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Optical spectrum analysis provides a wealth of information about the physical world. Throughout the development of optical spectrum analysis, sensitivity has been one of the major topics and has become essential in applications dealing with faint light. Various high-sensitivity optical detection technologies have been applied in optical spectrum analysis to enhance its sensitivity to single-photon level. As an emerging single-photon detection technology, superconducting nanowire single-photon detectors (SNSPDs) have many impressive features such as high detection efficiency, broad operation bandwidth, small timing jitter, and so on, which make them promising for enhancing the performance of optical spectral analysis. Diverse schemes for photon-counting spectrometers based on SNSPDs have been demonstrated. This article reviews these impressive works and prospects for the future development of this technology. Further breakthroughs can be expected in its theories, device performance, applications, and combinations with in-sensor computing, promoting it to be a mature and versatile solution for optical spectrum analysis on ultra-faint light.

Abstract Metasurfaces with tunable functionalities are greatly desired for modern optical system and various applications. To increase the operating channels of polarization-multiplexed metasurfaces, we proposed a structure of N cascaded dual-channel metasurfaces to achieve 2 N electrically switchable channels without intrinsic loss or cross-talk for certain functionalities, including beam steering, vortex beam generation, lens, etc. As proof of principles, we have implemented a 3-layer setup to achieve 8 channels. In success, we have demonstrated two typical functionalities of vortex beam generation with switchable topological charge of l = −3 ~ +4 or l = −1 ~ −8, and beam steering with the deflection direction switchable in an 8×1 line or a 4×2 grid. We believe that our proposal would provide a practical way to significantly increase the scalability and extend the functionality of polarization-multiplexed metasurfaces. Although this method is not universal, it is potential for the applications of LiDAR, glasses-free 3D display, OAM (de)multiplexing, and varifocal meta-lens.

Abstract The photonic Ising machine is a new paradigm of optical computing that takes advantage of the unique properties of light wave propagation, parallel processing, and low-loss transmission. Thus, the process of solving combinatorial optimization problems can be accelerated through photonic/optoelectronic devices, but implementing photonic Ising machines that can solve arbitrary large-scale Ising problems with fast speed remains challenging. In this work, we have proposed and demonstrated the Phase Encoding and Intensity Detection Ising Annealer (PEIDIA) capable of solving arbitrary Ising problems on demand. The PEIDIA employs the heuristic algorithm and requires only one step of optical linear transformation with simplified Hamiltonian calculation by encoding the Ising spins on the phase term of the optical field and performing intensity detection during the solving process. As a proof of principle, several 20 and 30-spin Ising problems have been solved with high ground state probability (≥0.97/0.85 for the 20/30-spin Ising model).

Abstract Topological photonics provides a new degree of freedom to robustly control electromagnetic fields. To date, most of established topological states in photonics have been employed in Euclidean space. Motivated by unique properties of hyperbolic lattices, which are regular tessellations in non-Euclidean space with a constant negative curvature, the boundary-dominated hyperbolic topological states have been proposed. However, limited by highly crowded boundary resonators and complicated site couplings, the hyperbolic topological insulator has only been experimentally constructed in electric circuits. How to achieve hyperbolic photonic topological insulators is still an open question. Here, we report the experimental realization of hyperbolic photonic topological insulators using coupled ring resonators on silicon chips. Boundary-dominated one-way edge states with pseudospin-dependent propagation directions have been observed. Furthermore, the robustness of edge states in hyperbolic photonic topological insulators is also verified. Our findings have potential applications in the field of designing high-efficient topological photonic devices with enhanced boundary responses.

