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Rape survivors face stigma when disclosing their experiences. We hypothesized that a rape survivor who formally reports their rape would experience more stigma than one who does not, and that this effect will be stronger when the perceiver is a man or low in support for sexual consent. Across two studies using self-report, observational, and psychophysiological measures, we found that a reporting survivor was seen more negatively than an identical survivor who did not report their rape. Men and those low in support for sexual consent also responded more negatively to the survivor. Implications of these findings are discussed. [ABSTRACT FROM AUTHOR]

Aims: The clinical significance of cancer‐related stigma on patients' well‐being has been widely established. Stigma can be perceived and internalised by cancer patients or implemented by the general population and healthcare workers. Various interventions have been carried out to reduce cancer‐related stigma, but their effectiveness is not well‐understood. This review aims to synthesise evidence on the effectiveness of interventions to reduce cancer‐related stigma. Design: An integrative review. Methods: This integrative review combined both qualitative and quantitative studies and followed five steps to identify problems, search for the literature, appraise the literature quality, analyse data, and present data. Mixed Methods Appraisal Tool (version 2018) was applied to evaluate the quality of the included studies. Data Sources: Databases included Web of Science, MEDLINE, SpringerLink, Wiley Online Journals, Cochrane Library, ScienceDirect, OVID, and China National Knowledge Infrastructure (from the inception of each database to 30 April 2021). Results: Eighteen quantitative, six qualitative, and five mixed‐methods studies were included in this review. Cultural factors should be considered when conducting interventions to reduce cancer‐related stigma. For cancer patients, multi‐component interventions have demonstrated a positive effect on their perceived stigma. For general population, interactive interventions show promise to reduce their implemented stigma towards cancer patients. For healthcare workers, there is a paucity of studies to reduce their implemented stigma. Existing studies reported inconclusive evidence, partially due to the lack of a robust study design with an adequate sample size. Conclusions: Multi‐component and interactive interventions show promise to relieve cancer‐related stigma. More methodologically robust studies should be conducted in different cultures to elucidate the most appropriate interventions for different populations to reduce cancer‐related stigma. Implication for the Profession and Patient Care: These findings will facilitate healthcare workers to design and implement interventions to reduce cancer‐related stigma, thus improving the quality of life for cancer patients. Patient and Public Contribution: No patient and public contribution. [ABSTRACT FROM AUTHOR]

Simple Summary: Digital health technologies can help manage the growing cancer burden, but understanding patients' needs is crucial for these tools to be effective. Our study reviewed existing research on what cancer patients want from digital health technologies. We analysed 128 studies, focusing on web-based platforms, mobile apps, and wearable devices used in cancer care. Patients highlighted the importance of these technologies being easy to use, effective in managing their care, and enhancing communication with healthcare providers. Our findings offer insights for future research to develop digital health tools that meet cancer patients' preferences, potentially improving their healthcare experience and outcomes. Digital health technologies have the potential to alleviate the increasing cancer burden. Incorporating patients' perspectives on digital health tools has been identified as a critical determinant for their successful uptake in cancer care. The main objective of this scoping review was to provide an overview of the existing evidence on cancer patients' perspectives and requirements for patient-facing digital health technologies. Three databases (CINAHL, MEDLINE, Science Direct) were searched and 128 studies were identified as eligible for inclusion. Web-based software/platforms, mobile or smartphone devices/applications, and remote sensing/wearable technologies employed for the delivery of interventions and patient monitoring were the most frequently employed technologies in cancer care. The abilities of digital tools to enable care management, user-friendliness, and facilitate patient–clinician interactions were the technological requirements predominantly considered as important by cancer patients. The findings from this review provide evidence that could inform future research on technology-associated parameters influencing cancer patients' decisions regarding the uptake and adoption of patient-facing digital health technologies. [ABSTRACT FROM AUTHOR]

Aim: To investigate how young Danes construct sexual consent generally, but also specifically in relation to heavy alcohol intoxication. Methods: Drawing on 30 qualitative in-depth interviews with young people, aged 19–25 years, and adopting a critical discursive psychological framework, we explored the interpretative repertoires that the participants made use of to construct sexual consent and the subject positions those repertoires enabled. Results: The participants made use of three interpretative repertoires that we named as follows: (1) sexual consent as an agreement between rational individuals; (2) sexual consent as a heteronormative practice; and (3) intoxicated sexual consent. Discussion: Young people draw on different repertoires when discussing sexual consent in general, sexual consent in relation to gendered practices and expectations, and sexual consent in relation to heavy alcohol intoxication. Conclusion: It is vital to keep the situational nature of young people's constructions of sexual consent in mind if we wish to understand and eventually reduce the number of non-consensual sexual experiences. [ABSTRACT FROM AUTHOR]

