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Your search keyword '"INOUE, HIROSHI"' showing total 278 results
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278 results on '"INOUE, HIROSHI"'

2. Coronary events in elderly patients with non-valvular atrial fibrillation: a prespecified sub-analysis of the ANAFIE registry

Author

Nakamura, Masato, Inoue, Hiroshi, Yamashita, Takeshi, Akao, Masaharu, Atarashi, Hirotsugu, Ikeda, Takanori, Koretsune, Yukihiro, Okumura, Ken, Shimizu, Wataru, Suzuki, Shinya, Tsutsui, Hiroyuki, Toyoda, Kazunori, Yasaka, Masahiro, Yamaguchi, Takenori, Teramukai, Satoshi, Morishima, Yoshiyuki, Fukuzawa, Masayuki, Takita, Atsushi, and Hirayama, Atsushi

Published
2024
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5. Anticoagulant therapy and home blood pressure-associated risk for stroke/bleeding events in elderly patients with non-valvular atrial fibrillation: the sub-cohort study of ANAFIE registry

Author

Kario, Kazuomi, Hasebe, Naoyuki, Okumura, Ken, Yamashita, Takeshi, Akao, Masaharu, Atarashi, Hirotsugu, Ikeda, Takanori, Koretsune, Yukihiro, Shimizu, Wataru, Suzuki, Shinya, Tsutsui, Hiroyuki, Toyoda, Kazunori, Hirayama, Atsushi, Yasaka, Masahiro, Yamaguchi, Takenori, Teramukai, Satoshi, Kimura, Tetsuya, Morishima, Yoshiyuki, Takita, Atsushi, and Inoue, Hiroshi

Published
2023
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9. Multi-step LRU: SIMD-based Cache Replacement for Lower Overhead and Higher Precision

Author

Inoue, Hiroshi

Subjects
Computer Science - Networking and Internet Architecture, Computer Science - Databases, Computer Science - Performance
Abstract

A key-value cache is a key component of many services to provide low-latency and high-throughput data accesses to a huge amount of data. To improve the end-to-end performance of such services, a key-value cache must achieve a high cache hit ratio with high throughput. In this paper, we propose a new cache replacement algorithm, multi-step LRU, which achieves high throughput by efficiently exploiting SIMD instructions without using per-item additional memory (LRU metadata) to record information such as the last access timestamp. For a small set of items that can fit within a vector register, SIMD-based LRU management without LRU metadata is known (in-vector LRU). It remembers the access history by reordering items in one vector using vector shuffle instruction. In-vector LRU alone cannot be used for a caching system since it can manage only few items. Set-associative cache is a straightforward way to build a large cache using in-vector LRU as a building block. However, a naive set-associative cache based on in-vector LRU has a poorer cache hit ratio than the original LRU although it can achieve a high throughput. Our multi-step LRU enhances naive set-associative cache based on in-vector LRU for improving cache accuracy by taking both access frequency and access recency of items into account while keeping the efficiency by SIMD instructions. Our results indicate that multi-step LRU outperforms the original LRU and GCLOCK algorithms in terms of both execution speed and cache hit ratio. Multi-step LRU improves the cache hit ratios over the original LRU by implicitly taking access frequency of items as well as access recency into account. The cache hit ratios of multi-step LRU are similar to those of ARC, which achieves a higher a cache hit ratio in a tradeoff for using more LRU metadata.

Published
2021

10. Impact of glycated hemoglobin on 2-year clinical outcomes in elderly patients with atrial fibrillation: sub-analysis of ANAFIE Registry, a large observational study

Author

Terauchi, Yasuo, Inoue, Hiroshi, Yamashita, Takeshi, Akao, Masaharu, Atarashi, Hirotsugu, Ikeda, Takanori, Koretsune, Yukihiro, Okumura, Ken, Suzuki, Shinya, Tsutsui, Hiroyuki, Toyoda, Kazunori, Hirayama, Atsushi, Yasaka, Masahiro, Yamaguchi, Takenori, Teramukai, Satoshi, Kimura, Tetsuya, Morishima, Yoshiyuki, Takita, Atsushi, and Shimizu, Wataru

