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Your search keyword '"Kenjiro Kamiguchi"' showing total 9 results
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9 results on '"Kenjiro Kamiguchi"'

1. Supplementary Table 1 from HSP DNAJB8 Controls Tumor-Initiating Ability in Renal Cancer Stem–like Cells

Author

Noriyuki Sato, Isao Hara, Tadashi Hasegawa, Toru Kondo, Harm H. Kampinga, Reona Fujii, Ren Yamada, Junichi Matsuzaki, Alice Sokolovskaya, Rena Morita, Hiroko Asanuma, Kenjiro Kamiguchi, Takayuki Kanaseki, Takashi Mori, Yasuaki Tamura, Akari Takahashi, Toshihiko Torigoe, Yoshihiko Hirohashi, and Satoshi Nishizawa

Abstract

PDF file - 23K, List of Primers

Published
2023
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2. Supplementary Figure 1 from A Novel Isoform of TUCAN Is Overexpressed in Human Cancer Tissues and Suppresses Both Caspase-8– and Caspase-9–Mediated Apoptosis

Author

Noriyuki Sato, Koichi Hirata, Takehiro Kurotaki, Koji Yamaguchi, Tousei Ohmura, Fumitake Hata, Takashi Sato, Tetsuhiro Tsuruma, Hiroko Asanuma, Chika Nabeta, Katsuya Nakanishi, Yoshihiko Hirohashi, Kenjiro Kamiguchi, Toshihiko Torigoe, and Masaaki Yamamoto

Abstract

Supplementary Figure 1 from A Novel Isoform of TUCAN Is Overexpressed in Human Cancer Tissues and Suppresses Both Caspase-8– and Caspase-9–Mediated Apoptosis

Published
2023
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3. Data from A Novel Isoform of TUCAN Is Overexpressed in Human Cancer Tissues and Suppresses Both Caspase-8– and Caspase-9–Mediated Apoptosis

Author

Noriyuki Sato, Koichi Hirata, Takehiro Kurotaki, Koji Yamaguchi, Tousei Ohmura, Fumitake Hata, Takashi Sato, Tetsuhiro Tsuruma, Hiroko Asanuma, Chika Nabeta, Katsuya Nakanishi, Yoshihiko Hirohashi, Kenjiro Kamiguchi, Toshihiko Torigoe, and Masaaki Yamamoto

Abstract

Caspase-associated recruitment domains (CARD) are protein-protein interaction modules found extensively in proteins that play important roles in apoptosis. One of the CARD-containing proteins, TUCAN (CARD8), was reported previously as an antiapoptotic protein with a molecular weight of 48 kDa, which was up-regulated in colon cancer cells. We identified a novel isoform of TUCAN with a molecular weight of 54 kDa. The new variant of TUCAN, termed TUCAN-54, was expressed in gastric, colon, and breast cancer tissues but was barely detected in normal noncancerous tissues, whereas 48-kDa TUCAN was detected in tumor tissues and noncancerous tissues. To know the function of TUCAN-54 in the apoptosis of cancer cells, TUCAN-54 was overexpressed in tumor cells by gene transfection. Its overexpression inhibited pro-caspase-9 activation, leading to the suppression of the cell death induced by a protein kinase inhibitor, staurosporine, or a chemotherapeutic reagent, etoposide (VP-16). In contrast, specific small interfering RNA–mediated suppression of TUCAN-54 expression in tumor cells increased the VP-16–induced cell death rate, indicating that expression of TUCAN-54 might be associated with chemoresistance of tumor cells. In addition, it inhibited caspase-8 activation as well, thereby suppressing Fas-induced cell death. It was revealed that Fas-associated death domain was physically associated with TUCAN-54 but not with 48-kDa TUCAN. Thus, TUCAN-54 might be a novel tumor-specific antiapoptotic molecule expressed in a variety of human cancer tissues, which might aggravate malignant potential of cancer cells, such as chemoresistance and immunoresistance.

