10 results on '"KISA, ERDEM"'
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2. Are the use of fluoroquinolones in prostate biopsy prophylaxis returning? Comment on “antibiotic prophylaxis in patients who had undergone to prostate biopsy in between the EMA warning era: effects of fluoroquinolones in diabetic and non-diabetic patients. Results of an observational cohort study”
- Author
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Kisa, Erdem
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- 2022
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3. Prostat Adenokarsinomlarında Morfolojik Tümör Heterojenitesinin Lenf Nodu Metastazı ile İlişkisi
- Author
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EKMEKCİ, Sümeyye, primary, KELTEN TALU, Esra Canan, additional, KISA, Erdem, additional, and KÜÇÜK, Ülkü, additional
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- 2023
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4. Intraoperative Assessment of Stone Free Status for Percutaneous Nephrolithotomy Surgery: Surgeon’s Eye
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YALÇIN, Mehmet Yiğit, primary, ERGANİ, Batuhan, additional, ÇETİN, Taha, additional, KARABIÇAK, Mustafa, additional, ÖZBİLEN, Mert Hamza, additional, BİLDİRİCİ, Çağdaş, additional, KARACA, Erkin, additional, YOLDAŞ, Mehmet, additional, KISA, Erdem, additional, ÖZGEN, Tufan Suel, additional, KOÇ, Gökhan, additional, ÇAKMAK, Özgür, additional, BOYACIOĞLU, Hayal, additional, and İLBEY, Yusuf Özlem, additional
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- 2023
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5. What Is Your Choice for Androgen Deprivation Therapy in Metastatic Prostate Carcinoma: Surgical or Medical?
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Caliskan Yildirim, EDA, Muezzinoglu, Talha, Arayici, Mehmet Emin, Kisa, Erdem, Semiz, HÜSEYİN SALİH, Karaoglu, AZİZ, and Atag, ELİF
- Abstract
At the time of diagnosis, approximately 16.5% of prostate cancer patients are metastatic. The main framework of metastatic prostate cancer treatment is androgen deprivation therapy, which is performed surgically or medically. The aim of this study is to evaluate the attitudes of medical oncologists and urologists about orchiectomy as androgen deprivation therapy.A total of 387 physicians working in the Departments of Urology (n=217) and Medical Oncology (n=170) were included in this descriptive study. Data were collected through an electronic survey.Only 7.5% of participants indicated that they offered surgical castration to their patients. Urologists preferred surgical castration more than oncologists for the treatment of metastatic castration-sensitive prostate carcinoma (P=.003). The reasons why medical oncologists preferred surgical castration less are that it is an invasive procedure, has risk of morbidity and mortality, high cost of hospitalization, and may cause deterioration of the patient's body image (P.05).This study showed that physicians were less likely to perform orchiectomy as an androgen deprivation therapy. Although the most important reason for this is the patient preference, the biased presentation of treatment options to patients, the lack of knowledge of physicians about orchiectomy, and the effect of the pharmaceutical industry should also be kept in mind.
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- 2022
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- View/download PDF
6. The Prognostic Role of Inflammatory Biomarkers in Metastatic Castration Sensitive Prostate Carcinoma.
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Semiz, Huseyin Salih, Keskinkilic, Merve, Ellez, Halil Ibrahim, Arslan, Ahmet Melih, Arayici, Mehmet Emin, and Kisa, Erdem
- Subjects
BIOMARKERS ,PLATELET lymphocyte ratio ,CONFIDENCE intervals ,INFLAMMATION ,CROSS-sectional method ,RESEARCH methodology ,RETROSPECTIVE studies ,MANN Whitney U Test ,NEUTROPHIL lymphocyte ratio ,DESCRIPTIVE statistics ,CHI-squared test ,PROSTATE tumors ,OVERALL survival - Abstract
Objectives: Due to limited data in the literature on the prognostic value of inflammatory markers neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and derived NLR (dNLR) in metastatic castration-sensitive prostate cancer (mCSPC), we aimed to determine the role of this markers in the prognosis of mCSPC. Methods: In this study, inflammatory marker values in mCSPC (NLR0, PLR0, dNLR0) and mCRPC (NLR1, PLR1, dNLR1) were calculated. Characteristics of the patients and the effects of inflammatory markers on overall survival (OS) and cancer-specific survival (CSS) were evaluated using appropriate statistical methods. Results: The median age of 124 patients was 68.71 years. No significant difference was found OS in mCSPC NLR0, dNLR0 and PLR0 groups (p>0,05). While the median CSS was statistically longer in the NLR0, dNLR0 and PLR0 low groups (Median:45.9 vs 35.7 months for NLR0, 47.0 vs 34.6 months for dNLR and 46.2 vs 33.9 months, p=0.037, p=0.036, p=0.041 respectively). There was no significant difference in terms of OS and CSS in NLR1 and dNLR1 groups (p>0.05). The patients with low PLR1 showed statistical significantly better OS and CSS (p=0.027 for OS and p=0.006 for CSS). Conclusion: Although inflammatory markers have prognostic value in many cancers, mCSPC which have heterogeneous and complex structures, are still controversial, and more studies are needed for their routine use. [ABSTRACT FROM AUTHOR]
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- 2023
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7. Biopsy with Ureterorenoscopy Before Radical Nephroureterectomy is Associated with Increased Intravesical Recurrence in Urothelial Cancer Located in the Kidney.
