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129 results on '"Keating, Michael J."'

5. Topological Structures in the Space of Treatment-Naïve Patients with Chronic Lymphocytic Leukemia.

Author

McGee II, Reginald L., Reed, Jake, Coombes, Caitlin E., Herling, Carmen D., Keating, Michael J., Abruzzo, Lynne V., and Coombes, Kevin R.

Subjects
CHRONIC lymphocytic leukemia, STATISTICAL models, COMPUTER-assisted image analysis (Medicine), RESEARCH funding, CANCER patients, TECHNOLOGY, DIGITAL image processing, GENETIC mutation
Abstract

Simple Summary: Clinical data sets incorporate continuous data like blood pressure or sodium levels, categorical data like cancer grade or stage, and binary data like sex or marital status. Measurements on an individual patient define a point in a high-dimensional space; data from many patients defines a "point cloud". The "shape" of the point cloud influences experimental design by describing patient variability. Topological data analysis (TDA) is a mathematical technique for understanding the shape of point clouds by finding "holes" that correspond to combinations of patient characteristics that are never observed. TDA results are stratified by dimension. Zero-dimensional features define patient subtypes. One-dimensional features ("loops") are analogs of the inside of a circle or a donut hole. Two-dimensional features ("voids") are analogs of the inside of a balloon. Here, we apply TDA to a clinical data set of previously untreated patients with Chronic Lymphocytic Leukemia to find loops and voids. Patients are complex and heterogeneous; clinical data sets are complicated by noise, missing data, and the presence of mixed-type data. Using such data sets requires understanding the high-dimensional "space of patients", composed of all measurements that define all relevant phenotypes. The current state-of-the-art merely defines spatial groupings of patients using cluster analyses. Our goal is to apply topological data analysis (TDA), a new unsupervised technique, to obtain a more complete understanding of patient space. We applied TDA to a space of 266 previously untreated patients with Chronic Lymphocytic Leukemia (CLL), using the "daisy" metric to compute distances between clinical records. We found clear evidence for both loops and voids in the CLL data. To interpret these structures, we developed novel computational and graphical methods. The most persistent loop and the most persistent void can be explained using three dichotomized, prognostically important factors in CLL: IGHV somatic mutation status, beta-2 microglobulin, and Rai stage. In conclusion, patient space turns out to be richer and more complex than current models suggest. TDA could become a powerful tool in a researcher's arsenal for interpreting high-dimensional data by providing novel insights into biological processes and improving our understanding of clinical and biological data sets. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Data from Trabectedin Reveals a Strategy of Immunomodulation in Chronic Lymphocytic Leukemia

Author

Banerjee, Priyanka, primary, Zhang, Ronghua, primary, Ivan, Cristina, primary, Galletti, Giovanni, primary, Clise-Dwyer, Karen, primary, Barbaglio, Federica, primary, Scarfò, Lydia, primary, Aracil, Miguel, primary, Klein, Christian, primary, Wierda, William, primary, Plunkett, William, primary, Caligaris-Cappio, Federico, primary, Gandhi, Varsha, primary, Keating, Michael J., primary, and Bertilaccio, Maria Teresa S., primary

Published
2023
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12. Supplementary Figures from Trabectedin Reveals a Strategy of Immunomodulation in Chronic Lymphocytic Leukemia

Author

Banerjee, Priyanka, primary, Zhang, Ronghua, primary, Ivan, Cristina, primary, Galletti, Giovanni, primary, Clise-Dwyer, Karen, primary, Barbaglio, Federica, primary, Scarfò, Lydia, primary, Aracil, Miguel, primary, Klein, Christian, primary, Wierda, William, primary, Plunkett, William, primary, Caligaris-Cappio, Federico, primary, Gandhi, Varsha, primary, Keating, Michael J., primary, and Bertilaccio, Maria Teresa S., primary

Published
2023
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13. Supplementary Tables from Trabectedin Reveals a Strategy of Immunomodulation in Chronic Lymphocytic Leukemia

Author

Banerjee, Priyanka, primary, Zhang, Ronghua, primary, Ivan, Cristina, primary, Galletti, Giovanni, primary, Clise-Dwyer, Karen, primary, Barbaglio, Federica, primary, Scarfò, Lydia, primary, Aracil, Miguel, primary, Klein, Christian, primary, Wierda, William, primary, Plunkett, William, primary, Caligaris-Cappio, Federico, primary, Gandhi, Varsha, primary, Keating, Michael J., primary, and Bertilaccio, Maria Teresa S., primary