Hematopoietic progenitor pinase1 (HPK1) knockout has been identified as an efficient route to enhance anti-tumor immune response. Here, this work develops an oral proteolysis targeting chimera (PROTAC) targeting HPK1 to efficiently and selectively degrade HPK1 to augment immunotherapeutic outcomes. In a postoperative tumor model of human cervical cancer in NSG mice, the orally-administrated PROTAC can reach tumors, down-regulate HPK1 levels in locally-administrated CAR-T cells, and promote their efficiency in inhibiting solid tumor recurrence, achieving 50% partial response (PR) and 50% complete response (CR). In addition, oral administration of PROTAC can amplify the suppression capability of the anti-PD-L1 antibody on the growth of CT26 solid tumors in BALB/c mice by promoting the infiltration of CD45-positive immune cells from 0.7% to 1.5% and CD3-positive T cells from 0.2% to 0.5% within the tumors., (© 2024 Wiley‐VCH GmbH.)

Rechargeable magnesium (Mg) batteries are promising candidates for the next generation of energy storage systems due to their potential high-energy density, intrinsic safety features and cost-effectiveness. Among the various electrochemical couples, the combination of an Mg anode with a sulfur (S) cathode stands out as an attractive option, as it offers a remarkable theoretical volumetric energy density exceeding 3,200 Wh L–1 . However, owing to the unique properties of Mg-ion electrolytes, Mg polysulfides and the surface passivation of Mg metal anodes, the development of Mg–S batteries is facing multiple challenges. In this review, recent advancements in designing efficient electrolytes for Mg–S battery systems are summarized. Apart from electrolytes, we also discuss the progress made in fabricating new S cathode composites, Mg anodes and functional separators, focusing on their roles in addressing the critical issues of the Mg–S systems. Finally, it is worth pointing out that the collaborative research combining experimental investigations and theoretical modelling could provide deeper insights into the mechanisms of Mg–S battery systems and promote their development. Overall, the comprehensive insights about the S-redox reaction, polysulfide shuttle problems and degradation mechanism in Mg–S batteries are discussed, which is of profound importance for creating solutions to enhance the overall performance of Mg–S batteries. This review aims to providing an overview of the current state of the research to stimulate innovative thoughts on the fundamental guidelines for facilitating development of Mg–S batteries. [ABSTRACT FROM AUTHOR]

This article aims to highlight the wear mechanisms and friction behavior of the 2017A T4 anodized aluminum alloy used for automotive and aerospace applications. The effect of the processing parameters on the durability of the anodized layer under high friction is studied. Scratch tests were carried out to study the level of the friction coefficient with the increase in the thickness of the oxide layer formed on the Al 2017 A (AU4G) substrate. The results of the scratch tests show that the variation in the anodization duration, which influences the thickness of the oxide layer, induces an increase in the coefficient of friction. Besides, the variations in friction coefficient with sliding distance are influenced by the changes in wear morphology and degree of oxidation. Treated surfaces with a thickness of 50 µm have the lowest friction coefficients and wear rates. Their improved wear resistance may be related to the increased bond strength compared to other anodized surfaces. The tribological damage was characterized by the detachment of debris, which increases with the increase of the duration of anodization. Upon sliding, its detachment leads to delamination of the underlying anodic aluminum oxides and subsequent abrasion of the aluminum substrate. [ABSTRACT FROM AUTHOR]

In this study, we analyze the microstructure, phase composition, aging process, and a set of characteristics of the performance properties of new casting Al–4Zn–4Mg–4Cu–0.2Zr alloys doped with yttrium (Y) or erbium (Er). Doping with Y or Er has been shown to decrease hot brittleness, enhance corrosion resistance, and slightly decrease strength characteristics at up to 200° C. When alloyed with Y or Er, enhanced casting properties are ensured through an increase in the proportion of eutectics and modification of the grain structure. The Al8Cu4Y, (Al, Cu)11Y3, Al8Cu4Er, and Al3Er phases containing Y and Er after homogenization at 465° C retain the shape of branched crystals, resulting in alloys with low ductility at up to 200° C. In all the alloys, after stretching at 250°C, the elongation considerably increases, and the yield strength is approximately the same and lies in the range of 217–222 MPa. Alloying with Y or Er results in less softening with increasing test temperature and considerably higher corrosion resistance under electrochemical corrosion conditions. [ABSTRACT FROM AUTHOR]