ABSTRACTAntibiotic resistance is a recognized and concerning public health issue. Gram-negative bacilli, such as Pseudomonas aeruginosa (P. aeruginosa), are notorious for their rapid development of drug resistance, leading to treatment failures. TanReQing injection (TRQ) was chosen to explore its pharmacological mechanisms against clinical multidrug-resistant P. aeruginosa (MDR-PA), given its antibacterial and anti-inflammatory properties. We revealed the expression of proteins and genes in P. aeruginosa after co-culture with TRQ. This study developed an assessment method to evaluate clinical resistance of P. aeruginosa using MALDI-TOF MS identification and Biotyper database searching techniques. Additionally, it combined MIC determination to investigate changes in MDR-PA treated by TRQ. TRQ effectively reduced the MICs of ceftazidime and cefoperazone and enhanced the confidence scores of MDR-PA as identified by mass spectrometry. Using this evaluation method, the fingerprints of standard P. aeruginosa and MDR-PA were compared, and the characteristic peptide sequence (Seq-PA No. 1) associated with flagellum was found. The phenotypic experiments were conducted to confirm the effect of TRQ on the motility and adhesion of P. aeruginosa. A combination of co-immunoprecipitation and proteome analysis was employed, and 16 proteins were significantly differentially expressed and identified as potential candidates for investigating the mechanism of inhibiting resistance in P. aeruginosa treated by TRQ. The candidates were verified by quantitative real-time PCR analysis, and TRQ may affect these core proteins (MexA, MexB, OprM, OprF, OTCase, IDH, and ASL) that influence resistance of P. aeruginosa. The combination of multiple methods helps elucidate the synergistic mechanism of TRQ in overcoming resistance of P. aeruginosa.IMPORTANCEPseudomonas aeruginosa is an opportunistic pathogen closely associated with various life-threatening acute and chronic infections. The presence of antimicrobial resistance and multidrug resistance in P. aeruginosa infections significantly complicates antibiotic treatment. The expression of β-lactamase, efflux systems such as MexAB-OprM, and outer membrane permeability are considered to have the greatest impact on the sensitivity of P. aeruginosa. The study used a method to assess the clinical resistance of P. aeruginosa using matrix-assisted laser desorption ionization time of flight mass spectrometry identification and Biotyper database search techniques. TanReQing injection (TRQ) effectively reduced the MICs of ceftazidime and cefoperazone in multidrug-resistant P. aeruginosa (MDR-PA) and improved the confidence scores for co-cultured MDR-PA. The study found a characteristic peptide sequence for distinguishing whether P. aeruginosa is resistant. Through co-immunoprecipitation and proteome analysis, we explored the mechanism of TRQ overcoming resistance of P. aeruginosa.

ABSTRACT: High-sensitivity mass sensors under ambient conditions are essential in various fields such as biological research, gas sensing and environmental monitoring. In the current work, a phonon lasing enhanced mass sensor was proposed based on an optomechanical crystal cavity under ambient conditions. The phonon lasing was harnessed to achieve ultra-high resolution since it resulted in an extremely narrow mechanical linewidth (less than 10 kHz). Masses with different weights were deposited on the cavity, it is predicted that the maximum resolution for mass sensing can be 65 ± 19 zg, which approaches the mass order of a protein and an oligonucleotide. This implies the potential application of the proposed method in the biomedical fields such as oligonucleotide drug delivery area and the Human Proteome Project.

Lasers differ from other light sources in that they are coherent, and their coherence makes them indispensable to both fundamental research and practical application. In optomechanical cavities, photon and phonon lasing is facilitated by the ability of photons and phonons to interact intensively and excite one another coherently. The lasing linewidths of both phonons and photons are critical for practical application. This study investigates the lasing linewidths of photons and phonons from the underlying dynamics in an optomechanical cavity. We find that the linewidths can be accounted for by two distinct physical mechanisms in two regimes, namely the normal regime and the reversed regime, where the intrinsic optical decay rate is either larger or smaller than the intrinsic mechanical decay rate. In the normal regime, an ultra-narrow spectral linewidth of 5.4 kHz for phonon lasing at 6.22 GHz can be achieved regardless of the linewidth of the pump light, while these results are counterintuitively unattainable for photon lasing in the reversed regime. These results pave the way towards harnessing the coherence of both photons and phonons in silicon photonic devices and reshaping their spectra, potentially opening up new technologies in sensing, metrology, spectroscopy, and signal processing, as well as in applications requiring sources that offer an ultra-high degree of coherence.