Published
2023
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14. Data from Constitutive Phosphorylation of STAT3 by the CK2–BLNK–CD5 Complex

Author

Rozovski, Uri, primary, Harris, David M., primary, Li, Ping, primary, Liu, Zhiming, primary, Jain, Preetesh, primary, Veletic, Ivo, primary, Ferrajoli, Alessandra, primary, Burger, Jan, primary, O'Brien, Susan, primary, Bose, Prithviraj, primary, Thompson, Philip, primary, Jain, Nitin, primary, Wierda, William, primary, Keating, Michael J., primary, and Estrov, Zeev, primary

Published
2023
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16. Data from Aberrant LPL Expression, Driven by STAT3, Mediates Free Fatty Acid Metabolism in CLL Cells

Author

Rozovski, Uri, primary, Grgurevic, Srdana, primary, Bueso-Ramos, Carlos, primary, Harris, David M., primary, Li, Ping, primary, Liu, Zhiming, primary, Wu, Ji Yuan, primary, Jain, Preetesh, primary, Wierda, William, primary, Burger, Jan, primary, O'Brien, Susan, primary, Jain, Nitin, primary, Ferrajoli, Alessandra, primary, Keating, Michael J., primary, and Estrov, Zeev, primary

Published
2023
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19. Supplemental Table 1 from Aberrant LPL Expression, Driven by STAT3, Mediates Free Fatty Acid Metabolism in CLL Cells

Author

Rozovski, Uri, primary, Grgurevic, Srdana, primary, Bueso-Ramos, Carlos, primary, Harris, David M., primary, Li, Ping, primary, Liu, Zhiming, primary, Wu, Ji Yuan, primary, Jain, Preetesh, primary, Wierda, William, primary, Burger, Jan, primary, O'Brien, Susan, primary, Jain, Nitin, primary, Ferrajoli, Alessandra, primary, Keating, Michael J., primary, and Estrov, Zeev, primary

Published
2023
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20. Supplementary Table 1 from Constitutive Phosphorylation of STAT3 by the CK2–BLNK–CD5 Complex

Author

Rozovski, Uri, primary, Harris, David M., primary, Li, Ping, primary, Liu, Zhiming, primary, Jain, Preetesh, primary, Veletic, Ivo, primary, Ferrajoli, Alessandra, primary, Burger, Jan, primary, O'Brien, Susan, primary, Bose, Prithviraj, primary, Thompson, Philip, primary, Jain, Nitin, primary, Wierda, William, primary, Keating, Michael J., primary, and Estrov, Zeev, primary

Published
2023
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25. Supplemental Figure 1 from Combining Anti-Mir-155 with Chemotherapy for the Treatment of Lung Cancers

Author

Van Roosbroeck, Katrien, primary, Fanini, Francesca, primary, Setoyama, Tetsuro, primary, Ivan, Cristina, primary, Rodriguez-Aguayo, Cristian, primary, Fuentes-Mattei, Enrique, primary, Xiao, Lianchun, primary, Vannini, Ivan, primary, Redis, Roxana S., primary, D'Abundo, Lucilla, primary, Zhang, Xinna, primary, Nicoloso, Milena S., primary, Rossi, Simona, primary, Gonzalez-Villasana, Vianey, primary, Rupaimoole, Rajesha, primary, Ferracin, Manuela, primary, Morabito, Fortunato, primary, Neri, Antonino, primary, Ruvolo, Peter P., primary, Ruvolo, Vivian R., primary, Pecot, Chad V., primary, Amadori, Dino, primary, Abruzzo, Lynne, primary, Calin, Steliana, primary, Wang, Xuemei, primary, You, M. James, primary, Ferrajoli, Alessandra, primary, Orlowski, Robert, primary, Plunkett, William, primary, Lichtenberg, Tara M., primary, Davuluri, Ramana V., primary, Berindan-Neagoe, Ioana, primary, Negrini, Massimo, primary, Wistuba, Ignacio I., primary, Kantarjian, Hagop M., primary, Sood, Anil K., primary, Lopez-Berestein, Gabriel, primary, Keating, Michael J., primary, Fabbri, Muller, primary, and Calin, George A., primary

Published
2023
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29. Supplementary Tables 1,2,3,4 from Ofatumumab and Lenalidomide for Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia: Correlation between Responses and Immune Characteristics

