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8 results on '"Kevin Gibbs"'

1. Macrophages modulate skeletal muscle wasting and recovery in acute lung injury in mice

Author

Jennifer T. W. Krall, Lanazha Belfield, Claire Strysick, Chun Liu, Lina Purcell, Renee Stapleton, Michael Toth, Matthew Poynter, Xuewei Zhu, Kevin Gibbs, and D. Clark Files

Subjects
acute lung injury, acute respiratory distress syndrome, intensive care unit acquired weakness, macrophage, skeletal muscle wasting, Physiology, QP1-981
Abstract

Abstract Skeletal muscle dysfunction in critical illnesses leaves survivors weak and functionally impaired. Macrophages infiltrate muscles; however, their functional role is unclear. We aim to examine muscle leukocyte composition and the effect of macrophages on muscle mass and function in the murine acute lung injury (ALI)‐associated skeletal muscle wasting model. We performed flow cytometry of hindlimb muscle to identify myeloid cells pre‐injury and time points up to 29 days after intratracheal lipopolysaccharide ALI. We evaluated muscle force and morphometrics after systemic and intramuscular clodronate‐induced macrophage depletions between peak lung injury and recovery (day 5–6) versus vehicle control. Our results show muscle leukocytes changed over ALI course with day 3 neutrophil infiltration (130.5 ± 95.6cells/mg control to 236.3 ± 70.6cells/mg day 3) and increased day 10 monocyte abundance (5.0 ± 3.4%CD45+CD11b+ day 3 to 14.0 ± 2.6%CD45+CD11b+ day 10, p = 0.005). Although macrophage count did not significantly change, pro‐inflammatory (27.0 ± 7.2% day 3 to 7.2 ± 3.8% day 10, p = 0.02) and anti‐inflammatory (30.5 ± 11.1% day 3 to 52.7 ± 9.7% day 10, p = 0.09) surface marker expression changed over the course of ALI. Macrophage depletion following peak lung injury increased muscle mass and force generation. These data suggest muscle macrophages beyond peak lung injury limit or delay muscle recovery. Targeting macrophages could augment muscle recovery following lung injury.

Published
2024
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2. Effect of Laryngoscope Blade Size on First Pass Success of Tracheal Intubation in Critically Ill Adults

Author

Kevin R. Landefeld, MD, Seiji Koike, MAS, Ran Ran, MD, Matthew W. Semler, MD, MSc, Christopher Barnes, MD, Susan B. Stempek, PA-C, MMSc, David R. Janz, MD, MSc, Todd W. Rice, MD, MSc, Derek W. Russell, MD, Wesley H. Self, MD, MPH, Derek Vonderhaar, MD, Jason R. West, MD, Jonathan D. Casey, MD, MSc, Akram Khan, MD, for the Pragmatic Critical Care Research Group, Adit A. Ginde, Sheetal Gandotra, Brian E. Driver, Matthew E. Prekker, Stacy Trent, David R. Janz, Derek W. Russell, Todd W. Rice, Wesley H. Self, and Kevin Gibbs

Subjects
Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

OBJECTIVES:. Tracheal intubation (TI) is a common procedure in critical care, often performed with a Macintosh curved blade used for direct laryngoscopy (DL). Minimal evidence informs the choice between Macintosh blade sizes during TI. We hypothesized that Macintosh 4 blade would have higher first-attempt success than Macintosh 3 blade during DL. DESIGN:. Retrospective analysis using a propensity score and inverse probability weighting of data from six prior multicenter randomized trials. SETTING AND PARTICIPANTS:. Adult patients who underwent nonelective TI at participating emergency departments and ICUs. We compared the first-pass success of TI with DL in subjects intubated with a size 4 Macintosh blade on the first TI attempt to subjects with a size 3 Macintosh blade on the first TI attempt. MAIN RESULTS:. Among 979 subjects, 592 (60.5%) had TI using DL with a Macintosh blade, of whom 362 (37%) were intubated with a size 4 blade and 222 (22.7%) with a size 3 blade. We used inverse probability weighting with a propensity score for analyzing data. We found that patients intubated with a size 4 blade had a worse (higher) Cormack-Lehane grade of glottic view than patients intubated with a size 3 blade (adjusted odds ratio [aOR], 1.458; 95% CI, 1.064–2.003; p = 0.02). Patients intubated with a size 4 blade had a lower first pass success than those with a size 3 blade (71.1% vs 81.2%; aOR, 0.566; 95% CI, 0.372–0.850; p = 0.01). CONCLUSIONS AND RELEVANCE:. In critically ill adults undergoing TI using DL with a Macintosh blade, patients intubated using a size 4 blade on first attempt had a worse glottic view and a lower first pass success than patients intubated with a size 3 Macintosh blade. Further prospective studies are needed to examine the optimal approach to selecting laryngoscope blade size during TI of critically ill adults.