Published
2023
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11. The transcription factor ATF3 switches cell death from apoptosis to necroptosis in hepatic steatosis in male mice

Author

Inaba, Yuka, Hashiuchi, Emi, Watanabe, Hitoshi, Kimura, Kumi, Oshima, Yu, Tsuchiya, Kohsuke, Murai, Shin, Takahashi, Chiaki, Matsumoto, Michihiro, Kitajima, Shigetaka, Yamamoto, Yasuhiko, Honda, Masao, Asahara, Shun-ichiro, Ravnskjaer, Kim, Horike, Shin-ichi, Kaneko, Shuichi, Kasuga, Masato, Nakano, Hiroyasu, Harada, Kenichi, and Inoue, Hiroshi

Published
2023
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17. Comprehension of Nonvalvular Atrial Fibrillation and Anticoagulant Adherence in Elderly Patients in a Subcohort Study of the All Nippon Atrial Fibrillation in the Elderly Registry

Author

Akao, Masaharu, Yamashita, Takeshi, Atarashi, Hirotsugu, Ikeda, Takanori, Koretsune, Yukihiro, Okumura, Ken, Shimizu, Wataru, Suzuki, Shinya, Tsutsui, Hiroyuki, Toyoda, Kazunori, Hirayama, Atsushi, Yasaka, Masahiro, Yamaguchi, Takenori, Teramukai, Satoshi, Kimura, Tetsuya, Morishima, Yoshiyuki, Takita, Atsushi, and Inoue, Hiroshi

Published
2023
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19. Coagulation Biomarkers and Clinical Outcomes in Elderly Patients With Nonvalvular Atrial Fibrillation: ANAFIE Subcohort Study

Author

Koretsune, Yukihiro, Yamashita, Takeshi, Akao, Masaharu, Atarashi, Hirotsugu, Ikeda, Takanori, Okumura, Ken, Shimizu, Wataru, Suzuki, Shinya, Tsutsui, Hiroyuki, Toyoda, Kazunori, Hirayama, Atsushi, Yasaka, Masahiro, Yamaguchi, Takenori, Teramukai, Satoshi, Kimura, Tetsuya, Morishima, Yoshiyuki, Takita, Atsushi, and Inoue, Hiroshi

Published
2023
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23. Gastrointestinal bleeding in elderly patients with atrial fibrillation: prespecified All Nippon Atrial Fibrillation in the Elderly (ANAFIE) Registry subgroup analysis

Author

Yamamoto, Takatsugu, primary, Mizokami, Yuji, additional, Yamashita, Takeshi, additional, Akao, Masaharu, additional, Atarashi, Hirotsugu, additional, Ikeda, Takanori, additional, Koretsune, Yukihiro, additional, Okumura, Ken, additional, Shimizu, Wataru, additional, Suzuki, Shinya, additional, Tsutsui, Hiroyuki, additional, Toyoda, Kazunori, additional, Hirayama, Atsushi, additional, Yasaka, Masahiro, additional, Yamaguchi, Takenori, additional, Teramukai, Satoshi, additional, Kimura, Tetsuya, additional, Morishima, Yoshiyuki, additional, Takita, Atsushi, additional, and Inoue, Hiroshi, additional

Published
2024
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25. Oral Anticoagulants in Very Elderly Nonvalvular Atrial Fibrillation Patients With High Bleeding Risks: ANAFIE Registry

Author

Okumura, Ken, Yamashita, Takeshi, Akao, Masaharu, Atarashi, Hirotsugu, Ikeda, Takanori, Koretsune, Yukihiro, Shimizu, Wataru, Suzuki, Shinya, Tsutsui, Hiroyuki, Toyoda, Kazunori, Hirayama, Atsushi, Yasaka, Masahiro, Yamaguchi, Takenori, Teramukai, Satoshi, Kimura, Tetsuya, Morishima, Yoshiyuki, Takita, Atsushi, and Inoue, Hiroshi

Published
2022
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26. Frailty and outcomes in older adults with non-valvular atrial fibrillation from the ANAFIE registry