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Culpan, Meftun, Cakici, Mehmet Caglar, Keser, Ferhat, Yalcin, Mehmet Yigit, Kargi, Taner, Kayar, Rıdvan, Abay, Erdal, Ozenc, Gorkem, Kumcu, Ali, Pehlivanoglu, Mehmet, Turk, Semih, Kisa, Erdem, Sahin, Selcuk, Ozturk, Metin Ishak, Otunctemur, Alper, Sobay, Resul, Demirel, Huseyin Cihan, Yilmaz, Omer, Atis, Gokhan, and Imamoglu, Muhammet Abdurrahim
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NEPHRECTOMY ,URETHRA surgery ,BIOPSY ,CONFIDENCE intervals ,CANCER relapse ,RISK assessment ,KIDNEY tumors ,SURVIVAL analysis (Biometry) ,DESCRIPTIVE statistics ,URETER tumors ,PROGRESSION-free survival ,URETEROSCOPY ,PROPORTIONAL hazards models ,DISEASE risk factors - Abstract
Objective: Diagnostic ureterorenoscopy is used to identify upper tract urothelial cancer before radical nephroureterectomy, especially for uncertain lesions in imaging modalities or urine cytology. However, diagnostic ureterorenoscopy can potentially cause intravesical tumor spillage and can increase intravesical recurrence rates. We aimed to investigate the impact of diagnostic ureterorenoscopy before radical nephroureterectomy, with and without biopsy, on intravesical recurrence rates of patients with upper tract urothelial cancer. Material and methods: Patients with localized upper tract urothelial cancer from 8 different tertiary referral centers, who underwent radical nephroureterectomy between 2001 and 2020, were included. Three groups were made: no URS (group 1); diagnostic ureterorenoscopy without biopsy (group 2); and diagnostic ureterorenoscopy with biopsy (group 3). Intravesical recurrence rates and survival outcomes were compared. Univariate and multivariate Cox regression analyses were performed to determine the factors that were associated with intravesical recurrence-free survival. Results: Twenty-two (20.8%), 10 (24.4%), and 23 (39%) patients experienced intravesical recurrence in groups 1, 2, and 3, respectively (P = .037) among 206 patients. The 2-year intravesical recurrence-free survival rate was 83.1%, 82.4%, and 69.2%, for groups 1, 2, and 3, respectively (P = .004). Cancer-specific survival and overall survival were comparable (P = .560 and P = .803, respectively). Diagnostic ureterorenoscopy + biopsy (hazard ratio: 6.88, 95% CI: 2.41-19.65, P < .001) was the only independent predictor of intravesical recurrence in patients with upper tract urothelial cancer located in the kidney, according to tumor location. Conclusion: Diagnostic ureterorenoscopy + biopsy before radical nephroureterectomy significantly increased the rates of intravesical recurrence in tumors located in kidney. This result suggests tumor spillage with this type of biopsy, so further studies with different biopsy options or without biopsy can be designed. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
8. What Is Your Choice for Androgen Deprivation Therapy in Metastatic Prostate Carcinoma: Surgical or Medical?
- Author
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Semiz, Huseyin Salih, Kisa, Erdem, Yildirim, Eda Caliskan, Atag, Elif, Arayici, Mehmet Emin, Muezzinoglu, Talha, and Karaoglu, Aziz
- Subjects
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PROSTATE tumors treatment , *ANTIANDROGENS , *PROFESSIONS , *ATTITUDES of medical personnel , *RESEARCH methodology , *METASTASIS , *UROLOGISTS , *SURVEYS , *PATIENTS' attitudes , *CASTRATION , *HOSPITAL care , *ONCOLOGISTS - Abstract
Objective: At the time of diagnosis, approximately 16.5% of prostate cancer patients are metastatic. The main framework of metastatic prostate cancer treatment is androgen deprivation therapy, which is performed surgically or medically. The aim of this study is to evaluate the attitudes of medical oncologists and urologists about orchiectomy as androgen deprivation therapy. Material and Methods: A total of 387 physicians working in the Departments of Urology (n = 217) and Medical Oncology (n = 170) were included in this descriptive study. Data were collected through an electronic survey. Results: Only 7.5% of participants indicated that they offered surgical castration to their patients. Urologists preferred surgical castration more than oncologists for the treatment of metastatic castration-sensitive prostate carcinoma (P = .003). The reasons why medical oncologists preferred surgical castration less are that it is an invasive procedure, has risk of morbidity and mortality, high cost of hospitalization, and may cause deterioration of the patient's body image (P < .05). Conclusion: This study showed that physicians were less likely to perform orchiectomy as an androgen deprivation therapy. Although the most important reason for this is the patient preference, the biased presentation of treatment options to patients, the lack of knowledge of physicians about orchiectomy, and the effect of the pharmaceutical industry should also be kept in mind. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
