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14 results on '"Koh, Tse Hsien"'

1. Detection and characterisation of a sixth Candida auris clade in Singapore: a genomic and phenotypic study

Author

Suphavilai, Chayaporn, Ko, Karrie Kwan Ki, Lim, Kar Mun, Tan, Mei Gie, Boonsimma, Patipan, Chu, Joash Jun Keat, Goh, Sui Sin, Rajandran, Prevena, Lee, Lai Chee, Tan, Kwee Yuen, Shaik Ismail, Bushra Binte, Aung, May Kyawt, Yang, Yong, Sim, Jean Xiang Ying, Venkatachalam, Indumathi, Cherng, Benjamin Pei Zhi, Spruijtenburg, Bram, Chan, Kian Sing, Oon, Lynette Lin Ean, Tan, Ai Ling, Tan, Yen Ee, Wijaya, Limin, Tan, Ban Hock, Ling, Moi Lin, Koh, Tse Hsien, Meis, Jacques F, Tsui, Clement Kin Ming, and Nagarajan, Niranjan

Published
2024
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2. Whole genome sequencing reveals hidden transmission of carbapenemase-producing Enterobacterales

Author

Marimuthu, Kalisvar, Venkatachalam, Indumathi, Koh, Vanessa, Harbarth, Stephan, Perencevich, Eli, Cherng, Benjamin Pei Zhi, Fong, Raymond Kok Choon, Pada, Surinder Kaur, Ooi, Say Tat, Smitasin, Nares, Thoon, Koh Cheng, Tambyah, Paul Anantharajah, Hsu, Li Yang, Koh, Tse Hsien, De, Partha Pratim, Tan, Thean Yen, Chan, Douglas, Deepak, Rama Narayana, Tee, Nancy Wen Sim, Kwa, Andrea, Cai, Yiying, Teo, Yik-Ying, Thevasagayam, Natascha May, Prakki, Sai Rama Sridatta, Xu, Weizhen, Khong, Wei Xin, Henderson, David, Stoesser, Nicole, Eyre, David W., Crook, Derrick, Ang, Michelle, Lin, Raymond Tzer Pin, Chow, Angela, Cook, Alex R., Teo, Jeanette, and Ng, Oon Tek

Published
2022
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3. Sequence Types and Antimicrobial Resistance Profiles of Salmonella Typhimurium in the Food Chain in Singapore.

Author

Lim, Yen Ching, Ong, Kar Hui, Khor, Wei Ching, Chua, Favian Yue Xuan, Lim, Jia Qi, Tan, Li Kiang, Chen, Swaine L., Wong, Wai Kwan, Maiwald, Matthias, Barkham, Timothy, Koh, Tse Hsien, Khoo, Joanna, Chan, Joanne Sheot Harn, and Aung, Kyaw Thu

Subjects
WHOLE genome sequencing, SALMONELLA typhimurium, DRUG resistance in microorganisms, FOOD pathogens, CHICKENS, LACTAMS
Abstract

Salmonella remains a significant foodborne pathogen globally with S. Typhimurium presenting as a frequently occurring serovar. This study aimed to characterize 67 S. Typhimurium isolates from humans, food, farms, and slaughterhouses collected in Singapore from 2016 to 2017. Using whole-genome sequencing analysis, the isolates were found to belong to either ST19 (n = 33) or ST36 (n = 34). ST36 predominated in human intestinal and chicken isolates, while human extra-intestinal and non-chicken food isolates belonged to ST19. Plasmids were predicted in 88.1% (n = 59) of the isolates with the most common incompatibility group profiles being IncFIB(S), IncFII(S) and IncQ1. IncFIB(S) (adjusted p-value < 0.05) and IncFII(S) (adjusted p-value < 0.05) were significantly more prevalent in ST19 isolates, while Col156 (adjusted p-value < 0.05) was more significantly found in ST36 isolates. ST36 isolates exhibited higher resistance to multiple antibiotic classes such as penicillins, phenicols, folate pathway inhibitors, aminoglycosides, β-lactam/β-lactamase inhibitor combinations, tetracyclines, and fluoroquinolones. Phylogenetics analysis suggested potential shared routes of transmission among human, chicken, farm and slaughterhouse environments. Taken together, this study offers a cross-sectional epidemiological insight into the genomic epidemiology and antimicrobial landscape of S. Typhimurium isolates in Singapore, informing strategies for future public health and food safety surveillance. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Author Correction: The higher prevalence of extended spectrum beta-lactamases among Escherichia coli ST131 in Southeast Asia is driven by expansion of a single, locally prevalent subclone

