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26 results on '"Khokha, Rama"'

2. Systemic inflammatory prognostic scores in advanced pancreatic adenocarcinoma

Author

Ma, Lucy X., Wang, Yifan, Espin-Garcia, Osvaldo, Allen, Michael J., Jang, Gun Ho, Zhang, Amy, Dodd, Anna, Ramotar, Stephanie, Hutchinson, Shawn, Tehfe, Mustapha, Ramjeesingh, Ravi, Biagi, James, Wilson, Julie M., Notta, Faiyaz, Fischer, Sandra E., Zogopoulos, George, Gallinger, Steven, Grant, Robert C., Khokha, Rama, Chan, Nathan, Grünwald, Barbara T., Knox, Jennifer J., and O’Kane, Grainne M.

Published
2023
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3. Differential DNA damage repair and PARP inhibitor vulnerability of the mammary epithelial lineages

Author

Kim, Hyeyeon, Aliar, Kazeera, Tharmapalan, Pirashaanthy, McCloskey, Curtis W., Kuttanamkuzhi, Abhijith, Grünwald, Barbara T., Palomero, Luis, Mahendralingam, Mathepan J., Waas, Matthew, Mer, Arvind S., Elliott, Mitchell J., Zhang, Bowen, Al-Zahrani, Khalid N., Langille, Ellen R., Parsons, Michael, Narala, Swami, Hofer, Stefan, Waterhouse, Paul D., Hakem, Razqallah, Haibe-Kains, Benjamin, Kislinger, Thomas, Schramek, Daniel, Cescon, David W., Pujana, Miquel A., Berman, Hal K., and Khokha, Rama

Published
2023
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5. Modification of BRCA1-associated breast cancer risk by HMMR overexpression

Author

Mateo, Francesca, He, Zhengcheng, Mei, Lin, de Garibay, Gorka Ruiz, Herranz, Carmen, García, Nadia, Lorentzian, Amanda, Baiges, Alexandra, Blommaert, Eline, Gómez, Antonio, Mirallas, Oriol, Garrido-Utrilla, Anna, Palomero, Luis, Espín, Roderic, Extremera, Ana I., Soler-Monsó, M. Teresa, Petit, Anna, Li, Rong, Brunet, Joan, Chen, Ke, Tan, Susanna, Eaves, Connie J., McCloskey, Curtis, Hakem, Razq, Khokha, Rama, Lange, Philipp F., Lázaro, Conxi, Maxwell, Christopher A., and Pujana, Miquel Angel

Published
2022
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7. Metabolicshift to serine pathway induced by lipids confers oncogenic properties in non-transformed breast cells

Author

Eduardo, Mariana Bustamante, primary, Cottone, Gannon, additional, McCloskey, Curtis W., additional, Liu, Shiyu, additional, Zappia, Maria Paula, additional, Benevolenskaya, Elizaveta V., additional, Islam, A.B.M.M.K., additional, Frolov, Maxim V., additional, Palma, Flavio R., additional, Gao, Peng, additional, Setya, Joel, additional, Gao, Hongyu, additional, Xuei, Xiaoling, additional, Khokha, Rama, additional, Locasale, Jason, additional, Bonini, Marcelo G., additional, Chandel, Navdeep S., additional, Khan, Seema A., additional, and Clare, Susan E., additional

Published
2024
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10. FABP7 Progenitors are a Targetable Metabolic Root in theBRCA1Breast

Author

McCloskey, Curtis W., primary, Zhang, Bowen, additional, Waas, Matthew, additional, Abazari, Golnaz, additional, Vyas, Foram, additional, Aliar, Kazeera, additional, Tharmapalan, Pirashaanthy, additional, Kuttanamkuzhi, Abhijith, additional, Narala, Swami, additional, Cruikshank, Jennifer, additional, Hofer, Stefan O.P., additional, Jackson, Hartland W., additional, Kislinger, Thomas, additional, Berman, Hal K., additional, and Khokha, Rama, additional

Published
2023
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12. Hourglass, a rapid analysis framework for heterogeneous bioimaging data, identifies sex disparity in IL‐6/STAT3‐associated immune phenotypes in pancreatic cancer

Author

Aliar, Kazeera, primary, Waterhouse, Henry R, additional, Vyas, Foram, additional, Krebs, Niklas, additional, Zhang, Bowen, additional, Poulton, Emily, additional, Chan, Nathan, additional, Gonzalez, Ricardo, additional, Jang, Gun Ho, additional, Bronsert, Peter, additional, Fischer, Sandra E, additional, Gallinger, Steven, additional, Grünwald, Barbara T, additional, and Khokha, Rama, additional