The current paper compares the prevalence and nature of childhood adversity among twenty former left-wing and right-wing extremists. Findings from the Adverse Childhood Experiences (ACE) questionnaire suggest that exposure to childhood adversity was common in the early lives of both extremist types. For example, 50 percent of LWE and 70 percent of RWE experienced four or more ACE exposures during the first eighteen years of their life. The results also demonstrate that participants in both samples experienced a range of adolescent conduct problems. These conduct issues highlight the cascading effects of childhood adversity, where negative events help produce a downward spiral that ultimately increases a person's susceptibility to extremism. Despite the relatively small sample, findings from this exploratory study build on the risk factor model of violent extremism by highlighting childhood adversity and adolescent misconduct as nonideological precursors to violent extremism among different types of extremists. [ABSTRACT FROM AUTHOR]

The high pressure die casting (HPDC) is a technique that allows us to produce parts for various sectors of industry. It has a great application in such sectors as automotive, energy, medicine, as the HPDC allows us to produce parts very fast and very cheaply. The HPDC casting quality depends on many parameters. The parameters among others, are cast alloy alloy metallurgy, filling system design, casting technology elements geometry and orientation, as well as, machine operation settings. In the article, different plunger motion schemes of the HPDC machine were taken into account. Analyses lead to learning about plunger motion influence on the casting porosity and solidification process run. Numerical experiments were run with the use of MAGMASoft® simulation software. Experiments were performed for industrial casting of water pump for automotive. Main parameter taken into account was maximal velocity of the plunger in the second phase. The analysis covered porosity distribution, feeding time through the gate, temperature field during whole process, solidification time. Cooling curves of the casting in chosen points were also analysed. Obtained results allow us to formulate conclusions that connect plunger motion scheme, gate solidification time and the casting wall thickness on the solidification rate and porosity of the casting. [ABSTRACT FROM AUTHOR]

Corrosion of aluminum alloys is a significant concern for shipbuilders to ensure the longevity of ocean vessels and equipment. Hence, the study aims to evaluate the corrosion performance of Al-Si as automotive alloys with varying concentrations of Si in deep seawater using electrochemical impedance spectroscopy and potentiodynamic polarization techniques. The surface condition prior to corrosion, as well as after corrosion, is analyzed using optical and scanning electron microscopy. The entire test is performed at an ambient condition. The results demonstrate that the corrosion resistance improves in alloys with increasing amounts of Si near the eutectic level, after which the corrosion protection deteriorates. Higher Si concentrations show higher values for polarization resistance and open circuit potential. In contrast, corrosion current and corrosion rate values decrease with increasing Si concentration up to eutectic composition. Si assists the formation of SiO2 and MgO films through Mg2Si intermetallics along with the Al2O3 on the surfaces, which aids in corrosion resistance. Optical and scanning electron micrographs reveal the presence of films on the surfaces after corrosion, which exhibit pits and pinholes on the surfaces of the alloys with lower Si concentrations. Hypereutectic alloy is affected by corrosion of its pinhole-like defects. The corresponding EDS analysis also confirms the protective layer of different oxides on the surfaces. [ABSTRACT FROM AUTHOR]

Friction stir processing (FSP) has been performed on 2024 aluminum alloy sheets. The process was carried out using two different cooling rate i.e., Air Cooling (FSP-AC) and cooling using the liquid nitrogen (FSP-NC). In the current research, the effect of different cooling rates on microstructures and relating precipitates has been investigated. The results have been shown that the average grain size in the stirred zone (SZ) has been decreased significantly in the FSP-NC (1.75 µm) condition, with respect to the FSP-AC (3.3 µm). The misorientation angle of grain boundaries created the special structure. The grain boundaries were facet in FSP-AC and FSP-NC and the rough boundaries was observed in FSP-AC specimen. TEM and EBSD analysis have been indicated the dissolution of ?-Al2Cu precipitates in the SZ in the FSP-NC specimen, while FSP-AC caused formation of supersaturated copper solid solution with ?-Al2Cu precipitates in the grain boundaries. Furthermore, in the both FSprocessed specimens (FSP-AC and FSP-NC) fine and dispersed Al20Cu2Mn3 precipitates have been observed. [ABSTRACT FROM AUTHOR]

