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23 results on '"Koay, Hui-Fern"'

1. High expression of oleoyl-ACP hydrolase underpins life-threatening respiratory viral diseases

Author

Jia, Xiaoxiao, Crawford, Jeremy Chase, Gebregzabher, Deborah, Monson, Ebony A., Mettelman, Robert C., Wan, Yanmin, Ren, Yanqin, Chou, Janet, Novak, Tanya, McQuilten, Hayley A., Clarke, Michele, Bachem, Annabell, Foo, Isabelle J., Fritzlar, Svenja, Carrera Montoya, Julio, Trenerry, Alice M., Nie, Shuai, Leeming, Michael G., Nguyen, Thi H.O., Kedzierski, Lukasz, Littler, Dene R., Kueh, Andrew, Cardamone, Tina, Wong, Chinn Yi, Hensen, Luca, Cabug, Aira, Laguna, Jaime Gómez, Agrawal, Mona, Flerlage, Tim, Boyd, David F., Van de Velde, Lee-Ann, Habel, Jennifer R., Loh, Liyen, Koay, Hui-Fern, van de Sandt, Carolien E., Konstantinov, Igor E., Berzins, Stuart P., Flanagan, Katie L., Wakim, Linda M., Herold, Marco J., Green, Amanda M., Smallwood, Heather S., Rossjohn, Jamie, Thwaites, Ryan S., Chiu, Christopher, Scott, Nichollas E., Mackenzie, Jason M., Bedoui, Sammy, Reading, Patrick C., Londrigan, Sarah L., Helbig, Karla J., Randolph, Adrienne G., Thomas, Paul G., Xu, Jianqing, Wang, Zhongfang, Chua, Brendon Y., and Kedzierska, Katherine

Published
2024
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2. A2AR eGFP reporter mouse enables elucidation of A2AR expression dynamics during anti-tumor immune responses

Author

Todd, Kirsten L., Lai, Junyun, Sek, Kevin, Huang, Yu-Kuan, Newman, Dane M., Derrick, Emily B., Koay, Hui-Fern, Nguyen, Dat, Hoang, Thang X., Petley, Emma V., Chan, Cheok Weng, Munoz, Isabelle, House, Imran G., Lee, Joel N., Kim, Joelle S., Li, Jasmine, Tong, Junming, N. de Menezes, Maria, Scheffler, Christina M., Yap, Kah Min, Chen, Amanda X. Y., Dunbar, Phoebe A., Haugen, Brandon, Parish, Ian A., Johnstone, Ricky W., Darcy, Phillip K., and Beavis, Paul A.

Published
2023
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5. RIPK3 controls MAIT cell accumulation during development but not during infection

Author

Patton, Timothy, Zhao, Zhe, Lim, Xin Yi, Eddy, Eleanor, Wang, Huimeng, Nelson, Adam G., Ennis, Bronte, Eckle, Sidonia B. G., Souter, Michael N. T., Pediongco, Troi J., Koay, Hui-Fern, Zhang, Jian-Guo, Djajawi, Tirta M., Louis, Cynthia, Lalaoui, Najoua, Jacquelot, Nicolas, Lew, Andrew M., Pellicci, Daniel G., McCluskey, James, Zhan, Yifan, Chen, Zhenjun, Lawlor, Kate E., and Corbett, Alexandra J.

Published
2023
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6. SARS-CoV-2 infection results in immune responses in the respiratory tract and peripheral blood that suggest mechanisms of disease severity

Author

Zhang, Wuji, Chua, Brendon Y., Selva, Kevin J., Kedzierski, Lukasz, Ashhurst, Thomas M., Haycroft, Ebene R., Shoffner-Beck, Suzanne K., Hensen, Luca, Boyd, David F., James, Fiona, Mouhtouris, Effie, Kwong, Jason C., Chua, Kyra Y. L., Drewett, George, Copaescu, Ana, Dobson, Julie E., Rowntree, Louise C., Habel, Jennifer R., Allen, Lilith F., Koay, Hui-Fern, Neil, Jessica A., Gartner, Matthew J., Lee, Christina Y., Andersson, Patiyan, Khan, Sadid F., Blakeway, Luke, Wisniewski, Jessica, McMahon, James H., Vine, Erica E., Cunningham, Anthony L., Audsley, Jennifer, Thevarajan, Irani, Seemann, Torsten, Sherry, Norelle L., Amanat, Fatima, Krammer, Florian, Londrigan, Sarah L., Wakim, Linda M., King, Nicholas J. C., Godfrey, Dale I., Mackay, Laura K., Thomas, Paul G., Nicholson, Suellen, Arnold, Kelly B., Chung, Amy W., Holmes, Natasha E., Smibert, Olivia C., Trubiano, Jason A., Gordon, Claire L., Nguyen, Thi H. O., and Kedzierska, Katherine