Published
2023
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13. Droplet based low input proteomic platform for rare cell populations

Author

Waas, Matthew, primary, Khoo, Amanda, additional, Tharmapalan, Pirashaanthy, additional, McCloskey, Curtis W, additional, Govindarajan, Meinusha, additional, Zhang, Bowen, additional, Khan, Shahbaz, additional, Waterhouse, Paul, additional, Khokha, Rama, additional, and Kislinger, Thomas, additional

Published
2023
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14. Supplementary Data from GATA6 Expression Distinguishes Classical and Basal-like Subtypes in Advanced Pancreatic Cancer

Author

O’Kane, Grainne M., primary, Grünwald, Barbara T., primary, Jang, Gun-Ho, primary, Masoomian, Mehdi, primary, Picardo, Sarah, primary, Grant, Robert C., primary, Denroche, Robert E., primary, Zhang, Amy, primary, Wang, Yifan, primary, Miller, Jessica K., primary, Lam, Bernard, primary, Krzyzanowski, Paul M., primary, Lungu, Ilinca M., primary, Bartlett, John M.S., primary, Peralta, Melanie, primary, Vyas, Foram, primary, Khokha, Rama, primary, Biagi, James, primary, Chadwick, Dianne, primary, Ramotar, Stephanie, primary, Hutchinson, Shawn, primary, Dodd, Anna, primary, Wilson, Julie M., primary, Notta, Faiyaz, primary, Zogopoulos, George, primary, Gallinger, Steven, primary, Knox, Jennifer J., primary, and Fischer, Sandra E., primary

Published
2023
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15. Figure S6 from A Four-Chemokine Signature Is Associated with a T-cell–Inflamed Phenotype in Primary and Metastatic Pancreatic Cancer

Author

Romero, Joan M., primary, Grünwald, Barbara, primary, Jang, Gun-Ho, primary, Bavi, Prashant P., primary, Jhaveri, Aaditeya, primary, Masoomian, Mehdi, primary, Fischer, Sandra E., primary, Zhang, Amy, primary, Denroche, Robert E., primary, Lungu, Ilinca M., primary, De Luca, Angela, primary, Bartlett, John M.S., primary, Xu, Jing, primary, Li, Niandong, primary, Dhaliwal, Sharon, primary, Liang, Sheng-Ben, primary, Chadwick, Dianne, primary, Vyas, Foram, primary, Bronsert, Peter, primary, Khokha, Rama, primary, McGaha, Tracy L., primary, Notta, Faiyaz, primary, Ohashi, Pamela S., primary, Done, Susan J., primary, O'Kane, Grainne M., primary, Wilson, Julie M., primary, Knox, Jennifer J., primary, Connor, Ashton, primary, Wang, Yifan, primary, Zogopoulos, George, primary, and Gallinger, Steven, primary

Published
2023
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16. Table S3 from A Four-Chemokine Signature Is Associated with a T-cell–Inflamed Phenotype in Primary and Metastatic Pancreatic Cancer

Author

Romero, Joan M., primary, Grünwald, Barbara, primary, Jang, Gun-Ho, primary, Bavi, Prashant P., primary, Jhaveri, Aaditeya, primary, Masoomian, Mehdi, primary, Fischer, Sandra E., primary, Zhang, Amy, primary, Denroche, Robert E., primary, Lungu, Ilinca M., primary, De Luca, Angela, primary, Bartlett, John M.S., primary, Xu, Jing, primary, Li, Niandong, primary, Dhaliwal, Sharon, primary, Liang, Sheng-Ben, primary, Chadwick, Dianne, primary, Vyas, Foram, primary, Bronsert, Peter, primary, Khokha, Rama, primary, McGaha, Tracy L., primary, Notta, Faiyaz, primary, Ohashi, Pamela S., primary, Done, Susan J., primary, O'Kane, Grainne M., primary, Wilson, Julie M., primary, Knox, Jennifer J., primary, Connor, Ashton, primary, Wang, Yifan, primary, Zogopoulos, George, primary, and Gallinger, Steven, primary

Published
2023
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17. Abstract A031: Proteogenomic analysis of the PDAC epithelium reveals tissue markers of subtype identity and biology

Author

Grünwald, Barbara T., primary, Vyas, Foram, additional, Geuenich, Michael, additional, Chan, Nathan, additional, Gonzalez, Ricardo, additional, Aliar, Kazeera, additional, Krebs, Niklas, additional, Devisme, Antoine, additional, Andrieux, Geoffroy, additional, Jang, Gun Ho, additional, O'Kane, Grainne, additional, Wilson, Julie, additional, Knox, Jennifer, additional, Notta, Faiyaz, additional, Campbell, Kieran, additional, Gallinger, Steven, additional, Boerries, Melanie, additional, Fischer, Sandra, additional, Kislinger, Thomas, additional, and Khokha, Rama, additional