Author

Chen, Swaine L., Ding, Ying, Apisarnthanarak, Anucha, Kalimuddin, Shirin, Archuleta, Sophia, Omar, Sharifah Faridah Syed, De, Partha Pratim, Koh, Tse Hsien, Chew, Kean Lee, Atiya, Nadia, Suwantarat, Nuntra, Velayuthan, Rukumani Devi, Wong, Joshua Guo Xian, and Lye, David C.

Published
2021
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5. Discovery of the sixth Candida auris clade in Singapore

Author

Suphavilai, Chayaporn, primary, Ko, Karrie K. K., additional, Lim, Kar Mun, additional, Tan, Mei Gie, additional, Boonsimma, Patipan, additional, Chu, Joash Jun Keat, additional, Goh, Sui Sin, additional, Rajandran, Prevena, additional, Lee, Lai Chee, additional, Tan, Kwee Yuen, additional, Shaik Ismail, Bushra, additional, Aung, May Kyawt, additional, Yang, Yong, additional, Sim, Jean Xiang Ying, additional, Venkatachalam, Indumathi, additional, Cherng, Benjamin Pei Zhi, additional, Spruijtenburg, Bram, additional, Chan, Kian Sing, additional, Oon, Lynette Lin Ean, additional, Tan, Ai Ling, additional, Tan, Yen Ee, additional, Wijaya, Limin, additional, Tan, Ban Hock, additional, Ling, Moi Lin, additional, Koh, Tse Hsien, additional, Meis, Jacques F., additional, Tsui, Clement Kin Ming, additional, and Nagarajan, Niranjan, additional

Published
2023
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6. SG-APSIC1097: The impact of COVID-19 on the incidence of carbapenem-resistant Enterobacterales (CRE) in Singapore: An interrupted time-series analysis

Author

Ong, Chong Hui Clara, primary, Cheng, Thoon Koh, additional, Pada, Surinder Kaur M S, additional, Narayana, Deepak Rama, additional, Ooi, Say Tat, additional, Smitasin, Nares, additional, Fong, Kok Choon Raymond, additional, Koh, Tse Hsien, additional, Cherng, Pei Zhi Benjamin, additional, Lin, Raymond, additional, Pratim, De Partha, additional, Yang, Hsu Li, additional, Teo, Jeanette, additional, Ng, Oon Tek, additional, Venkatachalam, Indumathi, additional, and Marimuthu, Kalisvar, additional

Published
2023
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8. Impact of COVID-19 pandemic on carbapenem-resistant Enterobacterales incidence in the South-East Asia region: an observational study

Author

Linn, Kyaw Zaw, primary, Sutjipto, Stephanie, additional, Ng, Oon Tek, additional, Teo, Jeanette, additional, Cherng, Benjamin Pei Zhi, additional, Tan, Thean Yen, additional, Pada, Surinder Kaur, additional, Ooi, Say Tat, additional, Smitasin, Nares, additional, Thoon, Koh Cheng, additional, Huan, Xiaowei, additional, De, Partha Pratim, additional, Chan, Douglas, additional, Tee, Nancy Wen Sim, additional, Ang, Michelle, additional, Hsu, Li Yang, additional, Lin, Raymond Tzer Pin, additional, Ng, Tong Yong, additional, Deepak, Rama Narayana, additional, Koh, Tse Hsien, additional, Apisarnthanarak, Anucha, additional, Ponnampalavanar, Sasheela, additional, Venkatachalam, Indumathi, additional, and Marimuthu, Kalisvar, additional

Published
2023
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10. Clonal serotype 1c multidrug-resistant Shigella flexneri detected in multiple institutions by sentinel-site sequencing

