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2. Invasive candidiasis

Author

Lass-Flörl, Cornelia, Kanj, Souha S., Govender, Nelesh P., Thompson, III, George R., Ostrosky- Zeichner, Luis, and Govrins, Miriam Alisa

Published
2024
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4. Invasive Fungal Diseases in Adult Patients in Intensive Care Unit (FUNDICU): 2024 consensus definitions from ESGCIP, EFISG, ESICM, ECMM, MSGERC, ISAC, and ISHAM

Author

Bassetti, Matteo, Giacobbe, Daniele R., Agvald-Ohman, Christina, Akova, Murat, Alastruey-Izquierdo, Ana, Arikan-Akdagli, Sevtap, Azoulay, Elie, Blot, Stijn, Cornely, Oliver A., Cuenca-Estrella, Manuel, de Lange, Dylan W., De Rosa, Francesco G., De Waele, Jan J., Dimopoulos, George, Garnacho-Montero, Jose, Hoenigl, Martin, Kanj, Souha S., Koehler, Philipp, Kullberg, Bart J., Lamoth, Frédéric, Lass-Flörl, Cornelia, Maertens, Johan, Martin-Loeches, Ignacio, Muñoz, Patricia, Poulakou, Garyphallia, Rello, Jordi, Sanguinetti, Maurizio, Taccone, Fabio S., Timsit, Jean-François, Torres, Antoni, Vazquez, Jose A., Wauters, Joost, Asperges, Erika, Cortegiani, Andrea, Grecchi, Cecilia, Karaiskos, Ilias, Le Bihan, Clément, Mercier, Toine, Mortensen, Klaus L., Peghin, Maddalena, Rebuffi, Chiara, Tejada, Sofia, Vena, Antonio, Zuccaro, Valentina, Scudeller, Luigia, and Calandra, Thierry

Published
2024
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7. Characteristics of medically attended influenza infection across age groups before the COVID-19 pandemic in Lebanon

Author

Haddara, Amani, Houry, Zeina, Zahreddine, Nada, Atallah, Mark, Boutros, Celina F., Tannous, Joseph, Sadaka, Christian, Wehbe, Sarah, Kadi, Tamara, Ibrahim, Ahmad, Ahmadieh, Rihab, Kardas, Tala, Soudani, Nadia, Kalamouni, Habib Al, Zgheib, Youssef, Yaman, Noha El, Khafaja, Sarah, Lteif, Mireille, Shaker, Rouba, Casals, Aia Assaf, Youssef, Yolla, Youssef, Nour, Zein, Zeinab El, Chamseddine, Sarah, Chmaisse, Ahmad, Haj, Magda, Fayad, Danielle, Kiblawi, Shereen, Isaac, Imad, Anan, Hind, Radwan, Najwa, Wakim, Rima Hanna, Zaraket, Hassan, Kanj, Souha S., and Dbaibo, Ghassan S.

Published
2024
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10. Clinical outcomes and bacterial characteristics of carbapenem-resistant Klebsiella pneumoniae complex among patients from different global regions (CRACKLE-2): a prospective, multicentre, cohort study

Author

Wang, Minggui, Earley, Michelle, Chen, Liang, Hanson, Blake M, Yu, Yunsong, Liu, Zhengyin, Salcedo, Soraya, Cober, Eric, Li, Lanjuan, Kanj, Souha S, Gao, Hainv, Munita, Jose M, Ordoñez, Karen, Weston, Greg, Satlin, Michael J, Valderrama-Beltrán, Sandra L, Marimuthu, Kalisvar, Stryjewski, Martin E, Komarow, Lauren, Luterbach, Courtney, Marshall, Steve H, Rudin, Susan D, Manca, Claudia, Paterson, David L, Reyes, Jinnethe, Villegas, Maria V, Evans, Scott, Hill, Carol, Arias, Rebekka, Baum, Keri, Fries, Bettina C, Doi, Yohei, Patel, Robin, Kreiswirth, Barry N, Bonomo, Robert A, Chambers, Henry F, Fowler, Vance G, Arias, Cesar A, van Duin, David, Investigators, Multi-Drug Resistant Organism Network, Abbo, Lilian M, Anderson, Deverick J, Chew, Kean Lee, Cross, Heather R, De, Partha Pratim, Desai, Samit, Dhar, Sorabh, Di Castelnuovo, Valentina, Diaz, Lorena, Dinh, AN Q, Eilertson, Brandon, Evans, Beth, Garcia-Diaz, Julia, Garner, Omai B, Greenwood-Quaintance, Kerryl, Hanson, Blake, Herc, Erica, Jacob, Jesse T, Jiang, Jianping, Kalayjian, Robert C, Kaye, Keith S, Kim, Angela, Lauterbach, Courtney, Marshall, Steven H, McCarty, Todd, Munita, Jose, Ng, Oon Tek, Gutierrez, Jose Millan Oñate, Peleg, Anton, Salata, Robert A, Schmidt-Malan, Suzannah, and Smitasin, Nares