New Findings: What is the central question of this study?Is the attenuation of the respiratory muscle metaboreflex preserved after detraining?What is the main finding and its importance?Inspiratory muscle training increased respiratory muscle strength and attenuated the respiratory muscle metaboreflex as evident by lower heart rate and blood pressure. After 5 weeks of no inspiratory muscle training (detraining), respiratory muscle strength was still elevated and the metaboreflex was still attenuated. The benefits of inspiratory muscle training persist after cessation of training, and attenuation of the respiratory metaboreflex follows changes in respiratory muscle strength. Respiratory muscle training (RMT) improves respiratory muscle (RM) strength and attenuates the RM metaboreflex. However, the time course of muscle function loss after the absence of training or 'detraining' is less known and some evidence suggest the respiratory muscles atrophy faster than other muscles. We sought to determine the RM metaboreflex in response to 5 weeks of RMT and 5 weeks of detraining. An experimental group (2F, 6M; 26 ± 4years) completed 5 weeks of RMT and tibialis anterior (TA) training (each 5 days/week at 50% of maximal inspiratory pressure (MIP) and 50% maximal isometric force, respectively) followed by 5 weeks of no training (detraining) while a control group (1F, 7M; 24 ± 1years) underwent no intervention. Prior to training (PRE), post‐training (POST) and post‐detraining (DETR), all participants underwent a loaded breathing task (LBT) to failure (60% MIP) while heart rate and mean arterial blood pressure (MAP) were measured. Five weeks of training increased RM (18 ± 9%, P < 0.001) and TA (+34 ± 19%, P < 0.001) strength and both remained elevated after 5 weeks of detraining (MIP‐POST vs. MIP‐DETR: 154 ± 31 vs. 153 ± 28 cmH2O, respectively, P = 0.853; TA‐POST vs. TA‐DETR: 86 ± 19 vs. 85 ± 16 N, respectively, P = 0.982). However, the rise in MAP during LBT was attenuated POST (−11 ± 17%, P = 0.003) and DETR (−9 ± 9%, P = 0.007) during the iso‐time LBT. The control group had no change in MIP (P = 0.33), TA strength (P = 0.385), or iso‐time MAP (P = 0.867) during LBT across all time points. In conclusion, RM and TA have similar temporal strength gains and the attenuation of the respiratory muscle metaboreflex remains after 5 weeks of detraining. [ABSTRACT FROM AUTHOR]

The direct modulation of T cell responses is an emerging therapeutic strategy with the potential to modulate undesired immune responses including, autoimmune disease, and allogeneic cells transplantation. We have previously demonstrated that poly(lactide‐co‐glycolide) particles were able to modulate T cell responses indirectly through antigen‐presenting cells (APCs). In this report, we investigated the design of nanoparticles that can directly interact and modulate T cells by coating the membranes from APCs onto nanoparticles to form membrane‐coated nanoparticles (MCNPs). Proteins within the membranes of the APCs, such as Major Histocompatibility Complex class II and co‐stimulatory factors, were effectively transferred to the MCNP. Using alloreactive T cell models, MCNP derived from allogeneic dendritic cells were able to stimulate proliferation, which was not observed with membranes from syngeneic dendritic cells and influenced cytokine secretion. Furthermore, we investigated the engineering of the membranes either on the dendritic cells or postfabrication of MCNP. Engineered membranes could be to promote antigen‐specific responses, to differentially activate T cells, or to directly induce apoptosis. Collectively, MCNPs represent a tunable platform that can directly interact with and modulate T cell responses. [ABSTRACT FROM AUTHOR]

Warm deep drawing of polypropylene, a semi‐crystalline thermoplastic polymer, is studied using finite element analysis. In this process, a circular polypropylene blank is preheated to a temperature much below its melting temperature and deep drawn into the shape of a flat‐bottom cylindrical cup using a punch‐die combination, both initially at 25°C. The material model used for the analysis considers the effects of varying temperature and strain rate during the deep drawing process on the depth of draw. The effects of blank holder force, initial blank temperature, blank diameter, and die and punch corner radii on the depth of draw are determined. Thickness, temperature, and strain variations in the drawn cups, punch forces, and failure modes are also determined. [ABSTRACT FROM AUTHOR]

Introduction: Rural communities contribute to national wellbeing, identities, economies, and social fabrics yet experience increased risk of mortality, morbidity, and disability, coupled with lower levels of income, formal education, and employment than urban citizens. Despite higher need, occupational therapy services are maldistributed to urban locations. Publications about non‐urban services discuss predominantly outreach‐based, individualist, rehabilitation for specified diagnoses/age groups. However, given this population level inequity, it is unclear why individualist focussed services are more commonly discussed. Understanding intentions expressed in publications about non‐urban service design may identify assumptions/limitations to current approaches and contribute to improved future services. Methods: Each of 117 publications identified in a scoping review was read by two reviewers to independently identify themes. Provisional themes were discussed and modified in an iterative process to develop final themes/subthemes. The first author reinterrogated the publications and coded data to identify relevant examples to support the identified themes. Results: Three key themes and nine subthemes were identified. Hegemonic perspectives were found in the themes (i) Extension of urban practice and (ii) Austerity, particularly in the Global North. Non‐urban services were typically extended to non‐urban contexts underpinned by austerity and neoliberal values such that non‐urban persons and their context were problematised rather than service or funding design. A counter‐hegemonic perspective was found in the theme (iii) Responses to situational realities more commonly in Global South publications, which valued non‐urban contexts, and focussed on developing non‐urban communities and promoting justice. Conclusion: The hegemonic paradigm links occupational therapy services with neoliberal notions of individualism, private provision of care, and efficiency/market value, rather than the occupational therapy values for justice. The profession must consider our role in perpetuating injustice for non‐urban people and consider if and how more contextually tailored counter hegemonic place‐based paradigms can be developed from and with regional, rural, and remote practice. [ABSTRACT FROM AUTHOR]

