiwani, Caraballo, Cesar, Secemsky, Eric A, Klok, Erik, Hunsaker, Andetta, Aghayev, Ayaz, Muriel, Alfonso, Hussain, Mohamad A, Appah-Sampong, Abena, MOJIBIAN, HAMID, Lu, Yuan, Lin, Zhenqiu, Aneja, Sanjay, Khera, Rohan, Goldhaber, Samuel, Zhou, Li, Monreal, Manuel, Krumholz, Harlan M, Piazza, Gregory, and Bikdeli, Behnood

Published
2023
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38. Abstract 16342: Age- and Sex-Differences in Accuracy of ICD-10 Codes for Identifying Adults With Pulmonary Embolism: PE-EHR+ Study

Author

Mahajan, Shiwani, Lo, Ying-Chih, Bejjani, Antoine, Khairani, Candrika D, Jimenez, David, Barco, Stefano, Caraballo, Cesar, Secemsky, Eric A, Klok, Erik, Hunsaker, Andetta, Aghayev, Ayaz, Muriel, Alfonso, Hussain, Mohamad A, Appah-Sampong, Abena, MOJIBIAN, HAMID, Lu, Yuan, Lin, Zhenqiu, Aneja, Sanjay, Khera, Rohan, Goldhaber, Samuel, Zhou, Li, Monreal, Manuel, Piazza, Gregory, Krumholz, Harlan M, and Bikdeli, Behnood

Published
2023
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43. Abstract 14344: Pitfalls of ICD-10 Codes for Identifying Pulmonary Embolism in Electronic Records: Results From the Multicenter PE-EHR+ Study

Author

Bikdeli, Behnood, Bejjani, Antoine, Khairani, Candrika D, Lo, Ying-Chih, Jimenez, David, Barco, Stefano, Mahajan, Shiwani, Caraballo, Cesar, Secemsky, Eric A, Klok, Erik, Hunsaker, Andetta, Aghayev, Ayaz, Muriel, Alfonso, Hussain, Mohamad A, Appah-Sampong, Abena, MOJIBIAN, HAMID, Lu, Yuan, Lin, Zhenqiu, Aneja, Sanjay, Khera, Rohan, Goldhaber, Samuel, Zhou, Li, Monreal, Manuel, Piazza, Gregory, and Krumholz, Harlan M

Published
2023
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47. Detection of Left Ventricular Systolic Dysfunction From Electrocardiographic Images

Author

Sangha, Veer, Nargesi, Arash A., Dhingra, Lovedeep S., Khunte, Akshay, Mortazavi, Bobak J., Ribeiro, Antônio H., Banina, Evgeniya, Adeola, Oluwaseun, Garg, Nadish, Brandt, Cynthia A., Miller, Edward J., Ribeiro, Antonio Luiz P., Velazquez, Eric J., Giatti, Luana, Barreto, Sandhi M., Foppa, Murilo, Yuan, Neal, Ouyang, David, Krumholz, Harlan M., and Khera, Rohan

Published
2023
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