Published
2023
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4. Supplementary Figure 1 from HSP DNAJB8 Controls Tumor-Initiating Ability in Renal Cancer Stem–like Cells

Author

Noriyuki Sato, Isao Hara, Tadashi Hasegawa, Toru Kondo, Harm H. Kampinga, Reona Fujii, Ren Yamada, Junichi Matsuzaki, Alice Sokolovskaya, Rena Morita, Hiroko Asanuma, Kenjiro Kamiguchi, Takayuki Kanaseki, Takashi Mori, Yasuaki Tamura, Akari Takahashi, Toshihiko Torigoe, Yoshihiko Hirohashi, and Satoshi Nishizawa

Abstract

PDF file - 68K, Isolation of CSCs/CICs from human RCC cells

Published
2023
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5. Supplementary Figure 2 from HSP DNAJB8 Controls Tumor-Initiating Ability in Renal Cancer Stem–like Cells

Author

Noriyuki Sato, Isao Hara, Tadashi Hasegawa, Toru Kondo, Harm H. Kampinga, Reona Fujii, Ren Yamada, Junichi Matsuzaki, Alice Sokolovskaya, Rena Morita, Hiroko Asanuma, Kenjiro Kamiguchi, Takayuki Kanaseki, Takashi Mori, Yasuaki Tamura, Akari Takahashi, Toshihiko Torigoe, Yoshihiko Hirohashi, and Satoshi Nishizawa

Abstract

PDF file - 74K, RT-PCR analysis

Published
2023
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6. Supplementary Figure 5 from HSP DNAJB8 Controls Tumor-Initiating Ability in Renal Cancer Stem–like Cells

Author

Noriyuki Sato, Isao Hara, Tadashi Hasegawa, Toru Kondo, Harm H. Kampinga, Reona Fujii, Ren Yamada, Junichi Matsuzaki, Alice Sokolovskaya, Rena Morita, Hiroko Asanuma, Kenjiro Kamiguchi, Takayuki Kanaseki, Takashi Mori, Yasuaki Tamura, Akari Takahashi, Toshihiko Torigoe, Yoshihiko Hirohashi, and Satoshi Nishizawa

Abstract

PDF file - 91K, SP analysis of DNAJB8- transduced cells

Published
2023
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7. Supplementary Figure 4 from HSP DNAJB8 Controls Tumor-Initiating Ability in Renal Cancer Stem–like Cells

Author

Noriyuki Sato, Isao Hara, Tadashi Hasegawa, Toru Kondo, Harm H. Kampinga, Reona Fujii, Ren Yamada, Junichi Matsuzaki, Alice Sokolovskaya, Rena Morita, Hiroko Asanuma, Kenjiro Kamiguchi, Takayuki Kanaseki, Takashi Mori, Yasuaki Tamura, Akari Takahashi, Toshihiko Torigoe, Yoshihiko Hirohashi, and Satoshi Nishizawa

Abstract

PDF file - 67K, Western blot analysis

Published
2023
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8. Supplementary Figure 3 from HSP DNAJB8 Controls Tumor-Initiating Ability in Renal Cancer Stem–like Cells

Author

Noriyuki Sato, Isao Hara, Tadashi Hasegawa, Toru Kondo, Harm H. Kampinga, Reona Fujii, Ren Yamada, Junichi Matsuzaki, Alice Sokolovskaya, Rena Morita, Hiroko Asanuma, Kenjiro Kamiguchi, Takayuki Kanaseki, Takashi Mori, Yasuaki Tamura, Akari Takahashi, Toshihiko Torigoe, Yoshihiko Hirohashi, and Satoshi Nishizawa

Abstract

PDF file - 142K, Protein expression of DNAJB8 in SP and MP cells

Published
2023
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9. Supplementary Figure 6 from HSP DNAJB8 Controls Tumor-Initiating Ability in Renal Cancer Stem–like Cells

Author

Noriyuki Sato, Isao Hara, Tadashi Hasegawa, Toru Kondo, Harm H. Kampinga, Reona Fujii, Ren Yamada, Junichi Matsuzaki, Alice Sokolovskaya, Rena Morita, Hiroko Asanuma, Kenjiro Kamiguchi, Takayuki Kanaseki, Takashi Mori, Yasuaki Tamura, Akari Takahashi, Toshihiko Torigoe, Yoshihiko Hirohashi, and Satoshi Nishizawa

Abstract

PDF file - 92K, Serine-rich region of DNAJB8 has role for induction of SP cells

Published
2023
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