Published
2022
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18. Hourglass, a tool to mine bioimaging data, uncovers sex-disparities in the IL-6-associated T cell response in pancreatic tumors

Author

Aliar, Kazeera, primary, Waterhouse, Henry R., additional, Vyas, Foram, additional, Krebs, Niklas, additional, Poulton, Emily, additional, Zhang, Bowen, additional, Chan, Nathan, additional, Bronsert, Peter, additional, Fischer, Sandra E., additional, Gallinger, Steven, additional, Grünwald, Barbara T., additional, and Khokha, Rama, additional

Published
2022
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19. Glycoproteomics Identifies Plexin-B3 as a Targetable Cell Surface Protein Required for the Growth and Invasion of Triple-Negative Breast Cancer Cells

Author

Kuhlmann, Laura, primary, Govindarajan, Meinusha, additional, Mejia-Guerrero, Salvador, additional, Ignatchenko, Vladimir, additional, Liu, Lydia Y., additional, Grünwald, Barbara T., additional, Cruickshank, Jennifer, additional, Berman, Hal, additional, Khokha, Rama, additional, and Kislinger, Thomas, additional

Published
2022
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20. Correction: GATA6 Expression Distinguishes Classical and Basal-like Subtypes in Advanced Pancreatic Cancer

Author

O'Kane, Grainne M., primary, Grünwald, Barbara T., additional, Jang, Gun-Ho, additional, Masoomian, Mehdi, additional, Picardo, Sarah, additional, Grant, Robert C., additional, Denroche, Robert E., additional, Zhang, Amy, additional, Wang, Yifan, additional, Miller, Jessica K., additional, Lam, Bernard, additional, Krzyzanowski, Paul M., additional, Lungu, Ilinca M., additional, Bartlett, John M.S., additional, Peralta, Melanie, additional, Vyas, Foram, additional, Khokha, Rama, additional, Biagi, James, additional, Chadwick, Dianne, additional, Ramotar, Stephanie, additional, Hutchinson, Shawn, additional, Dodd, Anna, additional, Wilson, Julie M., additional, Notta, Faiyaz, additional, Zogopoulos, George, additional, Gallinger, Steven, additional, Knox, Jennifer J., additional, and Fischer, Sandra E., additional

Published
2022
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21. Glycoproteomics Identifies Plexin-B3 as Targetable Cell Surface Protein Required for Growth and Invasion of Triple Negative Breast Cancer Cells

Author

Kuhlmann, Laura, primary, Govindarajan, Meinusha, additional, Mejia-Guerrero, Salvador, additional, Ignatchenko, Vladimir, additional, Liu, Lydia Y., additional, Grünwald, Barbara T., additional, Cruickshank, Jennifer, additional, Berman, Hal, additional, Khokha, Rama, additional, and Kislinger, Thomas, additional

Published
2022
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22. Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity

Author

Hezaveh, Kebria, primary, Shinde, Rahul S., additional, Klötgen, Andreas, additional, Halaby, Marie Jo, additional, Lamorte, Sara, additional, Ciudad, M. Teresa, additional, Quevedo, Rene, additional, Neufeld, Luke, additional, Liu, Zhe Qi, additional, Jin, Robbie, additional, Grünwald, Barbara T., additional, Foerster, Elisabeth G., additional, Chaharlangi, Danica, additional, Guo, Mengdi, additional, Makhijani, Priya, additional, Zhang, Xin, additional, Pugh, Trevor J., additional, Pinto, Devanand M., additional, Co, Ileana L., additional, McGuigan, Alison P., additional, Jang, Gun Ho, additional, Khokha, Rama, additional, Ohashi, Pamela S., additional, O’Kane, Grainne M., additional, Gallinger, Steven, additional, Navarre, William W., additional, Maughan, Heather, additional, Philpott, Dana J., additional, Brooks, David G., additional, and McGaha, Tracy L., additional

Published
2022
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23. Abstract PO-107: Fibroblast differentiation trajectories elicit regional tissue states in pancreatic cancer

Author

Grünwald, Barbara T., primary, McCloskey, Curtis, additional, Devisme, Antoine, additional, Vyas, Foram, additional, Andrieux, Geoffroy, additional, Aliar, Kazeera, additional, Notta, Faiyaz, additional, O’Kane, Grainne, additional, Wilson, Julie, additional, Knox, Jennifer, additional, Fischer, Sandra, additional, Kislinger, Thomas, additional, Boerries, Melanie, additional, Gallinger, Steven, additional, and Khokha, Rama, additional

