1. Nosocomial infections in female compared with male patients with decompensated liver cirrhosis.
- Author
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Griemsmann M, Tergast TL, Simon N, Kabbani AR, Manns MP, Wedemeyer H, Cornberg M, and Maasoumy B
- Subjects
- Female, Humans, Liver Cirrhosis complications, Male, Prognosis, Acute Kidney Injury etiology, Acute-On-Chronic Liver Failure, Bacterial Infections complications, Bacterial Infections epidemiology, Cross Infection epidemiology, Peritonitis complications
- Abstract
There are considerable differences between males and females regarding the etiology, progression and outcome of liver diseases. Infections are a frequent and severe complication in these patients. This study aimed to examine sex specific differences in the incidence and clinical course of nosocomial infections in patients with decompensated liver cirrhosis. A number of 556 consecutive hospitalized patients with decompensated liver cirrhosis and ascites were analyzed. The patients were followed up for the incidence of nosocomial infections, acute kidney injury (AKI), acute-on-chronic liver failure (ACLF) as well as liver transplantation and death (LTx-free survival). A number of 285 patients (111 women and 174 men) developed a nosocomial infection. Incidence was numerically lower in men (P = 0.076). While the frequency of a nosocomial spontaneous bacterial peritonitis was similar between males and females, the incidence of a nosocomial urinary tract infection was significantly higher in women (P < 0.001). No sex specific differences were documented regarding the outcome of an infection as indicated by a similar incidence of, AKI, ACLF as well as LTx-free survival. There seem to be no major differences in the incidence and outcome of nosocomial infections between male and female patients., (© 2022. The Author(s).)
- Published
- 2022
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