9. Effects of severe hydronephrosis on the outcomes of percutaneous nephrolithotomy with one-shot dilation method.
- Author
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Micoogullari, Uygar, Yucel, Cem, Sueluzgen, Tufan, Kisa, Erdem, Keskin, Mehmet Zeynel, Isoglu, Cemal Selcuk, and Ilbey, Yusuf Ozlem
- Subjects
PERCUTANEOUS nephrolithotomy ,HYDRONEPHROSIS ,KIDNEY stones ,AGE groups ,BODY mass index ,BLOOD transfusion - Abstract
Objective: To investigate the effect of the presence of severe hydronephrosis on percutaneous nephrolithotomy (PNL) outcome in patients who underwent PNL operation with one-shot dilatation technique. Materials and methods: Medical data of 989 patients underwent PNL operation in our clinic between 2012 and 2018 were retrospectively reviewed. We included 373 of the patients underwent PNL operation due to renal pelvic stone, who were older than 18 years of age, who did not have any urinary tract abnormality, and had no previous history of open renal stone operation. Patients were divided into two groups according to the presence of severe hydronephrosis and absence of hydronephrosis. These two groups were compared in terms of age, gender, body mass index (BMI), number of stones, stone burden, operation duration, fluoroscopy time, hospitalization time, hemoglobin and creatinine change, complications, and stone free rate. Results: There was no statistically significant difference between the groups in terms of age, gender, BMI, stone number, stone size, stone density, operation duration, fluoroscopy time, and hospitalization duration. The mean change in hemoglobin was 1.5 g/dL in group 1 and 1.1 g/dL in group 2. This difference was statistically significant (p = 0.006). Postoperative blood transfusion was required for 3 patients (2.1%) in group 1 and 12 patients (5.1%) in group 2. This difference was statistically significant (p < 0.001). Conclusion: Only the presence of severe hydronephrosis was found to be associated with the change in hemoglobin and postoperative blood transfusion. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
10. Evaluation of the role of thiol / disulfide homeostasis in the etiology of idiopathic male infertility with a novel and automated assay.
- Author
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Micoogullari, Uygar, Cakici, Mehmet Caglar, Kilic, Furkan Umut, Kisa, Erdem, Ozcift, Burak, Caglayan, Alper, Neselioglu, Salim, Karatas, Omer Faruk, and Erel, Ozcan
- Subjects
MALE infertility ,BODY mass index ,HOMEOSTASIS ,OXIDANT status ,RECEIVER operating characteristic curves - Abstract
Idiopathic male infertility (IMI) is the absence of a reason to explain a patient's infertility, and it occurs at a frequency of %31. In this study we aimed to investigate the oxidant/antioxidant status of patients with IMI and compare their results to those of healthy controls.A total of 79 patients with IMI (group 1) and 90 healthy individuals (group 2) were included in the study. We used Erel & Neşelioğlu's thiol/disulfide homeostasis test. Collective and individual measurements of oxidative/antioxidative balance components were carried out by this novel thiol/disulfide homeostasis test. Serum antioxidant (total thiol (toSH), native thiol (SH)) and oxidant (disulfide (SS)) levels of all study participants were measured. The results from both groups were compared and analyzed statistically. After toSH, SH, and SS levels were determined, SS/toSH% and SS/SH% levels for each group were analyzed separately and compared statistically.The toSH, SH levels, and SS/SH%, SS/toSH% ratios were significantly different between the groups (p < 0.05).While antioxidant parameters (toSH and SH values) decreased in group1, oxidant parameters (SS/SH%, SS/toSH%) increased significantly. Although SS values were higher in group 1, the difference was not significant (p = 0.214). The SH cutoff value of 507.15 µmol/L predicted the probability of IMI development with 72.2% sensitivity and 74.4% specificity and toSH cutoff value of 545.45 µmol/L predicted IMI development with 70.9% sensitivity and 73.3 specificity (p < 0.001). Multivariate logistic regression analysis showed that the only independent risk factor for the development of IMI is SH. Patients with IMI had a significant change in their thiol/disulfide homeostasis, which suggests the involvement of this imbalance in the pathophysiology of IMI. Furthermore, these results also support the notion of the involvement of oxidative stress in sperm dysfunction. It also points to the possibility of using antioxidants in IMI treatment. Abbreviations: IMI: idiopathic male infertility; toSH: total thiol; SH: native thiol; SS: disulfide; OS: oxidative stress; ROS: reactive oxygen species; DCF: dichlorofluorescein; MiOXSYS: male infertility oxidative system; MOSI: male oxidative stress infertility; LC: L-carnitine; LAC: L-acetylcarnitine; Vit: vitamin; OAT: oligoasthenozoospermia; TMSC: total motile sperm count; WHO: World Health Organization; BMI: body mass index; DTNB: 5,5ʹ‐dithiobis‐2‐nitrobenzoic acid; CV: coefficient variation; ROC: receiver operating characteristic; PR: progressive, NP: non-progressive. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
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