Subjects
Pneumonia & Influenza, Lung, Clinical Research, Pneumonia, Infectious Diseases, Infection, Good Health and Well Being, Anti-Bacterial Agents, Bacteremia, Carbapenem-Resistant Enterobacteriaceae, Carbapenems, Cohort Studies, Humans, Klebsiella Infections, Klebsiella pneumoniae, Prospective Studies, Respiratory Sounds, Multi-Drug Resistant Organism Network Investigators, Clinical Sciences, Medical Microbiology, Public Health and Health Services, Microbiology
Abstract

BackgroundCarbapenem-resistant Klebsiella pneumoniae (CRKP) is a global threat. We therefore analysed the bacterial characteristics of CRKP infections and the clinical outcomes of patients with CRKP infections across different countries.MethodsIn this prospective, multicentre, cohort study (CRACKLE-2), hospitalised patients with cultures positive for CRKP were recruited from 71 hospitals in Argentina, Australia, Chile, China, Colombia, Lebanon, Singapore, and the USA. The first culture positive for CRKP was included for each unique patient. Clinical data on post-hospitalisation death and readmission were collected from health records, and whole genome sequencing was done on all isolates. The primary outcome was a desirability of outcome ranking at 30 days after the index culture, and, along with bacterial characteristics and 30-day all-cause mortality (a key secondary outcome), was compared between patients from China, South America, and the USA. The desirability of outcome ranking was adjusted for location before admission, Charlson comorbidity index, age at culture, Pitt bacteremia score, and anatomical culture source through inverse probability weighting; mortality was adjusted for the same confounders, plus region where relevant, through multivariable logistic regression. This study is registered at ClinicalTrials.gov, NCT03646227, and is complete.FindingsBetween June 13, 2017, and Nov 30, 2018, 991 patients were enrolled, of whom 502 (51%) met the criteria for CRKP infection and 489 (49%) had positive cultures that were considered colonisation. We observed little intra-country genetic variation in CRKP. Infected patients from the USA were more acutely ill than were patients from China or South America (median Pitt bacteremia score 3 [IQR 2-6] vs 2 [0-4] vs 2 [0-4]) and had more comorbidities (median Charlson comorbidity index 3 [IQR 2-5] vs 1 [0-3] vs 1 [0-2]). Adjusted desirability of outcome ranking outcomes were similar in infected patients from China (n=246), South America (n=109), and the USA (n=130); the estimates were 53% (95% CI 42-65) for China versus South America, 50% (41-61) for the USA versus China, and 53% (41-66) for the USA versus South America. In patients with CRKP infections, unadjusted 30-day mortality was lower in China (12%, 95% CI 8-16; 29 of 246) than in the USA (23%, 16-30; 30 of 130) and South America (28%, 20-37; 31 of 109). Adjusted 30-day all-cause mortality was higher in South America than in China (adjusted odds ratio [aOR] 4·82, 95% CI 2·22-10·50) and the USA (aOR 3·34, 1·50-7·47), with the mortality difference between the USA and China no longer being significant (aOR 1·44, 0·70-2·96).InterpretationGlobal CRKP epidemics have important regional differences in patients' baseline characteristics and clinical outcomes, and in bacterial characteristics. Research findings from one region might not be generalisable to other regions.FundingThe National Institutes of Health.

