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5. Supplemental figure 1: Immunohistochemical (IHC) analysis of BCL2 and MCL1 proteins in formalin-fixed paraffin-embedded tissue samples obtained from patients at dignosis of DLBCL. from Targeting of BCL2 Family Proteins with ABT-199 and Homoharringtonine Reveals BCL2- and MCL1-Dependent Subgroups of Diffuse Large B-Cell Lymphoma

Author

Klanova, Magdalena, primary, Andera, Ladislav, primary, Brazina, Jan, primary, Svadlenka, Jan, primary, Benesova, Simona, primary, Soukup, Jan, primary, Prukova, Dana, primary, Vejmelkova, Dana, primary, Jaksa, Radek, primary, Helman, Karel, primary, Vockova, Petra, primary, Lateckova, Lucie, primary, Molinsky, Jan, primary, Maswabi, Bokang Calvin Lenyeletse, primary, Alam, Mahmudul, primary, Kodet, Roman, primary, Pytlik, Robert, primary, Trneny, Marek, primary, and Klener, Pavel, primary

Published
2023
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6. Supplemental figure 3: Comparison of sensitivity of 18 DLBCL cell lines to HHT and ABT-199. from Targeting of BCL2 Family Proteins with ABT-199 and Homoharringtonine Reveals BCL2- and MCL1-Dependent Subgroups of Diffuse Large B-Cell Lymphoma

Author

Klanova, Magdalena, primary, Andera, Ladislav, primary, Brazina, Jan, primary, Svadlenka, Jan, primary, Benesova, Simona, primary, Soukup, Jan, primary, Prukova, Dana, primary, Vejmelkova, Dana, primary, Jaksa, Radek, primary, Helman, Karel, primary, Vockova, Petra, primary, Lateckova, Lucie, primary, Molinsky, Jan, primary, Maswabi, Bokang Calvin Lenyeletse, primary, Alam, Mahmudul, primary, Kodet, Roman, primary, Pytlik, Robert, primary, Trneny, Marek, primary, and Klener, Pavel, primary

Published
2023
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7. Supplementary Data from TIM-3 Dictates Functional Orientation of the Immune Infiltrate in Ovarian Cancer

Author

Fucikova, Jitka, primary, Rakova, Jana, primary, Hensler, Michal, primary, Kasikova, Lenka, primary, Belicova, Lucie, primary, Hladikova, Kamila, primary, Truxova, Iva, primary, Skapa, Petr, primary, Laco, Jan, primary, Pecen, Ladislav, primary, Praznovec, Ivan, primary, Halaska, Michael J., primary, Brtnicky, Tomas, primary, Kodet, Roman, primary, Fialova, Anna, primary, Pineau, Josephine, primary, Gey, Alain, primary, Tartour, Eric, primary, Ryska, Ales, primary, Galluzzi, Lorenzo, primary, and Spisek, Radek, primary

Published
2023
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8. Supplemental figure 5: Additional cytotoxic mechanism of action of HHT in DLBCL. from Targeting of BCL2 Family Proteins with ABT-199 and Homoharringtonine Reveals BCL2- and MCL1-Dependent Subgroups of Diffuse Large B-Cell Lymphoma

Author

Klanova, Magdalena, primary, Andera, Ladislav, primary, Brazina, Jan, primary, Svadlenka, Jan, primary, Benesova, Simona, primary, Soukup, Jan, primary, Prukova, Dana, primary, Vejmelkova, Dana, primary, Jaksa, Radek, primary, Helman, Karel, primary, Vockova, Petra, primary, Lateckova, Lucie, primary, Molinsky, Jan, primary, Maswabi, Bokang Calvin Lenyeletse, primary, Alam, Mahmudul, primary, Kodet, Roman, primary, Pytlik, Robert, primary, Trneny, Marek, primary, and Klener, Pavel, primary

Published
2023
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9. Supplemental figure 4: Comparison of sensitivity of 18 DLBCL cell lines to HHT, ABT-199 and ABT-737. from Targeting of BCL2 Family Proteins with ABT-199 and Homoharringtonine Reveals BCL2- and MCL1-Dependent Subgroups of Diffuse Large B-Cell Lymphoma

Author

Klanova, Magdalena, primary, Andera, Ladislav, primary, Brazina, Jan, primary, Svadlenka, Jan, primary, Benesova, Simona, primary, Soukup, Jan, primary, Prukova, Dana, primary, Vejmelkova, Dana, primary, Jaksa, Radek, primary, Helman, Karel, primary, Vockova, Petra, primary, Lateckova, Lucie, primary, Molinsky, Jan, primary, Maswabi, Bokang Calvin Lenyeletse, primary, Alam, Mahmudul, primary, Kodet, Roman, primary, Pytlik, Robert, primary, Trneny, Marek, primary, and Klener, Pavel, primary

