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6. Effects of oral anticoagulation in people with atrial fibrillation after spontaneous intracranial haemorrhage (COCROACH): prospective, individual participant data meta-analysis of randomised trials

Author

Klug, Didier, Casolla, Barbara, Puy, Laurent, Coffee, Morgane, Kuchcinski, Grégory, Labreuche, Julien, van Nieuwenhuizen, Koen M., Algra, Ale, van Gelder, Isabelle C., Kappelle, L. Jaap, Rinkel, Gabriel J.E., Schutgens, Roger E.G., Khatri, Pooja, Conwit, Robin, Falcone, Guido, Elm, Jordan, Anderson, Craig S., Song, Lili, Pandian, Jeyaraj, Hart, Robert G., Sharma, Mukul, Aref, Hany, Tarhuni, Wadea, Fabregas, Joan Marti, Diener, Hans-Christoph, Endres, Matthias, Lemmens, Robin, Kwon, Sun U., Lee, Byung-Chul, Ameriso, Sebastian, Milling, Truman J., Kasner, Scott E., Mikulik, Robert, Xavier, Denis, Beer, Ronny, Toni, Danilo, Eckstein, Jens, Seiffge, David, Ferro, Jose M., Tsivgoulis, Georgios, Sharma, Sanjib K., Wei-Liou, Chia, Hohnloser, Stefan H., Katsanos, Aristeidis, Bosch, Jackie, Healey, Jeff, Eikelboom, John, Khaw, Alexander, Gladstone, David, Pikula, Aleksandra, Coutts, Shelagh, Smith, Eric E., Butcher, Ken, Field, Thalia, Gioia, Laura, Stapf, Christian, Halse, Omid, Ringleb, Peter, Enzinger, Christian, Sibon, Igor, Montaner, Joan, Caso, Valeria, Heuschmann, Peter, Lip, Gregory Y.H., Haefeli, Walter, Debette, Stefanie, Dennis, Martin S., Wyller, Torgeir Bruun, Rønning, Ole M., Eilertsen, Helle, Ihle-Hansen, Hege, Sandset, Else Charlotte, Pennlert, Johanna, Glader, Eva-Lotta, Kruuse, Christina, Wester, Per, Carlsson, Maria, Forfang, Elisabeth, Al-Shahi Salman, Rustam, Stephen, Jacqueline, Tierney, Jayne F, Lewis, Steff C, Newby, David E, Parry-Jones, Adrian R, White, Philip M, Connolly, Stuart J, Benavente, Oscar R, Dowlatshahi, Dar, Cordonnier, Charlotte, Viscoli, Catherine M, Sheth, Kevin N, Kamel, Hooman, Veltkamp, Roland, Larsen, Kristin T, Hofmeijer, Jeannette, Kerkhoff, Henk, Schreuder, Floris H B M, Shoamanesh, Ashkan, Klijn, Catharina J M, and van der Worp, H Bart

Published
2023
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12. Paramedic Norwegian Acute Stroke Prehospital Project (ParaNASPP) study protocol: a stepped wedge randomised trial of stroke screening using the National Institutes of Health Stroke Scale in the ambulance

Author

Bugge, Helge Fagerheim, Guterud, Mona, Bache, Kristi C. G., Braarud, Anne-Cathrine, Eriksen, Erik, Fremstad, Kjell Otto, Ihle-Hansen, Hege, Ingebretsen, Svein Håkon, Kramer-Johansen, Jo, Larsen, Karianne, Røislien, Jo, Thorsen, Kjetil, Toft, Mathias, Sandset, Else Charlotte, and Hov, Maren Ranhoff

Published
2022
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17. Sleep Duration and Cognitive Function: The Akershus Cardiac Examination 1950 Study.

