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Assessing the potential herb-drug interactions is necessary to ensure clinical safety and to prevent any untoward effects. Studies have identified a variety of adverse effects on herb-drug interactions. Common mechanisms include the modulation of drug-metabolic enzymes, which leads to irreversible impacts. Physicians should constantly double-check if patients see numerous prescribers or visit multiple hospital settings before prescribing drugs to avoid pharmaceutical toxicity. Chinese herbal medicines are an essential part of TCM practice. Thus, the elevation and classification of toxic herb-drug interactions are helpful to ensure the safet usage by practitioners in optimizing the effectiveness of treatment strategies. According to WHO, cardiovascular diseases caused about 17.9 million deaths, accounting for 32% of all global deaths in 2019. This literature review will be focusing on cardiovascular drugs due to the high global mortality rate of cardiovascular diseases.