Published
2022
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10. MAIT cells regulate NK cell-mediated tumor immunity

Author

Petley, Emma V., Koay, Hui-Fern, Henderson, Melissa A., Sek, Kevin, Todd, Kirsten L., Keam, Simon P., Lai, Junyun, House, Imran G., Li, Jasmine, Zethoven, Magnus, Chen, Amanda X. Y., Oliver, Amanda J., Michie, Jessica, Freeman, Andrew J., Giuffrida, Lauren, Chan, Jack D., Pizzolla, Angela, Mak, Jeffrey Y. W., McCulloch, Timothy R., Souza-Fonseca-Guimaraes, Fernando, Kearney, Conor J., Millen, Rosemary, Ramsay, Robert G., Huntington, Nicholas D., McCluskey, James, Oliaro, Jane, Fairlie, David P., Neeson, Paul J., Godfrey, Dale I., Beavis, Paul A., and Darcy, Phillip K.

Published
2021
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12. Immune profiling of SARS-CoV-2 infection during pregnancy reveals NK cell and γδ T cell perturbations

Author

Habel, Jennifer R., primary, Chua, Brendon Y., additional, Kedzierski, Lukasz, additional, Selva, Kevin J., additional, Damelang, Timon, additional, Haycroft, Ebene R., additional, Nguyen, Thi H.O., additional, Koay, Hui-Fern, additional, Nicholson, Suellen, additional, McQuilten, Hayley A., additional, Jia, Xiaoxiao, additional, Allen, Lilith F., additional, Hensen, Luca, additional, Zhang, Wuji, additional, van de Sandt, Carolien E., additional, Neil, Jessica A., additional, Pragastis, Katherine, additional, Lau, Jillian S.Y., additional, Jumarang, Jaycee, additional, Allen, E. Kaitlynn, additional, Amanant, Fatima, additional, Krammer, Florian, additional, Wragg, Kathleen M., additional, Juno, Jennifer A., additional, Wheatley, Adam K., additional, Tan, Hyon-Xhi, additional, Pell, Gabrielle, additional, Walker, Susan, additional, Audsley, Jennifer, additional, Reynaldi, Arnold, additional, Thevarajan, Irani, additional, Denholm, Justin T., additional, Subbarao, Kanta, additional, Davenport, Miles P., additional, Hogarth, P. Mark, additional, Godfrey, Dale I., additional, Cheng, Allen C., additional, Tong, Steven Y.C., additional, Bond, Katherine, additional, Williamson, Deborah A., additional, McMahon, James H., additional, Thomas, Paul G., additional, Pannaraj, Pia S., additional, James, Fiona, additional, Holmes, Natasha E., additional, Smibert, Olivia C., additional, Trubiano, Jason A., additional, Gordon, Claire L., additional, Chung, Amy W., additional, Whitehead, Clare L., additional, Kent, Stephen J., additional, Lappas, Martha, additional, Rowntree, Louise C., additional, and Kedzierska, Katherine, additional

Published
2023
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13. A2AR eGFP reporter mouse enables elucidation of A2AR expression dynamics during anti-tumor immune responses.

Author

Todd, Kirsten L., Lai, Junyun, Sek, Kevin, Huang, Yu-Kuan, Newman, Dane M., Derrick, Emily B., Koay, Hui-Fern, Nguyen, Dat, Hoang, Thang X., Petley, Emma V., Chan, Cheok Weng, Munoz, Isabelle, House, Imran G., Lee, Joel N., Kim, Joelle S., Li, Jasmine, Tong, Junming, N. de Menezes, Maria, Scheffler, Christina M., and Yap, Kah Min

Subjects
IMMUNE response, LYMPHOCYTE subsets, T cells, RECEPTOR antibodies, PROGRAMMED cell death 1 receptors, SMALL molecules, ADENOSINES
Abstract