Author

Ihle-Hansen, Hege, Einvik, Gunnar, Hagberg, Guri, Thommessen, Bente, Rønning, Ole Morten, Vigen, Thea, Lyngbakken, Magnus Nakrem, Berge, Trygve, Røsjø, Helge, Tveit, Arnljot, and Ihle-Hansen, Håkon

Subjects
*COGNITION disorder risk factors, *SELF-evaluation, *RISK assessment, *CROSS-sectional method, *COGNITIVE testing, *RESEARCH funding, *DESCRIPTIVE statistics, *SLEEP duration, *LONGITUDINAL method, *MEMORY, *AGING, *NEUROPSYCHOLOGICAL tests, *MIDDLE age, *OLD age
Abstract

Introduction: Sleep duration is proposed as a lifestyle-related risk factor for cognitive impairment. We investigated the association between sleep duration and cognitive function in a large population-based cohort aged 62–65 years. Methods: Cross-sectional analyses from the Akershus Cardiac Examination 1950 Study. Linear and nonlinear models were conducted to explore the association between self-reported sleep duration and cognitive function, adjusted for established risk factors for cognitive impairment. Results: We included 3,348 participants, mean age (SD) was 63.9 ± 0.6 years, 48.2% were women, and 47.9% had education >12 years. Mean sleep duration (SD) was 7.0 ± 1.0 h, and 10.2% had abnormal sleep duration (<6 or >8 h). Individuals reporting <6 h or >8 h of sleep scored significantly lower on MoCA test and delayed recall trial in adjusted analysis. Conclusions: Sleep duration showed an inverted U-shaped association with global cognitive function and memory, suggesting that both shortened and prolonged sleep are related to adverse brain health. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Exploring the associations between physical activity level, cognitive performance, and response to computerized cognitive training among chronic stroke patients

Author

Sanders, Anne‐Marthe, primary, Richard, Geneviève, additional, Kolskår, Knut, additional, Ulrichsen, Kristine M., additional, Alnæs, Dag, additional, Dørum, Erlend S., additional, Ihle‐Hansen, Hege, additional, Pedersen, Mads L., additional, Nordvik, Jan Egil, additional, and Westlye, Lars T., additional

Published
2024
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21. Effects of oral anticoagulation in people with atrial fibrillation after spontaneous intracranial haemorrhage (COCROACH): prospective, individual participant data meta-analysis of randomised trials

Author

Al-Shahi Salman, Rustam, primary, Stephen, Jacqueline, additional, Tierney, Jayne F, additional, Lewis, Steff C, additional, Newby, David E, additional, Parry-Jones, Adrian R, additional, White, Philip M, additional, Connolly, Stuart J, additional, Benavente, Oscar R, additional, Dowlatshahi, Dar, additional, Cordonnier, Charlotte, additional, Viscoli, Catherine M, additional, Sheth, Kevin N, additional, Kamel, Hooman, additional, Veltkamp, Roland, additional, Larsen, Kristin T, additional, Hofmeijer, Jeannette, additional, Kerkhoff, Henk, additional, Schreuder, Floris H B M, additional, Shoamanesh, Ashkan, additional, Klijn, Catharina J M, additional, van der Worp, H Bart, additional, Klug, Didier, additional, Casolla, Barbara, additional, Puy, Laurent, additional, Coffee, Morgane, additional, Kuchcinski, Grégory, additional, Labreuche, Julien, additional, van Nieuwenhuizen, Koen M., additional, Algra, Ale, additional, van Gelder, Isabelle C., additional, Kappelle, L. Jaap, additional, Rinkel, Gabriel J.E., additional, Schutgens, Roger E.G., additional, Khatri, Pooja, additional, Conwit, Robin, additional, Falcone, Guido, additional, Elm, Jordan, additional, Anderson, Craig S., additional, Song, Lili, additional, Pandian, Jeyaraj, additional, Hart, Robert G., additional, Sharma, Mukul, additional, Aref, Hany, additional, Tarhuni, Wadea, additional, Fabregas, Joan Marti, additional, Diener, Hans-Christoph, additional, Endres, Matthias, additional, Lemmens, Robin, additional, Kwon, Sun U., additional, Lee, Byung-Chul, additional, Ameriso, Sebastian, additional, Milling, Truman J., additional, Kasner, Scott E., additional, Mikulik, Robert, additional, Xavier, Denis, additional, Beer, Ronny, additional, Toni, Danilo, additional, Eckstein, Jens, additional, Seiffge, David, additional, Ferro, Jose M., additional, Tsivgoulis, Georgios, additional, Sharma, Sanjib K., additional, Wei-Liou, Chia, additional, Hohnloser, Stefan H., additional, Katsanos, Aristeidis, additional, Bosch, Jackie, additional, Healey, Jeff, additional, Eikelboom, John, additional, Khaw, Alexander, additional, Gladstone, David, additional, Pikula, Aleksandra, additional, Coutts, Shelagh, additional, Smith, Eric E., additional, Butcher, Ken, additional, Field, Thalia, additional, Gioia, Laura, additional, Stapf, Christian, additional, Halse, Omid, additional, Ringleb, Peter, additional, Enzinger, Christian, additional, Sibon, Igor, additional, Montaner, Joan, additional, Caso, Valeria, additional, Heuschmann, Peter, additional, Lip, Gregory Y.H., additional, Haefeli, Walter, additional, Debette, Stefanie, additional, Dennis, Martin S., additional, Wyller, Torgeir Bruun, additional, Rønning, Ole M., additional, Eilertsen, Helle, additional, Ihle-Hansen, Hege, additional, Sandset, Else Charlotte, additional, Pennlert, Johanna, additional, Glader, Eva-Lotta, additional, Kruuse, Christina, additional, Wester, Per, additional, Carlsson, Maria, additional, and Forfang, Elisabeth, additional