Author

Vitale, Candida, primary, Falchi, Lorenzo, primary, ten Hacken, Elisa, primary, Gao, Hui, primary, Shaim, Hila, primary, Van Roosbroeck, Katrien, primary, Calin, George, primary, O'Brien, Susan, primary, Faderl, Stefan, primary, Wang, Xuemei, primary, Wierda, William G., primary, Rezvani, Katayoun, primary, Reuben, James M., primary, Burger, Jan A., primary, Keating, Michael J., primary, and Ferrajoli, Alessandra, primary

Published
2023
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33. Supplemental Figure 3 from Combining Anti-Mir-155 with Chemotherapy for the Treatment of Lung Cancers

Author

Van Roosbroeck, Katrien, primary, Fanini, Francesca, primary, Setoyama, Tetsuro, primary, Ivan, Cristina, primary, Rodriguez-Aguayo, Cristian, primary, Fuentes-Mattei, Enrique, primary, Xiao, Lianchun, primary, Vannini, Ivan, primary, Redis, Roxana S., primary, D'Abundo, Lucilla, primary, Zhang, Xinna, primary, Nicoloso, Milena S., primary, Rossi, Simona, primary, Gonzalez-Villasana, Vianey, primary, Rupaimoole, Rajesha, primary, Ferracin, Manuela, primary, Morabito, Fortunato, primary, Neri, Antonino, primary, Ruvolo, Peter P., primary, Ruvolo, Vivian R., primary, Pecot, Chad V., primary, Amadori, Dino, primary, Abruzzo, Lynne, primary, Calin, Steliana, primary, Wang, Xuemei, primary, You, M. James, primary, Ferrajoli, Alessandra, primary, Orlowski, Robert, primary, Plunkett, William, primary, Lichtenberg, Tara M., primary, Davuluri, Ramana V., primary, Berindan-Neagoe, Ioana, primary, Negrini, Massimo, primary, Wistuba, Ignacio I., primary, Kantarjian, Hagop M., primary, Sood, Anil K., primary, Lopez-Berestein, Gabriel, primary, Keating, Michael J., primary, Fabbri, Muller, primary, and Calin, George A., primary

Published
2023
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35. Supplemental Figure 2 from Combining Anti-Mir-155 with Chemotherapy for the Treatment of Lung Cancers

Author

Van Roosbroeck, Katrien, primary, Fanini, Francesca, primary, Setoyama, Tetsuro, primary, Ivan, Cristina, primary, Rodriguez-Aguayo, Cristian, primary, Fuentes-Mattei, Enrique, primary, Xiao, Lianchun, primary, Vannini, Ivan, primary, Redis, Roxana S., primary, D'Abundo, Lucilla, primary, Zhang, Xinna, primary, Nicoloso, Milena S., primary, Rossi, Simona, primary, Gonzalez-Villasana, Vianey, primary, Rupaimoole, Rajesha, primary, Ferracin, Manuela, primary, Morabito, Fortunato, primary, Neri, Antonino, primary, Ruvolo, Peter P., primary, Ruvolo, Vivian R., primary, Pecot, Chad V., primary, Amadori, Dino, primary, Abruzzo, Lynne, primary, Calin, Steliana, primary, Wang, Xuemei, primary, You, M. James, primary, Ferrajoli, Alessandra, primary, Orlowski, Robert, primary, Plunkett, William, primary, Lichtenberg, Tara M., primary, Davuluri, Ramana V., primary, Berindan-Neagoe, Ioana, primary, Negrini, Massimo, primary, Wistuba, Ignacio I., primary, Kantarjian, Hagop M., primary, Sood, Anil K., primary, Lopez-Berestein, Gabriel, primary, Keating, Michael J., primary, Fabbri, Muller, primary, and Calin, George A., primary

Published
2023
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36. Supplemental Figure 4 from Combining Anti-Mir-155 with Chemotherapy for the Treatment of Lung Cancers

