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Abstract Climate action to achieve the Paris Agreement should respect the United Nations Sustainable Development Goals. Here, we use an integrated assessment modelling framework comprising nine climate policy models and quantify the impacts of decarbonisation pathways on Sustainable Development Goals in the European Union at regional and national levels. We show that scenario-consistent assumptions of future socio-economic trends and current climate policies would improve energy- and carbon-related aspects of sustainability and reduce inequalities. Ambitious net-zero emissions pathways would further improve health and agricultural productivity. Furthermore, countries currently lagging in achieving sustainable development goals would see the greatest benefits from ambitious climate action. Negative socio-economic impacts from climate action on poverty, hunger, and economic growth will require specific corrective policies. While our analysis does not quantify the negative effects of less ambitious climate policy, it demonstrates where co-benefits and trade-offs of greenhouse gas mitigation and sustainable development agenda exist and can guide policy formulation.

In this paper, we present the application of a special soil resistivity model, the Exponentially Graded Multilayered Soil model, to the interpretation of Borehole Resistivity Logging surveys. The model, which was recently introduced by the authors, offers an alternative to the interpretation provided by constant resistivity layer models. The model is applied to synthetic soil surveys as well as to a real survey that is not satisfactorily interpreted using conventional models. This model aids in the design and calculation of grounding systems in electrical engineering, providing an alternative to calculations performed by traditional layered models.

ABSTRACTWhey is a source of protein of high nutritional value. In this work, the effects of block cryoconcentration assisted by centrifugation and vacuum evaporation on the physicochemical properties and in vitro digestibility of whey were determined. In vitro digestibility analysis was performed by evaluating the degrees of protein hydrolysis of the fresh, evaporated and cryoconcentrated whey protein samples from the third cycle. The results showed that the samples after the second and third cryoconcentration cycles had no significant differences in protein or lactose content. The in vitro digestibility analysis indicated that the protein obtained by cryoconcentration showed better gastrointestinal digestibility than that obtained by evaporation, with values of 68.2% and 55.4%, respectively. This study demonstrates that block cryoconcentration assisted by centrifugation is an efficient and novel technique that enables the preparation of concentrated protein solutions of high nutritional and biological value.

The measurement of the grounding resistance of grounding grids in large installations as well as grounding electrodes in urban areas is addressed in this article. The resistance value is obtained using a three-pin array by measuring the fall-of-potential on the ground surface. The resistance measured by this method is adjusted to its true value using a correction factor that aligns the measured resistance with the actual value. The proposed measurement method obtains correct values of the grounding resistance even when the auxiliary and potential electrodes of the tree-pin array are close to the electrode to be measured. Thus, it can be applied to large electrodes as well as electrodes in urban areas. Several simulated examples are used to illustrate the method, and some real cases with field measurements are presented for a final validation of the method.

Pregnancy is a complex and challenging process associated with physiological changes whose objective is to adapt the maternal organism to the increasing energetic requirements due to embryo and fetal development. A failed adaptation to these demands may lead to pregnancy complications that threaten the health of both mothers and their offspring. Since mitochondria are the main organelle responsible for energy generation in the form of ATP, the adequate state of these organelles seems crucial for proper pregnancy development and healthy pregnancy outcomes. The homeostasis of these organelles depends on several aspects, including their content, biogenesis, energy production, oxidative stress, dynamics, and signaling functions, such as apoptosis, which can be modified in relation to diseases during pregnancy. The etiology of pregnancy disorders like preeclampsia, fetal growth restriction, and gestational diabetes mellitus is not yet well understood. Nevertheless, insufficient placental perfusion and oxygen transfer are characteristic of many of them, being associated with alterations in the previously cited different aspects of mitochondrial homeostasis. Therefore, and due to the capacity of these multifactorial organelles to respond to physiological and pathophysiological stimuli, it is of great importance to gather the currently available scientific information regarding the relationship between main pregnancy complications and mitochondrial alterations. According to this, the present review is intended to show clear insight into the possible implications of mitochondria in these disorders, thus providing relevant information for further investigation in relation to the investigation and management of pregnancy diseases.