Published
2023
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3. Disaster, survival and recovery: the resettlement of Tanegashima Island following the Kikai-Akahoya ‘super-eruption’, 7.3ka cal BP

Author

Junzo Uchiyama, Mitsuhiro Kuwahata, Yukino Kowaki, Nobuhiko Kamijō, Julia Talipova, Kevin Gibbs, Peter D. Jordan, and Sven Isaksson

Subjects
Archeology, General Arts and Humanities
Abstract

Archaeologists have traditionally framed the impacts of natural disasters in terms of societal collapse versus cultural resilience. The 7.3ka cal BP Kikai-Akahoya (K-Ah) ‘super-eruption’ in south-western Japan was among the largest volcanic events of the Holocene. Here, the authors deploy a multi-proxy approach to examine how K-Ah devastated Tanegashima Island. While local Jōmon populations were annihilated, surrounding communities survived and eventually returned, adjusting their subsistence base to survive in the damaged environment. The article concludes that neither ‘collapse’ nor ‘resilience’ fully capture the complex dynamics of this process and that more research is needed to understand how disasters shape cultural trajectories.

Published
2023

4. Protection of Messenger RNA Vaccines Against Hospitalized Coronavirus Disease 2019 in Adults Over the First Year Following Authorization in the United States

Author

Daniel Clark Files, Christopher Lindsell, Kevin Gibbs, Christopher Mallow, Mena Botros, Manjusha Gaglani, H. Keipp Talbot, Samuel Brown, Katherine Adams, and Nicholas Mohr

Subjects
Microbiology (medical), Infectious Diseases
Abstract

Background Coronavirus disease 2019 (COVID-19) messenger RNA (mRNA) vaccines were authorized in the United States in December 2020. Although vaccine effectiveness (VE) against mild infection declines markedly after several months, limited understanding exists on the long-term durability of protection against COVID-19–associated hospitalization. Methods Case-control analysis of adults (≥18 years) hospitalized at 21 hospitals in 18 states 11 March–15 December 2021, including COVID-19 case patients and reverse transcriptase-polymerase chain reaction–negative controls. We included adults who were unvaccinated or vaccinated with 2 doses of a mRNA vaccine before the date of illness onset. VE over time was assessed using logistic regression comparing odds of vaccination in cases versus controls, adjusting for confounders. Models included dichotomous time ( Results A total of 10 078 patients were included, 4906 cases (23% vaccinated) and 5172 controls (62% vaccinated). Median age was 60 years (interquartile range, 46–70), 56% were non-Hispanic White, and 81% had ≥1 medical condition. Among immunocompetent adults, VE Conclusions In a period largely predating Omicron variant circulation, effectiveness of 2 mRNA doses against COVID-19–associated hospitalization was largely sustained through 9 months.