ABSTRACT: Spectral imaging extends the concept of traditional color cameras to capture images across multiple spectral channels and has broad application prospects. Conventional spectral cameras based on scanning methods suffer from the drawbacks of low acquisition speed and large volume. On-chip computational spectral imaging based on metasurface filters provides a promising scheme for portable applications, but endures long computation time due to point-by-point iterative spectral reconstruction and mosaic effect in the reconstructed spectral images. In this study, on-chip rapid spectral imaging was demonstrated, which eliminated the mosaic effect in the spectral image by deep-learning-based spectral data cube reconstruction. The experimental results show that 4 orders of magnitude faster than the iterative spectral reconstruction were achieved, and the fidelity of the spectral reconstruction for the standard color plate was over 99% for a standard color board. In particular, video-rate spectral imaging was demonstrated for moving objects and outdoor driving scenes with good performance for recognizing metamerism, where the concolorous sky and white cars can be distinguished via their spectra, showing great potential for autonomous driving and other practical applications in the field of intelligent perception.

Abstract Quantum key distribution (QKD) would play an important role in future information technologies due to its theoretically proven security based on the laws of quantum mechanics. How to realize QKDs among multiple users in an effective and simple way is crucial for its real applications in communication networks. In this work, we propose and demonstrate a fully connected QKD network without trusted node for a large number of users. Using flexible wavelength division multiplexing/demultiplexing and space division multiplexing, entanglement resources generated by a broadband energy-time entangled quantum light source are distributed to 40 users. Any two users share a part of entanglement resources, by which QKD is established between them. As a result, it realizes a fully connected network with 40 users and 780 QKD links. The performance of this network architecture is also discussed theoretically, showing its potential on developing quantum communication networks with large user numbers owing to its simplicity, scalability, and high efficiency.

ABSTRACT The rise of antibiotic resistance and dearth of novel antibiotics have posed a serious health crisis worldwide. In this study, we screened a combination of antibiotics and nonantibiotics providing a viable strategy to solve this issue by broadening the antimicrobial spectrum. We found that chenodeoxycholic acid (CDCA), a cholic acid derivative of the traditional Chinese medicine (TCM) Tanreqing (TRQ), synergizes with amikacin against Staphylococcus aureus in vitro, and this synergistic killing was effective against diverse methicillin-resistant S. aureus (MRSA) variants, including small-colony variants (SCVs), biofilm strains, and persisters. The CDCA-amikacin combination protects a mouse model from S. aureus infections. Mechanistically, CDCA increases the uptake of aminoglycosides in a proton motive force-dependent manner by dissipating the chemical potential and potentiates reactive oxygen species (ROS) generation by inhibiting superoxide dismutase activity. This work highlights the potential use of TCM components in treating S. aureus-associated infections and extend the use of aminoglycosides in eradicating Gram-positive pathogens. IMPORTANCE Multidrug resistance (MDR) is spreading globally with increasing speed. The search for new antibiotics is one of the key strategies in the fight against MDR. Antibiotic resistance breakers that may or may not have direct antibacterial action and can either be coadministered or conjugated with other antibiotics are being studied. To better expand the antibacterial spectrum of certain antibiotics, we identified one component from a traditional Chinese medicine, Tanreqing (TRQ), that increased the activity of aminoglycosides. We found that this so-called agent, chenodeoxycholic acid (CDCA), sensitizes Staphylococcus aureus to aminoglycoside killing and protects a mouse model from S. aureus infections. CDCA increases the uptake of aminoglycosides in a proton motive force-dependent manner by dissipating the chemical potential and potentiates ROS generation by inhibiting superoxide dismutase activity in S. aureus. Our work highlights the potential use of TCM or its effective components, such as CDCA, in treating antibiotic resistance-associated infections.

The hybrid integration of superconducting nanowire single-photon detectors (SNSPDs) on various substrates and photonic structures has great potential on developing complicated photonic devices based on single-photon detections, such as photon-counting reconstructive spectrometers for the spectral sensing of single-photon level faint light. In this paper, we introduce the cascaded absorption effect of SNSPDs to develop a photon-counting reconstructive spectrometer. The device includes a Rowland grating as the spatial dispersion element and a tailored cascaded SNSPD array in the focusing region of the grating. The spectral responses of the SNSPDs could be flexibly modulated by their coiled patterns and the cascaded absorption in the array, which are used as the bases for spectral reconstruction. A prototype device was designed and fabricated to demonstrate the principle of the scheme. The experiment results showed the feasibility of the spectral response modulations by the coiled pattern design and the cascaded absorption effect of the SNSPD array. It supports the spectral measurement and reconstruction in the wavelength range of 1,495 to 1,515 nm, with a spectral resolution of 0.4 nm. The proposed scheme achieves the bases for spectral reconstruction only by the design of SNSPDs and without the spectral modulation effects of additional photonic structures. It provides an interesting and promising way to develop devices with high photon utilization.

