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21 results on '"Kevin Robinson"'

1. AAV9:PKP2 improves heart function and survival in a Pkp2-deficient mouse model of arrhythmogenic right ventricular cardiomyopathy

Author

Iris Wu, Aliya Zeng, Amara Greer-Short, J. Alex Aycinena, Anley E. Tefera, Reva Shenwai, Farshad Farshidfar, Melissa Van Pell, Emma Xu, Chris Reid, Neshel Rodriguez, Beatriz Lim, Tae Won Chung, Joseph Woods, Aquilla Scott, Samantha Jones, Cristina Dee-Hoskins, Carolina G. Gutierrez, Jessie Madariaga, Kevin Robinson, Yolanda Hatter, Renee Butler, Stephanie Steltzer, Jaclyn Ho, James R. Priest, Xiaomei Song, Frank Jing, Kristina Green, Kathryn N. Ivey, Timothy Hoey, Jin Yang, and Zhihong Jane Yang

Subjects
Medicine
Abstract

Abstract Background Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a familial cardiac disease associated with ventricular arrhythmias and an increased risk of sudden cardiac death. Currently, there are no approved treatments that address the underlying genetic cause of this disease, representing a significant unmet need. Mutations in Plakophilin-2 (PKP2), encoding a desmosomal protein, account for approximately 40% of ARVC cases and result in reduced gene expression. Methods Our goal is to examine the feasibility and the efficacy of adeno-associated virus 9 (AAV9)-mediated restoration of PKP2 expression in a cardiac specific knock-out mouse model of Pkp2. Results We show that a single dose of AAV9:PKP2 gene delivery prevents disease development before the onset of cardiomyopathy and attenuates disease progression after overt cardiomyopathy. Restoration of PKP2 expression leads to a significant extension of lifespan by restoring cellular structures of desmosomes and gap junctions, preventing or halting decline in left ventricular ejection fraction, preventing or reversing dilation of the right ventricle, ameliorating ventricular arrhythmia event frequency and severity, and preventing adverse fibrotic remodeling. RNA sequencing analyses show that restoration of PKP2 expression leads to highly coordinated and durable correction of PKP2-associated transcriptional networks beyond desmosomes, revealing a broad spectrum of biological perturbances behind ARVC disease etiology. Conclusions We identify fundamental mechanisms of PKP2-associated ARVC beyond disruption of desmosome function. The observed PKP2 dose-function relationship indicates that cardiac-selective AAV9:PKP2 gene therapy may be a promising therapeutic approach to treat ARVC patients with PKP2 mutations.

Published
2024
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4. Scaling Instruction-Finetuned Language Models.

Author

Hyung Won Chung, Le Hou, Shayne Longpre, Barret Zoph, Yi Tay, William Fedus, Yunxuan Li, Xuezhi Wang 0002, Mostafa Dehghani 0001, Siddhartha Brahma, Albert Webson, Shixiang Shane Gu, Zhuyun Dai, Mirac Suzgun, Xinyun Chen, Aakanksha Chowdhery, Alex Castro-Ros, Marie Pellat, Kevin Robinson, Dasha Valter, Sharan Narang, Gaurav Mishra, Adams Yu, Vincent Y. Zhao, Yanping Huang, Andrew M. Dai, Hongkun Yu 0001, Slav Petrov, Ed H. Chi, Jeff Dean, Jacob Devlin, Adam Roberts, Denny Zhou, Quoc V. Le, and Jason Wei

