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In this article some Jewish sources are taken into consideration in order to outline on one side a conflict, on the other a connection between truth and interpretation, prophecy and hermeneutics. These sources are the story of the akhnai‘s oven (Talmud Bavli, Bava Metzia 59 a-b), Maimonides’ Guide of the perplexed, Moses Mendelssohn’s Jerusalem, Hermann Cohen’s opus postumum, Emmanuel Levinas’ philosophical and Jewish writings. Through the analysis of these texts, belonging to Judaism and Jewish thought, about the problem of the relationship between the unity of truth and the plurality of opinions, the unconditional and the historical, the transcendent God and human activity within time, the article intends to point out a paradigm which could give suggestions to the discussion on the possibility of a critical hermeneutics., Critical Hermeneutics, Vol 6 No 2 (2022): Hermeneutic Realism and Veritative Hermeneutics

Adenovirus (HAdV) F41 is a common cause of gastroenteritis and has rarely been reported associated with disseminated disease. In this report, a fifty-eight-year-case with a history of ulcerative colitis, cryptogenic cirrhosis, stage III adenocarcinoma, high-grade diffuse large B-cell lymphoma on chemotherapy was diagnosed with disseminated adenovirus infection. HAdV DNA was quantified in stool, plasma, and urine with viral loads of 7, 4, and 3 log10 copies/mL, respectively. The patient’s course was rapidly progressive and he passed away 2 days after initiation of antiviral therapy. The patient’s infecting virus was characterized as HAdV-F41 by whole genome sequencing.

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Human adenovirus type 4 (HAdV-E4) is the only type (and serotype) classified within species Human mastadenovirus E that has been isolated from a human host to the present. Recent phylogenetic analysis of whole genome sequences of strains representing the spectrum of intratypic genetic diversity described to date identified two major evolutionary lineages designated phylogroups (PG) I, and II, and validated the early clustering of HAdV-E4 genomic variants into two major groups by low resolution restriction fragment length polymorphism analysis. In this study we expanded our original analysis of intra- and inter-PG genetic variability, and used a panel of viruses representative of the spectrum of genetic diversity described for HAdV-E4 to examine the magnitude of inter- and intra-PG phenotypic diversity using an array of cell-based assays and a cotton rat model of HAdV respiratory infection. Our proteotyping of HAdV-E strains using concatenated protein sequences in selected coding regions including E1A, E1B-19K and −55K, DNA polymerase, L4-100K, various E3 proteins, and E4-34K confirmed that the two clades encode distinct variants/proteotypes at most of these loci. Our in vitro and in vivo studies demonstrated that PG I and PG II differ in their growth, spread, and cell killing phenotypes in cell culture and in their pulmonary pathogenic phenotypes. Surprisingly, the differences in replicative fitness documented in vitro between PGs did not correlate with the differences in virulence observed in the cotton rat model. This body of work is the first reporting phenotypic correlates of naturally occurring intratypic genetic variability for HAdV-E4.IMPORTANCEHuman adenovirus type 4 (HAdV-E4) is a prevalent causative agent of acute respiratory illness of variable severity and of conjunctivitis and comprises two major phylogroups that carry distinct coding variations in proteins involved in viral replication and modulation of host responses to infection. Our data show that PG I and PG II are intrinsically different regarding their ability to grow and spread in culture and to cause pulmonary disease in cotton rats.This is the first report of phenotypic divergence among naturally occurring known genetic variants of a HAdV type of medical importance. This research reveals readily detectable phenotypic differences between strains representing phylogroups I and II, and it introduces a unique experimental system for the elucidation of the genetic basis of adenovirus fitness and virulence and thus for increasing our understanding of the implications of intratypic genetic diversity in the presentation and course of HAdV-E4-associated disease.

The family Adenoviridae includes non-enveloped viruses with linear dsDNA genomes of 25–48 kb and medium-sized icosahedral capsids. Adenoviruses have been discovered in vertebrates from fish to humans. The family is divided into six genera, each of which is more common in certain animal groups. The outcome of infection may vary from subclinical to lethal disease. This is a summary of the ICTV Report on the family Adenoviridae, which is available at ictv.global/report/adenoviridae.

This study compares the effects of rubber tire waste and rubber band waste on physical, mechanical, and thermal properties of cement composite for roofing application. The rubber particles, prepared from waste rubber tire (RT) and/or calcium carbonate filled rubber band (RB), were mixed with cement paste and tested for workability and flexural strength. It was found that RT yields higher workability than RB when mixed with the cement paste. The rubber-cement composites (CR) with the combination of RT and RB at the RT:RB volume fraction of 1.00:0.00 (CRT), 0.75:0.25 (CRT.75/B.25) and 0.50:0.50 (CRT.50/B.50) have sufficient workability and flexural strength. When mixing different rubber particles with oil palm fibers and the cement paste to obtain CFRT, CFRT.75/B.25, CFRT.50/B.50 rubber-fiber-cement composites, the composites with higher RT content have higher flexural strength, while those with higher RB content have lower thermal conductivity, implying better thermal insulation property. More importantly, all three types of rubber-fiber-cement composites yield excellent thermal insulation property, and meet the flexural strength required by the industrial standard for the fiber-cement roof tile sheets. The results suggest that the waste rubber-waste oil palm fiber-cement composites can be viable candidates for roofing application with promising potential for energy saving.