Published
2023
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22. Carotid Plaque Score for Stroke and Cardiovascular Risk Prediction in a Middle‐Aged Cohort From the General Population

Author

Ihle‐Hansen, Håkon, primary, Vigen, Thea, additional, Berge, Trygve, additional, Walle‐Hansen, Marte M., additional, Hagberg, Guri, additional, Ihle‐Hansen, Hege, additional, Thommessen, Bente, additional, Ariansen, Inger, additional, Røsjø, Helge, additional, Rønning, Ole Morten, additional, Tveit, Arnljot, additional, and Lyngbakken, Magnus, additional

Published
2023
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23. Predictors of cognitive and emotional symptoms 12 months after first-ever mild stroke

Author

Vlachos, Georgios, Ihle-Hansen, Hege, Wyller, Torgeir Bruun, Brækhus, Anne, Mangset, Margrete, Hamre, Charlotta, Fure, Brynjar, Vlachos, Georgios, Ihle-Hansen, Hege, Wyller, Torgeir Bruun, Brækhus, Anne, Mangset, Margrete, Hamre, Charlotta, and Fure, Brynjar

Abstract

Even mild strokes may affect the patients' everyday life by impairing cognitive and emotional functions. Our aim was to study predictors of such impairments one year after first-ever mild stroke. We included cognitively healthy patients ≤ 70 years with acute mild stroke. Vascular risk factors, sociodemographic factors and stroke classifications were recorded. At one-year post-stroke, different domains related to cognitive and emotional function were assessed with validated instruments. Logistic regression analyses were performed to identify predictors of cognitive and emotional outcome. Of 117 patient assessed at follow-up, only 21 patients (18%) scored within the reference range on all cognitive and emotional assessments. Younger age, multiple infarcts, and being outside working life at stroke onset were independent predictors of cognitive impairments (psychomotor speed, attention, executive and visuospatial function, memory). Female gender and a higher National Institutes of Health Stroke Scale (NIHSS) score at discharge were significantly associated with emotional impairments (anxiety, depressive symptoms, fatigue, apathy, emotional lability) after one year, but these associations were only seen in the unadjusted models. In conclusion, patients in working age may profit from a follow-up during the post-stroke period, with extra focus on cognitive and emotional functions., Funding agency:Department of Geriatric Medicine, Oslo University Hospital

Published
2023
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26. Systolic blood pressure at age 40 and cognitive function 25 years later: the Akershus Cardiac Examination (ACE) 1950 Study

Author

Walle-Hansen, Marte M., primary, Berge, Trygve, additional, Vigen, Thea, additional, Myrstad, Marius, additional, Hagberg, Guri, additional, Ihle-Hansen, Hege, additional, Sandset, Else C., additional, Thommessen, Bente, additional, Ariansen, Inger K.H., additional, Lyngbakken, Magnus N., additional, Røsjø, Helge, additional, Rønning, Ole M., additional, Tveit, Arnljot, additional, and Ihle-Hansen, Håkon, additional

Published
2022
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28. Monitoring following acute stroke should be improved