Published
2022

13. Carbapenem-resistant Enterobacterales in solid organ transplant recipients

Author

Kanj, Souha S., Francois (Jeff) Jabbour, Jean, Zhang, Fujie, Lok, Judith J., Salata, Robert A., Stryjewski, Martin, Di Castelnuovo, Valentina, Oñate Gutierrez, Jose Millan, Cober, Eric, Richter, Susan, Anderson, Deverick J., Evans, Beth, Hill, Carol, Cross, Heather R., Baum, Keri, Arias, Rebekka, Fowler, Vance G., Jr., Ordoñez, Karen, Jacob, Jesse T., Li, Linghua, Kreiswirth, Barry N., Manca, Claudia, Chen, Liang, Desai, Samit, Herc, Erica, Cordova, Ezequiel, Rioseco, Maria, Vichez, Samuel, Sanchez, Marisa L., Valderrama, Sandra, Figueroa, Jairo, Arias, Cesar A., Dinh, An Q., Panesso, Diane, Rydell, Kirsten, Tran, Truc T., Hu, Fupin, Su, Jiachun, Jiang, Jianping, Wang, Minggui, Xu, Xiaogang, Yang, Yang, Munita, Jose M., Spencer, Maria, Alenazi, Thamer, Bonomo, Robert A., Marshall, Steven H., Rudin, Susan D., Huskins, Charles, Kerry, Patel, Robin, Schmidt-Malan, Suzannah, Revolinski, Sara, Wortmann, Glenn, Kalayjian, Robert C., Weston, Greg, Ostrowsky, Belinda, Patel, Gopi, Eiras, Daniel, Kim, Angela, Garcia-Diaz, Julia, Salcedo, Soraya, Farrell, John J., Liu, Zhengyin, Henderson, Andrew, Paterson, David L., Xie, Qing, Kaye, Keith S., Gao, Hainv, Yu, Yunsong, Waters, Mary, Fries, Bettina C., Eilertson, Brandon, Marimuthu, Kalisvar, Lee Chew, Kean, Smitasin, Nares, Tambyah, Paul Ananth, Gallagher, Jason C., Peleg, Anton, Leroi, Marcel, Li, Lanjuan, Komarow, Lauren, Ge, Lizhao, Evans, Scott, McCarty, Todd, Chambers, Henry F., Garner, Omai B., Abbo, Lilian M., van Duin, David, Lautenbach, Ebbing, Han, Jennifer H., Doi, Yohei, Wong, Darren, Hanson, Blake, Reyes, Jinnethe, Villegas Botero, Maria Virginia, Diaz, Lorena, Perez, Federico, Banerjee, Ritu, Dhar, Sorabh, Satlin, Michael J., Zong, Zhiyong, Boutzoukas, Angelique E., Dai, Weixiao, Grant, Matthew, and McCarty, Todd P.

Published
2024
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22. EPI-Net One Health reporting guideline for antimicrobial consumption and resistance surveillance data: a Delphi approach

Author

Adegnika, Ayola Akim, Avery, Lisa, Bonten, Marc, Cassini, Alessandro, Chauvin, Claire, Compri, Monica, Damborg, Peter, De Greeff, Sabine, Del Toro, Maria Dolores, Filter, Matthias, Franklin, Alison, Gonzalez-Zorn, Bruno, Grave, Kari, Hocquet, Didier, Hoelzle, Ludwig E., Kalanxhi, Erta, Laxminarayan, Ramanan, Leibovici, Leonard, Malhotra-Kumar, Surbhi, Mendelson, Marc, Paul, Mical, Muñoz Madero, Cristina, Murri, Rita, Piddock, Laura J.V., Ruesen, Carolien, Sanguinetti, Maurizio, Schilling, Thorben, Schrijver, Remco, Schwaber, Mitchell J., Scudeller, Luigia, Torumkuney, Didem, Van Boeckel, Thomas, Vanderhaeghen, Wannes, Voss, Andreas, Wozniak, Teresa, Babu Rajendran, Nithya, Arieti, Fabiana, Mena-Benítez, Carla Alejandra, Galia, Liliana, Tebon, Maela, Alvarez, Julio, Gladstone, Beryl Primrose, Collineau, Lucie, De Angelis, Giulia, Duro, Raquel, Gaze, William, Göpel, Siri, Kanj, Souha S., Käsbohrer, Annemarie, Limmathurotsakul, Direk, Lopez de Abechuco, Estibaliz, Mazzolini, Elena, Mutters, Nico T., Pezzani, Maria Diletta, Presterl, Elisabeth, Renk, Hanna, Rodríguez-Baño, Jesús, Săndulescu, Oana, Scali, Federico, Skov, Robert, Velavan, Thirumalaisamy P., Vuong, Cuong, and Tacconelli, Evelina

