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Your search keyword '"Koichi Hirabayashi"' showing total 9 results
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9 results on '"Koichi Hirabayashi"'

2. Intraoperative Placement of an Absorbable Spacer Prior to Radiation Therapy for a Malignant Peripheral Nerve Sheath Tumor

Author

Yuki Endo, Taichi Fukuzawa, Masahiro Irie, Hideyuki Sasaki, Hironori Kudo, Ryo Ando, Ryuji Okubo, Saori Katayama, Masatoshi Hashimoto, Kosuke Sato, Masahito Tachibana, Hidekazu Aoki, Masayuki Araya, Koichi Hirabayashi, Shoji Saito, Hidekazu Masaki, Yozo Nakazawa, Yoji Sasahara, and Motoshi Wada

Subjects
absorbable spacer, malignant peripheral nerve sheath tumor, radiation therapy, proton beam therapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

A 7-year-6-month-old female was diagnosed with a pelvic malignant peripheral nerve sheath tumor and lymph node metastases. Tumorectomy was performed after four cycles of chemotherapy. A 33-mm cystic lesion was observed around the left iliac muscle after three cycles of postoperative chemotherapy, and proton beam therapy (PBT) was recommended. She was referred for absorbable spacer (AS) placement. The left ovarian appendage (OA) was resected due to the direct tumor infiltration. The right OA was fixed to the uterosacral ligament. The AS was fixed to the lateral pelvis. The PBT (70.3 Gy relative biological effectiveness) was performed successfully with the AS, and she also had the reproducing possibility due to prevention of severe irradiation damage of the right OA. AS eliminated the surgical removal of spacers and enabled us high-dose PBT for residual tumor without severe irradiation damage including infertility.

Published
2022
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3. Targeting brain lesions of non-small cell lung cancer by enhancing CCL2-mediated CAR-T cell migration

Author

Hongxia Li, Emily B. Harrison, Huizhong Li, Koichi Hirabayashi, Jing Chen, Qi-Xiang Li, Jared Gunn, Jared Weiss, Barbara Savoldo, Joel S. Parker, Chad V. Pecot, Gianpietro Dotti, and Hongwei Du

Subjects
Science
Abstract

Therapeutic options for non-small cell lung cancer patients with brain metastases are limited. Here the authors design B7-H3 targeting CAR-T cells engineered to express the chemokine receptor CCR2b, and show improved accumulation in the brain and enhanced anti-tumor activity in preclinical models of lung cancer brain metastases.

Published
2022
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4. Data from Cancer Immunotherapy with T Cells Carrying Bispecific Receptors That Mimic Antibodies

Author

Gianpietro Dotti, Rihe Liu, Barbara Savoldo, Hongxia Li, Koichi Hirabayashi, Keliang Gao, Chuang Sun, Jingjing Li, and Sarah Ahn

Abstract

Tumors are inherently heterogeneous in antigen expression, and escape from immune surveillance due to antigen loss remains one of the limitations of targeted immunotherapy. Despite the clinical use of adoptive therapy with chimeric antigen receptor (CAR)–redirected T cells in lymphoblastic leukemia, treatment failure due to epitope loss occurs. Targeting multiple tumor-associated antigens (TAAs) may thus improve the outcome of CAR-T cell therapies. CARs developed to simultaneously target multiple targets are limited by the large size of each single-chain variable fragment and compromised protein folding when several single chains are linearly assembled. Here, we describe single-domain antibody mimics that function within CAR parameters but form a very compact structure. We show that antibody mimics targeting EGFR and HER2 of the ErbB receptor tyrosine kinase family can be assembled into receptor molecules, which we call antibody mimic receptors (amR). These amR can redirect T cells to recognize two different epitopes of the same antigen or two different TAAs in vitro and in vivo.

Published
2023

8. Skin and soft tissue infections in adolescent chronic myeloid leukemia under dasatinib treatment

Author

Eriko Uchida, Shoji Saito, Daisuke Morita, Eri Okura, Koichi Hirabayashi, Miyuki Tanaka, Hideyuki Nakazawa, Akane Minagawa, and Yozo Nakazawa

Subjects
Adult, Pyrimidines, Oncology, Adolescent, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Soft Tissue Infections, Pediatrics, Perinatology and Child Health, Dasatinib, Imatinib Mesylate, Humans, Hematology, Protein Kinase Inhibitors, Retrospective Studies
Abstract

Although skin complications are common adverse events from tyrosine kinase inhibitors (TKIs) for the treatment of chronic myeloid leukemia (CML), no reports have focused on skin and soft tissue infections (SSTIs) associated with TKI use. We herein present five episodes of SSTIs in three CML patients under dasatinib treatment. All patients were adolescents and had been receiving dasatinib for more than 4 years. In contrast, none of 41 adult CML patients experienced SSTIs in a retrospective analysis. Our findings suggest that long-term dasatinib treatment in adolescent patients may be associated with the increased risk of SSTIs.

Published
2022

9. Dual Targeting CAR-T Cells with Optimal Costimulation and Metabolic Fitness enhance Antitumor Activity and Prevent Escape in Solid Tumors

Author

Koichi, Hirabayashi, Hongwei, Du, Yang, Xu, Peishun, Shou, Xin, Zhou, Giovanni, Fucá, Elisa, Landoni, Chuang, Sun, Yuhui, Chen, Barbara, Savoldo, and Gianpietro, Dotti

Subjects
Receptors, Chimeric Antigen, CD28 Antigens, Neoplasms, T-Lymphocytes, Receptors, Antigen, T-Cell, Humans, Xenograft Model Antitumor Assays
Abstract

Chimeric antigen receptor (CAR) T cells showed great activity in hematologic malignancies. However, heterogeneous antigen expression in tumor cells and suboptimal CAR-T cell persistence remain critical aspects to achieve clinical responses in patients with solid tumors. Here we show that CAR-T cells targeting simultaneously two tumor-associated antigens and providing transacting CD28 and 4-1BB costimulation, while sharing the sane CD3ζ-chain cause rapid antitumor effects in

Published
2021

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