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Large deformation of sand due to soil liquefaction is a major cause for seismic damage. In this study, the mechanisms and modeling of large post-liquefaction deformation of sand considering the significant influence of water absorption in shearing and seismic wave conditions. Assessment of case histories from past earthquakes and review of existing studies highlight the importance of the two factors. Based on the micro and macro scale mechanisms for post-liquefaction shear deformation, the mechanism for water absorption in shearing after initial liquefaction is revealed. This is aided by novel designed constant water-absorption-rate shear tests. Water absorption in shearing can be classified into three types, including partial water absorption, complete water absorption, and compulsory water absorption. Under the influence of water absorption in shearing, even a strongly dilative sand under naturally drained conditions could experience instability and large shear deformation. The mechanism for amplification of post-liquefaction deformation under surface wave load is also explained via element tests and theoretical analysis. This shows that surface wave–shear wave coupling can induce asymmetrical force and resistance in sand, resulting in asymmetrical accumulation of deformation, which is amplified by liquefaction. A constitutive model, referred to as CycLiq, is formulated to capture the large deformation of sand considering water absorption in shearing and seismic wave conditions, along with its numerical implementation algorithm. The model is comprehensively calibrated based on various types of element tests and validated against centrifuge shaking table tests in the liquefaction experiments and analysis projects (LEAP). The model, along with various numerical analysis methods, is adopted in the successful simulation of water absorption in shearing and Rayleigh wave-shear wave coupling induced large liquefaction deformation. Furthermore, the model is applied to high-performance simulation for large-scale soil-structure interaction in liquefiable ground, including underground structures, dams, quay walls, and offshore wind turbines.

Abstract Li4Ti5O12 (LTO) is known for its zero-strain characteristic in electrochemical applications, making it a suitable material for fast-charging applications. Here, we systematically studied the quasi-equilibrium and non-equilibrium lithium-ion transportation kinetics in LTO thin-film electrodes, across a range of scales from the crystal lattice to the microstructured electrodes. At the crystal lattice scale, during the non-equilibrium lithiation process, lithium ions are dispersedly embedded into the 16c position, resulting in more 8a → 16c migration compared with the quasi-equilibrium lithiation, and forming numerous fast lithium diffusion channels inside the LTO lattice. At the microstructural electrode scale, optical spectrum characterizations supported the “nano-filaments” lithiation model in polycrystalline LTO thin-film electrodes during the lithiation process. Our results reveal the patterns of lithium migration and distribution within the LTO thin film electrode under the non-equilibrium and quasi-equilibrium lithiation process, offering profound insights into the potential optimization strategies for enhancing the performance of fast-charging thin film batteries.

Introduction Sjögren’s syndrome (SS) and rheumatoid arthritis (RA) are two chronic autoimmune diseases. To date, there have been few reports on the overlap between SS and RA in China, especially regarding correlated acute renal failure cases. Material and methods To provide a reference for our clinical peers, this article presents the case report of an elderly female patient who was diagnosed with acute renal failure caused by SS and RA overlap syndrome. Results We also provide a relevant analysis of SS and RA overlap syndrome treatment. Conclusions We also provide a relevant analysis of SS and RA overlap syndrome treatment.

Abstract Background Skeletal muscle development plays a crucial role in yield and quality of pork; however, this process is influenced by various factors. In this study, we employed whole-genome bisulfite sequencing (WGBS) and transcriptome sequencing to comprehensively investigate the longissimus dorsi muscle (LDM), aiming to identify key genes that impact the growth and development of Duroc pigs with different average daily gains (ADGs). Results Eight pigs were selected and divided into two groups based on ADGs: H (774.89 g) group and L (658.77 g) group. Each pair of the H and L groups were half-siblings. The results of methylation sequencing revealed 2631 differentially methylated genes (DMGs) involved in metabolic processes, signalling, insulin secretion, and other biological activities. Furthermore, a joint analysis was conducted on these DMGs and the differentially expressed genes (DEGs) obtained from transcriptome sequencing of the same individual. This analysis identified 316 differentially methylated and differentially expressed genes (DMEGs), including 18 DMEGs in promoter regions and 294 DMEGs in gene body regions. Finally, LPAR1 and MEF2C were selected as candidate genes associated with muscle development. Bisulfite sequencing PCR (BSP) and quantitative real-time PCR (qRT–PCR) revealed that the promoter region of LPAR1 exhibited significantly lower methylation levels (P < 0.05) and greater expression levels (P < 0.05) in the H group than in the L group. Additionally, hypermethylation was observed in the gene body region of MEF2C, as was a low expression level, in the H group (P < 0.05). Conclusions These results suggest that the differences in the ADGs of Duroc pigs fed the same diet may be influenced by the methylation levels and expression levels of genes related to skeletal muscle development.