There is significant clinical interest in targeting adenosine-mediated immunosuppression, with several small molecule inhibitors having been developed for targeting the A2AR receptor. Understanding of the mechanism by which A2AR is regulated has been hindered by difficulty in identifying the cell types that express A2AR due to a lack of robust antibodies for these receptors. To overcome this limitation, here an A2AR eGFP reporter mouse is developed, enabling the expression of A2AR during ongoing anti-tumor immune responses to be assessed. This reveals that A2AR is highly expressed on all tumor-infiltrating lymphocyte subsets including Natural Killer (NK) cells, NKT cells, γδ T cells, conventional CD4+ and CD8+ T lymphocytes and on a MHCIIhiCD86hi subset of type 2 conventional dendritic cells. In response to PD-L1 blockade, the emergence of PD-1+A2AR- cells correlates with successful therapeutic responses, whilst IL-18 is identified as a cytokine that potently upregulates A2AR and synergizes with A2AR deficiency to improve anti-tumor immunity. These studies provide insight into the biology of A2AR in the context of anti-tumor immunity and reveals potential combination immunotherapy approaches. Adenosine is an immunosuppressive metabolite known to limit anti-tumor immune responses. Here the authors report the characterization of an adenosine A2A receptor (A2AR) eGFP reporter mouse, providing immunological insights into the biology of A2AR expression in the context of anti-tumor immunity. [ABSTRACT FROM AUTHOR]

Published
2023
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17. A three-stage developmental pathway for human Vγ9Vδ2 T cells within the postnatal thymus.

Author

Perriman, Louis, Tavakolinia, Naeimeh, Jalali, Sedigheh, Li, Shuo, Hickey, Peter F., Amann-Zalcenstein, Daniela, Ho, William Wing Ho, Baldwin, Tracey M., Piers, Adam T., Konstantinov, Igor E., Anderson, Jeremy, Stanley, Edouard G., Licciardi, Paul V., Kannourakis, George, Naik, Shalin H., Koay, Hui-Fern, Mackay, Laura K., Berzins, Stuart P., and Pellicci, Daniel G.

Abstract

Vγ9Vδ2 T cells are the largest population of γδ T cells in adults and can play important roles in providing effective immunity against cancer and infection. Many studies have suggested that peripheral Vγ9Vδ2 T cells are derived from the fetal liver and thymus and that the postnatal thymus plays little role in the development of these cells. More recent evidence suggested that these cells may also develop postnatally in the thymus. Here, we used high-dimensional flow cytometry, transcriptomic analysis, functional assays, and precursor-product experiments to define the development pathway of Vγ9Vδ2 T cells in the postnatal thymus. We identify three distinct stages of development for Vγ9Vδ2 T cells in the postnatal thymus that are defined by the progressive acquisition of functional potential and major changes in the expression of transcription factors, chemokines, and other surface markers. Furthermore, our analysis of donor-matched thymus and blood revealed that the molecular requirements for the development of functional Vγ9Vδ2 T cells are delivered predominantly by the postnatal thymus and not in the periphery. Tbet and Eomes, which are required for IFN-γ and TNFα expression, are up-regulated as Vγ9Vδ2 T cells mature in the thymus, and mature thymic Vγ9Vδ2 T cells rapidly express high levels of these cytokines after stimulation. Similarly, the postnatal thymus programs Vγ9Vδ2 T cells to express the cytolytic molecules, perforin, granzyme A, and granzyme K. This study provides a greater understanding of how Vγ9Vδ2 T cells develop in humans and may lead to opportunities to manipulate these cells to treat human diseases. Editor's summary: Unconventional T cells play an important role in protective immunity; however, the development of these distinctive cell populations is poorly understood. Using tissues donated from children undergoing heart surgery, Perriman et al. investigated the development of Vγ9Vδ2 T cells, a large population of unconventional γδ T cells found in adults, addressing the uncertainty about the role of the postnatal thymus in their maturation. This work identified three distinct populations of Vγ9Vδ2 T cells, distinguished by their transcriptional profiles and functional ability to produce cytokines, consistent with a three-stage developmental transition in the thymus before egress of functionally mature cells into the periphery. The identification of precursor Vγ9Vδ2 T cells extends understanding of factors potentially involved in the differentiation of these cells in humans. —Sarah H. Ross [ABSTRACT FROM AUTHOR]