Published
2023
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23. Global epidemiology and clinical outcomes of carbapenem-resistant Pseudomonas aeruginosa and associated carbapenemases (POP): a prospective cohort study

Author

Reyes, Jinnethe, Komarow, Lauren, Chen, Liang, Ge, Lizhao, Hanson, Blake, Cober, Eric, Herc, Erica, Alenazi, Thamer, Kaye, Keith, Garcia-Diaz, Julia, Li, Lanjuan, Kanj, Souha, Liu, Zhengyin, Oñate, Jose, Salata, Robert, Marimuthu, Kalisvar, Gao, Hainv, Zong, Zhiyong, Valderrama-Beltrán, Sandra, Yu, Yunsong, Tambyah, Paul, Weston, Gregory, Salcedo, Soraya, Abbo, Lillian, Xie, Qing, Ordoñez, Karen, Wang, Minggui, Stryjewski, Martin, Munita, Jose, Paterson, David, Evans, Scott, Hill, Carol, Baum, Keri, Bonomo, Robert, Kreiswirth, Barry, Virginia Villegas, Maria, Patel, Robin, Arias, Cesar, Chambers, Henry, Fowler, Vance, Doi, Yohei, van Duin, David, Satlin, Michael, Hanson, Blake M, Kaye, Keith S, Kanj, Souha S, Oñate, Jose M, Salata, Robert A, Valderrama-Beltrán, Sandra L, Abbo, Lillian M, Stryjewski, Martin E, Munita, Jose M, Paterson, David L, Bonomo, Robert A, Kreiswirth, Barry N, Villegas, Maria Virginia, Arias, Cesar A, Chambers, Henry F, Fowler, Vance G, Jr, and Satlin, Michael J

Published
2023
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26. Clinical outcomes and bacterial characteristics of carbapenem-resistant Klebsiella pneumoniae complex among patients from different global regions (CRACKLE-2): a prospective, multicentre, cohort study

Author

Abbo, Lilian M, Anderson, Deverick J, Arias, Rebekka, Arias, Cesar A, Baum, Keri, Bonomo, Robert A, Chambers, Henry F, Chen, Liang, Chew, Kean Lee, Cober, Eric, Cross, Heather R, De, Partha Pratim, Desai, Samit, Dhar, Sorabh, Di Castelnuovo, Valentina, Diaz, Lorena, Dinh, AN Q, Doi, Yohei, Earley, Michelle, Eilertson, Brandon, Evans, Beth, Evans, Scott, Fowler Jr, Vance G, Fries, Bettina C, Gao, Hainv, Garcia-Diaz, Julia, Garner, Omai B, Greenwood-Quaintance, Kerryl, Hanson, Blake, Herc, Erica, Hill, Carol, Jacob, Jesse T, Jiang, Jianping, Kalayjian, Robert C, Kanj, Souha S, Kaye, Keith S, Kim, Angela, Komarow, Lauren, Kreiswirth, Barry N, Lauterbach, Courtney, Li, Lanjuan, Liu, Zhengyin, Manca, Claudia, Marimuthu, Kalisvar, Marshall, Steven H, McCarty, Todd, Munita, Jose, Ng, Oon Tek, Oñate Gutierrez, Jose Millan, Ordoñez, Karen, Patel, Robin, Paterson, David L, Peleg, Anton, Reyes, Jinnethe, Rudin, Susan D, Salata, Robert A, Salcedo, Soraya, Satlin, Michael J, Schmidt-Malan, Suzannah, Smitasin, Nares, Spencer, Maria, Stryjewski, Martin, Su, Jiachun, Tambyah, Paul Ananth, Valderrama, Sandra, van Duin, David, Villegas Botero, Maria Virginia, Wang, Minggui, Waters, Mary, Weston, Greg, Wong, Darren, Wortmann, Glenn, Yang, Yang, Yu, Yunsong, Zhang, Fujie, Hanson, Blake M, Munita, Jose M, Valderrama-Beltrán, Sandra L, Stryjewski, Martin E, Luterbach, Courtney, Marshall, Steve H, Villegas, Maria V, and Fowler, Vance G, Jr

Published
2022
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27. It is time to define an organizational model for the prevention and management of infections along the surgical pathway: a worldwide cross-sectional survey