Summary: Background: Understanding the impact of CYP2D6 metabolism on paroxetine, a widely used antidepressant, is essential for precision dosing. Methods: We conducted an 8-week, multi-center, single-drug, 2-week wash period prospective cohort study in 921 Chinese Han patients with depressive or anxiety disorders (ChiCTR2000038462). We performed CYP2D6 genotyping (single nucleotide variant and copy number variant) to derive the CYP2D6 activity score and evaluated paroxetine treatment outcomes including steady-state concentration, treatment efficacy, and adverse reaction. CYP2D6 metabolizer status was categorized into poor metabolizers (PMs), intermediate metabolizers (IMs), extensive metabolizers (EMs), and ultrarapid metabolizers (UMs). The influence of CYP2D6 metabolic phenotype on paroxetine treatment outcomes was examined using multiple regression analysis and cross-ethnic meta-analysis. The therapeutic reference range of paroxetine was estimated by receiver operating characteristic (ROC) analyses. Findings: After adjusting for demographic factors, the steady-state concentrations of paroxetine in PMs, IMs, and UMs were 2.50, 1.12, and 0.39 times that of EMs, with PM and UM effects being statistically significant (multiple linear regression, P = 0.03 and P = 0.04). Sex and ethnicity influenced the comparison between IMs and EMs. Moreover, poor efficacy of paroxetine was associated with UM, and a higher risk of developing adverse reactions was associated with lower CYP2D6 activity score. Lastly, cross-ethnic meta-analysis suggested dose adjustments for PMs, IMs, EMs, and UMs in the East Asian population to be 35%, 40%, 143%, and 241% of the manufacturer's recommended dose, and 62%, 68%, 131%, and 159% in the non-East Asian population. Interpretation: Our findings advocate for precision dosing based on the CYP2D6 metabolic phenotype, with sex and ethnicity being crucial considerations in this approach. Funding: National Natural Science Foundation of China; Academy of Medical Sciences Research Unit.

The present work was related to synthesis of graphene (0, 1.25 and 2.5 %) incorporation in cobalt-zinc ferrites by using sol–gel auto combustions method. The face center cubic (FCC) crystal structure and crystallite size varies from 16 to 18 nm was examined by XRD analysis. While as the irregular, non-uniform and flake like surface morphology of cobalt zinc/graphene nanocomposite (Co-Zn-G NCs) were observed via SEM images. In addition, the phase identification and presence of different functional groups such as M−O (metal oxide), OH, C-C, C = O and C = C were investigated by Raman spectroscopy and FTIR analyses. Further, I-V two probe method was used to observed the resistivity decrease (7.5x 108 to 2.5x 106 ohm-cm) and conductivity increased (1.2x10-9 to 3.8x10-7S/cm) of Co-Zn-G NCs. After that the thermoelectric behavior of Co-Zn-G NCs indicated that due to increase the temperature then seebeck coefficient decrease as vice versa. The overall result shows that the 2.5 % graphene incorporation in Co-Zn ferrites expressed the excellent electrical and thermoelectric properties. In future the Co-Zn-G nanocomposite used for the development of temperature sensor, reduce eddy current loss and spintronic devices.

As for spintronic applications, all information is encoded in the spin degree of freedom, so the key issues are the high spin-polarization, large half-metallic (HM) bandgap, large magnetic moment and higher Curie temperature than room temperature. In this paper, we studied halogen based CsYZ2 (Y = V or Cr; Z = F, Cl, Br or I) full-Heusler alloys. Our study reveals that CsVF2, CsVCl2, CsVI2 and CsCrI2 alloys are all HM ferromagnets while remaining alloys exhibits magnetic semiconductor behavior. The electronic structures indicate that these alloys open very large bandgaps in the spin-down channel. Following the Slater-Pauling rule Mt=Zt-16, these alloys exhibit very large total magnetic moments Mt of 4.00 μBf.u. when Y = V and 5.00 μBf.u. when Y = Cr. The high Curie temperatures indicate these alloys are appropriate for spintronic applications at room temperature. Furthermore, the absorption coefficient α(ω) of the CsVF2 alloy is better from other alloys in the visible region. The maximum ZT = 0.7 is obtained for CsCrBr2 and is an ideal candidate for thermoelectric (TE) applications.

This paper provides a review of the implementation of different materials and how they have impacted the efficiency of solar cells. This work elaborates on all solar generation methods that have been developed in the past and covers disparate technologies that are being implemented in different generations. A review of the characterization and factors involved in these processes are also discussed briefly. Furthermore, the economic, environmental, and technical perspectives related to solar cells have also been expounded. This paper also provides some insights into potential research directions that can be pursued in the field of solar energy. Energy demands are increasing all over the world, and substantial amounts of fossil fuels are currently exhausted all over the world in order to meet those needs, which in turn contaminates our environment; moreover, non-renewable sources of energy are diminishing at higher rates as well. Solar energy is of prime importance in all renewable energy sources as the Sun shines at the Earth for 8 to 10 h on average. Thus, heat can be harnessed to generate electricity, but solar cells are not substantially efficient because the materials used in them are quite costly and waste a considerable amount of energy, mostly as heat, which subsequently reduces the efficiency of the cell and increases the overall price as well. These challenges can be dealt with by designing more efficient, economical systems of storage and manufacturing PV cells with high efficacy. Scientists and engineers are more inclined toward advanced technologies and material manipulation to enhance the efficiency of solar energy and reduce its cost. In this regard, substantial research is being carried out, especially on the structure of materials and advanced materials like nanomaterials and quantum dots. Due to their distinct electromechanical and material properties, carbon-based nanomaterials like carbon nanotubes, graphene, fullerene, and nanohybrids are being employed as the electrodes, transport layers, active layers, or intermediate (interfacial) layers of solar cells in this regard.