Published
2023
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18. Integrated immune networks in SARS-CoV-2 infected pregnant women reveal differential NK cell and unconventional T cell activation

Author

Habel, Jennifer R, primary, Chua, Brendon Y, additional, Kedzierski, Lukasz, additional, Selva, Kevin J, additional, Damelang, Timon, additional, Haycroft, Ebene R, additional, Nguyen, Thi HO, additional, Koay, Hui-Fern, additional, Nicholson, Suellen, additional, McQuilten, Hayley, additional, Jia, Xiaoxiao, additional, Allen, Lilith F, additional, Hensen, Luca, additional, Zhang, Wuji, additional, van de Sandt, Carolien E, additional, Neil, Jessica A, additional, Amanant, Fatima, additional, Krammer, Florian, additional, Wragg, Kathleen, additional, Juno, Jennifer A, additional, Wheatley, Adam K, additional, Tan, Hyon-Xhi, additional, Pell, Gabrielle, additional, Audsley, Jennifer, additional, Reynaldi, Arnold, additional, Thevarajan, Irani, additional, Denholm, Justin, additional, Subbarao, Kanta, additional, Davenport, Miles P, additional, Hogarth, Mark, additional, Godrey, Dale I, additional, Cheng, Allen C, additional, Tong, Steven YC, additional, Bond, Katherine, additional, Williamson, Deborah A, additional, James, Fiona, additional, Holmes, Natasha E, additional, Smibert, Olivia C, additional, Trubiano, Jason A, additional, Gordon, Claire L, additional, Chung, Amy W, additional, Whitehead, Claire, additional, Kent, Stephen J, additional, Lappas, Martha, additional, Rowntree, Louise C, additional, and Kedzierska, Katherine, additional

Published
2022
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19. Are NKT cells a useful predictor of COVID-19 severity?

Author

Koay, Hui-Fern, primary, Gherardin, Nicholas A., additional, Nguyen, Thi H.O., additional, Zhang, Wuji, additional, Habel, Jennifer R., additional, Seneviratna, Rebecca, additional, James, Fiona, additional, Holmes, Natasha E., additional, Smibert, Olivia C., additional, Gordon, Claire L., additional, Trubiano, Jason A., additional, Kedzierska, Katherine, additional, and Godfrey, Dale I., additional

Published
2022
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20. Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)