Humanoid tactility has been boosting robotic intelligence in object recognition, dexterous manipulation, and human–robot interaction. For many artificial tactile sensors, especially those based on optical principles, inflexibility, bulkiness, and monomodality limit their potential to function as humanoid skins. Herein, by embedding lab‐made optical nanofibers (ONFs) into elastomeric films, soft, flexible, thin (around 500 μm, similar to human skin), and multimodal (force and thermosensitive) robotic skins are achieved. These superior characteristics arise from the low flexural rigidity and large evanescent field of ONFs, due to their subwavelength diameters (down to 450 nm). By tuning light wavelength, ONF diameter, and skin thickness, variable sensitivities and sensing ranges for both force and temperature are reported. Depending on different sensing requirements, special modules can be further assembled on the ONF skins for various surface properties, including hardness, texture, and thermal conductivity. The ONF skins can enable a commercial robot to emulate human behaviors, including adaptive grasping of flimsy objects, contactless temperature measurement, and even the perception of leaf veins. It is anticipated that these ONF skins could offer a unique solution in multiple intelligent systems such as robotics, prosthetics, human–machine interface and wearable devices. [ABSTRACT FROM AUTHOR]

We present the first gridded and temporally continuous quantitative pollen-based plant-cover reconstruction for temperate and northern subtropical China over the Holocene (11.7 ka to present) obtained by applying the Regional Estimates of VEgetation Abundance from Large Sites (REVEALS) model. The objective is to provide a dataset of pollen-based land cover for the last ca. 12 millennia that is suitable for palaeoclimate modelling and for the evaluation of simulated past vegetation cover from dynamic vegetation models and anthropogenic land-cover change (ALCC) scenarios. The REVEALS reconstruction was achieved using 94 selected pollen records from lakes and bogs at a 1 ∘ × 1 ∘ spatial scale and a temporal resolution of 500 years between 11.7 and 0.7 ka and in three recent time windows (0.7–0.35 ka, 0.35–0.1 ka, and 0.1 ka to present). The dataset includes REVEALS estimates of cover and their standard errors (SEs) for 27 plant taxa in 75 1 ∘ × 1 ∘ grid cells distributed within the study region. The 27 plant taxa were also grouped into 6 plant functional types and 3 land-cover types (coniferous trees CT, broadleaved trees BT, and C 3 herbs/open land (C 3 H/OL)), and their REVEALS estimates of cover and related SEs were calculated. We describe the protocol used for the selection of pollen records and the REVEALS application (with parameter settings) and explain the major rationales behind the protocol. As an illustration, we present, for eight selected time windows, gridded maps of the pollen-based REVEALS estimates of cover for the three land-cover types (CT, BT, and C 3 H/OL). We then discuss the reliability and limitations of the Chinese dataset of Holocene gridded REVEALS plant cover, and its current and potential uses. The dataset is available at the National Tibetan Plateau Data Center (TPDC; Li, 2022; 10.11888/Paleoenv.tpdc.272292). [ABSTRACT FROM AUTHOR]