Optical frequency combs are typically generated in the near-infrared wavelength range, where many mode-locked lasers operate. Nonlinear frequency conversion can then be used to extend optical frequency metrology to other spectral regions, such as the extreme ultraviolet (XUV). High-power frequency combs at the fundamental wavelength can efficiently drive nonlinear frequency conversions. Low phase noise is an important requirement because the frequency conversion process not only multiplies the carrier frequency but also the phase fluctuations. In this work, we have developed a low-noise frequency comb centered at 1030 nm with an average power of 230 W, a temporal pulse duration of 59 fs, and a peak power of 32 MW. One of the modes of the seed laser is phase-locked to a continuous wave reference laser stabilized to an ultra-stable high-finesse cavity. The residual integrated phase noise from 10 Hz to 10 MHz is 41 mrad, which is sufficiently low to address narrow transitions with kHz-level linewidths after the frequency conversion to XUV wavelengths.

A kinematic misalignment of the stellar and gas components is a phenomenon observed in a significant fraction of galaxies. However, the underlying physical mechanisms are not well understood. A commonly proposed scenario for the formation of a misaligned component requires any preexisting gas disk to be removed, via flybys or ejective feedback from an active galactic nucleus. In this Letter, we study the evolution of a Milky Way mass galaxy in the FIREbox cosmological volume that displays a thin, counterrotating gas disk with respect to its stellar component at low redshift. In contrast to scenarios involving gas ejection, we find that preexisting gas is mainly removed via the conversion into stars in a central starburst, triggered by a merging satellite galaxy. The newly accreted, counterrotating gas eventually settles into a kinematically misaligned disk. About 4% (8 out of 182) of FIREbox galaxies with stellar masses larger than 5 × 10 ^9 M _⊙ at z = 0 exhibit gas–star kinematic misalignment. In all cases, we identify central starburst-driven depletion as the main reason for the removal of the preexisting corotating gas component, with no need for feedback from, e.g., a central active black hole. However, during the starburst, the gas is funneled toward the central regions, likely enhancing black hole activity. By comparing the fraction of misaligned discs between FIREbox and other simulations and observations, we conclude that this channel might have a non-negligible role in inducing kinematic misalignment in galaxies.

Abstract Background Previous works have observed an increase of depression and other psychological disorders on nursing home residents as a consequence of coronavirus disease 2019 (COVID-19) lockdown; however, there are few studies that have performed a comprehensive evaluation of all people involved in nursing homes environment. The objective of the work was to analyse the impact of lockdown on psychosocial factors of nursing home residents, relatives and clinical staff and how these variables have influenced residents’ survival. Methods A prospective study was designed. Evaluations were performed at three different times: a) at the beginning of Spanish confinement, in March 2020; b) just before the second wave of the pandemic, with relaxation of security measures but in lockdown, and c) in January–February 2021, at the end of the second wave, when visits were already allowed. The study was conducted on three different nursing homes. Three hundred and one residents, 119 clinical staff and 51 relatives took part in the study. Anxiety and depression were evaluated in all participants. A scale on the meaning of suffering was also performed. In addition, burnout status was also determined in the clinical staff. Results All participants showed lower depression during lockdown, while at the beginning and at the end of the confinement, these values were significantly increased. In residents, these changes were dependent of cognitive status (p = 0.012). Anxiety was significantly higher in residents. The evolution of anxiety was similar than with depression, with lower values during confinement, although clinical staff showed higher anxiety levels at the beginning. The feeling of suffering was significantly lower in the clinical staff than in resident and relative groups. Residents’ survival was dependent of cognitive status (p = 0.018) and voluntary confinement (p

