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14 results on '"Ko, Tun Kiat"'

6. High-Throughput Transcriptomics Identifies Chemoresistance-Associated Gene Expression Signatures in Human Angiosarcoma.

Author

Khor, Glenys Mai Shia, Haghani, Sara, Tan, Tiffany Rui En, Lee, Elizabeth Chun Yong, Kannan, Bavani, Lim, Boon Yee, Lee, Jing Yi, Guo, Zexi, Ko, Tun Kiat, and Chan, Jason Yongsheng

Subjects
GENE expression, GENETIC overexpression, GENE expression profiling, OVERALL survival, TRANSCRIPTOMES
Abstract

Angiosarcomas, clinically aggressive cancers of endothelial origin, are a rare subtype of soft-tissue sarcomas characterized by resistance to chemotherapy and dismal prognosis. In this study, we aim to identify the transcriptomic biomarkers of chemoresistance in angiosarcoma. We examined 72 cases of Asian angiosarcomas, including 35 cases treated with palliative chemotherapy, integrating information from NanoString gene expression profiling, whole transcriptome profiling (RNA-seq), immunohistochemistry, cell line assays, and clinicopathological data. In the chemoresistant cohort (defined as stable disease or progression), we observed the significant overexpression of genes, including SPP1 (log2foldchange 3.49, adj. p = 0.0112), CXCL13, CD48, and CLEC5A, accompanied by the significant enrichment of myeloid compartment and cytokine and chemokine signaling pathways, as well as neutrophils and macrophages. RNA-seq data revealed higher SPP1 expression (p = 0.0008) in tumor tissues over adjacent normal compartments. Immunohistochemistry showed a significant moderate positive correlation between SPP1 protein and gene expression (r = 0.7016; p < 0.00110), while higher SPP1 protein expression correlated with lower chemotherapeutic sensitivity in patient-derived angiosarcoma cell lines MOLAS and ISOHAS. In addition, SPP1 mRNA overexpression positively correlated with epithelioid histology (p = 0.007), higher tumor grade (p = 0.0023), non-head and neck location (p = 0.0576), and poorer overall survival outcomes (HR 1.84, 95% CI 1.07–3.18, p = 0.0288). There was no association with tumor mutational burden, tumor inflammation signature, the presence of human herpesvirus-7, ultraviolet exposure signature, and metastatic state at diagnosis. In conclusion, SPP1 overexpression may be a biomarker of chemoresistance and poor prognosis in angiosarcoma. Further investigation is needed to uncover the precise roles and underlying mechanisms of SPP1. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Single-cell landscape of idiopathic multicentric Castleman disease in identical twins

Author

Chan, Jason Yongsheng, primary, Loh, Jui Wan, additional, Lim, Jing Quan, additional, Liany, Herty, additional, Lee, Elizabeth Chun Yong, additional, Lee, Jing Yi, additional, Kannan, Bavani, additional, Lim, Boon Yee, additional, Guo, Zexi, additional, Lim, Kerry, additional, Ha, Jeslin Chian Hung, additional, Ng, Cedric Chuan-Young, additional, Ko, Tun Kiat, additional, Huang, Dachuan, additional, Seow, Dominique Yuan Bin, additional, Cheng, Chee Leong, additional, Chan, Sock Hoai, additional, Ngeow, Joanne, additional, Teh, Bin Tean, additional, Lim, Soon Thye, additional, and Ong, Choon Kiat, additional

Published
2024
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9. Cholangiocarcinoma: Recent Advances in Molecular Pathobiology and Therapeutic Approaches

Author

Khosla, Divya, primary, Misra, Shagun, additional, Chu, Pek Lim, additional, Guan, Peiyong, additional, Nada, Ritambhra, additional, Gupta, Rajesh, additional, Kaewnarin, Khwanta, additional, Ko, Tun Kiat, additional, Heng, Hong Lee, additional, Srinivasalu, Vijay Kumar, additional, Kapoor, Rakesh, additional, Singh, Deepika, additional, Klanrit, Poramate, additional, Sampattavanich, Somponnat, additional, Tan, Jing, additional, Kongpetch, Sarinya, additional, Jusakul, Apinya, additional, Teh, Bin Tean, additional, Chan, Jason Yongsheng, additional, and Hong, Jing Han, additional

Published
2024
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10. Establishment and characterization of a patient-derived solitary fibrous tumor/hemangiopericytoma cell line model

Author

Lee, Jing Yi, primary, Guan, Peiyong, additional, Lim, Abner Herbert, additional, Guo, Zexi, additional, Li, Zhimei, additional, Kok, Jessica Sook Ting, additional, Lee, Elizabeth Chun Yong, additional, Lim, Boon Yee, additional, Kannan, Bavani, additional, Loh, Jui Wan, additional, Ng, Cedric Chuan-Young, additional, Lim, Kah Suan, additional, Teh, Bin Tean, additional, Ko, Tun Kiat, additional, and Chan, Jason Yongsheng, additional

Published
2023
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11. Therapeutic Repurposing of Brincidofovir in Natural Killer/T-Cell Lymphoma Reveals Potent Induction of Replication Stress, Sting Pathway Activation and Immunogenic Cell Death

Author

Chan, Jason Yongsheng, primary, Lee, Elizabeth Chun Yong, additional, Chai, Kelila Xin Ye, additional, Lee, Jing Yi, additional, Kannan, Bavani, additional, Lim, Boon Yee, additional, Kok, Jessica Sook-Ting, additional, Li, Zhimei, additional, Loh, Jui Wan, additional, Ko, Tun Kiat, additional, Lim, Kah Suan, additional, Ng, Cedric Chuan-Young, additional, Lim, Kerry, additional, Huang, Dachuan, additional, Lim, Jing Quan, additional, Hazama, Masatoshi, additional, Fukushima, Koji, additional, Teh, Bin Tean, additional, Lim, Soon Thye, additional, and Ong, Choon Kiat, additional

Published
2022
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