Low-cycle fatigue testing was carried out for the welded joints of constructional steels containing 0% V + 0.0021% N and 0.10% V + 0.0078% N, and the effects of V-N microalloying on the low-cycle fatigue property of the welded joints were investigated. The results showed that when the total strain amplitudes were 1.2%, 1.4% and 1.6%, the mean low-cycle fatigue lives of the welded joints of steel containing 0.10% V + 0.0078% N were 5050, 2372 and 1535 cycles, respectively, which were significantly higher than those of the welded joints of steel containing 0% V + 0.0021% N; however, when the total strain amplitudes increased to 1.8% and 2.0%, the mean low-cycle fatigue lives of the welded joints of steel containing 0.10% V + 0.0078% N were 575 and 367 cycles, respectively, which were gradually lower than those of the welded joints of steel containing 0% V + 0.0021% N. The reasons causing the difference of low-cycle fatigue life were explained by the dislocation structure and precipitates in the welding heat-affected zone, plastic strain energy density of the welded joints, and fatigue fracture morphology. When the low-cycle fatigue life is between 100 and 200 cycles, the cyclic toughness of the welded joint of steel containing 0.10% V + 0.0078% N is between 57.48 and 78.22 J/cm3, which is higher than that of the welded joint of steel containing 0% V + 0.0021% N, indicating that the welded joint of steel containing 0.10% V + 0.0078% N is able to absorb more energy in a seismic condition, therefore possessing better seismic resistance.

For weathering steel used in building, it is necessary not only to ensure weather resistance, but also to improve the strength and yield ratio. This study investigates the strengthening effect of Ti microalloying on the tested steel by conducting continuous cooling transformation tests of undercooled austenite and comparative tests of microstructure and performance at different coiling temperatures, with 0.07 wt.% Ti added to the weathering building test steel. The results show that, with an increase in cooling rate (0.1~50 °C/s), the room temperature microstructure of different cooling rates gradually transitions as follows: F + P, F + P + B, F + B and B + M; in addition, the hardness increases. Polygonal ferrite and pearlite were obtained by coiling at 650 °C; quasi-polygonal ferrite, acicular ferrite, pearlite and a small amount of bainite were obtained by coiling at 600 °C; and bainite was obtained by coiling at 550 °C. With a decrease in coiling temperature, the strength of the test steel increased, the yield ratio increased, the elongation after fracture decreased and the elongation at the yield point decreased. Compared with those observed at 650 °C, the nano precipitation phases observed in the sample at 600 °C were smaller in size, higher in number and higher in dislocation density. The combined action of second-phase precipitation strengthening and dislocation strengthening increased the strength and yield ratio of the test steel. This study will be helpful in guiding the improvement of strength grades for weathering steel used in building and industrial production.

This study reports the welded joint of a novel 590 MPa V-N microalloyed wheel steel on microstructure and mechanical properties after flash butt welding. The welding parameters were flash current 48°/582.0 A, upsetting current 44°/516.6 A, and workpiece clearance 1.5 mm. The evolution of microstructure in the welded joint occurred as follows: welding seam (ferrite side plate + acicular ferrite +martensite)→coarse-grained zone (acicular ferrite + granular bainite)→fine-grained zone (fine-grained ferrite + M/A island)→base metal (equiaxed ferrite + pearlite). The standard impact energy value of welding seam, coarse grain zone, fine grain zone, and base metal at −40 °C was 116, 128, 144, and 88 J, respectively. The mechanical property of the joint was excellent. The microstructure, the number of grain boundaries, and the dislocation density directly affected the strength and hardness of the joint. The increase of large angle grain boundaries and the decrease of effective grain size were beneficial to the improvement of toughness. The hot-rolled 590 MPa V-N microalloyed wheel steel had superior weldability.