Author

Van Roosbroeck, Katrien, primary, Fanini, Francesca, primary, Setoyama, Tetsuro, primary, Ivan, Cristina, primary, Rodriguez-Aguayo, Cristian, primary, Fuentes-Mattei, Enrique, primary, Xiao, Lianchun, primary, Vannini, Ivan, primary, Redis, Roxana S., primary, D'Abundo, Lucilla, primary, Zhang, Xinna, primary, Nicoloso, Milena S., primary, Rossi, Simona, primary, Gonzalez-Villasana, Vianey, primary, Rupaimoole, Rajesha, primary, Ferracin, Manuela, primary, Morabito, Fortunato, primary, Neri, Antonino, primary, Ruvolo, Peter P., primary, Ruvolo, Vivian R., primary, Pecot, Chad V., primary, Amadori, Dino, primary, Abruzzo, Lynne, primary, Calin, Steliana, primary, Wang, Xuemei, primary, You, M. James, primary, Ferrajoli, Alessandra, primary, Orlowski, Robert, primary, Plunkett, William, primary, Lichtenberg, Tara M., primary, Davuluri, Ramana V., primary, Berindan-Neagoe, Ioana, primary, Negrini, Massimo, primary, Wistuba, Ignacio I., primary, Kantarjian, Hagop M., primary, Sood, Anil K., primary, Lopez-Berestein, Gabriel, primary, Keating, Michael J., primary, Fabbri, Muller, primary, and Calin, George A., primary

Published
2023
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40. Supplementary Figures 1,2,3,4,5 from Ofatumumab and Lenalidomide for Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia: Correlation between Responses and Immune Characteristics

Author

Vitale, Candida, primary, Falchi, Lorenzo, primary, ten Hacken, Elisa, primary, Gao, Hui, primary, Shaim, Hila, primary, Van Roosbroeck, Katrien, primary, Calin, George, primary, O'Brien, Susan, primary, Faderl, Stefan, primary, Wang, Xuemei, primary, Wierda, William G., primary, Rezvani, Katayoun, primary, Reuben, James M., primary, Burger, Jan A., primary, Keating, Michael J., primary, and Ferrajoli, Alessandra, primary

Published
2023
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41. Supplemental Figure 5 from Combining Anti-Mir-155 with Chemotherapy for the Treatment of Lung Cancers

Author

Van Roosbroeck, Katrien, primary, Fanini, Francesca, primary, Setoyama, Tetsuro, primary, Ivan, Cristina, primary, Rodriguez-Aguayo, Cristian, primary, Fuentes-Mattei, Enrique, primary, Xiao, Lianchun, primary, Vannini, Ivan, primary, Redis, Roxana S., primary, D'Abundo, Lucilla, primary, Zhang, Xinna, primary, Nicoloso, Milena S., primary, Rossi, Simona, primary, Gonzalez-Villasana, Vianey, primary, Rupaimoole, Rajesha, primary, Ferracin, Manuela, primary, Morabito, Fortunato, primary, Neri, Antonino, primary, Ruvolo, Peter P., primary, Ruvolo, Vivian R., primary, Pecot, Chad V., primary, Amadori, Dino, primary, Abruzzo, Lynne, primary, Calin, Steliana, primary, Wang, Xuemei, primary, You, M. James, primary, Ferrajoli, Alessandra, primary, Orlowski, Robert, primary, Plunkett, William, primary, Lichtenberg, Tara M., primary, Davuluri, Ramana V., primary, Berindan-Neagoe, Ioana, primary, Negrini, Massimo, primary, Wistuba, Ignacio I., primary, Kantarjian, Hagop M., primary, Sood, Anil K., primary, Lopez-Berestein, Gabriel, primary, Keating, Michael J., primary, Fabbri, Muller, primary, and Calin, George A., primary

Published
2023
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43. A phase 1 study to evaluate the safety, pharmacology, and feasibility of continuous infusion nelarabine in patients with relapsed and/or refractory lymphoid malignancies

Author

Boddu, Prajwal C., primary, Senapati, Jayastu, additional, Ravandi‐Kashani, Farhad, additional, Jabbour, Elias J., additional, Jain, Nitin, additional, Ayres, Mary, additional, Chen, Yuling, additional, Keating, Michael J., additional, Kantarjian, Hagop M., additional, Gandhi, Varsha, additional, and Kadia, Tapan M., additional

Published
2022
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44. Combined Ibrutinib and Venetoclax for First-Line Treatment of Patients with Chronic Lymphocytic Leukemia (CLL): 4-Year Follow-up Data