Published
2023
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10. Supplemental table 1: Semi-quantitative immunohistochemical (IHC) analysis of s.c. DLBCL cell line xenografts. from Targeting of BCL2 Family Proteins with ABT-199 and Homoharringtonine Reveals BCL2- and MCL1-Dependent Subgroups of Diffuse Large B-Cell Lymphoma

Author

Klanova, Magdalena, primary, Andera, Ladislav, primary, Brazina, Jan, primary, Svadlenka, Jan, primary, Benesova, Simona, primary, Soukup, Jan, primary, Prukova, Dana, primary, Vejmelkova, Dana, primary, Jaksa, Radek, primary, Helman, Karel, primary, Vockova, Petra, primary, Lateckova, Lucie, primary, Molinsky, Jan, primary, Maswabi, Bokang Calvin Lenyeletse, primary, Alam, Mahmudul, primary, Kodet, Roman, primary, Pytlik, Robert, primary, Trneny, Marek, primary, and Klener, Pavel, primary

Published
2023
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11. Supplemental table 2: Comparison of sensitivity of 18 DLBCL cell lines to ABT-199 and HHT. from Targeting of BCL2 Family Proteins with ABT-199 and Homoharringtonine Reveals BCL2- and MCL1-Dependent Subgroups of Diffuse Large B-Cell Lymphoma

Author

Klanova, Magdalena, primary, Andera, Ladislav, primary, Brazina, Jan, primary, Svadlenka, Jan, primary, Benesova, Simona, primary, Soukup, Jan, primary, Prukova, Dana, primary, Vejmelkova, Dana, primary, Jaksa, Radek, primary, Helman, Karel, primary, Vockova, Petra, primary, Lateckova, Lucie, primary, Molinsky, Jan, primary, Maswabi, Bokang Calvin Lenyeletse, primary, Alam, Mahmudul, primary, Kodet, Roman, primary, Pytlik, Robert, primary, Trneny, Marek, primary, and Klener, Pavel, primary

Published
2023
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12. Supplemental figure 2: Protein expression profiles of key regulators of apoptosis in DLBCL cell lines. from Targeting of BCL2 Family Proteins with ABT-199 and Homoharringtonine Reveals BCL2- and MCL1-Dependent Subgroups of Diffuse Large B-Cell Lymphoma

Author

Klanova, Magdalena, primary, Andera, Ladislav, primary, Brazina, Jan, primary, Svadlenka, Jan, primary, Benesova, Simona, primary, Soukup, Jan, primary, Prukova, Dana, primary, Vejmelkova, Dana, primary, Jaksa, Radek, primary, Helman, Karel, primary, Vockova, Petra, primary, Lateckova, Lucie, primary, Molinsky, Jan, primary, Maswabi, Bokang Calvin Lenyeletse, primary, Alam, Mahmudul, primary, Kodet, Roman, primary, Pytlik, Robert, primary, Trneny, Marek, primary, and Klener, Pavel, primary

Published
2023
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13. Supplemental figure 6: Acquired resistance of DLBCL cells to HHT is associated with upregulation of BCL-XL protein. from Targeting of BCL2 Family Proteins with ABT-199 and Homoharringtonine Reveals BCL2- and MCL1-Dependent Subgroups of Diffuse Large B-Cell Lymphoma

Author

Klanova, Magdalena, primary, Andera, Ladislav, primary, Brazina, Jan, primary, Svadlenka, Jan, primary, Benesova, Simona, primary, Soukup, Jan, primary, Prukova, Dana, primary, Vejmelkova, Dana, primary, Jaksa, Radek, primary, Helman, Karel, primary, Vockova, Petra, primary, Lateckova, Lucie, primary, Molinsky, Jan, primary, Maswabi, Bokang Calvin Lenyeletse, primary, Alam, Mahmudul, primary, Kodet, Roman, primary, Pytlik, Robert, primary, Trneny, Marek, primary, and Klener, Pavel, primary

Published
2023
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16. Vznik západní zahraniční komunity v Japonsku

Author

Kodet, Roman

Subjects
Jokohama, kisebbségek, Yokohama, politika, menšiny, obchod, Japán, Nagy-Britannia, Velká Británie, Japonsko, kereskedelmi, USA, irányelv
Abstract