Author

Akishita, Masahiro, Suzuki, Shinya, Inoue, Hiroshi, Akao, Masaharu, Atarashi, Hirotsugu, Ikeda, Takanori, Koretsune, Yukihiro, Okumura, Ken, Shimizu, Wataru, Tsutsui, Hiroyuki, Toyoda, Kazunori, Hirayama, Atsushi, Yasaka, Masahiro, Yamaguchi, Takenori, Teramukai, Satoshi, Kimura, Tetsuya, Morishima, Yoshiyuki, Takita, Atsushi, and Yamashita, Takeshi

Published
2022
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28. In vivo transomic analyses of glucose-responsive metabolism in skeletal muscle reveal core differences between the healthy and obese states

Author

Kokaji, Toshiya, Eto, Miki, Hatano, Atsushi, Yugi, Katsuyuki, Morita, Keigo, Ohno, Satoshi, Fujii, Masashi, Hironaka, Ken-ichi, Ito, Yuki, Egami, Riku, Uematsu, Saori, Terakawa, Akira, Pan, Yifei, Maehara, Hideki, Li, Dongzi, Bai, Yunfan, Tsuchiya, Takaho, Ozaki, Haruka, Inoue, Hiroshi, Kubota, Hiroyuki, Suzuki, Yutaka, Hirayama, Akiyoshi, Soga, Tomoyoshi, and Kuroda, Shinya

Published
2022
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33. An Efficient Method for Isolating and Purifying Nuclei from Mice Brain for Single-Molecule Imaging Using High-Speed Atomic Force Microscopy

Author

Qiu, Yujia, primary, Sajidah, Elma Sakinatus, additional, Kondo, Sota, additional, Narimatsu, Shinnosuke, additional, Sandira, Muhammad Isman, additional, Higashiguchi, Yoshiki, additional, Nishide, Goro, additional, Taoka, Azuma, additional, Hazawa, Masaharu, additional, Inaba, Yuka, additional, Inoue, Hiroshi, additional, Matsushima, Ayami, additional, Okada, Yuki, additional, Nakada, Mitsutoshi, additional, Ando, Toshio, additional, Lim, Keesiang, additional, and Wong, Richard W., additional

Published
2024
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35. Clinical outcomes and anticoagulation therapy in elderly non‐valvular atrial fibrillation and heart failure patients.

Author

Ikeda, Shota, Hiasa, Ken‐ichi, Inoue, Hiroshi, Yamashita, Takeshi, Akao, Masaharu, Atarashi, Hirotsugu, Koretsune, Yukihiro, Okumura, Ken, Shimizu, Wataru, Suzuki, Shinya, Ikeda, Takanori, Toyoda, Kazunori, Hirayama, Atsushi, Yasaka, Masahiro, Yamaguchi, Takenori, Teramukai, Satoshi, Kimura, Tetsuya, Morishima, Yoshiyuki, Takita, Atsushi, and Tsutsui, Hiroyuki

Subjects
HEART failure, HEART failure patients, ATRIAL fibrillation, OLDER patients, OLDER people, ORAL medication
Abstract

