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1. International Society of Urological Pathology (ISUP)-Grade Grouping in Prostatic Adenocarcinoma and its Prognostic Implications

Author

Atif Ali Hashmi, Syeda Narisa Iftikhar, Shahzeb Munawar, Omer Ahmed, Syed Rafay Yaqeen, Ishaq Azeem Asghar, Muhammad Irfan, Javaria Ali, Muhammad M. Edhi, and Shumaila Kanwal Hashmi

Subjects
Aged, 80 and over, Male, Cancer Research, Prostatic Neoplasms, General Medicine, Adenocarcinoma, Middle Aged, Prostate-Specific Antigen, Prognosis, Cross-Sectional Studies, Oncology, Humans, Neoplasm Grading, Aged, Retrospective Studies
Abstract

In this study, we evaluated the association of ISUP/WHO-grade groups with various pathological prognostic parameters and cancer-specific survival in patients with prostatic adenocarcinoma. We found 27 (15.7%) cases of grade group 1, 22 (12.8%) grade group 2, 30 (17.4%) grade group 3, 40 (23.3%) grade group 4 and 53 (30.8%) grade group 5 prostatic adenocarcinoma. We found that high-grade tumors (grade 3-5) had a higher frequency of perineural invasion and higher tumor volumes (50%). Moreover, a significant association of tumor grade was noted with cancer-specific survival of patients, signifying prognostic significance of grade grouping in prostatic adenocarcinoma.

Published
2021

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