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Your search keyword '"Kanamura, Cristina T."' showing total 3 results
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3 results on '"Kanamura, Cristina T."'

1. RBD and Spike DNA-Based Immunization in Rabbits Elicited IgG Avidity Maturation and High Neutralizing Antibody Responses against SARS-CoV-2

Author

da Costa, Hernan H. M., primary, Orts, Diego J. B., additional, Moura, Andrew D., additional, Duarte-Neto, Amaro N., additional, Cirqueira, Cinthya S., additional, Réssio, Rodrigo A., additional, Kanamura, Cristina T., additional, Miguita, Karen, additional, Ferreira, Jerenice E., additional, Santos, Raimunda T. M., additional, Adriani, Patricia P., additional, Cunha-Junior, Jair P., additional, Astray, Renato M., additional, Catarino, Regina M., additional, Lancelotti, Marcelo, additional, and Prudencio, Carlos R., additional

Published
2023
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2. Understanding Sabiá virus infections (Brazilian mammarenavirus)

Author

Nastri, Ana Catharina, primary, Duarte-Neto, Amaro Nunes, additional, Casadio, Luciana Vilas Boas, additional, Souza, William Marciel de, additional, Claro, Ingra M., additional, Manuli, Erika R., additional, Selegatto, Gloria, additional, Salomão, Matias C., additional, Fialkovitz, Gabriel, additional, Taborda, Mariane, additional, Almeida, Bianca Leal de, additional, Magri, Marcello C., additional, Guedes, Ana Rúbia, additional, Perdigão Neto, Lauro Vieira, additional, Sataki, Fatima Mitie, additional, Guimarães, Thais, additional, Mendes-Correa, Maria Cassia, additional, Tozetto-Mendoza, Tania R., additional, Fumagalli, Marcilio Jorge, additional, Ho, Yeh-Li, additional, Maia da Silva, Camila Alves, additional, Coletti, Thaís M., additional, Goes de Jesus, Jaqueline, additional, Romano, Camila M., additional, Hill, Sarah C., additional, Pybus, Oliver, additional, Rebello Pinho, João Renato, additional, Ledesma, Felipe Lourenço, additional, Casal, Yuri R., additional, Kanamura, Cristina T., additional, Tadeu de Araújo, Leonardo José, additional, Ferreira, Camila Santos da Silva, additional, Guerra, Juliana Mariotti, additional, Figueiredo, Luiz Tadeu Moraes, additional, Dolhnikoff, Marisa, additional, Faria, Nuno R., additional, Sabino, Ester C., additional, Alves, Venâncio Avancini Ferreira, additional, and Levin, Anna S., additional

Published
2022
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3. Testicular pathology in fatal COVID‐19: A descriptive autopsy study.

Author

Duarte‐Neto, Amaro N., Teixeira, Thiago A., Caldini, Elia G., Kanamura, Cristina T., Gomes‐Gouvêa, Michele S., dos Santos, Angela B. G., Monteiro, Renata A. A., Pinho, João R. R., Mauad, Thais, da Silva, Luiz F. F., Saldiva, Paulo H. N., Dolhnikoff, Marisa, Leite, Katia R. M., and Hallak, Jorge

Subjects
SERTOLI cells, LEYDIG cells, AUTOPSY, CELL adhesion molecules, VIRAL antigens
Abstract

Background: Multi‐organ damage is a common feature of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection, going beyond the initially observed severe pneumonia. Evidence that the testis is also compromised is growing. Objective: To describe the pathological findings in testes from fatal cases of COVID‐19, including the detection of viral particles and antigens, and inflammatory cell subsets. Materials and methods: Postmortem testicular samples were obtained by percutaneous puncture from 11 deceased men and examined by reverse‐transcription polymerase chain reaction (RT‐PCR) for RNA detection and by light and electron microscopy (EM) for SARS‐CoV‐2. Immunohistochemistry (IHC) for the SARS‐CoV‐2 N‐protein and lymphocytic and histiocytic markers was also performed. Results: Eight patients had mild interstitial orchitis, composed mainly of CD68+ and TCD8+ cells. Fibrin thrombi were detected in five cases. All cases presented congestion, interstitial edema, thickening of the tubular basal membrane, decreased Leydig and Sertoli cells with reduced spermatogenesis, and strong expression of vascular cell adhesion molecule (VCAM) in vessels. IHC detected SARS‐Cov‐2 antigen in Leydig cells, Sertoli cells, spermatogonia, and fibroblasts in all cases. EM detected viral particles in the cytoplasm of fibroblasts, endothelium, Sertoli and Leydig cells, spermatids, and epithelial cells of the rete testis in four cases, while RT‐PCR detected SARS‐CoV‐2 RNA in three cases. Discussion and conclusion: The COVID‐19‐associated testicular lesion revealed a combination of orchitis, vascular changes, basal membrane thickening, Leydig and Sertoli cell scarcity, and reduced spermatogenesis associated with SARS‐CoV‐2 local infection that may impair hormonal function and fertility in men. [ABSTRACT FROM AUTHOR]

Published
2022
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