Published
2022

5. Organization of Outpatient Care After COVID-19 Hospitalization

Author

Thomas S. Valley, Amanda Schutz, Ithan D. Peltan, Kelly C. Vranas, Kusum S. Mathews, Sarah E. Jolley, Jessica A. Palakshappa, Catherine L. Hough, Jay S. Steingrub, Mark A. Tidswell, Lori-Ann Kozikowski, Cynthia Kardos, Lesley DeSouza, Rebecca M. Baron, Mayra Pinilla-Vera, David M. Rubins, Antonio Arciniegas, Richard Riker, Christine Lord, Marie-Carmelle Elie, Daniel Talmor, Nathan Shapiro, Valerie Banner-Goodspeed, Kathryn A. Hibbert, Kelsey Brait, Natalie Pulido, Alan Jones, James Galbraith, Utsav Nandi, Rebekah Peacock, Jenna Davis, Matthew Prekker, Michael Puskarich, Seth Jones, Anne Roerhl, Audrey Hendrickson, Michael Matthay, Kirsten Kangelaris, Kathleen Liu, Kimberly Yee, Hanjing Zhuo, Gregory Hendey, Steven Chang, Nida Qadir, Andrea Tam, Rebecca Beutler, Trisha Agarwal, Joseph Levitt, Jennifer G. Wilson, Angela Rogers, Jonasel Roque, Rosemary Vojnik, Timothy E. Albertson, James A. Chenoweth, Jason Y. Adams, Brian M. Morrissey, Skyler J. Pearson, Eyad Almasri, Alyssa Hughes, Marc Moss, Adit Ginde, Jeffrey McKeehan, Lani Finck, Michelle Howell, Carrie Higgins, Jason Haukoos, Stephanie Gravitz, Carolynn Lyle, Ivor S. Douglas, Terra Hiller, Audrey Goold, James Finigan, Robert Hyzy, Pauline Park, Michael Sjoding, Stephen Kay, Kristine Nelson, Kelli McDonough, Namita Jayaprakash, Emanuel P. Rivers, Jennifer Swiderek, Jasreen Kaur Gill, Jacqueline Day, Robert Sherwin, James Wooden, Thomas Mazzoco, Michelle Ng Gong, Michael Aboodi, Ayesha Asghar, Omowunmi Amosu, Hiwet Tzehaie, Aluko A. Hope, Jen-Ting Chen, Rahul Nair, Brenda Lopez, Obiageli Offor, Jarrod M. Mosier, Cameron D. Hypes, Elizabeth Salvagio, Christian Bime, Elaine Cristan, Lynne D. Richardson, Neha Goel, Patrick Maher, Samuel Acquah, Donald Cardone, Gary Oldenburg, Andrew Dunn, Duncan Hite, Kristin Hudock, Jose Gomez Arroyo, Tammy Roads, Abhijit Duggal, Eduardo Mireles-Cabodevila, Bryce R.H. Robinson, Nicholas J. Johnson, Stephanie Gundel, Laura Evans, D. Shane O'Mahony, Julie A. Wallick, Isabel Pedraza, Akram Khan, Olivia Krol, Milad Karami Jouzestani, Kelly Vranas, Donald M. Yealy, Derek C. Angus, Alexandra Weissman, David T. Huang, Aimee Boeltz-Skrtich, Steven Moore, Derek Isenberg, D. Clark Files, Chadwick Miller, Kevin Gibbs, Lori Flores, Mary LaRose, Lauren Koehler, Leigha Landreth, Peter Morris, Evan Cassity, Jamie Sturgill, Kirby Mayer, Ashley Montgomery-Yates, Marjolein de Wit, Jessica Mason, Andrew Goodwin, Abigail Grady, Patterson Burch, Kyle B. Enfield, Jeffrey M. Sturek, Mary Marshall, Joseph R. Bledsoe, Samuel M. Brown, Colin K. Grissom, Brent Armbruster, Estelle Harris, John Eppensteiner, Bria Johnston Hall, Grace L. Hall, Lauren McGowan, Andrew Bouffler, Erica Walker, Samuel Francis, Tedra Porter, Bennett P. deBoisblanc, Matthew R. Lammi, David R. Janz, Paula Lauto, Connie Romaine, Marie Sandi, Todd W. Rice, Wesley H. Self, Nancy Ringwood, Alexander Nagrebetsky, Laura Fitzgerald, Roy G. Brower, Lora A. Reineck, Neil R. Aggarwal, and Karen Bienstock

Subjects
Hospitalization, Pulmonary and Respiratory Medicine, Ambulatory Care, COVID-19, Humans, Cardiology and Cardiovascular Medicine, Critical Care and Intensive Care Medicine
Published
2022

6. The emergence of ceramics in Southwest Asia: Early pottery in farming communities

Author

Kevin Gibbs

Subjects
010506 paleontology, Southern Levant, business.industry, Mesopotamia, 010502 geochemistry & geophysics, 01 natural sciences, Archaeology, law.invention, Geography, law, Agriculture, Radiocarbon dating, Pottery, business, 0105 earth and related environmental sciences, Earth-Surface Processes
Abstract

In Southwest Asia, early ceramics are generally associated with sedentary farming communities. This is unlike many other parts of Asia, where ceramics were first manufactured by hunter-gatherers. Radiocarbon evidence indicates that sustained production of ceramic containers (pottery) began at several sites in Anatolia, Upper Mesopotamia and the northern Levant around 7000 BC or slightly later, although there are indications that very small-scale production of pottery sometimes occurred at even earlier dates. In other regions (e.g. the southern Levant, Cyprus) pottery does not become common until centuries later. This paper examines Southwest Asian ceramic production in terms of its timing, technology and use, as well as its social and economic contexts. It also considers the legacy of early archaeological studies of Southwest Asian pottery for our general understanding of the emergence of ceramics. For example, Gordon Childe's concept of a ‘Neolithic package’ promoted a close association between the emergence of farming and pottery, which cannot be supported for many parts of Asia.

Published
2022

8. Clinical trial design during and beyond the pandemic: the I-SPY COVID trial

Author

Daniel Clark Files, Jerry Lee, Kevin Gibbs, Fady A Youssef, Laura Rodrigues, Ariel Weisman, Martin Eklund, Kimberly Yee, Philip Yang, Sheetal Gandotra, Derek W. Russell, and Adam Asare

Subjects
Clinical Trials as Topic, Research Design, SARS-CoV-2, COVID-19, Humans, General Medicine, Cooperative Behavior, Pandemics, General Biochemistry, Genetics and Molecular Biology, Article
Published
2022

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