Abstract Background Breastmilk is a dynamic fluid whose initial function is to provide the most adapted nutrition to the neonate. Additional attributes have been recently ascribed to breastmilk, with the evidence of a specific microbiota and the presence of various components of the immune system, such as cytokines and leukocytes. The composition of breastmilk varies through time, according to the health status of mother and child, and altogether contributes to the future health of the infant. Obesity is a rising condition worldwide that creates a state of systemic, chronic inflammation including leukocytosis. Here, we asked whether colostrum, the milk produced within the first 48 h post-partum, would contain a distinct leukocyte composition depending on the body mass index (BMI) of the mother. Methods We collected peripheral blood and colostrum paired samples from obese (BMI > 30) and lean (BMI < 25) mothers within 48 h post-partum and applied a panel of 6 antibodies plus a viability marker to characterize 10 major leukocyte subpopulations using flow cytometry. Results The size, internal complexity, and surface expression of CD45 and CD16 of multiple leukocyte subpopulations were selectively regulated between blood and colostrum irrespective of the study groups, suggesting a generalized cell-specific phenotype alteration. In obesity, the colostrum B lymphocyte compartment was significantly reduced, and CD16+ blood monocytes had an increased CD16 expression compared to the lean group. Conclusions This is the first characterization of major leukocyte subsets in colostrum of mothers suffering from obesity and the first report of colostrum leukocyte subpopulations in Latin America. We evidence various significant alterations of most leukocyte populations between blood and colostrum and demonstrate a decreased colostrum B lymphocyte fraction in obesity. This pioneering study is a stepping stone to further investigate active immunity in human breastmilk.

Liver as iron storage organ is particularly susceptible to oxidative stress-induced injury from excess iron. Thus, antioxidant therapies are often used to reverse oxidative damage and protect cells and tissues. This study investigated the protective effects of phenolic acids; ferulic acid (FA) and its metabolite, ferulic acid 4-O-sulfate disodium salt (FAS) against oxidative stress under iron overload conditions in mouse and HepG2 cells. Cells were exposed to FA or FAS and then treated with iron-induced oxidative stress complex of 50 μmol/L FAC and 20 μmol/L of 8-hydroxyquinoline 8HQ (8HQ-FAC). Iron dextran was injected intraperitoneally on alternate days for 10 days to induce the iron overload condition in BALB/c mice. The study revealed that the phenolic acids were protective against ROS production, lipid peroxidation and antioxidant depletion in HepG2 cells and liver tissues of BALB/c mice during iron-induced oxidative stress. The protective function of phenolic acids was achieved by the transcriptional activation of nuclear factor erythroid-2-related factor 2 (Nrf2) to regulate antioxidant genes. In conclusion, the study provides evidence that FA has the potential as a therapeutic agent against iron-related diseases such as T2D.

Feedback from supermassive black holes is believed to be a critical driver of the observed color bimodality of galaxies above the Milky Way mass scale. Active galactic nuclei (AGN) feedback has been modeled in many galaxy formation simulations, but most implementations have involved simplified prescriptions or a coarse-grained interstellar medium (ISM). We present the first set of Feedback In Realistic Environments (FIRE)-3 cosmological zoom-in simulations with AGN feedback evolved to z ∼ 0, examining the impact of AGN feedback on a set of galaxies with halos in the mass range 10 ^12 –10 ^13 M _⊙ . These simulations combine detailed stellar and ISM physics with multichannel AGN feedback including radiative feedback, mechanical outflows, and, in some simulations, cosmic rays (CRs). We find that massive (> L *) galaxies in these simulations can match local scaling relations including the stellar mass–halo mass relation and the M _BH – σ relation; in the stronger model with CRs, they also match the size–mass relation and the Faber–Jackson relation. Many of the massive galaxies in the simulations with AGN feedback have quenched star formation and elliptical morphologies, in qualitative agreement with observations. In contrast, simulations at the massive end without AGN feedback produce galaxies that are too massive and form stars too rapidly, are order-of-magnitude too compact, and have velocity dispersions well above Faber–Jackson. Despite these successes, the AGN models analyzed do not produce uniformly realistic galaxies when the feedback parameters are held constant: While the stronger model produces the most realistic massive galaxies, it tends to overquench the lower-mass galaxies. This indicates that further refinements of the AGN modeling are needed.

We present an in-depth analysis of gas morphologies for a sample of 25 Milky Way–like galaxies from the IllustrisTNG TNG50 simulation. We constrain the morphology of cold, warm, hot gas, and gas particles as a whole using a local shell iterative method and explore its observational implications by computing the hard-to-soft X-ray ratio, which ranges between 10 ^−3 and 10 ^−2 in the inner ∼50 kpc of the distribution and 10 ^−5 –10 ^−4 at the outer portion of the hot gas distribution. We group galaxies into three main categories: simple, stretched, and twisted. These categories are based on the radial reorientation of the principal axes of the reduced inertia tensor. We find that a vast majority (77%) of the galaxies in our sample exhibit twisting patterns in their radial profiles. Additionally, we present detailed comparisons between (i) the gaseous distributions belonging to individual temperature regimes, (ii) the cold gas distributions and stellar distributions, and (iii) the gaseous distributions and dark matter (DM) halos. We find a strong correlation between the morphological properties of the cold gas and stellar distributions. Furthermore, we find a correlation between gaseous distributions with a DM halo that increases with gas temperature, implying that we may use the warm–hot gaseous morphology as a tracer to probe the DM morphology. Finally, we show gaseous distributions exhibit significantly more prolate morphologies than the stellar distributions and DM halos, which we hypothesize is due to stellar and active galactic nucleus feedback.

