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Introduction and Objectives: Liver disease accounts for approximately 2 million deaths per year worldwide and is often not detected early in the general population. This study aimed to study the presence of liver disease in the general population of Rosario, Argentina (1.5 million inhabitants). Materials and Methods: 600 individuals over 18 years were studied who spontaneously attended our Hospital as part of a campaign called ''Take care of your liver,'' carried out from October 4 to 14, 2019. Anthropometric data, history of previous diseases and socioeconomic status were documented. Liver tests, serology for hepatitis A, B and C and abdominal ultrasound were also performed. IgG-HEV was analyzed in 400/600 (66%) of the cases. Hepatic elastography was performed in a subgroup of patients with steatosis. Results: 365/600 (61%) were women, a median age of 54 years (range 18-84). 222/600 (37%) had a BMI between 25-29.9 and >30 in 270/600 (45%). Alcohol intake between 30-60 gr/day was observed in 41/600 (7%) and >60 gr/day in 27/600 (4.5%). Anti-core IgG was positive in 33/600 (5.5%), while 3/600 (0.5%) were HBsAg positive. 8/600 (1.3%) presented HCV positive. ALT, AST, FAL and GGT levels were elevated at 6% (median 60 UI/L), 8,3% (median 64,5 UI/L), 17% (median 133 UI/L), 15% (median 109 UI/L), respectively. A diagnosis of steatosis was made in 235/600 (39%), of whom 17/600 (2.4%) had a BMI less than 25. Elastography in 65 pts with steatosis showed F4: 3, F3: 5, F2: 4, F0/F1: 53. As a finding, 40/600 (6.6%) presented liver cysts, 7/600 (1%) angiomas and 18/600 (3%) solid nodules. IgG-VHE was positive in 23/400 (5.75%). Conclusions: A high prevalence of fatty liver was observed in the general population of Rosario, where 2.4% corresponded to thin pts. Advanced hepatic fibrosis was found in 8 cases with steatosis. A strikingly elevated presence of IgG-HEV was documented.

Abstract Background Cognitive impairment and depressive symptoms are highly prevalent after Intracerebral Hemorrhage (ICH). We leveraged Latent Profile Analysis (LPA) to identify profiles for cognitive decline and depression onset after ICH. We also investigated differences in clinical, genetic and neuroimaging characteristics across patients’ profiles. Methods We analyzed data from the ICH study conducted at Massachusetts General Hospital between January 1998 and December 2019. We collected information from electronical health records, follow-up interviews, CT and MRI imaging, and APOE genotype. We conducted LPA and multinomial logistic regression analyses to: 1) identify distinct profiles for cognitive decline and depression onset after ICH; 2) identify clinical, neuroimaging and genetic factors predicting individuals’ likelihood to express a specific profile. Results We followed 784 ICH survivors for a median of 45.8 months. We identified four distinct profiles in cognitive and depressive symptoms after ICH: low depression and dementia risk, early-onset depression and dementia, late-onset depression and dementia, high depression with low dementia risk. Cerebral small vessel disease severity and APOE genotype were specifically associated with the late-onset profile (both p

Background Survivors of intracranial hemorrhage (ICH) are at increased risk for major adverse cardiovascular and cerebrovascular events (MACCE), in the form of recurrent stroke and myocardial Infarction. We investigated whether long‐term blood pressure (BP) variability represents a risk factor for MACCE after ICH, independent of average BP. Methods and Results We analyzed data from prospective ICH cohort studies at Massachusetts General Hospital and the University of Hong Kong. We captured long‐term (ie, visit‐to‐visit) BP variability, quantified as individual participants’ variation coefficient. We explored determinants of systolic and diastolic BP variability and generated survival analyses models to explore their association with MACCE. Among 1828 survivors of ICH followed for a median of 46.2 months we identified 166 with recurrent ICH, 68 with ischemic strokes, and 69 with myocardial infarction. Black (coefficient +3.8, SE 1.3) and Asian (coefficient +2.2, SE 0.4) participants displayed higher BP variability. Long‐term systolic BP variability was independently associated with recurrent ICH (subhazard ratio [SHR], 1.82; 95% CI, 1.19–2.79), ischemic stroke (SHR, 1.62; 95% CI, 1.06–2.47), and myocardial infarction (SHR, 1.54; 95% CI, 1.05–2.24). Average BP during follow‐up did not modify the association between long‐term systolic BP variability and MACCE. Conclusions Long‐term BP variability is a potent risk factor for recurrent hemorrhage, ischemic stroke, and myocardial infarction after ICH, even among survivors with well‐controlled hypertension. Our findings support the hypothesis that combined control of average BP and its variability after ICH is required to minimize incidence of MACCE.