Author

Ko, Karrie K. K., primary, Chu, Joash Jun Keat, additional, Lim, Kar Mun, additional, Yingtaweesittikul, Hatairat, additional, Huang, Wenjie, additional, Tan, Shireen Yan Ling, additional, Goh, Kenneth Choon Meng, additional, Tan, Si Huei, additional, Ng, Tong Yong, additional, Maiwald, Matthias, additional, Chia, Jonathan Wei Zhong, additional, Cao, Delphine Yanhong, additional, Tan, Yen Ee, additional, Sim, James Heng Chiak, additional, Koh, Tse Hsien, additional, Nagarajan, Niranjan, additional, and Suphavilai, Chayaporn, additional

Published
2022
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11. Characterisation of Salmonella enteritidis ST11 and ST1925 Associated with Human Intestinal and Extra-Intestinal Infections in Singapore

Author

Aung, Kyaw Thu, Khor, Wei Ching, Ong, Kar Hui, Tan, Wei Ling, Wong, Zhi Ning, Oh, Jia Quan, Wong, Wai Kwan, Tan, Brian Zi Yan, Maiwald, Matthias, Tee, Nancy Wen Sim, Barkham, Timothy, Koh, Tse Hsien, Dalsgaard, Anders, Chen, Swaine L., Schlundt, Joergen, Ng, Lee Ching, Aung, Kyaw Thu, Khor, Wei Ching, Ong, Kar Hui, Tan, Wei Ling, Wong, Zhi Ning, Oh, Jia Quan, Wong, Wai Kwan, Tan, Brian Zi Yan, Maiwald, Matthias, Tee, Nancy Wen Sim, Barkham, Timothy, Koh, Tse Hsien, Dalsgaard, Anders, Chen, Swaine L., Schlundt, Joergen, and Ng, Lee Ching

Abstract

Salmonella enteritidis is a major foodborne pathogen worldwide. In this study, a total of 276 S. enteritidis isolates, collected between 2016 and 2017 from human, food and farm/slaughterhouse samples, were studied to enhance the understanding of the epidemiology of human salmonellosis in Singapore. Results showed all 276 isolates belonged either to ST1925 (70.3%) or ST11 (29.7%), with ST11 being significantly more frequent in extra-intestinal isolates and chicken isolates. Food isolates, most of which were from poultry, showed the highest prevalence of resistance (33–37%) against beta-lactams or beta-lactams/beta-lactamase inhibitor combination (ampicillin, piperacillin and ampicillin/sulbactam). The analysis showed the detection of genes associated with resistance to aminoglycoside genes (99.6%), tetracycline (55.1%), and beta-lactams (14.9%) of all isolates. Nine types of plasmids were found in 266 isolates; the most common incompatibility group profiles were IncFIB(S)-IncFII(S)-IncX1 (72.2%) and IncFIB(S)-IncFII(S) (15.8%). Most plasmid harbouring isolates from chicken (63.6%, 14/22) and from human (73.8%, 175/237) shared the same plasmid profile (IncFIB(S)-IncFII(S)-IncX1). SNP analysis showed clustering of several isolates from poultry food products and human isolates, suggesting phylogenetic relatedness among these isolates. Lastly, this study provides important epidemiological insights on the application of phenotypic and next-generation sequencing (NGS) tools for improved food safety and public health surveillance and outbreak investigation of S. enteritidis.

Published
2022

12. Characterisation of Salmonella Enteritidis ST11 and ST1925 Associated with Human Intestinal and Extra-Intestinal Infections in Singapore

Author

Aung, Kyaw Thu, primary, Khor, Wei Ching, additional, Ong, Kar Hui, additional, Tan, Wei Ling, additional, Wong, Zhi Ning, additional, Oh, Jia Quan, additional, Wong, Wai Kwan, additional, Tan, Brian Zi Yan, additional, Maiwald, Matthias, additional, Tee, Nancy Wen Sim, additional, Barkham, Timothy, additional, Koh, Tse Hsien, additional, Dalsgaard, Anders, additional, Chen, Swaine L., additional, Schlundt, Joergen, additional, and Ng, Lee Ching, additional

Published
2022
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