Aims: Atrial fibrillation (AF) and heart failure (HF) often coexist. Older age is strongly associated with stroke, HF, and mortality. The association between coexistence of HF and a risk of clinical outcomes and the effectiveness of anticoagulation therapy including direct oral anticoagulants (DOACs) in elderly patients with AF and HF have not been investigated. We aimed to evaluate 2 years of outcomes and to elucidate the efficacy of DOACs or warfarin in elderly AF patients in the All Nippon AF In the Elderly (ANAFIE) Registry with and without a history of HF. Methods and results: The ANAFIE Registry is a multicentre, prospective observational study following elderly non‐valvular AF patients aged ≥75 years for 2 years. Hazard ratios (HRs) were calculated based on the presence or absence of an HF diagnosis and DOAC or warfarin use at enrolment. Among 32 275 eligible patients, 12 116 (37.5%) had been diagnosed with HF. Patients with HF had significantly higher rates of HF hospitalization or cardiovascular death (HR 1.94, P < 0.001), cardiovascular events (HR 1.59, P < 0.001), cardiovascular death (HR 1.49, P < 0.001), all‐cause death (HR 1.32, P < 0.001), and net clinical outcome including stroke/systemic embolism, major bleeding, and all‐cause death (HR 1.23, P < 0.001), compared with those without HF; however, HRs for stroke/systemic embolism (HR 0.96, P = 0.56) and major bleeding (HR 1.14, P = 0.13) were similar. DOAC use was associated with a low risk of stroke/systemic embolism (HR 0.86, P = 0.19 in HF; HR 0.79, P = 0.016 in non‐HF; P for interaction = 0.56), major bleeding (HR 0.71, P = 0.008 in HF; HR 0.75, P = 0.016 in non‐HF; P for interaction = 0.74), HF hospitalization or cardiovascular death (HR 0.81, P < 0.001 in HF; HR 0.78, P < 0.001 in non‐HF; P for interaction = 0.26), cardiovascular events (HR 0.83, P < 0.001 in HF; HR 0.82, P = 0.001 in non‐HF; P for interaction = 0.65), cardiovascular death (HR 0.84, P = 0.12 in HF; HR 0.75, P = 0.035 in non‐HF; P for interaction = 0.18), all‐cause death (HR 0.89, P = 0.082 in HF; HR 0.80, P = 0.001 in non‐HF; P for interaction = 0.091), and net clinical outcome (HR 0.88, P = 0.019 in HF; HR 0.81, P < 0.001 in non‐HF; P for interaction = 0.21) compared with warfarin, irrespective of the presence or absence of HF. Analysis using the propensity score matching method showed similar associations. Conclusions: Non‐valvular AF patients aged ≥75 years with a history of HF had higher risks of cardiovascular events and mortality. DOACs were favourable to warfarin regardless of the coexistence of HF. These results might encourage the use of DOACs in elderly patients with non‐valvular AF with or without HF. [ABSTRACT FROM AUTHOR]

Published
2024
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38. Trans-omic analysis reveals opposite metabolic dysregulation between feeding and fasting in liver associated with obesity

Author

Bai, Yunfan, primary, Morita, Keigo, additional, Kokaji, Toshiya, additional, Hatano, Atsushi, additional, Ohno, Satoshi, additional, Egami, Riku, additional, Pan, Yifei, additional, Li, Dongzi, additional, Yugi, Katsuyuki, additional, Uematsu, Saori, additional, Inoue, Hiroshi, additional, Inaba, Yuka, additional, Suzuki, Yutaka, additional, Matsumoto, Masaki, additional, Takahashi, Masatomo, additional, Yoshihiro, Izumi, additional, Bamba, Takeshi, additional, Hirayama, Akiyoshi, additional, Soga, Tomoyoshi, additional, and Kuroda, Shinya, additional

Published
2023
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40. Corrigendum to ‘Comprehension of Nonvalvular Atrial Fibrillation and Anticoagulant Adherence in Elderly Patients in a Subcohort Study of the All Nippon Atrial Fibrillation in the Elderly Registry’ The American Journal of Cardiology, Volume 204, 1 October 2023, Pages 159-167

Author

Akao, Masaharu, primary, Yamashita, Takeshi, additional, Atarashi, Hirotsugu, additional, Ikeda, Takanori, additional, Koretsune, Yukihiro, additional, Okumura, Ken, additional, Shimizu, Wataru, additional, Suzuki, Shinya, additional, Tsutsui, Hiroyuki, additional, Toyoda, Kazunori, additional, Hirayama, Atsushi, additional, Yasaka, Masahiro, additional, Yamaguchi, Takenori, additional, Teramukai, Satoshi, additional, Kimura, Tetsuya, additional, Morishima, Yoshiyuki, additional, Takita, Atsushi, additional, and Inoue, Hiroshi, additional

Published
2023
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41. Effect of SnO2 and Rh modifications on CO-stripping kinetics and ethanol oxidation mechanism of Pt electrode.