We present the case of a patient with chronic type B aortic dissection with a previous iliac to visceral debranching graft and thoracoabdominal endograft who, because of a type Ib endoleak and aortic diameter enlargement, required a complex solution involving placement of a thoracic endovascular graft inside a Dacron graft with a 180° curved shape in three-stage surgery. At 9 months of follow-up, he had no evidence of type I endoleaks, and the aortic diameter had decreased.

ABSTRACT: Formulating diets with high AME, especially in the grower and finisher phases, hinders the inclusion of alternative ingredients that are usually cheaper and have lower AME. Moreover, as the chicken grows the feed intake capacity is greater and may be able to maintain BW over a wide range of AME. The objective of this study was to evaluate the performance of chickens fed diets with progressive AME reductions, at constant or increased standardized ileal digestible (SID) lysine:AME ratio (Lys:AME). Treatment 1 (control) was formulated following the SID lysine and AME recommendations for a 4-phase feeding program. Treatment 5 was formulated with −4, −8, and −12% AME in the grower-1, grower-2, and finisher phases, respectively, and with the same Lys:AME compared with the control. Treatment 9 had the same AME as treatment 5 but higher SID lysine, increasing the Lys:AME by 1.5, 3.5, and 5.0% compared with treatment 5. In the grower-1, grower-2, and finisher phases, the final 9 dietary treatments were prepared by mixing the control diet with either treatment 5 or 9 at different proportions (75:25, 50:50, or 25:75). All birds were fed the same starter control diet. Treatments were replicated in 10 pens with 31 male chickens each, and the growth performance of birds was monitored for 42 d. Final BW linearly decreased (P < 0.05) when lowering dietary AME, but it followed a positive quadratic response with higher Lys:AME (P < 0.05). Feed intake increased (P < 0.05) with low AME, independently of the Lys:AME; but the linear regression in the feed conversion ratio (FCR) had a lower slope when the Lys:AME increased. At the end of the study, there were no differences in carcass or breast meat yield (P > 0.10). Progressively reducing AME in the last feeding phases may be a viable nutritional strategy to increase the inclusion of alternative ingredients and potentially reduce feeding costs, despite increments in feed intake and FCR. Adjusting the Lys:AME in low AME diets may help maintain the final BW of birds.

Calculation expressions for the electric and magnetic fields produced by a horizontal cloud-to-cloud lightning channel, assuming a perfectly conducted ground, are proposed in this paper. These expressions depend on the current model traveling through the channel and serve as the starting point to calculate the induced fields and potentials at any point in space. The derived expressions for the fields are used to calculate the induced potentials by the channel on metallic structures such as vertically driven rods in the ground and aircraft in flight. The influence of soil with finite conductivity is discussed, and an estimation of the induced potentials in this situation is proposed.

This study evaluated the effectiveness of phenolic compound incorporation from blueberry juice into pear slices (PS) using a combination of ohmic heating (OH) and vacuum impregnation (VI), followed by air-drying (AD) or freeze-drying (FD). Our results showed that OH increased the content of bioactive compounds and antioxidant capacity of blueberry juice, with the optimal OH condition set at 50 °C for 20 min under an electric field of 13 V·cm−1. Furthermore, the combination of VI and OH was efficient in enriching PS with bioactive compounds from blueberry juice (such as cyanidin and epigallocatechin), with the optimal VI/OH condition set at 50 °C for 90 min under an electric field of 7.8 V·cm−1. Moreover, anthocyanin pigments from blueberry juice affected the color parameters of PS by increasing the a* parameter and decreasing the b* and L* parameters. However, both FD and AD (at 40, 50, and 60 °C) negatively affected (p ≤ 0.05) the phenolic content and antioxidant capacity. Notably, AD at 60 °C showed the highest levels of phenolic compounds and antioxidant potential for both impregnated and non-impregnated PS.

