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Chronic Kidney Disease is a health condition in which the kidneys experience a progressive decline in function. Kidneys are vital organs that filter waste and excess blood fluids. CKD can lead to excess products in the body and cause various health issues, so early detection of CKD is necessary. While traditional machine learning techniques have performed well in predicting CKD in existing studies, this study investigates the potential of long short-term memory (LSTM) optimized with Genetic Algorithm to enhance predictive accuracy and efficiency by optimizing its hyperparameters, including number of units, hidden layers, activation function, recurrent activation, and dropout rate. The result demonstrates that the optimized LSTM slightly performs better than without optimization, achieving higher precision, recall, accuracy, and f1 score by 100% respectively. This outstanding result can be attributed to several key factors, such as ensuring rigorous data preprocessing and utilizing k-fold cross-validation to make the model more reliable. This indicates the hybrid approach can be a powerful method for the early detection of CKD, leading to better patient outcomes. Despite the promising performance, further research is suggested, specifically using a larger dataset to ensure applicability to more general population and exploring other optimization methods to reduce computational cost.

This paper examines two-stage iterative methods, specifically the Geometric Mean (GM) method and its variants, for solving dense linear systems associated with first-kind Fredholm integral equations with semi-smooth kernels. These equations, characterised by ill-posedness and sensitivity to input perturbations, are discretised using a composite closed Newton-Cotes quadrature scheme. The study evaluates the computational performance and accuracy of the standard GM method, also referred to as the Full-Sweep Geometric Mean (FSGM), in comparison with the Half-Sweep Geometric Mean (HSGM) and Quarter-Sweep Geometric Mean (QSGM) methods. Numerical experiments demonstrate significant reductions in computational complexity and execution time while maintaining high solution accuracy. The QSGM method achieves the best performance among the tested methods, highlighting its effectiveness in addressing computational challenges associated with first-kind Fredholm integral equations.

Cancer is a disease induced by the abnormal growth of cells in body tissues. This disease is commonly treated by chemotherapy. However, at first, cancer cells can respond to the activity of chemotherapy over time, but over time, resistance to cancer cells appears. Therefore, it is required to develop new anti-cancer drugs. Indenopyrazole and its derivative have been investigated to be a potential drug to treat cancer. This study aims to predict indenopyrazole derivative compounds as anti-cancer drugs by using Ant Colony Optimization (ACO) and Artificial Neural Network (ANN) methods. We used 93 compounds of indenopyrazole derivative with a total of 1876 descriptors. Then, the descriptors were reduced by using the Pearson Correlation Coefficient (PCC) and followed by the ACO algorithm to get the most relevant features. We found that the best number of descriptors obtained from ACO is ten descriptors. The ANN prediction model was developed with three architectures, which are different in hidden layer number, i.e., 1, 2, and 3 hidden layers. Based on the results, we found that the model with three hidden layers gives the best performance, with the value of the R2 test, R2 train, and Q2 train being 0.8822, 0.8495, and 0.8472, respectively.

Cancer is known as the second leading cause of death worldwide. About 7-10 million cases of death by cancer occur every year. The recent treatment to heal the cancer is chemotherapy. However, chemotherapy treatment is known to have side effects and cell resistance issues to certain drugs. Therefore, it is required to develop a new drug that can reduce the side effects and provide a better treatment effect. In general, anti-cancer drugs are developed by targeting Cyclin-Dependent Kinase 2 (CDK2) enzyme. Conventional drug design is not effective and efficient for obtaining new drug candidates because of no information about the biological activity before it is synthesized. In this study, we aim to develop a model to predict the activity of CDK2 inhibitors by using ensemble methods, i.e., XGBoost, Random Forest, and AdaBoost. The study was conducted by calculating several fingerprints, i.e., Estate, Extended, Maccs, and Pubchem, as feature variables. Based on the results, we found that Random Forest with Pubchem fingerprint gives the best result with the value of Matthews Correlation Coefficient (MCC) and Area Under the ROC Curve (AUC) values are 0.979 and 0.999, respectively. From this study, we contributed to revealing the potency of the ensemble with fingerprint in bioactivity prediction, especially CDK2 inhibitors as anti-cancer agents.

Diabetes mellitus is a chronic illness that can affect anyone, while the medicine that can entirely cure diabetes has not been discovered yet. Dipeptidyl Peptidase IV (DPP IV) inhibitor is one of the agents with potency as an anti-diabetic treatment. In this work, we utilized the machine learning method to predict the activity of DPP IV as an anti-diabetic agent. We combined Particle Swarm Optimization (PSO) method for features selection and the Support Vector Machine (SVM) for the prediction model. Three SVM kernels, i.e., radial basis function (RBF), polynomial, and linear, were utilized, and their performance was compared. A Hyperparameter tuning procedure was conducted to improve the performance of models. According to the results, we found that the best model obtained from SVM with RBF kernel with the value R2 of train and test set are 0.79 and 0.85, respectively.

Diabetes mellitus is a chronic disease that can occurred to anyone. Up until now, there are no specific drugs that have been found which can completely cure diabetes. One of the possible steps to treat diabetes mellitus is by inhibiting the growth of Diacylglycerol Acyltransferase-1 (DGAT-1) enzyme. This study aims to build a QSAR model on DGAT-1 inhibitors as anti-diabetic using Particle Swarm Optimization (PSO) and Support Vector Machine (SVM). Acyl-CoA: DGAT1 is a mikrosomal enzyme in lipogenesis which is increased in metabolically active cells to meet nutrient requirements. Microsomal-enzymes-that have an-important in the triglyceride-synthesis process-of 1,2-diacylglycerol by-catalyzing-acyl-coa-dependent-acylations as anti-diabetics. The dataset used in this study consists of 228 samples containing molecular structures and their inhibitor activities. We reduce the number of features by removing features with a standard deviation less than the threshold value, followed by the PSO algorithm. The best-predicted result is obtained through the implementation of SVM with RBF kernel, with the score of and are 0.75 and 0.67, respectively.

Aedes aegypti is one of the most dangerous mosquitoes that can cause several deadly diseases, such as dengue fever, Chikungunya, Zika, and jaundice with high mortality rate. For now, no specific drug has been found that can cure the disease caused by Aedes Aegypti. One possible solution for handling this problem is to inhibit the growth and development of Aedes aegypti larvae. This study aims to implement Genetic Algorithm-Support Vector Machine to develop Quantitative Structure-Activity Relationship model for identification larvicidal phytocompounds as anti-aedes-aegypti. Hyperparameter tuning was performed to improve the performance of the models. Based on the result, we found that the best model was developed by the RBF kernel with the value of and score are 0.64 and 0.64, respectively.

Schizophrenia is a chronic mental illness that leads the patient to hallucinations and delusions with a prevalence of 0.4% worldwide. The importance early detection of Schizophrenia is tracking the pre-syndrome of Schizophrenia during the active phase, and could reduce psychosis symptomatic. However, the method sometimes cannot detect the symptoms accurately. As an alternative, machine learning can be implemented on microarray data for early detection. This study aimed to implement three ensemble methods, i.e., Random Forest (RF), Adaptive Boosting (AdaBoost), and Extreme Gradient Boosting (XGBoost) to identify Schizophrenia. Hyperparameter tuning was performed to improve the performance of the models. Based on the results, we found that the model 6, which is developed by the XGBoost method, performs better than other models with the value of accuracy and F1-score are 0.87 and 0.87, respectively.