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ObjectivesIdiopathic inflammatory myopathies (IIM) are a group of rare disorders that can affect the heart. This work aimed to find predictors of cardiac involvement in IIM.MethodsMulticenter, open cohort study, including patients registered in the IIM module of the Rheumatic Diseases Portuguese Register (Reuma.pt/Myositis) until January 2022. Patients without cardiac involvement information were excluded. Myo(peri)carditis, dilated cardiomyopathy, conduction abnormalities, and/or premature coronary artery disease were considered.Results230 patients were included, 163 (70.9%) of whom were females. Thirteen patients (5.7%) had cardiac involvement. Compared with IIM patients without cardiac involvement, these patients had a lower bilateral manual muscle testing score (MMT) at the peak of muscle weakness [108.0 ± 55.0 vs 147.5 ± 22.0, p=0.008] and more frequently had oesophageal [6/12 (50.0%) vs 33/207 (15.9%), p=0.009] and lung [10/13 (76.9%) vs 68/216 (31.5%), p=0.001] involvements. Anti-SRP antibodies were more commonly identified in patients with cardiac involvement [3/11 (27.3%) vs 9/174 (5.2%), p=0.026]. In the multivariate analysis, positivity for anti-SRP antibodies (OR 104.3, 95% CI: 2.5-4277.8, p=0.014) was a predictor of cardiac involvement, regardless of sex, ethnicity, age at diagnosis, and lung involvement. Sensitivity analysis confirmed these results.ConclusionAnti-SRP antibodies were predictors of cardiac involvement in our cohort of IIM patients, irrespective of demographical characteristics and lung involvement. We suggest considering frequent screening for heart involvement in anti-SRP-positive IIM patients.

In the past decade, unprecedented progress has been made in understanding the pathogenesis, diagnosis, assessment, and treatment of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAVs). International collaborations and input from several fields (e.g. immunology, rheumatology, and nephrology) have been critical for analyzing demographics, disease manifestations, and outcomes in clinical research studies. Such efforts opened new avenues for generating novel questions and rationale to design better clinical trials. In addition, clinical research has been a source of several biological discoveries and the starting point for knowledge seeking on the pathophysiology of AAV. Interestingly, the blending of clinical and basic research provides a platform for personalized medicine. Despite recent revisions on AAV classification, the incorporation of new findings on disease genetics and immunologic responses may soon result in changes in clinical practice. These advances will enhance the selection of more specific and targeted therapies. However, current unmet needs in the management of AAV are still sizable and heavily impact long-term survival. Especially, frequent relapses, damage accrual, and high morbidity contribute to poor outcomes. Finally, the lack of defined biomarkers for disease activity and the prognosis is a permanent challenge in AAV research. Our work provides an overview of the current state of the art in AAV literature and suggests bridges for the remaining knowledge gaps. It offers potential future directions for the clinical assessment, management, and research in the field toward a more personalized medicine approach.

RESUMO: O presente artigo tem como temática central pensar a instituição escolar e sua relação direta com o Estado. Trata-se de escrutinar sobre tal díade e problematizar as estratégias que são colocadas em operação para que a defesa pela sua obrigatoriedade se torne quase inquestionável no campo educacional. Acompanhado por Friedrich Nietzsche e Michel Foucault, o texto examina as críticas desenvolvidas por esses autores quanto ao par escola-Estado. De Nietzsche, valemo-nos das problematizações a respeito da pequenez que se faz da escola quando da união com o Estado. De Foucault, utilizamos as discussões a respeito do Estado para problematizar o modo como a sua articulação com a escola se tornou um instrumento privilegiado para o fortalecimento de uma governamentalidade. Defendemos que somente é possível pensar problematicamente a escola quando acionamos em nós a crítica ácida à governamentalidade. Cabe recusar o que somos para abrir passagem a outros horizontes de subjetividade, tramados pela resistência ao instituído e às verdades de autoridade.

This paper presents a qualitative review of research on science capital considering 51 studies with topics related to this concept, between 2015 and 2021. In addition to the increase in research evidenced by the number of publications on the topic during this period, and the dominance of the United Kingdom in leading research in the area, we observed that topics associated to science capital vary from choosing careers in science, identifying with science and promoting a science culture, to the role of school in developing science capital and the ways to evaluate it. It is common for science engagement, associated to science capital, to be seen through the alignment of three important Bourdieusian concepts: capital, habitus and field. In this sense, due to the relevance that the topic has had in science research, we assert the importance of a systematic review that can provide an overview of current investigations involving science capital.