Reconstructing historical land use and land cover change using explicit temporal, quantitative, and spatial information is not only the prerequisite for simulating long-term climate change and ecological effects but is also a scientific basis for comprehensively understanding the process and mechanism of anthropogenic land use alterations. Considering changes in historical borders and administrative divisions, a provincial cropland area dataset for China over the past millennium was created on the basis of existing estimations since the Song Dynasty. Land suitability for cultivation was then assessed by incorporating altitude, slope, soil texture, and the maximum potential productivity of climate. Subsequently, a gridding allocation model for cropland was constructed, and the provincial cropland area for 24 years over the past millennium was allocated into grids with a resolution of 10 km. The cropland area in China increased from 3.71×107 ha in AD 1000 to 12.92×107 ha in AD 1999, with a peak of 13.50×107 ha in AD 1980. The total cropland area in China showed fluctuating increasing trends that can be divided into three phases: fluctuation without notable net change for AD 1000–1290, slow increase for AD 1290–1661, and rapid increase for AD 1661–1999. Spatially, cropland intensified in the middle-lower reaches of the Yellow and Yangtze Rivers and expanded to mountainous and frontier areas over the last millennium. Specifically, over the entire period, the fractional cropland areas (FCAs) in the middle-lower reaches of the Yellow and Yangtze Rivers increased by 1.4 and 0.8 times, respectively. Since the mid-Qing Dynasty, large-scale land reclamation expanded to areas of low reclamation in southwest and northeast China. The FCAs for southwest and northeast China increased from 2.13% and 0.55% in AD 1661 to 18.00% and 26.61% in AD 1999, respectively. For AD 1661–1999, the proportion of cropland increased by 55% in the hills and low mountains and 27% in the middle and high mountains. The comparison with remote sensing cropland data shows that the grid cells with absolute differences of 0–10% accounted for 70.35% of all grid cells, while grids with differences exceeding 60% accounted for only 0.83%. This finding indicates that the reconstruction method is feasible, and the reconstruction results objectively reveal the historical spatiotemporal changes in cropland. [ABSTRACT FROM AUTHOR]

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Understanding long-term soil and landscape evolution can help us understand the threats to current-day soils, landscapes and their functions. The temporal evolution of soils and landscapes can be studied using geochronometers, such as optically stimulated luminescence (OSL) particle ages or radionuclide inventories. Also, soil–landscape evolution models (SLEMs) can be used to study the spatial and temporal evolution of soils and landscapes through numerical modelling of the processes responsible for the evolution. SLEMs and geochronometers have been combined in the past, but often these couplings focus on a single geochronometer, are designed for specific idealized landscape positions, or do not consider multiple transport processes or post-depositional mixing processes that can disturb the geochronometers in sedimentary archives. We present ChronoLorica, a coupling of the soil–landscape evolution model Lorica with a geochronological module. The module traces spatiotemporal patterns of particle ages, analogous to OSL ages, and radionuclide inventories during the simulations of soil and landscape evolution. The geochronological module opens rich possibilities for data-based calibration of simulated model processes, which include natural processes, such as bioturbation and soil creep, as well as anthropogenic processes, such as tillage. Moreover, ChronoLorica can be applied to transient landscapes that are subject to complex, non-linear boundary conditions, such as land use intensification, and processes of post-depositional disturbance which often result in complex geo-archives. In this contribution, we illustrate the model functionality and applicability by simulating soil and landscape evolution along a two-dimensional hillslope. We show how the model simulates the development of the following three geochronometers: OSL particle ages, meteoric 10 Be inventories and in situ 10 Be inventories. The results are compared with field observations from comparable landscapes. We also discuss the limitations of the model and highlight its potential applications in pedogenical, geomorphological or geological studies. [ABSTRACT FROM AUTHOR]

Load carriage (LC) refers to the use of personal protective equipment (PPE) and/or load‐bearing apparatus that is mostly worn over the thoracic cavity. A commonplace task across various physically demanding occupational groups, the mass being carried during LC duties can approach the wearer's body mass. When compared to unloaded exercise, LC imposes additional physiological stress that negatively impacts the respiratory system by restricting chest wall movement and altering ventilatory mechanics as well as circulatory responses. Consequently, LC activities accelerate the development of fatigue in the respiratory muscles and reduce exercise performance in occupational tasks. Therefore, understanding the implications of LC and the effects specific factors have on physiological capacities during LC activity are important to the implementation of effective mitigation strategies to ameliorate the detrimental effects of thoracic LC. Accordingly, this review highlights the current physiological understanding of LC activities and outlines the knowledge and efficacy of current interventions and research that have attempted to improve LC performance, whilst also highlighting pertinent knowledge gaps that must be explored via future research activities. [ABSTRACT FROM AUTHOR]

AlSi casting alloys combine excellent castability with high strength. Hence, this group of alloys is often used in the automotive sector. The challenge for this application is the brittle character of these alloys which leads to cracks during joint formation when mechanical joining technologies are used. A rise in ductility can be achieved by a considerable increase in the solidification rate which results in grain refinement. High solidification rates can be realized in twin–roll casting (TRC) by water‐cooled rolls. Therefore, a hypoeutectic EN AC–AlSi9 (for European Norm ‐ aluminum cast product) is manufactured by the TRC process and analyzed. Subsequently, joining investigations are performed on castings in as‐cast and heat‐treated condition using the self‐piercing riveting process considering the joint formation and the load‐bearing capacity. Due to the fine microstructure, the crack initiation can be avoided during joining, while maintaining the joining parameters, especially by specimens in heat treatment conditions. Furthermore, due to the extremely fine microstructure, the load‐bearing capacity of the joint can be significantly increased in terms of the maximum load‐bearing force and the energy absorbed. [ABSTRACT FROM AUTHOR]