Published
2024

9. PaLM: Scaling Language Modeling with Pathways.

Author

Aakanksha Chowdhery, Sharan Narang, Jacob Devlin, Maarten Bosma, Gaurav Mishra, Adam Roberts, Paul Barham 0001, Hyung Won Chung, Charles Sutton, Sebastian Gehrmann, Parker Schuh, Kensen Shi, Sasha Tsvyashchenko, Joshua Maynez, Abhishek Rao, Parker Barnes, Yi Tay, Noam Shazeer, Vinodkumar Prabhakaran, Emily Reif, Nan Du 0002, Ben Hutchinson, Reiner Pope, James Bradbury, Jacob Austin, Michael Isard, Guy Gur-Ari, Pengcheng Yin, Toju Duke, Anselm Levskaya, Sanjay Ghemawat, Sunipa Dev, Henryk Michalewski, Xavier Garcia, Vedant Misra, Kevin Robinson, Liam Fedus, Denny Zhou, Daphne Ippolito, David Luan, Hyeontaek Lim, Barret Zoph, Alexander Spiridonov, Ryan Sepassi, David Dohan, Shivani Agrawal, Mark Omernick, Andrew M. Dai, Thanumalayan Sankaranarayana Pillai, Marie Pellat, Aitor Lewkowycz, Erica Moreira, Rewon Child, Oleksandr Polozov, Katherine Lee, Zongwei Zhou, Xuezhi Wang 0002, Brennan Saeta, Mark Diaz, Orhan Firat, Michele Catasta, Jason Wei, Kathy Meier-Hellstern, Douglas Eck, Jeff Dean, Slav Petrov, and Noah Fiedel

Published
2023

10. GLaM: Efficient Scaling of Language Models with Mixture-of-Experts.

Author

Nan Du 0002, Yanping Huang, Andrew M. Dai, Simon Tong, Dmitry Lepikhin, Yuanzhong Xu, Maxim Krikun, Yanqi Zhou, Adams Wei Yu, Orhan Firat, Barret Zoph, Liam Fedus, Maarten P. Bosma, Zongwei Zhou, Tao Wang, Yu Emma Wang, Kellie Webster, Marie Pellat, Kevin Robinson, Kathleen S. Meier-Hellstern, Toju Duke, Lucas Dixon, Kun Zhang 0043, Quoc V. Le, Yonghui Wu, Zhifeng Chen, and Claire Cui

Published
2022

12. PaLM 2 Technical Report.

Author

Rohan Anil, Andrew M. Dai, Orhan Firat, Melvin Johnson, Dmitry Lepikhin, Alexandre Passos, Siamak Shakeri, Emanuel Taropa, Paige Bailey, Zhifeng Chen, Eric Chu, Jonathan H. Clark, Laurent El Shafey, Yanping Huang, Kathy Meier-Hellstern, Gaurav Mishra, Erica Moreira, Mark Omernick, Kevin Robinson, Sebastian Ruder, Yi Tay, Kefan Xiao, Yuanzhong Xu, Yujing Zhang, Gustavo Hernández ábrego, Junwhan Ahn, Jacob Austin, Paul Barham 0001, Jan A. Botha, James Bradbury, Siddhartha Brahma, Kevin Brooks, Michele Catasta, Yong Cheng, Colin Cherry, Christopher A. Choquette-Choo, Aakanksha Chowdhery, Clément Crepy, Shachi Dave, Mostafa Dehghani 0001, Sunipa Dev, Jacob Devlin, Mark Díaz, Nan Du 0002, Ethan Dyer, Vladimir Feinberg, Fangxiaoyu Feng, Vlad Fienber, Markus Freitag, Xavier Garcia, Sebastian Gehrmann, Lucas Gonzalez, and et al.

Published
2023
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13. PaLM: Scaling Language Modeling with Pathways.

Author

Aakanksha Chowdhery, Sharan Narang, Jacob Devlin, Maarten Bosma, Gaurav Mishra, Adam Roberts, Paul Barham 0001, Hyung Won Chung, Charles Sutton, Sebastian Gehrmann, Parker Schuh, Kensen Shi, Sasha Tsvyashchenko, Joshua Maynez, Abhishek Rao, Parker Barnes, Yi Tay, Noam Shazeer, Vinodkumar Prabhakaran, Emily Reif, Nan Du 0002, Ben Hutchinson, Reiner Pope, James Bradbury, Jacob Austin, Michael Isard, Guy Gur-Ari, Pengcheng Yin, Toju Duke, Anselm Levskaya, Sanjay Ghemawat, Sunipa Dev, Henryk Michalewski, Xavier Garcia, Vedant Misra, Kevin Robinson, Liam Fedus, Denny Zhou, Daphne Ippolito, David Luan, Hyeontaek Lim, Barret Zoph, Alexander Spiridonov, Ryan Sepassi, David Dohan, Shivani Agrawal, Mark Omernick, Andrew M. Dai, Thanumalayan Sankaranarayana Pillai, Marie Pellat, Aitor Lewkowycz, Erica Moreira, Rewon Child, Oleksandr Polozov, Katherine Lee, Zongwei Zhou, Xuezhi Wang 0002, Brennan Saeta, Mark Diaz, Orhan Firat, Michele Catasta, Jason Wei, Kathy Meier-Hellstern, Douglas Eck, Jeff Dean, Slav Petrov, and Noah Fiedel