Author

Cossarizza, Andrea, primary, Chang, Hyun‐Dong, additional, Radbruch, Andreas, additional, Abrignani, Sergio, additional, Addo, Richard, additional, Akdis, Mübeccel, additional, Andrä, Immanuel, additional, Andreata, Francesco, additional, Annunziato, Francesco, additional, Arranz, Eduardo, additional, Bacher, Petra, additional, Bari, Sudipto, additional, Barnaba, Vincenzo, additional, Barros‐Martins, Joana, additional, Baumjohann, Dirk, additional, Beccaria, Cristian G., additional, Bernardo, David, additional, Boardman, Dominic A., additional, Borger, Jessica, additional, Böttcher, Chotima, additional, Brockmann, Leonie, additional, Burns, Marie, additional, Busch, Dirk H., additional, Cameron, Garth, additional, Cammarata, Ilenia, additional, Cassotta, Antonino, additional, Chang, Yinshui, additional, Chirdo, Fernando Gabriel, additional, Christakou, Eleni, additional, Čičin‐Šain, Luka, additional, Cook, Laura, additional, Corbett, Alexandra J., additional, Cornelis, Rebecca, additional, Cosmi, Lorenzo, additional, Davey, Martin S., additional, De Biasi, Sara, additional, De Simone, Gabriele, additional, del Zotto, Genny, additional, Delacher, Michael, additional, Di Rosa, Francesca, additional, Di Santo, James, additional, Diefenbach, Andreas, additional, Dong, Jun, additional, Dörner, Thomas, additional, Dress, Regine J., additional, Dutertre, Charles‐Antoine, additional, Eckle, Sidonia B. G., additional, Eede, Pascale, additional, Evrard, Maximilien, additional, Falk, Christine S., additional, Feuerer, Markus, additional, Fillatreau, Simon, additional, Fiz‐Lopez, Aida, additional, Follo, Marie, additional, Foulds, Gemma A., additional, Fröbel, Julia, additional, Gagliani, Nicola, additional, Galletti, Giovanni, additional, Gangaev, Anastasia, additional, Garbi, Natalio, additional, Garrote, José Antonio, additional, Geginat, Jens, additional, Gherardin, Nicholas A., additional, Gibellini, Lara, additional, Ginhoux, Florent, additional, Godfrey, Dale I., additional, Gruarin, Paola, additional, Haftmann, Claudia, additional, Hansmann, Leo, additional, Harpur, Christopher M., additional, Hayday, Adrian C., additional, Heine, Guido, additional, Hernández, Daniela Carolina, additional, Herrmann, Martin, additional, Hoelsken, Oliver, additional, Huang, Qing, additional, Huber, Samuel, additional, Huber, Johanna E., additional, Huehn, Jochen, additional, Hundemer, Michael, additional, Hwang, William Y. K., additional, Iannacone, Matteo, additional, Ivison, Sabine M., additional, Jäck, Hans‐Martin, additional, Jani, Peter K., additional, Keller, Baerbel, additional, Kessler, Nina, additional, Ketelaars, Steven, additional, Knop, Laura, additional, Knopf, Jasmin, additional, Koay, Hui‐Fern, additional, Kobow, Katja, additional, Kriegsmann, Katharina, additional, Kristyanto, H., additional, Krueger, Andreas, additional, Kuehne, Jenny F., additional, Kunze‐Schumacher, Heike, additional, Kvistborg, Pia, additional, Kwok, Immanuel, additional, Latorre, Daniela, additional, Lenz, Daniel, additional, Levings, Megan K., additional, Lino, Andreia C., additional, Liotta, Francesco, additional, Long, Heather M., additional, Lugli, Enrico, additional, MacDonald, Katherine N., additional, Maggi, Laura, additional, Maini, Mala K., additional, Mair, Florian, additional, Manta, Calin, additional, Manz, Rudolf Armin, additional, Mashreghi, Mir‐Farzin, additional, Mazzoni, Alessio, additional, McCluskey, James, additional, Mei, Henrik E., additional, Melchers, Fritz, additional, Melzer, Susanne, additional, Mielenz, Dirk, additional, Monin, Leticia, additional, Moretta, Lorenzo, additional, Multhoff, Gabriele, additional, Muñoz, Luis Enrique, additional, Muñoz‐Ruiz, Miguel, additional, Muscate, Franziska, additional, Natalini, Ambra, additional, Neumann, Katrin, additional, Ng, Lai Guan, additional, Niedobitek, Antonia, additional, Niemz, Jana, additional, Almeida, Larissa Nogueira, additional, Notarbartolo, Samuele, additional, Ostendorf, Lennard, additional, Pallett, Laura J., additional, Patel, Amit A., additional, Percin, Gulce Itir, additional, Peruzzi, Giovanna, additional, Pinti, Marcello, additional, Pockley, A. Graham, additional, Pracht, Katharina, additional, Prinz, Immo, additional, Pujol‐Autonell, Irma, additional, Pulvirenti, Nadia, additional, Quatrini, Linda, additional, Quinn, Kylie M., additional, Radbruch, Helena, additional, Rhys, Hefin, additional, Rodrigo, Maria B., additional, Romagnani, Chiara, additional, Saggau, Carina, additional, Sakaguchi, Shimon, additional, Sallusto, Federica, additional, Sanderink, Lieke, additional, Sandrock, Inga, additional, Schauer, Christine, additional, Scheffold, Alexander, additional, Scherer, Hans U., additional, Schiemann, Matthias, additional, Schildberg, Frank A., additional, Schober, Kilian, additional, Schoen, Janina, additional, Schuh, Wolfgang, additional, Schüler, Thomas, additional, Schulz, Axel R., additional, Schulz, Sebastian, additional, Schulze, Julia, additional, Simonetti, Sonia, additional, Singh, Jeeshan, additional, Sitnik, Katarzyna M., additional, Stark, Regina, additional, Starossom, Sarah, additional, Stehle, Christina, additional, Szelinski, Franziska, additional, Tan, Leonard, additional, Tarnok, Attila, additional, Tornack, Julia, additional, Tree, Timothy I. M., additional, van Beek, Jasper J. P., additional, van de Veen, Willem, additional, van Gisbergen, Klaas, additional, Vasco, Chiara, additional, Verheyden, Nikita A., additional, von Borstel, Anouk, additional, Ward‐Hartstonge, Kirsten A., additional, Warnatz, Klaus, additional, Waskow, Claudia, additional, Wiedemann, Annika, additional, Wilharm, Anneke, additional, Wing, James, additional, Wirz, Oliver, additional, Wittner, Jens, additional, Yang, Jennie H. M., additional, and Yang, Juhao, additional

