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Guided by intergroup contact theory, this survey study investigates how White American adults' (N = 697 , Mage = 44.42, SD = 14.6, age range = 18 –67) social media intergroup expression frequency and valence, direct contact quality, and perceptions of institutional bias were associated with behavioral and affective attitudes toward ethnic Chinese during COVID-19. Structural Equation Modeling analyses indicate that social media intergroup expression valence and direct contact quality play a critical role in improving intergroup attitudes toward ethnic Chinese directly, and indirectly through building empathy and/or reducing anxiety. In addition, analyses demonstrate the negative role of social media intergroup expression frequency, which had: (1) a direct negative effect on behavioral attitudes and (2) an indirect negative effect on both attitudinal measures through increased anxiety and decreased empathy. Lastly, perceptions of institutional bias were negatively associated with affective attitudes through increased intergroup anxiety. Overall, findings reveal the dynamic interplay of the intergroup processes between social media intergroup expression, intergroup contact, and perceptions of institutional bias in shaping intergroup anxiety, empathy, and attitudes during COVID-19. [ABSTRACT FROM AUTHOR]

Background: Patient and public involvement and engagement (PPIE) in the design of trials is important, as participant experience critically impacts delivery. The Edmond J Safra Accelerating Clinical Trials in PD (EJS ACT-PD) initiative is a UK consortium designing a platform trial for disease modifying therapies in PD. Objective: The integration of PPIE in all aspects of trial design and its evaluation throughout the project. Methods: PwP and care partners were recruited to a PPIE working group (WG) via UK Parkinson's charities, investigator patient groups and participants of a Delphi study on trial design. They are supported by charity representatives, trial delivery experts, researchers and core project team members. PPIE is fully embedded within the consortium's five other WGs and steering group. The group's terms of reference, processes for effective working and PPIE evaluation were co-developed with PPIE contributors. Results: 11 PwP and 4 care partners have supported the PPIE WG and contributed to the development of processes for effective working. A mixed methods research-in-action study is ongoing to evaluate PPIE within the consortium. This includes the Patient Engagement in Research Scale -a quantitative PPIE quality measure; semi-structured interviews -identifying areas for improvement and overall impressions of involvement; process fidelity- recording adherence; project documentation review – identifying impact of PPIE on project outputs. Conclusions: We provide a practical example of PPIE in complex projects. Evaluating feasibility, experiences and impact of PPIE involvement in EJS ACT-PD will inform similar programs on effective strategies. This will help enable future patient-centered research. [ABSTRACT FROM AUTHOR]