Author

Sartelli, Massimo, Labricciosa, Francesco M., Coccolini, Federico, Coimbra, Raul, Abu-Zidan, Fikri M., Ansaloni, Luca, Al-Hasan, Majdi N., Ansari, Shamshul, Barie, Philip S., Caínzos, Miguel Angel, Ceresoli, Marco, Chiarugi, Massimo, Claridge, Jeffrey A., Cicuttin, Enrico, Dellinger, Evan Patchen, Fry, Donald E., Guirao, Xavier, Hardcastle, Timothy Craig, Hecker, Andreas, Leppäniemi, Ari K., Litvin, Andrey, Marwah, Sanjay, Maseda, Emilio, Mazuski, John E., Memish, Ziad Ahmed, Kirkpatrick, Andrew W., Pagani, Leonardo, Podda, Mauro, Rasa, Huseyin Kemal, Sakakushev, Boris E., Sawyer, Robert G., Tumietto, Fabio, Xiao, Yonghong, Aboubreeg, Wedad Faraj, Adamou, Harissou, Akhmeteli, Lali, Akin, Emrah, Alberio, Maria Grazia, Alconchel, Felipe, Magagi, Ibrahim Amadou, Araúz, Ana Belén, Argenio, Giulio, Atanasov, Boyko C., Atici, Semra Demirli, Awad, Selmy Sabry, Baili, Efstratia, Bains, Lovenish, Bala, Miklosh, Baraket, Oussama, Baral, Suman, Belskii, Vladislav A., Benboubker, Moussa, Ben-Ishay, Offir, Bordoni, Pierpaolo, Boumédiène, Abdalia, Brisinda, Giuseppe, Cavazzuti, Laura, Chandy, Sujith J., Chiarello, Maria Michela, Cillara, Nicola, Clarizia, Guglielmo, Cocuz, Maria-Elena, Cocuz, Iuliu Gabriel, Conti, Luigi, Coppola, Raffaella, Cui, Yunfeng, Czepiel, Jacek, D’Acapito, Fabrizio, Damaskos, Dimitrios, Das, Koray, De Simone, Belinda, Delibegovic, Samir, Demetrashvili, Zaza, Detanac, Dzemail S., Dhingra, Sameer, Di Bella, Stefano, Dimitrov, Evgeni N., Dogjani, Agron, D’Oria, Mario, Dumitru, Irina Magdalena, Elmangory, Mutasim M., Enciu, Octavian, Fantoni, Massimo, Filipescu, Daniela, Fleres, Francesco, Foghetti, Domitilla, Fransvea, Pietro, Gachabayov, Mahir, Galeiras, Rita, Gattuso, Gianni, Ghannam, Wagih M., Ghisetti, Valeria, Giraudo, Giorgio, Gonfa, Kebebe Bekele, Gonullu, Emre, Hamad, Yousif Tag Elsir Y., Hecker, Matthias, Isik, Arda, Ismail, Nizar, Ismail, Azzain, Jain, Sumita Agarwal, Kanj, Souha S., Kapoor, Garima, Karaiskos, Ilias, Kavalakat, Alfie J., Kenig, Jakub, Khamis, Faryal, Khokha, Vladimir, Kiguba, Ronald, Kim, Jae Il, Kobe, Yoshiro, Kok, Kenneth Yuh Yen, Kovacevic, Bojan M., Kryvoruchko, Igor Andreevich, Kuriyama, Akira, Landaluce-Olavarria, Aitor, Lasithiotakis, Konstantinos, Lohsiriwat, Varut, Lostoridis, Eftychios, Luppi, Davide, Vega, Gustavo Miguel Machain, Maegele, Marc, Marinis, Athanasios, Martines, Gennaro, Martínez-Pérez, Aleix, Massalou, Damien, Mesina, Cristian, Metan, Gökhan, Miranda-Novales, María Guadalupe, Mishra, Shyam Kumar, Mohamed, Mohaned Ibrahim Hussein, Mohamedahmed, Ali Yasen Y., Mora-Guzmán, Ismael, Mulita, Francesk, Musina, Ana-Maria, Navsaria, Pradeep H., Negoi, Ionut, Nita, Gabriela Elisa, O’Connor, Donal B., Ordoñez, Carlos Alberto, Pantalone, Desiré, Panyko, Arpád, Papadopoulos, Aristeidis, Pararas, Nikolaos, Pata, Francesco, Patel, Tapan, Pellino, Gianluca, Perra, Teresa, Perrone, Gennaro, Pesce, Antonio, Pintar, Tadeja, Popivanov, Georgi Ivanov, Porcu, Alberto, Quiodettis, Martha Alexa, Rahim, Razrim, Mitul, Ashrarur Rahman, Reichert, Martin, Rems, Miran, Campbell, Glendee Yolande Reynolds, Rocha-Pereira, Nuno, Rodrigues, Gabriel, Villamil, Gustavo Eduardo Roncancio, Rossi, Stefano, Sall, Ibrahima, Kafil, Hossein Samadi, Sasia, Diego, Seni, Jeremiah, Seretis, Charalampos, Serradilla-Martín, Mario, Shelat, Vishal G., Siribumrungwong, Boonying, Slavchev, Mihail, Solaini, Leonardo, Tan, Boun Kim, Tarasconi, Antonio, Tartaglia, Dario, Toma, Elena Adelina, Tomadze, Gia, Toro, Adriana, Tovani-Palone, Marcos Roberto, van Goor, Harry, Vasilescu, Alin, Vereczkei, Andras, Veroux, Massimiliano, Weckmann, Sergio Alberto, Widmer, Lukas Werner, Yahya, AliIbrahim, Zachariah, Sanoop K., Zakaria, Andee Dzulkarnaen, Zubareva, Nadezhda, Zuidema, Wietse P., Di Carlo, Isidoro, Cortese, Francesco, Baiocchi, Gian Luca, Maier, Ronald V., and Catena, Fausto