Author

Kien, Nguyen Trung, Ozaki, Ai, Chiku, Masanobu, Higuchi, Eiji, and Inoue, Hiroshi

Subjects
ETHANOL, OXIDATION kinetics, STANNIC oxide, DIRECT ethanol fuel cells, ELECTRODES
Abstract

Tin dioxide-modified Pt electrodes with different coverages ( θ SnO 2 ) were prepared by potentiostatically depositing tin on a Pt electrode in 0.1 M H2SO4 solutions containing various concentrations of SnCl2, followed by oxidizing in air. The θ SnO 2 was controlled by the SnCl2 concentration. The CO-stripping voltammogram of the Pt/SnO2 electrode with θ SnO 2 = 0.61 (Pt/SnO2(0.61)) exhibited two peaks, a prepeak due to the oxidation of adsorbed CO at Pt sites adjacent to SnO2 and a main peak due to that at Pt sites far from SnO2. In the kinetic analysis of both peaks using CO-stripping voltammograms at various sweep rates, the rate-determining steps for the prepeak and main peak were the coupling of adsorbed CO on Pt with OH on SnO2 surface by bifunctional effect and the dissociatively adsorption reaction of water to adsorbed OH on Pt, similar to the Pt electrode, respectively. In the linear sweep voltammograms of Pt/SnO2 electrodes in a (0.1 M HClO4 + 1 M ethanol) solution, the current for ethanol oxidation reaction (EOR) was the highest for θ SnO 2 = 0.61. The analysis of EOR products at different potentials for the Pt/SnO2(0.61) electrode by in situ infrared reflectance-absorption spectroscopy exhibited the Pt/SnO2(0.61) electrode facilitated acetic acid production. Moreover, rhodium was electrochemically deposited on the Pt sites adjacent to SnO2 using the limited CO-stripping technique. The area-controlled Rh deposition did not change the rate-determining steps of both peaks, but it not only enhanced EOR activity, but also decreased acetic acid selectivity and increased CO2 selectivity. [ABSTRACT FROM AUTHOR]

Published
2024
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42. Hepatic FASN deficiency differentially affects nonalcoholic fatty liver disease and diabetes in mouse obesity models

Author

Matsukawa, Toshiya, primary, Yagi, Takashi, additional, Uchida, Tohru, additional, Sakai, Mashito, additional, Mitsushima, Masaru, additional, Naganuma, Takao, additional, Yano, Hiroyuki, additional, Inaba, Yuka, additional, Inoue, Hiroshi, additional, Yanagida, Keisuke, additional, Uematsu, Masaaki, additional, Nakao, Kazuki, additional, Nakao, Harumi, additional, Aiba, Atsu, additional, Nagashima, Yoji, additional, Kubota, Tetsuya, additional, Kubota, Naoto, additional, Izumida, Yoshihiko, additional, Yahagi, Naoya, additional, Unoki-Kubota, Hiroyuki, additional, Kaburagi, Yasushi, additional, Asahara, Shun-ichiro, additional, Kido, Yoshiaki, additional, Shindou, Hideo, additional, Itoh, Michiko, additional, Ogawa, Yoshihiro, additional, Minami, Shiro, additional, Terauchi, Yasuo, additional, Tobe, Kazuyuki, additional, Ueki, Kohjiro, additional, Kasuga, Masato, additional, and Matsumoto, Michihiro, additional

Published
2023
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47. Relationship Between Direct Oral Anticoagulant Doses and Clinical Outcomes in Elderly Patients With Non-Valvular Atrial Fibrillation ― ANAFIE Registry Sub-Analysis ―

Author

Akao, Masaharu, primary, Inoue, Hiroshi, additional, Yamashita, Takeshi, additional, Atarashi, Hirotsugu, additional, Ikeda, Takanori, additional, Koretsune, Yukihiro, additional, Okumura, Ken, additional, Suzuki, Shinya, additional, Tsutsui, Hiroyuki, additional, Toyoda, Kazunori, additional, Hirayama, Atsushi, additional, Yasaka, Masahiro, additional, Yamaguchi, Takenori, additional, Teramukai, Satoshi, additional, Kimura, Tetsuya, additional, Morishima, Yoshiyuki, additional, Takita, Atsushi, additional, and Shimizu, Wataru, additional

Published
2023
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