Aim: In this study, we aim to investigate the effect of two polymorphisms (rs2077119 and rs4918) in the fetuin-A (Alpha-2-Heremans Schmid Glycoprotein, AHSG) gene and their relationship with Polycystic Ovary Syndrome (PCOS). Material and Methods: We enrolled 122 patients with PCOS who were referred to the Harran University Medical Faculty Obstetrics and Gynaecology Outpatient Clinic. We also enrolled 124 healthy women without PCOS as controls. The molecular analysis of these polymorphisms, 767 C>G and 4613 T>G of the AHSG gene, was performed on whole blood using the real-time PCR method. The amplification curves of the polymorphisms in the samples were obtained as a result of the real-time PCR method and genotyped. Results: As a result of our study, homozygous GG genotype, which is polymorphic in terms of fetuin-A gene 767 C>G polymorphism, was observed in 6 of the 122 patient groups, while it was observed in 10 individuals in the 124 control group. The difference between homozygous GG and homozygous CC genotypes in the control and patient groups was not statistically significant (p > 0.05). The homozygous TT genotype, which is polymorphic in terms of the fetuin-A gene 4613 T>G polymorphism, was observed in 35 individuals in the 122 patient group, while it was observed in 26 individuals in the 124-person control group. There was no statistically significant difference between homozygous TT and homozygous GG genotypes in the control and patient groups (p > 0.05). Conclusion: According to the data obtained as a result of this research, it is concluded that both the AHSG gene 767 C>G (rs4918) and 4613 T>G (rs2077119) polymorphisms are not related to PCOS. [ABSTRACT FROM AUTHOR]