Published
2022
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32. Pseudomonas aeruginosa Bloodstream Infections Presenting with Septic Shock in Neutropenic Cancer Patients: Impact of Empirical Antibiotic Therapy

Author

Royo-Cebrecos, Cristina, primary, Laporte-Amargós, Júlia, additional, Peña, Marta, additional, Ruiz-Camps, Isabel, additional, Garcia-Vidal, Carolina, additional, Abdala, Edson, additional, Oltolini, Chiara, additional, Akova, Murat, additional, Montejo, Miguel, additional, Mikulska, Malgorzata, additional, Martín-Dávila, Pilar, additional, Herrera, Fabián, additional, Gasch, Oriol, additional, Drgona, Lubos, additional, Morales, Hugo Manuel Paz, additional, Brunel, Anne-Sophie, additional, García, Estefanía, additional, Isler, Burcu, additional, Kern, Winfried V., additional, Palacios-Baena, Zaira R., additional, de la Calle, Guillermo Maestr, additional, Montero, Maria Milagro, additional, Kanj, Souha S., additional, Sipahi, Oguz R., additional, Calik, Sebnem, additional, Márquez-Gómez, Ignacio, additional, Marin, Jorge I., additional, Gomes, Marisa Z. R., additional, Hemmatii, Philipp, additional, Araos, Rafael, additional, Peghin, Maddalena, additional, Del Pozo, Jose L., additional, Yáñez, Lucrecia, additional, Tilley, Robert, additional, Manzur, Adriana, additional, Novo, Andrés, additional, Carratalà, Jordi, additional, and Gudiol, Carlota, additional

Published
2024
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34. Molecular Characteristics of Colistin Resistance in Acinetobacter baumannii and the Activity of Antimicrobial Combination Therapy in a Tertiary Care Medical Center in Lebanon

Author

Abou Fayad, Antoine, primary, Haraoui, Louis-Patrick, additional, Sleiman, Ahmad, additional, Hussein, Hadi, additional, Grenier, Frédéric, additional, Derbaj, Ghada, additional, Itani, Dana, additional, Iweir, Sereen, additional, Sherri, Nour, additional, Bazzi, Wael, additional, Rasheed, Sari, additional, Tanelian, Arax, additional, Miari, Mariam, additional, el Hafi, Bassam, additional, Kanj, Souha S., additional, Kanafani, Zeina A., additional, Daoud, Ziad, additional, Araj, George F., additional, and Matar, Ghassan M., additional

Published
2024
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35. Investigating an outbreak of extensively drug-resistant Acinetobacter baumannii in a tertiary healthcare centre in lebanon using next-generation sequencing

Author

Darwiche, Fatima I., Hussein, Hadi M., Harb, Souad Bou, Nahhal, Sarah, Kurdi, Abdallah, Sleiman, Ahmad, Hamadeh, Lama, Barada, Sara, Gerges, Jose-Rita, Araj, George F., Zahreddine, Nada Kara, Ibrahim, Ahmad, Kanafani, Zeina, Mahfouz, Rami, Kanj, Souha S., Matar, Ghassan M., and Fayad, Antoine G. Abou

Published
2024
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37. Invasive fungal infections in wars, following explosives and natural disasters: A narrative review.

