1. Clonal redemption of B cells in cancer
- Author
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Tyler R. McCaw, Serena Y. Lofftus, and Joseph G. Crompton
- Subjects
clonal redemption ,cancer ,atypical memory B cell ,polyreactive antibodies ,anergic B cells ,autoimmunity ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Potentially self-reactive B cells constitute a large portion of the peripheral B cell repertoire in both mice and humans. Maintenance of autoreactive B cell populations could conceivably be detrimental to the host but their conservation throughout evolution suggests performance of a critical and beneficial immune function. We discuss herein how the process of clonal redemption may provide insight to preservation of an autoreactive B cell pool in the context of infection and autoimmunity. Clonal redemption refers to additional recombination or hypermutation events decreasing affinity for self-antigen, while increasing affinity for foreign antigens. We then review findings in murine models and human patients to consider whether clonal redemption may be able to provide tumor antigen-specific B cells and how this may or may not predispose patients to autoimmunity.
- Published
- 2023
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