Author

Rønning, Ole Morten, primary, Carlsson, Maria, primary, Ihle-Hansen, Hege, primary, Aamodt, Anne Hege, primary, Tveiten, Arnstein, primary, Eltoft, Agnethe, primary, Fromm, Annette, primary, Ellekjær, Hanne, primary, and Kurz, Martin, primary

Published
2022
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29. Author response for 'No add-on effect of tDCS on fatigue and depression in chronic stroke patients: A randomized sham-controlled trial combining tDCS with computerized cognitive training'

Author

null Ulrichsen, Kristine M., null Kolskar, Knut K., null Richard, Genevieve, null Pedersen, Mads Lund, null Alnaes, Dag, null Dorum, Erlend S., null Sanders, Anne-Marthe, null Tornas, Sveinung, null Maglanoc, Luigi A., null Engvig, Andreas, null Ihle-Hansen, Hege, null Nordvik, Jan E., and null Westlye, Lars T.

Published
2022
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31. No add‐on effect of tDCS on fatigue and depression in chronic stroke patients: A randomized sham‐controlled trial combining tDCS with computerized cognitive training

Author

Ulrichsen, Kristine M., primary, Kolskår, Knut K., additional, Richard, Geneviève, additional, Pedersen, Mads Lund, additional, Alnæs, Dag, additional, Dørum, Erlend S., additional, Sanders, Anne‐Marthe, additional, Tornås, Sveinung, additional, Maglanoc, Luigi A., additional, Engvig, Andreas, additional, Ihle‐Hansen, Hege, additional, Nordvik, Jan E., additional, and Westlye, Lars T., additional

Published
2022
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34. Biomarkers predictive of atrial fibrillation in patients with cryptogenic stroke. Insights from the Nordic Atrial Fibrillation and Stroke (NOR‐FIB) study.

Author

Tancin Lambert, Anna, Ratajczak‐Tretel, Barbara, Al‐Ani, Riadh, Arntzen, Kathrine, Bakkejord, Grete Kristin, Bekkeseth, Hanna Marie Otterholt, Bjerkeli, Vigdis, Eldøen, Guttorm, Gulsvik, Anne Kristine, Halvorsen, Bente, Høie, Gudrun Anette, Ihle‐Hansen, Hege, Ihle‐Hansen, Håkon, Ingebrigtsen, Susanne, Johansen, Henriette, Kremer, Christine, Krogseth, Siv Bohne, Kruuse, Christina, Kurz, Martin, and Nakstad, Ingvild

Subjects
ISCHEMIC stroke, ATRIAL fibrillation, BRAIN natriuretic factor, TRANSIENT ischemic attack, RECEIVER operating characteristic curves
Abstract

Background and purpose: There are currently no biomarkers to select cryptogenic stroke (CS) patients for monitoring with insertable cardiac monitors (ICMs), the most effective tool for diagnosing atrial fibrillation (AF) in CS. The purpose of this study was to assess clinically available biomarkers as predictors of AF. Methods: Eligible CS and cryptogenic transient ischaemic attack patients underwent 12‐month monitoring with ICMs, clinical follow‐up and biomarker sampling. Levels of cardiac and thromboembolic biomarkers, taken within 14 days from symptom onset, were compared between patients diagnosed with AF (n = 74) during monitoring and those without AF (n = 185). Receiver operating characteristic curves were created. Biomarkers reaching area under the receiver operating characteristic curve ≥ 0.7 were dichotomized by finding optimal cut‐off values and were used in logistic regression establishing their predictive value for increased risk of AF in unadjusted and adjusted models. Results: B‐type natriuretic peptide (BNP), N‐terminal pro‐brain natriuretic peptide (NT‐proBNP), creatine kinase, D‐dimer and high‐sensitivity cardiac troponin I and T were significantly higher in the AF than non‐AF group. BNP and NT‐proBNP reached the predefined area under the curve level, 0.755 and 0.725 respectively. Optimal cut‐off values were 33.5 ng/l for BNP and 87 ng/l for NT‐proBNP. Regression analysis showed that NT‐proBNP was a predictor of AF in both unadjusted (odds ratio 7.72, 95% confidence interval 3.16–18.87) and age‐ and sex‐adjusted models (odds ratio 4.82, 95% confidence interval 1.79–12.96). Conclusion: Several clinically established biomarkers were associated with AF. NT‐proBNP performed best as AF predictor and could be used for selecting patients for long‐term monitoring with ICMs. [ABSTRACT FROM AUTHOR]