The Al–9Si–0.3Fe–0.15Mn alloy was chosen as the base alloy, 0.2Mo and 0.2Zr were added in combination (0.2Mo+0.2Zr) to the base alloy to maintain the ductility and improve the strength in tensile properties. The 0.2Mo+0.2Zr addition alloy showed improvement in both ultimate tensile strength (σUTS) (160 MPa) and fracture strain (εf) (7.1%) at the as-cast conditions, compared with those (145 MPa, 6.1%) of the base alloy. The increment in the σUTS and εf by 8% and 14%, respectively, was obtained by 0.2Mo+0.2Zr addition. The eutectic α-Al with the smallest minimum nanoindentation hardness (HIT, min), showing high Al or low ΔMkeα due to heavy micro-segregation existed as a continuous phase in the 0.2Mo+0.2Zr addition alloy led to improvement in ductility. The size of the cell structure caused by the dense tangles of dislocations was about 250 nm, which corresponded to a similar size to the high Al or low ΔMkeα regions in the 0.2Mo+0.2Zr addition alloy. It was found on the basis of improvement in tensile properties that both usage of the gravity casting method and the addition of Mo and Zr, suggested the possibility for the as-cast application because the eutectic Si particles were refined, and the eutectic α-Al phase was characterized by high Al content or low ΔMkeα region caused by micro-segregation of the Mo and Zr atoms. The inhomogeneity eutectic grains including IMCs acted as the harmonic structure for the improvement in both strength and ductility. [ABSTRACT FROM AUTHOR]

Aluminum (Al) containing Fe–Mn–C–Al steel exhibits lightweight and outstanding mechanical properties, bringing considerable applications in vehicle, airplane, and mining industries as structural materials and components. The addition of C and Al elements into Fe–Mn iron matrix, following with subsequent heat treatment, plays an important role in microstructure controlling, such as single phase (austenite structure) or duplex phases (mixing with ferritic and austenite) matrix, as well as the short range order and κ‐carbide precipitation. These microstructural evolutions considerably influence the mechanical properties of low‐density steel, especially of the work hardening, tribological, cryogenic, and hydrogen embrittlement performance. The current article introduces the progress of alloying and heat treatment, as well as the subsequent heat treatment effects on microstructural evolution and mechanical properties of Al‐containing low‐density steel. The recent research progress on Al‐containing low‐density steel shall provide a valuable source of ideas for high‐quality, low‐density steel design, and engineering applications. [ABSTRACT FROM AUTHOR]

In many alloy systems, the segregation and strengthening of the solute atoms are caused by mechanical and chemical contributions. To uncover the origins of segregation behaviors and strengthening behaviors of the solute atoms Cd, Si, Sc and Zr at (001)α-Al//(001)′ and (010)α-Al//(010)′ interfaces, first-principles calculations were conducted. Results show that the chemical contribution primarily dominates the oscillatory segregation behaviors of Cd, Si, Sc and Zr on the Al matrix side. The oscillatory segregation behaviors of Cd, Si, Sc and Zr on the ′ side are mainly governed by both chemical and mechanical contributions. The segregation tendency of Cd at the (001)α-Al//(001)′ interface (or (010)α-Al//(010)′ interface) throughout the platelets is small (or strong) because the charge accumulation between Cd and the host atoms is weak (or significant). The segregation trend of Sc (or Zr) on the Al matrix side at the (001)α-Al//(001)′ and (010)α-Al//(010)′ interfaces is strong, which is attributed to significant charge accumulation between Sc (or Zr) and the host atoms. Si exhibits a favorable segregation tendency on the ′ side at both the (001)α-Al//(001)′ and (010)α-Al//(010)′ interfaces, which is ascribed to significant charge accumulation between Si and the host atoms. With the increase of Si, Sc and Zr coverage, the segregation tendencies of Si, Sc and Zr enhance. The segregation tendency of Cd decreases with the increase of Cd coverage. The first-principles tensile test for the interface was conducted. The work of dislocation emission was computed. Results show that the strengthening effects of solute atoms on the interface are primarily dominated by the chemical contribution. Sc (or Zr) segregation leads to an increase in the strength of the interface, which is majorly attributed to a strong electronic interaction between Sc (or Zr) and the host atoms. Cd segregation causes a weakening effect on the interface because of the weak electronic interaction between Cd and the host atoms. The ductility of the (001)α-Al//(001)′ interface with the Sc (or Zr) is more significant than that with the Cd (or Si). This work provides a strategy for improving the mechanical properties of the Al–Cu alloys. [ABSTRACT FROM AUTHOR]