Laboratory tests on soil adopts simplified stress paths compared to real world counterparts due to mechanical limitations. This study investigates the deformation of granular material under combined principal stress value and orientation change in full 3D space using the discrete element method. Such stress paths are achieved by applying a 3D force line boundary condition on spherical granular material samples. Continuous cyclic tests with stress paths restricted in a fixed plane and in full 3D space, simulating a bidirectional seismic load event, are both conducted. The importance of taking both principal stress value and orientation change into consideration is highlighted. In the tests, the greatest deformation is observed under pure stress orientation change, while the smallest deformation is observed when the principal stress axes are fixed. The change of stress value and orientation in 3D is also shown to result in deformations different to those within a fixed plane. The origins of these differences are found to be associated with difference in shear modulus, dilatancy, and non-coaxiality at the macroscale, and particle contact and fabric anisotropy at the microscale.

The suction installation process for bucket foundations for offshore wind turbines (OWTs) can cause the formation of soil plug within the bucket, which can affect the seismic performance of the OWT. Therefore, it is important to evaluate the influence of soil plug on the seismic performance of OWT on bucket foundations. In this study, a comprehensive set of high-fidelity solid–fluid coupled dynamic numerical simulations are conducted to analyze the seismic response of bucket foundations with a focus on the influence of soil plug and its potential mitigation. The influence of different bucket models, seabed soil densities, seabed inclination and reinforcement types, as well as soil plug removal techniques, are investigated. The results clearly show that the existence of soil plug has a significant unfavorable influence on the seismic performance of OWT on bucket foundations, especially for wide bucket foundations in mildly inclined seabeds, and should be considered in seismic design. Reinforcement methods, such as the application of an inner compartments, outer wings and inner pile, can improve the seismic performance of OWT on bucket foundations, with the application of an inner compartment being the most effective. Soil plug removal can alleviate the negative influence of soil plug, and should be adopted when possible.

The moiré pattern restricts the electronic states of transition metal bilayers, thus extending the concept of the magic angle found in twisted bilayer graphene to semiconductors. Here, we have studied the electronic structure of the twisted bilayer WTe2 using first-principle calculations. Our result shows that a twist significantly changes the band structure, resulting in the bandgap engineering when the twisted bilayer of WTe2 is turning to a specific angle. The electronic structure is changed by the change of the twist angle. Interestingly, a semiconductor-to-metal phase transition is found at a twist angle of 15°. Our results provide a reference for the regulation of two-dimensional band structures. These results are important for understanding the electronic structure of twisted systems and for future applications in electronic devices.

Electronic structures of non-twisted and twisted WTe2/WSe2 heterojunction bilayers were investigated using first-principles calculations. Our results show that, for the twisted WTe2/WSe2 heterojunction bilayer, the bandgaps are all direct bandgaps, and the bandgap (K–K) increases significantly when the twist angle is from 0° to 10°. However, when the twist angle is from 11° to 14.2°, the bandgaps are all indirect bandgaps and the bandgap (G–K) significantly reduces. The band structure of the twisted WTe2/WSe2 heterojunction bilayer differs significantly from that of the non-twisted. Twisted WTe2/WSe2 heterojunction bilayers can be seen as a direct bandgap to an indirect bandgap conversion when turned to a certain angle. Interestingly, the bandgap of the WTe2/WSe2 heterojunction bilayer is very sensitive to the change in the twist angle. For example, when the twist angle is 10.5°, a maximum bandgap will appear. However, the minimum bandgap is 0.041 eV at 14.2°. Our findings have important guidance for device tuning of two-dimensional heterojunction materials.

Defects profoundly affect the magnetic, electronic structure and topological behaviour of intrinsic magnetic topological insulators. Here, we investigate the magnetic, structural stability and topological properties of different Te atomic sites in the intrinsic magnetic topological insulator FeBi _2 Te _4 with Se substitution of the FM- z magnetic order. When Se replaces the outermost site of the septuple layer (the Te atomic layer connected by van der Waals bonds), the Se–Bi bond length formed with its nearest neighbour Bi is drastically shortened and the lattice constant and volume contract accordingly. We speculate that this defect-induced chemical bond enhancement is related to the strong electronegativity of Se over Te. In contrast, the system has lower formation energy, a more stable structure, and enhanced magnetic moment when Se replaces the Te atomic layer inside the septuple layer. Also, we reveal a variety of topological phase transitions due to substitution defects. FeBi _2 Te _4 is considered to belong to the $z_{2} \times z_{4}$ topological classification of higher-order topological insulators with z _4 = 2. The system after Se substitution can be transformed into Weyl semimetals, strong 3D topological insulators, and unknown topological materials without symmetry-base indicators, respectively.