Published
2021
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24. Spatially confined sub-tumor microenvironments in pancreatic cancer

Author

Grünwald, Barbara T., primary, Devisme, Antoine, additional, Andrieux, Geoffroy, additional, Vyas, Foram, additional, Aliar, Kazeera, additional, McCloskey, Curtis W., additional, Macklin, Andrew, additional, Jang, Gun Ho, additional, Denroche, Robert, additional, Romero, Joan Miguel, additional, Bavi, Prashant, additional, Bronsert, Peter, additional, Notta, Faiyaz, additional, O’Kane, Grainne, additional, Wilson, Julie, additional, Knox, Jennifer, additional, Tamblyn, Laura, additional, Udaskin, Molly, additional, Radulovich, Nikolina, additional, Fischer, Sandra E., additional, Boerries, Melanie, additional, Gallinger, Steven, additional, Kislinger, Thomas, additional, and Khokha, Rama, additional

Published
2021
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25. Identifying Stress Granules As Determinants of Leukemia Stem Cell Maintenance and Stress Adaptation

Author

Tajik, Amanda, Tsao, Emily, Seale, Brendon, Jahangiri, Soheil, Abidin, Belma, Liu, Lina, Balde, Zaldy, Chen, He Tian (Tony), Wong, Nicholas, Keyvani Chahi, Ava, Joshi, Pratik, Moreira, Steven, McCloskey, Curtis W., Khan, Shahbaz, Boutzen, Helena, Wong, Cassandra, Bansal, Suraj, Zeng, Andy G.X., Aigner, Stefan, Lu, Yu, Dick, John E., Kislinger, Thomas, Khokha, Rama, Minden, Mark D., Yeo, Gene W., Gingras, Anne-Claude, and Hope, Kristin J.

Abstract

The development of novel leukemic stem cell (LSC)-targeted therapeutics, which spare hematopoietic stem cells (HSC), is an urgent goal towards reducing the high, LSC-driven, relapse rates in acute myeloid leukemia (AML) patients. Towards elucidating key post-transcriptional networks underlying LSC maintenance we previously performed an in vivo pooled CRISPR dropout screen targeting 128 RNA binding proteins (RBPs) highly expressed in AML LSCs while having low expression in HSCs. This screen highlighted 12 RBPs crucial for murine AML LSC-mediated leukemic growth, of which there was a significant enrichment of stress granule (SG) RBPs. Further, gene set enrichment analysis shows the SG proteome is enriched in human AML LSCs vs non-LSCs while normal HSCs have reduced SG RBP expression relative to multipotent progenitor cells. SGs are dynamic biomolecular condensates, composed of ribonucleoprotein complexes, which may form as a protective mechanism against a variety of stress conditions. SGs are gaining increasing attention as contributors to cancer metastasis and chemoresistance, but their role in LSCs is virtually unexplored.

Published
2023
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26. TIMP1 expression underlies sex disparity in liver metastasis and survival in pancreatic cancer

Author

Hermann, Chris D., Schoeps, Benjamin, Eckfeld, Celina, Munkhbaatar, Enkhtsetseg, Kniep, Lukas, Prokopchuk, Olga, Wirges, Nils, Steiger, Katja, Häußler, Daniel, Knolle, Percy, Poulton, Emily, Khokha, Rama, Grünwald, Barbara T., Demir, Ihsan Ekin, and Krüger, Achim

Abstract

Sex disparity in cancer is so far inadequately considered, and components of its basis are rather unknown. We reveal that male versus female pancreatic cancer (PC) patients and mice show shortened survival, more frequent liver metastasis, and elevated hepatic metastasis-promoting gene expression. Tissue inhibitor of metalloproteinases 1 (TIMP1) was the secreted factor with the strongest male-biased expression in patient-derived pancreatic tumors. Male-specific up-regulation of systemic TIMP1 was demonstrated in PC mouse models and patients. Using TIMP1-competent and TIMP1-deficient PC mouse models, we established a causal role of TIMP1 in determining shortened survival and increased liver metastasis in males. Observing TIMP1 expression as a risk parameter in males led to identification of a subpopulation exhibiting increased TIMP1 levels (T1HI males) in both primary tumors and blood. T1HI males showed increased risk for liver metastasis development not only in PC but also in colorectal cancer and melanoma. This study reveals a lifestyle-independent sex disparity in liver metastasis and may open new avenues toward precision medicine.

Published
2021
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