Japánnak sok évszázadon át kevés tapasztalata volt a külföldi állampolgárokkal vagy nagyobb nemzeti kisebbségekkel való együttélésről. A 16. században azonban meglehetősen intenzív kapcsolatokat épített ki néhány európai állammal, ami viszonylag erős kapcsolatokhoz vezetett a nemzetközi kereskedelemhez és a kereszténység tömeges elterjedéséhez az országban. Azonban az új vallás sikere miatt az ország központi hatóságai a 17. század első felében fokozatosan elzárták Japánt a külföldiek elől. A kis holland közösség szigorúan a Nagaszakiban található Dejima kis szigetére korlátozódott, és Japánban szigorúan szabályozták az életét. Csak Perry küldetése és Japán és a nyugati hatalmak közötti hivatalos kapcsolatok kikényszerítése volt a feltétele egy szélesebb külföldi közösség megjelenésének Japánban. Ez elsősorban az újonnan alapított Yokohama kikötőben összpontosult, amely a japán külföldi enklávé fontos székhelyévé vált. Míg egyrészt a külföldiek jelentős kiváltságokat élveztek az országban az egyenlőtlen szerződések megléte miatt, másrészt jelentős problémákkal kellett szembenézniük, különösen a japán lakosság egy részének idegengyűlöletével. Ennek ellenére az itteni gazdasági, politikai és kulturális színtér állandó részévé váltak, és a Meidzsi-korszak Japán fejlődésére gyakorolt ​​hatásuk tagadhatatlan. Po dlouhá staletí mělo Japonsko jen malé zkušenosti se soužitím s cizími státními příslušníky či významnějšími národnostními menšinami. V 16. století však navázalo poměrně intenzivní kontakty s některými evropskými státy, díky čemuž byla země silně provázána s mezinárodním obchodem a na jejím území bylo masově šířeno křesťanství. Právě úspěch nového náboženství však vedl centrální autority v zemi, aby Japonsko cizincům v první polovině 17. století postupně uzavřela. Malá nizozemská komunita byla striktně omezena na malý ostrůvek Dedžima v Nagasaki a její život v Japonsku byl přísně regulován. Až Perryho mise a vynucení navázání oficiálních vztahů mezi Japonskem a západními mocnostmi vytvořily předpoklady pro vznik širší zahraniční komunity v Japonsku. Ta se koncentrovala primárně v nově založeném přístavu Jokohama, který se stal významným sídlem zahraniční enklávy v Japonsku. Cizinci se sice v zemi na jedné straně těšili značným privilegiím díky existenci nerovných smluv, na straně druhé se museli potýkat se značnými problémy, především xenofobií části japonského obyvatelstva. Navzdory tomu se však stali trvalou součástí zdejší ekonomické, politické a kulturní scény, přičemž jejich vliv na rozvoj Japonska v éře Meidži je bezpochyby nepopiratelný.

Published
2022

17. A nyugati külföldi közösség kialakulása Japánban.

Author

KODET, ROMAN

Subjects
JAPANESE people, CULTS, COMMUNITIES, INTERNATIONAL trade, XENOPHOBIA, COUNTRIES, SMALL states, SIXTEENTH century
Abstract

For many centuries, Japan had little experience of coexistence with foreign nationals or major national minorities. In the 16th century, however, it established fairly intensive contacts with some European states, which led to relatively strong links with international trade and the mass spread of Christianity within the country. However, it was the success of the new religion that led the central authorities in the country to gradually close Japan to foreigners in the first half of the 17th century. The small Dutch community was strictly confined to the small island of Dejima in Nagasaki, and its life in Japan was tightly regulated. It was not until Perry’s mission and the forcing of the establishment of official relations between Japan and the Western powers that the conditions were set for the emergence of a wider foreign community in Japan. This was concentrated primarily in the newly established port of Yokohama, which became an important seat of the foreign enclave in Japan. While on the one hand foreigners enjoyed considerable privileges in the country due to the existence of unequal treaties, on the other hand they had to face considerable problems, especially xenophobia on the part of part of the Japanese population. Despite this, they became a permanent part of the economic, political, and cultural scene here, and their influence on the development of Japan in the Meiji era is undeniable. [ABSTRACT FROM AUTHOR]

Published
2022

19. Unusual case of inflammatory rhabdomyoblastic tumor in a pediatric patient.

Author

Krsková L, Šípalová B, Balko J, Zimová S, Voříšková D, Brož P, Kodet R, and Vícha A

Subjects
Humans, Biomarkers, Tumor metabolism, Neoplasms
Abstract

Inflammatory rhabdomyoblastic tumor (IRMT) is a rare, recently described skeletal muscle neoplasm of uncertain malignant potential. We report an unusual tumor in the right arm of a 5-year-old boy, which is the first case of a pediatric IRMT. Immunohistochemically, most cells in the tumor were positive for CD163 and CD68 staining. The neoplastic cells themselves showed a skeletal muscle phenotype with a diffuse expression of desmin and a focal expression of myoD1. Mitotic activity was low (1/10 HPF), and no necrosis was observed., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier GmbH. All rights reserved.)

Published
2023
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20. Western medicine as a stimulant of scientific progress in Tokugawa Japan.

Author

Kodet R

Abstract

Until the 17th century, Japan was almost exclusively influenced by the Chinese medical tradition. A brief experience with European medicine was interrupted in the mid-17th century by edicts that isolated the country from outside world. However, thanks to the Dutch presence in Nagasaki, some Japanese intellectuals maintained contact with Western physicians. Thanks to them, the latest medical publications and textbooks gradually spread to Japan. This intellectual exchange led to a surge of interest in new discoveries and stimulated the development of scientific research. Medicine thus played a crucial role in Japan's subsequent modernization.

Published
2023

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