Published
2021
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22. Expansion of MAIT cells in the combined absence of NKT and gdT cells

Author

Xu, Calvin, Li, Shihan, Fulford, Thomas S, Christo, Susan N, Mackay, Laura K, HD Gray, Daniel, Uldrich, Adam P, Pellicci, Daniel G, I Godfrey, Dale, and Koay, Hui-Fern

Abstract

Mucosal-associated invariant T (MAIT) cells, natural killer T (NKT) cells, and γδT cells are collectively referred to as ‘unconventional T cells due to their recognition of non-peptide antigens and restriction to non-classical MHC-I-like molecules. Though the frequencies of MAIT, NKT, and γδT cells and the distribution of their functional subsets vary widely between organs and individuals, the factors controlling these differences are poorly understood. Here, we show that MAIT cells are increased in mice deficient in either NKT or γδT cells and even more so in mice deficient in both NKT and γδT cells. In addition, characterization of the TCRα repertoire within γδT cell-deficient thymocytes revealed an altered Travgene segment usage relative to that of wild-type thymocytes, highlighting a retention of the Tcra-Tcrdlocus from 129 strain embryonic stem cells used to generate Tcrd−/−mice. Accordingly, this resulted in a moderate increase in distal Travsegment usage such as Trav1, potentially contributing to increased generation of Trav1-Traj33+MAIT cells in the Tcrd−/−thymus. However, peripheral MAIT cells also underwent increased homeostatic proliferation in the absence of NKT and γδT cells and adoptively transferred MAIT cell subsets exhibited tissue-specific homing patterns. Collectively, our data reveal a shared niche for MAIT, NKT, and γδT cells, suggesting a competition for common factors that could be exploited for treating disease. Importantly, these data highlight that careful assessment of studies using NKT or γδT cell-deficient mouse models is required when investigating the role of unconventional T cells in disease.

Published
2023
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23. Human Granzyme K Is a Feature of Innate T Cells in Blood, Tissues, and Tumors, Responding to Cytokines Rather than TCR Stimulation.

Author

Duquette D, Harmon C, Zaborowski A, Michelet X, O'Farrelly C, Winter D, Koay HF, and Lynch L

Subjects
Humans, Killer Cells, Natural, Receptors, Antigen, T-Cell metabolism, CD8-Positive T-Lymphocytes, Cytokines metabolism, Granzymes metabolism
Abstract

NK cells and CD8 T cells use cytotoxic molecules to kill virally infected and tumor cell targets. While perforin and granzyme B (GzmB) are the most commonly studied lytic molecules, less is known about granzyme K (GzmK). However, this granzyme has been recently associated with improved prognosis in solid tumors. In this study, we show that, in humans, GzmK is predominantly expressed by innate-like lymphocytes, as well as a newly identified population of GzmK+CD8+ non- mucosal-associated invariant T cells with innate-like characteristics. We found that GzmK+ T cells are KLRG1+EOMES+IL-7R+CD62L-Tcf7int, suggesting that they are central memory T and effector memory T cells. Furthermore, GzmK+ cells are absent/low in cord blood, suggesting that GzmK is upregulated with immune experience. Surprisingly, GzmK+ cells respond to cytokine stimuli alone, whereas TCR stimulation downregulates GzmK expression, coinciding with GzmB upregulation. GzmK+ cells have reduced IFN-γ production compared with GzmB+ cells in each T cell lineage. Collectively, this suggests that GzmK+ cells are not naive, and they may be an intermediate memory-like or preterminally differentiated population. GzmK+ cells are enriched in nonlymphoid tissues such as the liver and adipose. In colorectal cancer, GzmK+ cells are enriched in the tumor and can produce IFN-γ, but GzmK+ expression is mutually exclusive with IL-17a production. Thus, in humans, GzmK+ cells are innate memory-like cells that respond to cytokine stimulation alone and may be important effector cells in the tumor., (Copyright © 2023 by The American Association of Immunologists, Inc.)

Published
2023
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