Author

El Eid, Rozana, Chowdhary, Anuradha, El Zakhem, Aline, and Kanj, Souha S.

Subjects
NATURAL disasters, INJURY complications, SOFT tissue infections, MYCOSES, WAR, DIAGNOSTIC microbiology, SYMPTOMS
Abstract

Infections are well‐known complications in patients following traumatic injuries, frequently leading to high morbidity and mortality. In particular, trauma occurring in disaster settings, both natural and man‐made, such as armed conflicts and explosives detonation, results in challenging medical conditions that impede the best management practices. The incidence of invasive fungal infections (IFI) is increasing in trauma patients who lack the typical risk factors like an immune compromised state or others. This narrative review will focus on IFI as a direct complication after natural disasters, wars, and man‐made mass destruction with a summary of the available evidence about the epidemiology, clinical manifestations, risk factors, microbiology, and proper management. In this setting, the clinical manifestations of IFI may include skin and soft tissue infections, osteomyelitis, visceral infections, and pneumonia. IFI should be considered in the war inflicted patients who are exposed to unsterile environments or have wounds contaminated with soil and decaying organic matter. [ABSTRACT FROM AUTHOR]

Published
2024
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45. Metallo-beta-lactamases: mechanisms, treatment challenges, and future prospects.

Author

Zakhour, Johnny, El Ayoubi, L'Emir Wassim, and Kanj, Souha S.

Abstract

Metallo-beta-lactamases (MBLs) are responsible for resistance to almost all beta-lactam antibiotics. Found predominantly in Gram-negative bacteria, they severely limit treatment options. Understanding the epidemiology, risk factors, treatment, and prevention of infections caused by MBL-producing organisms is essential to reduce their burden. The origins and structure of MBLs are discussed. We describe the mechanisms of action that differentiate MBLs from other beta-lactamases. We discuss the global epidemiology of MBL-producing organisms and their impact on patients' outcomes. By exposing the mechanisms of transmission of MBLs among bacterial populations, we emphasize the importance of infection prevention and control. MBLs are spreading globally and challenging the majority of available antibacterial agents. Genotypic tests play an important role in the identification of MBL production. Phenotypic tests are less specific but may be used in low-resource settings, where MBLs are more predominant. Infection prevention and control are critical to reduce the spread of organisms producing MBL in healthcare systems. New combinations such as avibactam-aztreonam and new agents such as cefiderocol have shown promising results for the treatment of infections caused by MBL-producing organisms. New antibiotic and non-antibiotic agents are being developed and may improve the management of infections caused by MBL-producing organisms. [ABSTRACT FROM AUTHOR]

Published
2024
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46. Clinical Outcomes and Bacterial Characteristics of Carbapenem-resistant Acinetobacter baumannii Among Patients From Different Global Regions.

Author

Wang, Minggui, Ge, Lizhao, Chen, Liang, Komarow, Lauren, Hanson, Blake, Reyes, Jinnethe, Cober, Eric, Alenazi, Thamer, Zong, Zhiyong, Xie, Qing, Liu, Zhengyin, Li, Lanjuan, Yu, Yunsong, Gao, Hainv, Kanj, Souha S, Figueroa, Jairo, Herc, Erica, Cordova, Ezequiel, Weston, Gregory, and Tambyah, Paul Ananth

Subjects
ANTIBIOTICS, ACINETOBACTER infections, SCIENTIFIC observation, MULTIVARIATE analysis, MULTIPLE regression analysis, CARBAPENEM-resistant bacteria, TREATMENT effectiveness, COMPARATIVE studies, RESEARCH funding, HOSPITAL care, GENOMES, CARBAPENEMS, DRUG resistance in microorganisms, DEATH, LONGITUDINAL method
Abstract