Published
2022
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14. On-call topics : in Neurology

Author

Perez Guijarro, Yaritza Jamileth, Matute Alao, David Sebastián; Universidad Católica de Cuenca, Ortega Vázquez, Nataly Estefanía; Universidad Católica de Cuenca, Pérez Guijarro, Yaritza Jamileth; Universidad Católica de Cuenca, Perugachi Marcillo, Kevin Robinson; Universidad Católica de Cuenca, Calle León, Freddy Daniel; Universidad Católica de Cuenca, Jaramillo Paredes, Gabriela Mishell; Universidad Católica de Cuenca, Lojano Munzón, Esteban German; Universidad Católica de Cuenca, Samaniego Jara, Gerald Alexander; Universidad Católica de Cuenca, Quezada Matute, Eva Alexandra; Universidad Católica de Cuenca, Pauta Verdugo, Paula Victoria; Universidad Católica de Cuenca, Lara Bedón, Hamilton Andrés; Universidad Católica de Cuenca, Jennifer Mariuxi, Quiñonez Boconsaca; Universidad Católica de Cuenca, Esthela Lisbeth, Vega Valladarez; Universidad Católica de Cuenca, Salinas Huerta, María Caridad; Universidad Católica de Cuenca, Calle Cantos, Wendy Maritza; Universidad Católica de Cuenca, Valladolid Sangurima, Jennifer Liliana; Universidad Católica de Cuenca, Torres Criollo, Larry Miguel; Hospital IESS- Babahoyo. Universidad Católica de Cuenca. Sede Azogues- Carrera de Medicina, Perez Guijarro, Yaritza Jamileth, Matute Alao, David Sebastián; Universidad Católica de Cuenca, Ortega Vázquez, Nataly Estefanía; Universidad Católica de Cuenca, Pérez Guijarro, Yaritza Jamileth; Universidad Católica de Cuenca, Perugachi Marcillo, Kevin Robinson; Universidad Católica de Cuenca, Calle León, Freddy Daniel; Universidad Católica de Cuenca, Jaramillo Paredes, Gabriela Mishell; Universidad Católica de Cuenca, Lojano Munzón, Esteban German; Universidad Católica de Cuenca, Samaniego Jara, Gerald Alexander; Universidad Católica de Cuenca, Quezada Matute, Eva Alexandra; Universidad Católica de Cuenca, Pauta Verdugo, Paula Victoria; Universidad Católica de Cuenca, Lara Bedón, Hamilton Andrés; Universidad Católica de Cuenca, Jennifer Mariuxi, Quiñonez Boconsaca; Universidad Católica de Cuenca, Esthela Lisbeth, Vega Valladarez; Universidad Católica de Cuenca, Salinas Huerta, María Caridad; Universidad Católica de Cuenca, Calle Cantos, Wendy Maritza; Universidad Católica de Cuenca, Valladolid Sangurima, Jennifer Liliana; Universidad Católica de Cuenca, and Torres Criollo, Larry Miguel; Hospital IESS- Babahoyo. Universidad Católica de Cuenca. Sede Azogues- Carrera de Medicina