Staphylococcus aureus has been recognized as an important human pathogen and poses a serious health threat worldwide. With the advent of antibiotic resistance, such as the increased number of methicillin-resistant Staphylococcus aureus (MRSA), there is an urgent need to develop new therapeutical agents. In this study, Chinese traditional medicine Tanreqing (TRQ) has been used as an alternative treating agent against MRSA and we aim to unravel the mode of action of TRQ underlying MRSA inhibition. TRQ treatment affected numerous gene expression as revealed by RNA-seq analysis. Meanwhile, TRQ targeted cell division to inhibit cell growth as shown by illumination microscopy. Besides, we confirmed that TRQ downregulates the expression of virulence factors such as hemolysin and autolysin. Finally, we used a murine model to demonstrate that TRQ efficiently reduces bacterial virulence. Altogether, we have proved TRQ formula to be an effective agent against S. aureus infections.

Methicillin-resistant Staphylococcus aureus (MRSA) has posed a severe global health threat. In this study, we screened an antibiotic and non-antibiotic combination that provides a viable strategy to solve this issue by broadening the antimicrobial spectrum. We found that chenodeoxycholic acid (CDCA) could synergistically act with carbapenem antibiotics to eradicate MRSA-related infections. This synergy specifically targets MRSA and was also validated using 25 clinical MRSA strains using time–kill analysis. We speculated that the underlying mechanism was associated with the interaction of penicillin-binding proteins (PBPs). As a result, the synergistic efficiency of CDCA with carbapenems targeting PBP1 was better than that of β-lactams targeting PBPs. Moreover, we showed that CDCA did not affect the expression level of PBPs, but sensitized MRSA to carbapenems by disrupting the cell membrane. In our study, we have revealed a novel synergistic combination of antibiotics and non-antibiotics to combat potential bacterial infections.

Shielded metal arc welding and welding thermal simulation experiment were carried out for constructional steel containing 0% V and 0.10% V, and the microstructure, precipitation feature, microhardness HV0.2, and −20 °C impact value in the welding heat affected zone (HAZ) were investigated. The results showed that in the coarse-grained heat affected zone (CGHAZ), V and N were completely dissolved in the matrix of steel containing 0.10% V to promote the growth of prior austenite grains, meanwhile the fraction of high angle grain boundaries (HAGBs) decreased, thereby leading to the mean −20 °C impact value decreases from 87 J to 18 J. In the grain refined heat affected zone (GRHAZ), V(C, N) precipitates experience re-dissolution and re-precipitation at grain boundaries, V–N microalloying changes the microstructure from lath bainite + granular bainite + small amount of polygonal ferrite to polygonal ferrite + pearlite + martensite, thereby leading to the mean microhardness decreases from 335 HV0.2 to 207 HV0.2, and the mean −20 °C impact value decreased from 117 J to 103 J. In the intercritical heat affected zone (ICHAZ), V(C, N) precipitates experience re-dissolution, re-precipitation, and growth, causing the formation of micro-sized V(C, N) precipitates, thereby leading to the mean −20 °C impact value decreases from 93 J to 62 J.

Multimode optomechanics exhibiting several intriguing phenomena, such as coherent wavelength conversion, optomechanical synchronization, and mechanical entanglements, has garnered considerable research interest for realizing a new generation of information processing devices and exploring macroscopic quantum effect. In this study, we proposed and designed a hetero-optomechanical crystal (OMC) zipper cavity comprising double OMC nanobeams as a versatile platform for multimode optomechanics. Herein, the heterostructure and breathing modes with high mechanical frequency ensured the operation of the zipper cavity at the deep-sideband-resolved regime and the mechanical coherence. Consequently, the mechanical breathing mode at 5.741 GHz and optical odd mode with an intrinsic optical Q factor of 3.93 × 105 were experimentally demonstrated with an optomechanical coupling rate g0 = 0.73 MHz between them, which is comparable to state-of-the-art properties of the reported OMC. In addition, the hetero-zipper cavity structure exhibited adequate degrees of freedom for designing multiple mechanical and optical modes. Thus, the proposed cavity will provide a playground for studying multimode optomechanics in both the classical and quantum regimes.

The article discuses the physics related to on-chip mechanical exceptional points (EPs) with a silicon optomechanical zipper cavity and their possible applications for ultrasensitive measurements. It is reported that exceptional points are special degenerate points of spectra that exist in the non Hermitian system. It is further reported that optical EPs has been demonstrated in various platforms including optical & microwave cavities, photonic crystal slabs & multilayered plasmonic structures.