Published
2023
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36. Pressor therapy in acute ischaemic stroke: an updated systematic review

Author

Strømsnes, Torbjørn Austveg, primary, Kaugerud Hagen, Truls Jørgen, additional, Ouyang, Menglu, additional, Wang, Xia, additional, Chen, Chen, additional, Rygg, Silje-Emilie, additional, Hewson, David, additional, Lenthall, Rob, additional, McConachie, Norman, additional, Izzath, Wazim, additional, Bath, Philip M, additional, Dhillon, Permesh Singh, additional, Podlasek, Anna, additional, England, Timothy, additional, Sprigg, Nikola, additional, Robinson, Thompson G, additional, Advani, Rajiv, additional, Ihle-Hansen, Hege, additional, Sandset, Else Charlotte, additional, and Krishnan, Kailash, additional

Published
2022
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39. Forhåndssamtaler om siste livsfase.

Author

Ihle-Hansen, Hege, Ihle-Hansen, Håkon, Rostoft, Siri, Munkhaugen, John, Westbye, Siri Ferden, Romøren, Maria, LereimSævareid, Trygve Johannes, Brøderud, Linn, BergHermansen, Karin, Larsen, Marie Hamilton, Wahl, Astrid Klopstad, MarcAhmed, and Pedersen, Reidar

Published
2024

40. Veien inn til sykehus for pasienter innlagt ved mistanke om akutt hjerneslag.

Author

Fremstad, Kjell Otto, Lindenskov, Paal H. H., Ihle-Hansen, Hege, Jamtli, Bjørn, Kramer-Johansen, Jo, Hardeland, Camilla, Hov, Maren Ranhoff, and Sandset, Else Charlotte

Abstract

Copyright of Norwegian Journal of Clinical Nursing / Sykepleien Forskning is the property of Sykepleien Forskning and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022
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42. Prehospital computed tomography in a rural district for rapid diagnosis and treatment of stroke

Author

Ibsen, Jørgen, Hov, Maren Ranhoff, Tokerud, Gunn Eli, Fuglum, Julia, Linnerud Krogstad, Marianne, Stugaard, Marie, Ihle-Hansen, Hege, Lund, Christian Georg, and Hall, Christian

Abstract

Background: Early diagnosis and triage of patients with ischemic stroke is essential for rapid reperfusion therapy. The prehospital delay may be substantial and patients from rural districts often arrive at their local hospital too late for disability-preventing thrombolytic therapy due to prolonged transport times.Methods: Hallingdal District Medical Centre (HDMC) is located in a rural area of Norway and is equipped with a computed tomography (CT) scanner. We established emergency pathways of CT imaging and thrombolytic treatment of patients with acute ischemic stroke at HDMC. During office hours these pathways were managed by a radiographer and a general physician supported by videoconference from the Primary Stroke Centre. Outside office hours we remotely controlled the CT exam and supported telestroke guided paramedics handling and examining the patients. With a primary aim of demonstrating the feasibility of this de novo concept we enrolled patients in the period 2017–2021 into a comparative cohort observational study. We compared patients treated at HDMC (the Rural CT group) to patients from two other rural regions in Norway with similar distances to their local hospital but without access to a rural CT scanner (the Reference group).Results: A total of 86 patients were included in the Rural CT group (mean age 74, 52% male, 43% stroke mimics), and 69 patients were included in the Reference group (mean age 70, 42% male, 28% stroke mimics). Median time from onset of symptoms to completed CT examination was 93 min in the Rural CT group as compared to 240 min in the Reference group (p< 0.05). In patients receiving intravenous thrombolysis time from onset of symptoms to treatment was median 124 min in the Rural CT group and 213 min in the Reference group, p< 0.05. The frequency of thrombolysis for ischemic stroke did not significantly differ between the two groups.Conclusion: Combining prehospital rural CT examination with telestroke guided diagnosis and thrombolytic treatment by paramedics may facilitate earlier initiation of thrombolysis for patients with ischemic stroke.