Abstract

Prologue Neurology is a medical discipline that covers the study and treatment of disorders of the nervous system. This book seeks to provide a complete and updated guide on various neurology topics that are of vital importance both in clinical practice and in on-call situations. Each chapter has been meticulously prepared by students committed to academic excellence and the advancement of medical knowledge, under the supervision of their faculty tutors. This joint effort ensures that the content is not only scientifically rigorous, but also relevant and accessible to healthcare professionals and students. The book is organized into the following 11 chapters of common neurological pathologies in daily medical practice. The work with the publisher REDLIC (Latin American Editorial Network for Contemporary Research) has allowed this book to be freely accessible (Open Access), which facilitates its dissemination and access to updated scientific information. The sources used to prepare the chapters include Uptodate, neurology books and recent scientific articles, ensuring the quality and relevance of the content. Additionally, this book has gone through several filters in the editorial process, including a rigorous peer review process. This ensures that the content not only meets high academic standards, but has also been evaluated and validated by subject matter experts, ensuring its accuracy and relevance. Aimed especially at health professionals and medical students, we hope that this book will be a valuable tool, providing key information that can be used in daily clinical practice and in on-call situations, thus contributing to the better management of neurological patients. Dr. Gina Heredia, Prólogo La Neurología es una disciplina médica que abarca el estudio y tratamiento de los trastornos del sistema nervioso. Este libro busca proporcionar una guía completa y actualizada sobre diversos temas de neurología que son de vital importancia tanto en la práctica clínica como en situaciones de guardia. Cada capítulo ha sido meticulosamente preparado por estudiantes comprometidos con la excelencia académica y el avance del conocimiento médico, bajo la supervisión de sus docentes tutores. Este esfuerzo conjunto asegura que el contenido sea no solo científicamente riguroso, sino también relevante y accesible para profesionales y estudiantes de la salud. El libro se organiza en los siguientes 11 capítulos de patologías neurológicas frecuentes en la atención diaria de la práctica médica. El trabajo con la editorial REDLIC (Red Editorial Latinoamericana de Investigación Contemporánea) ha permitido que este libro sea de acceso gratuito (Open Access), lo que facilita su difusión y el acceso a información científica actualizada. Las fuentes utilizadas para la elaboración de los capítulos incluyen Uptodate, libros de neurología y artículos científicos recientes, asegurando la calidad y relevancia del contenido. Además, este libro ha pasado por varios filtros en el proceso editorial, incluyendo un riguroso proceso de revisión por pares. Esto garantiza que el contenido no solo cumple con altos estándares académicos, sino que también ha sido evaluado y validado por expertos en la materia, asegurando su precisión y pertinencia. Dirigido especialmente a profesionales de la salud y estudiantes de medicina, esperamos que este libro sea una herramienta valiosa, proporcionando información clave que pueda ser utilizada en la práctica clínica diaria y en situaciones de guardia, contribuyendo así al mejor manejo de los pacientes neurológicos. Dra. Gina Heredia

Published
2024

21. Overground gait kinematics and muscle activation patterns in the Yucatan mini pig

Author

Soroush Mirkiani, David A Roszko, Carly L O’Sullivan, Pouria Faridi, David S Hu, Daniel Fang, Dirk G Everaert, Amirali Toossi, Peter E Konrad, Kevin Robinson, and Vivian K Mushahwar

Subjects
Cellular and Molecular Neuroscience, Electromyography, Swine, Muscles, Biomedical Engineering, Animals, Swine, Miniature, Walking, Gait, human activities, Biomechanical Phenomena
Abstract

Objective. The objectives of this study were to assess gait biomechanics and the effect of overground walking speed on gait parameters, kinematics, and electromyographic (EMG) activity in the hindlimb muscles of Yucatan minipigs (YMPs). Approach. Nine neurologically-intact, adult YMPs were trained to walk overground in a straight line. Whole-body kinematics and EMG activity of hindlimb muscles were recorded and analyzed at six different speed ranges (0.4–0.59, 0.6–0.79, 0.8–0.99, 1.0–1.19, 1.2–1.39, and 1.4–1.6 m s−1). A MATLAB program was developed to detect strides and gait events automatically from motion-captured data. The kinematics and EMG activity were analyzed for each stride based on the detected events. Main results. Significant decreases in stride duration, stance and swing times and an increase in stride length were observed with increasing speed. A transition in gait pattern occurred at the 1.0 m s−1 walking speed. Significant increases in the range of motion of the knee and ankle joints were observed at higher speeds. Also, the points of minimum and maximum joint angles occurred earlier in the gait cycle as the walking speed increased. The onset of EMG activity in the biceps femoris muscle occurred significantly earlier in the gait cycle with increasing speed. Significance. YMPs are becoming frequently used as large animal models for preclinical testing and translation of novel interventions to humans. A comprehensive characterization of overground walking in neurologically-intact YMPs is provided in this study. These normative measures set the basis against which the effects of future interventions on locomotor capacity in YMPs can be compared.

Published
2022
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