The benefits of physical exercise on health are diminished when it is non-planned, strenuous, or vigorous, which causes an increase in oxygen consumption and production of free radicals, particularly serious at the muscular level. Ubiquinol could help achieve an antioxidant, anti-inflammatory, and ergogenic effect. The aim of this study is to evaluate whether a supplementation of ubiquinol during a short period could have a positive effect on muscle aggression, physical performance, and fatigue perception in non-elite athletes after high intensity circuit weight training. One hundred healthy and well-trained men, (firemen of the Fire Department of Granada) were enrolled in a placebo-controlled, double-blinded, and randomized study, and separated into two groups: the placebo group (PG, n = 50); and the ubiquinol group (UG, n = 50), supplemented with an oral dose. Before and after the intervention, data related to the number of repetitions, muscle strength, and perceived exertion, as well as blood samples were collected. An increase was observed in the UG regarding average load and repetitions, revealing an improvement in muscle performance. Ubiquinol supplementation also reduced muscle damage markers, showing a protective effect on muscle fibers. Therefore, this study provides evidence that ubiquinol supplementation improves muscle performance and prevents muscle damage after strenuous exercise in a population of well-trained individuals who are not elite athletes.

Since the coronavirus disease 2019 (COVID-19) pandemic appeared, both governments and the scientific community have focused their efforts on the search for prophylactic and therapeutic alternatives in order to reduce its effects. Vaccines against SARS-CoV-2 have been approved and administered, playing a key role in the overcoming of this situation. However, they have not reached the whole world population, and several doses will be needed in the future in order to successfully protect individuals. The disease is still here, so other strategies should be explored with the aim of supporting the immune system before and during the infection. An adequate diet is certainly associated with an optimal inflammatory and oxidative stress status, as poor levels of different nutrients could be related to altered immune responses and, consequently, an augmented susceptibility to infections and severe outcomes derived from them. Minerals exert a wide range of immune-modulatory, anti-inflammatory, antimicrobial, and antioxidant activities, which may be useful for fighting this illness. Although they cannot be considered as a definitive therapeutic solution, the available evidence to date, obtained from studies on similar respiratory diseases, might reflect the rationality of deeper investigations of the use of minerals during this pandemic.

Background: Obesity and being overweight have become one of the world’s most severe health issues, not only because of the pathology but also because of the development of related comorbidities. Even when children reach adulthood, the mother’s environment during pregnancy has been found to have a significant impact on obesity prevention in children. Thus, both maternal dietary habits and other factors such as gestational diabetes mellitus, excessive weight gain during pregnancy, smoking, or endocrine factors, among others, could influence newborn growth, adiposity, and body composition at birth, in childhood and adolescence, hence programming health in adulthood. Methods: The aim of this review is to analyze the most recent human studies on the programming of fetal adipose tissue to determine which modifiable factors may influence adiposity and thus prevent specific disorders later in life by means of a bibliographic review of articles related to the subject over the last ten years. Conclusions: The importance of a healthy diet and lifestyle not only during pregnancy and the first months of life but also throughout childhood, especially during the first two years of life as this is a period of great plasticity, where the foundations for optimal health in later life will be laid, preventing the emergence of noncommunicable diseases including obesity, diabetes mellitus type 2, hypertension, being overweight, and any other pathology linked to metabolic syndrome, which is so prevalent today, through health programs beginning at a young age.

En tanto una sociedad libre debe fundamentarse en intercambios voluntarios, veremos en qué consisten estos y los definiremos, desarrollando sus dos tipos: el directo, con sus limitaciones, y el indirecto, con los beneficios que conlleva. Los indirectos necesitan de un medio para su ejecución, el dinero, que definiremos, estudiando su origen y las características que han de cumplirse para que un medio de intercambio pueda ser efectivamente considerado como dinero. Señalaremos los tipos de dinero, y la importancia que tienen en la formación de los precios, y estudiaremos la determinación del poder adquisitivo del propio dinero. Se señalará por qué pensamos que las criptomonedas no pueden ser consideradas como dinero, y se terminará el artículo con las características que debería poseer el dinero en una sociedad libre.