Published
2024
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43. Lesion Volume as a Predictor of Return to Work After Stroke

Author

Helland, Gisle Berg, Beyer, Mona, Enriquez, Brian, Ihle-Hansen, Hege, Ihle-Hansen, Håkon, Andersson, Stein, Stangeland, Helle, Ujhelyi, Bettina, Hagberg, Guri, Harbo, Hanne, Aamodt, Anne Hege, and Høgestøl, Einar August

Abstract

Facilitating a successful return to work plays a pivotal role in reintegrating stroke survivors into the community. This study aims to explore the significance of lesion volume in the acute phase of stroke as a predictor for returning to work.

Published
2024
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44. Biomarkers of inflammation and brain damage seven years post-stroke

Author

Hagberg, Guri, Ihle-Hansen, Hege, Seljeflot, Ingebjørg, and Bratseth, Vibeke

Abstract

Biomarkers of inflammation and brain damage are associated with neurodegeneration and dementia but are scarcely investigated post-stroke. We hypothesized that biomarkers of brain tissue damage and inflammation are associated with i) cognition and imaging markers of brain pathology seven years post-stroke and ii) long-term cognitive deterioration post-stroke.

Published
2024
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45. Impact of Pre-Stroke Frailty on Outcome Three Years after Acute Stroke: The Nor-COAST Study.

Author

Munthe-Kaas, Ragnhild, Lydersen, Stian, Quinn, Terry, Aam, Stina, Pendlebury, Sarah T., and Ihle-Hansen, Hege

Subjects
*STROKE, *LOGISTIC regression analysis, *STROKE patients, *OLDER people, *COGNITION disorders
Abstract

\nIntroduction: We aimed to explore the predictive value of pre-stroke frailty index (FI) on functional dependency and mortality 3 years after stroke. Methods: Based on the Rockwood 36-item FI score, we calculated the pre-stroke FI from medical conditions recorded at baseline in the multicenter prospective Nor-COAST study 2015–2017. Participants with a FI score and a modified Rankin scale (mRS) 0–6 3 years post-stroke were included in this study. We used logistic regression analysis with unfavorable mRS (over 2 vs. 0–2) at 3 years, or dead within 3 years, as dependent variable, and frailty and pre-stroke mRS, one at a time, and simultaneously, as predictors. The analyses were carried out unadjusted and adjusted for the following variables one at a time: Age, sex, years of education, stroke severity at admission, infections treated with antibiotics and stroke progression. We report odds ratio (OR) per 0.10 increase in FI. Results: At baseline, the 609 included patients had mean age 72.8 (standard deviation [SD] 11.8), 261 (43%) were females, and had a FI mean score of 0.16 (SD 0.12), range 0–0.69. During 3 years, 138 (23%) had died. Both the FI, and pre-stroke mRS, were strong predictors for unfavorable mRS (OR 4.1 and 2.7) and dead within 3 years (OR 2.2 and 1.7). Only adjusting for age affected the result. The OR for pre-stroke mRS decreased relatively more than the OR for FI when entered as predictors simultaneously. Conclusions: FI is a stronger predictor than premorbid mRS for prognostication after stroke. Stroke is a leading cause of dead and disability in the world. It is an acute condition prevalent in older populations. As more older adults surviving previously fatal strokes, the prevalence of stroke survivors with different functional and cognitive impairments increase. There is a great heterogeneity in outcome after stroke, even in milder strokes. We know less of what predict poor outcome. While increasing age in general is associated with poor outcome, at individual plan the relationship with age is more uncertain. Frailty is a concept gaining more attention over the recent years. It is defined as a condition of vulnerability associated with an increased risk of adverse health outcomes such as functional decline and mortality. Frail people have an increased risk of developing disease when something extraordinary occurs. Less is known about the relationship between stroke and frailty. Frailty assessment is not yet part of routine stroke care. In this study, we explored the impact of pre-stroke frailty on functional dependency and mortality 3 years after stroke. We found that the degree of frailty before stroke had a huge impact on functional status and mortality 3 years after stroke, even when we adjusted for important factors, like stroke severity and age. This demonstrates the importance of implementing frailty measures as a routine tool in stroke medicine. It also underline the value of developing preventing mechanisms of frailty in the older population. [ABSTRACT FROM AUTHOR]

Published
2024
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