Author

Jain, Nitin, primary, Keating, Michael J., additional, Thompson, Philip A., additional, Ferrajoli, Alessandra, additional, Senapati, Jayastu, additional, Burger, Jan A., additional, Borthakur, Gautam, additional, Takahashi, Koichi, additional, Estrov, Zeev E., additional, Konopleva, Marina, additional, Sasaki, Koji, additional, Kadia, Tapan M., additional, Pemmaraju, Naveen, additional, Daver, Naval, additional, Jabbour, Elias, additional, DiNardo, Courtney D., additional, Alvarado, Yesid, additional, Yilmaz, Musa, additional, Bose, Prithviraj, additional, Ohanian, Maro, additional, Kanagal-Shamanna, Rashmi, additional, Patel, Keyur, additional, Jorgensen, Jeffrey L., additional, Wang, Sa A, additional, Nassar, Sameh, additional, Garg, Naveen, additional, Hwang, Hyunsoo, additional, Wang, Xuemei, additional, Cruz, Nichole, additional, Ayala, Ana, additional, Plunkett, William, additional, Kantarjian, Hagop, additional, Gandhi, Varsha, additional, and Wierda, William G., additional

Published
2022
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45. Venetoclax Consolidation Achieves Durable Off-Treatment Remissions in Patients with High Risk CLL Who Have Been on Ibrutinib More Than a Year

Author

Thompson, Philip A., primary, Keating, Michael J., additional, Ferrajoli, Alessandra, additional, Jain, Nitin, additional, Peterson, Christine B., additional, Garg, Naveen, additional, Ayala, Ana, additional, Hernandez, Jon A, additional, Kadia, Tapan M., additional, Bose, Prithviraj, additional, Pemmaraju, Naveen, additional, Short, Nicholas, additional, and Wierda, William G., additional

Published
2022
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46. Early Treatment with Ofatumumab in Patients with High-Risk CLL

Author

Desikan, Sai Prasad, primary, Keating, Michael J., additional, Ferrajoli, Alessandra, additional, Jain, Nitin, additional, Ohanian, Maro, additional, Pemmaraju, Naveen, additional, DiNardo, Courtney D., additional, Konopleva, Marina, additional, Kadia, Tapan M., additional, O'Brien, Susan, additional, Estrov, Zeev E., additional, Thomas, Deborah A, additional, Burger, Jan A., additional, Thompson, Philip A., additional, and Wierda, William G., additional

Published
2022
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47. Utility of Flow Cytometry in Monitoring of Measurable Residual Disease in Patients with Hairy Cell Leukemia

Author

Abuasab, Tareq, primary, Haddad, Fadi, additional, Mohamed, Shehab Fareed, additional, Jorgensen, Jeffrey L., additional, Wang, Sa A, additional, Thompson, Philip A., additional, Kadia, Tapan M., additional, Alvarado, Yesid, additional, Pierce, Sherry A., additional, Keating, Michael J., additional, McCue, David, additional, Kantarjian, Hagop, additional, and Ravandi, Farhad, additional

Published
2022
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48. A Phase 2 Study of Nivolumab Combined with Ibrutinib in Patients with Diffuse Large B-cell Richter Transformation of CLL

Author

Jain, Nitin, primary, Senapati, Jayastu, additional, Thakral, Beenu, additional, Ferrajoli, Alessandra, additional, Thompson, Philip A, additional, Burger, Jan A., additional, Basu, Sreyashi, additional, Kadia, Tapan M., additional, Daver, Naval G., additional, Borthakur, Gautam, additional, Konopleva, Marina, additional, Pemmaraju, Naveen, additional, Parry, Erin M., additional, Wu, Catherine J., additional, Khoury, Joseph D., additional, Bueso-Ramos, Carlos E., additional, garg, naveen, additional, Wang, Xuemei, additional, Lopez, Wanda, additional, AYALA, ANA, additional, O'Brien, Susan M., additional, Kantarjian, Hagop M., additional, Keating, Michael J, additional, Allison, James P, additional, Sharma, Padmanee, additional, and Wierda, William G., additional

Published
2022
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49. STAT3 Activates the Pentraxin 3 Gene in Chronic Lymphocytic Leukemia Cells

Author

Rozovski, Uri, primary, Veletic, Ivo, additional, Harris, David M., additional, Li, Ping, additional, Liu, Zhiming, additional, Jain, Preetesh, additional, Manshouri, Taghi, additional, Ferrajoli, Alessandra, additional, Burger, Jan A., additional, Bose, Prithviraj, additional, Thompson, Phillip A., additional, Jain, Nitin, additional, Wierda, William G., additional, Verstovsek, Srdan, additional, Keating, Michael J., additional, and Estrov, Zeev, additional

Published
2022
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