Background Carbapenem-resistant Acinetobacter baumannii (CRAb) is 1 of the most problematic antimicrobial-resistant bacteria. We sought to elucidate the international epidemiology and clinical impact of CRAb. Methods In a prospective observational cohort study, 842 hospitalized patients with a clinical CRAb culture were enrolled at 46 hospitals in five global regions between 2017 and 2019. The primary outcome was all-cause mortality at 30 days from the index culture. The strains underwent whole-genome analysis. Results Of 842 cases, 536 (64%) represented infection. By 30 days, 128 (24%) of the infected patients died, ranging from 1 (6%) of 18 in Australia-Singapore to 54 (25%) of 216 in the United States and 24 (49%) of 49 in South-Central America, whereas 42 (14%) of non-infected patients died. Bacteremia was associated with a higher risk of death compared with other types of infection (40 [42%] of 96 vs 88 [20%] of 440). In a multivariable logistic regression analysis, bloodstream infection and higher age-adjusted Charlson comorbidity index were independently associated with 30-day mortality. Clonal group 2 (CG2) strains predominated except in South-Central America, ranging from 216 (59%) of 369 in the United States to 282 (97%) of 291 in China. Acquired carbapenemase genes were carried by 769 (91%) of the 842 isolates. CG2 strains were significantly associated with higher levels of meropenem resistance, yet non-CG2 cases were over-represented among the deaths compared with CG2 cases. Conclusions CRAb infection types and clinical outcomes differed significantly across regions. Although CG2 strains remained predominant, non-CG2 strains were associated with higher mortality. Clinical Trials Registration. NCT03646227. [ABSTRACT FROM AUTHOR]

Published
2024
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49. EPI-Net One Health reporting guideline for antimicrobial consumption and resistance surveillance data: a Delphi approach

Author

European Commission, European Federation of Pharmaceutical Industries and Associations, Babu Rajendran, Nithya, Arieti, Fabiana, Mena-Benítez, Carla Alejandra, Galia, Liliana, Tebon, Maela, Alvarez, Julio, Gladstone, Beryl Primrose, Collineau, Lucie, De Angelis, Giulia, Duro, Raquel, Gaze, William, Göpel, Siri, Kanj, Souha S., Käsbohrer, Annemarie, Limmathurotsakul, Direk, Lopez de Abechuco, Estibaliz, Mazzolini, Elena, Mutters, Nico T., Pezzani, Maria Diletta, Presterl, Elisabeth, Renk, Hanna, Rodríguez-Baño, Jesús, Săndulescu, Oana, Scali, Federico, Skov, Robert, Velavan, Thirumalaisamy P., Vuong, Cuong, Tacconelli, Evelina, European Commission, European Federation of Pharmaceutical Industries and Associations, Babu Rajendran, Nithya, Arieti, Fabiana, Mena-Benítez, Carla Alejandra, Galia, Liliana, Tebon, Maela, Alvarez, Julio, Gladstone, Beryl Primrose, Collineau, Lucie, De Angelis, Giulia, Duro, Raquel, Gaze, William, Göpel, Siri, Kanj, Souha S., Käsbohrer, Annemarie, Limmathurotsakul, Direk, Lopez de Abechuco, Estibaliz, Mazzolini, Elena, Mutters, Nico T., Pezzani, Maria Diletta, Presterl, Elisabeth, Renk, Hanna, Rodríguez-Baño, Jesús, Săndulescu, Oana, Scali, Federico, Skov, Robert, Velavan, Thirumalaisamy P., Vuong, Cuong, and Tacconelli, Evelina

Abstract

Strategic and standardised approaches to analysis and reporting of surveillance data are essential to inform antimicrobial resistance (AMR) mitigation measures, including antibiotic policies. Targeted guidance on linking full-scale AMR and antimicrobial consumption (AMC)/antimicrobial residues (AR) surveillance data from the human, animal, and environmental sectors is currently needed. This paper describes the initiative whereby a multidisciplinary panel of experts (56 from 20 countries-52 high income, 4 upper middle or lower income), representing all three sectors, elaborated proposals for structuring and reporting full-scale AMR and AMC/AR surveillance data across the three sectors. An evidence-supported, modified Delphi approach was adopted to reach consensus among the experts for dissemination frequency, language, and overall structure of reporting; core elements and metrics for AMC/AR data; core elements and metrics for AMR data. The recommendations can support multisectoral national and regional plans on antimicrobials policy to reduce resistance rates applying a One Health approach.

Published
2023

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