We examine the effect of parental entreprenurial role model in nascent entrepreneur's activity by gender perspective. We distinguish between father and mother entreprenurial role models and investigate how their influence on students’ decision to become nascent entreprenuer activity is moderated by gender We employ a logit model on a sample of 15.424 university students from Colombia GUESSS 2018. The findings show not only that the presence of parental entreprenurial role model impact the decision to become nascent entrepreneur, but also the effect of this impact is moderated by gender. This effect is significant in the case of father entrepreneurial role model. We discuss the implications of our findings for research on entrepreneurial families and parental role models.

We employ the Feedback In Realistic Environments (FIRE-2) physics model to study how the properties of giant molecular clouds (GMCs) evolve during galaxy mergers. We conduct a pixel-by-pixel analysis of molecular gas properties in both the simulated control galaxies and galaxy major mergers. The simulated GMC pixels in the control galaxies follow a similar trend in a diagram of velocity dispersion ( σ _v ) versus gas surface density (Σ _mol ) to the one observed in local spiral galaxies in the Physics at High Angular resolution in Nearby GalaxieS (PHANGS) survey. For GMC pixels in simulated mergers, we see a significant increase of a factor of 5–10 in both Σ _mol and σ _v , which puts these pixels above the trend of PHANGS galaxies in the σ _v versus Σ _mol diagram. This deviation may indicate that GMCs in the simulated mergers are much less gravitationally bound compared with simulated control galaxies with virial parameters ( α _vir ) reaching 10–100. Furthermore, we find that the increase in α _vir happens at the same time as the increase in global star formation rate, which suggests that stellar feedback is responsible for dispersing the gas. We also find that the gas depletion time is significantly lower for high- α _vir GMCs during a starburst event. This is in contrast to the simple physical picture that low- α _vir GMCs are easier to collapse and form stars on shorter depletion times. This might suggest that some other physical mechanisms besides self-gravity are helping the GMCs in starbursting mergers collapse and form stars.

We present the first detailed comparison of populations of dwarf galaxy stellar streams in cosmological simulations and the Milky Way. In particular, we compare streams identified around 13 Milky Way analogs in the FIRE-2 simulations to streams observed by the Southern Stellar Stream Spectroscopic Survey ( S ^5 ). For an accurate comparison, we produce mock Dark Energy Survey (DES) observations of the FIRE streams and estimate the detectability of their tidal tails and progenitors. The number and stellar mass distributions of detectable stellar streams is consistent between observations and simulations. However, there are discrepancies in the distributions of pericenters and apocenters, with the detectable FIRE streams, on average, forming at larger pericenters (out to >110 kpc) and surviving only at larger apocenters (≳40 kpc) than those observed in the Milky Way. We find that the population of high-stellar-mass dwarf galaxy streams in the Milky Way is incomplete. Interestingly, a large fraction of the FIRE streams would only be detected as intact satellites in DES-like observations, since their tidal tails have too low surface brightness to be detectable. We thus predict a population of yet-undetected tidal tails around Milky Way satellites, as well as a population of fully undetected low-surface-brightness stellar streams, and estimate their detectability with the Rubin Observatory. Finally, we discuss the causes and implications of the discrepancies between the stream populations in FIRE and the Milky Way, and explore future avenues for tests of satellite disruption in cosmological simulations.

¿Cómo se mueven las fotografías familiares dentro del espacio doméstico? ¿Qué ocurre cuando esas imágenes pertenecen a las víctimas del franquismo? El artículo examina los usos intergeneracionales que sufren esas imágenes y que permiten analizar la transmisión de la memoria familiar en un contexto traumático. Esto se realiza a partir del estudio de un caso paradigmático: el de la familia de Emilio Silva, fundador de la Asociación para la Recuperación de la Memoria Histórica. Será precisamente una fotografía familiar escondida en la rendija de la pared la que impulse a Emilio a reconstruir la historia de su abuelo, algo que fortuitamente desencadenará con el inicio del movimiento memorialista en España.