Hox genes encode transcription factors that play an important role in establishing the basic body plan of animals. In Drosophila, Antennapedia is one of the five genes that make up the Antennapedia complex (ANT-C). Antennapedia determines the identity of the second thoracic segment, known as the mesothorax. Misexpression of Antennapedia at different developmental stages changes the identity of the mesothorax, including the muscles, nervous system, and cuticle. In Drosophila, Antennapedia has two distinct promoters highly regulated throughout development by several transcription factors. Antennapedia proteins are found with other transcription factors in different ANTENNAPEDIA transcriptional complexes to regulate multiple subsets of target genes. In this review, we describe the different mechanisms that regulate the expression and function of Antennapedia and the role of this Hox gene in the development of Drosophila., (© 2023 The Authors. genesis published by Wiley Periodicals LLC.)

Peripheral chemoreceptors (PChRs), because of their strategic localization at the bifurcation of the common carotid artery and along the aortic arch, play an important protective role against hypoxia. Stimulation of PChRs evokes hyperventilation and hypertension to maintain adequate oxygenation of critical organs. A relationship between increased sensitivity of PChRs (hyperreflexia) and exercise intolerance (ExIn) in patients with heart failure (HF) has been previously reported. Moreover, some studies employing an acute blockade of PChRs (e.g., using oxygen or opioids) demonstrated improvement in exercise capacity, suggesting that hypertonicity is also involved in the development of ExIn in HF. Nonetheless, the precise mechanisms linking dysfunctional PChRs to ExIn remain unclear. From the clinical perspective, there are two main factors limiting exercise capacity in HF patients: subjective perception of dyspnoea and muscle fatigue. Both have many determinants that might be influenced by abnormal signalling from PChRs, including: exertional hyperventilation, oscillatory ventilation, ergoreceptor oversensitivity, and augmented sympathetic tone. The latter results in reduced muscle perfusion and altered muscle structure. In this review, we intend to present the milieu of abnormalities tied to malfunctioning PChRs and discuss their role in the complex relationships leading, ultimately, to ExIn. [ABSTRACT FROM AUTHOR]

Studies of Fe‐contaminated Al‐based scraps have drawn attention for years. However, little has been researched about the effects of cobalt (Co) and nickel (Ni) additions to contaminated scraps both under slow solidification (directional solidification, DS) and fast solidification regime (copper mold centrifugal casting, CC). As such, the current study examines a representative low‐alloy Al–Si chemistry from industrial scraps, i.e., the Al–7%Si–0.6%Fe–0.35%Cu–0.25%Zn (% by weight). This alloy is changed independently using Ni and Co. It is observed that a mixture of uneven distributed α and β Fe‐bearing particles prevails for all tested alloys and solidification conditions. The coexistence of both phases agrees with the charts proposed by Gorny's work for the range of secondary dendritic spacing, λ2, observed. Although the Fe‐containing particles are smaller for fast‐solidified samples, they still maintain the acute morphology and, in some cases, the Chinese script shape. This results in a reduction in ductility of the order of 65% for the nonmodified and Ni‐modified samples considering mean λ2 varying from 20 μm (DS) to 6.5 μm (CC), despite improvements in mechanical strength. Furthermore, addition of Co results in a higher number of Fe‐based particles within the microstructure. In this case, the largest particle/α‐Al interfacial area results in slightly poor ductility (~6–8%) and higher strength (175–205 MPa), with less ductility loss when DS and CC samples are compared. [ABSTRACT FROM AUTHOR]

A systematic study of structure and hardening of two‐phase Al–8% Ca, Al–10% Ce, and Al–10% La eutectic aluminum alloys under high‐pressure torsion (HPT) has been carried out. HPT leads to an increase in microhardness as a result of the formation of a nanocrystalline structure with a high density of crystal defects in the Al–8% Ca alloy and a nano‐ and submicrocrystalline structure with a low density of crystal defects in the Al–10% Ce and Al–10% La alloys, as well as the eutectic particle refinement in all alloys. The predominant crystallite sizes after HPT through five turns are 70–210, 60–120, and 25–45 nm, respectively, in the Al–10% La, Al–10% Ce, and Al–8% Ca alloys. The change in the shape of the curve of the microhardness distribution over the samples' surface with an increase in the number of turns from 1 to 5 is different for three alloys. The results demonstrate the ultrafine‐grained microstructure development varied depending on the binary alloy systems. Initial as‐cast eutectic particles have a significant effect on the structure and hardening of alloys through their morphology, volume fraction, hardness, and orientational ratio with the aluminum base. [ABSTRACT FROM AUTHOR]