The calculation of the grounding resistance of electrodes built with partially oxidized non-perfect conductors is addressed in this paper. A model based on circuit analysis to account for internal resistance is used, while the oxidation or partial coating of the conductor surface is modeled using the concept of the equivalent radius of the coated electrode. From the proposed model, the values of the electrical parameters of the grounding electrodes, such as the grounding resistance and the step and touch potentials, are calculated for real electrodes affected by coating or corrosion and compared with those values under ideal conditions. The results show significant differences in certain configurations that may compromise the safety margins established by current regulations.

COVID-19 has reached pandemic proportions worldwide, with considerable consequences for both health and the economy. In pregnant women, COVID-19 can alter the metabolic environment, iron metabolism, and oxygen supply of trophoblastic cells, and therefore have a negative influence on essential mechanisms of fetal development. The purpose of this study was to investigate, for the first time, the effects of COVID-19 infection during pregnancy with regard to the oxidative/antioxidant status in mothers’ serum and placenta, together with placental iron metabolism. Results showed no differences in superoxide dismutase activity and placental antioxidant capacity. However, antioxidant capacity decreased in the serum of infected mothers. Catalase activity decreased in the COVID-19 group, while an increase in 8-hydroxy-2’-deoxyguanosine, hydroperoxides, 15-FT-isoprostanes, and carbonyl groups were recorded in this group. Placental vitamin D, E, and Coenzyme-Q10 also showed to be increased in the COVID-19 group. As for iron-related proteins, an up-regulation of placental DMT1, ferroportin-1, and ferritin expression was recorded in infected women. Due to the potential role of iron metabolism and oxidative stress in placental function and complications, further research is needed to explain the pathogenic mechanism of COVID-19 that may affect pregnancy, so as to assess the short-term and long-term outcomes in mothers’ and infants’ health.

Since the appearance of the coronavirus disease 2019 (COVID-19) and its announcement as a global pandemic, the search for prophylactic and therapeutic options have become a priority for governments and the scientific community. The approval of several vaccines against SARS-CoV-2 is being crucial to overcome this situation, although the victory will not be achieved while the whole population worldwide is not protected against the virus. This is why alternatives should be studied in order to successfully support the immune system before and during a possible infection. An optimal inflammatory and oxidative stress status depends on an adequate diet. Poor levels of several nutrients could be related to an impaired immune response and, therefore, an increased susceptibility to infection and serious outcomes. Vitamins exert a number of anti-microbial, immunomodulatory, anti-inflammatory, and antioxidant activities, which can be of use to fight against this and several other diseases (especially vitamin D and C). Even though they cannot be considered as a definitive therapeutic option, in part owing to the lack of solid conclusions from well-designed clinical trials, currently available evidence from similar respiratory diseases may indicate that it would be rational to deeply explore the use of vitamins during this global pandemic.

This work aims to study the trajectory of the architect Frei Otto (FO) using an exploratory analysis of his projects, which pays special attention to the conceptual and chronological temporal evolution, the type of structures designed, and the relationship with his partners for his built and unbuilt projects. In the latter case, the projects developed, not requested, that are not part of his built works have been approached (i.e., not considered under competition). The main results indicate that FO's architectural trajectory, from a chronological point of view, was intense, which is generally reflected throughout the years. The 1950s–1970s were very productive. In addition to the large number of projects, there were innovative designs for quantity and structural innovation in Germany and other countries (e.g., France and Saudi Arabia). The analyses that were carried out made it possible to ascertain FO's professional and academic influence, which has been reflected in his projects. Likewise, his relationships with his collaborators have been long-lasting in some cases. Practical Applications: This work aimed to study the work of the architect and engineer Frei Otto (FO), of recognized prestige by the awards received and his colleagues. Some mention the scarce diffusion of his work. The interest of this work lies mainly in making known to professionals, academics, and the general public, in a short format, such as that used in scientific papers, the design of his structures, built and unbuilt. As Félix Candela mentions about FO's career, he is a typical and outstanding example of architectural innovation who concentrated his vocation and efforts on the study and research of tensile structures. His international projection and toward the citizen, give Frei Otto academic interest. This work is developed from different perspectives, which include chronological, type of structure, the location and function of the project, and the collaborators he worked with, with whom he shared his innovation and construction activities. Attention has been paid to a collection of unpublished or little-known projects by FO. [ABSTRACT FROM AUTHOR]