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Abstract Wildfires can produce large plumes of smoke that are transported across vast distances, altering nutrient cycling of undisturbed watersheds exposed downwind. To date, wildfire smoke influence on stream biogeochemical signatures remains an important knowledge gap. Here we evaluate the impacts of wildfire smoke on phosphorus (P) biogeochemical cycling in a temperate watershed in the Finger Lakes Region of Central New York located downwind from record setting Canadian forest fires during the summer of 2023. Daily sampling of stream and rainwaters was conducted over the 2 month smoke period, generating a robust geochemical dataset. Stream dissolved P showed high sensitivity to smoke events, attaining concentrations 2–3 × greater than the pre-smoke period. Subsequent rain events after smoke deposition were identified as a potentially important factor in magnitude and timing of dissolved P responses. These findings demonstrate the capacity for wildfire smoke to trigger rapid, observable changes to stream P chemistry.

Psychedelic compounds have displayed antidepressant potential in both humans and rodents. Despite their promise, psychedelics can induce undesired effects that pose safety concerns and limit their clinical scalability. The rational development of optimized psychedelic-related medicines will require a full mechanistic understanding of how these molecules produce therapeutic effects. While the hallucinogenic properties of psychedelics are generally attributed to activation of serotonin 2A receptors (5-HT2ARs), it is currently unclear if these receptors also mediate their antidepressant effects as several nonhallucinogenic analogues of psychedelics with antidepressant-like properties have been developed. Moreover, many psychedelics exhibit promiscuous pharmacology, making it challenging to identify their primary therapeutic target(s). Here, we use a combination of pharmacological and genetic tools to demonstrate that activation of 5-HT2A receptors is essential for tryptamine-based psychedelics to produce antidepressant-like effects in rodents. Our results suggest that psychedelic tryptamines can induce hallucinogenic and therapeutic effects through activation of the same receptor.

Marla C Dubinsky,1 Louise Newton,2 Laure Delbecque,3 Theresa Hunter,4 Aiste Guobyte,5 April N Naegeli,4 Shehan McFadden,5 Jill Donaldson,6 Tara Symonds,2 James D Lewis7 1Icahn School of Medicine, Mount Sinai, NY, USA; 2Clinical Outcomes Solutions, Folkestone, UK; 3Eli Lilly and Company, Brussels, Belgium; 4Eli Lilly and Company, Indianapolis, IN, USA; 5Clinical Outcomes Solutions, Chicago, IL, USA; 6Crohn’s and Colitis Foundation, New York, NY, USA; 7Perelman School of Medicine, Division of Gastroenterology and Hepatology, University of Pennsylvania, Philadelphia, PA, USACorrespondence: Laure Delbecque, Principal Research Scientist, Eli Lilly and Company, Brussels, Belgium, Tel +32 (0)499 72 31 37, Email delbecque_laure@lilly.comPurpose: Achieving and maintaining symptom control is a key treatment goal in ulcerative colitis (UC). Bowel urgency is an important symptom of UC, thus measurement of urgency is critical. This research explored the patient experience of UC and “remission” in UC, with a focus on urgency, and cognitively debriefed the Urgency Numeric Rating Scale (NRS), including score interpretation and examination of meaningful improvement.Patients and Methods: Semi-structured hybrid concept elicitation and cognitive debriefing interviews with adults with moderately-severely active UC were conducted to explore experiences of UC and urgency, as well as examine meaningful improvement and score interpretation of the Urgency NRS. Purposive sampling was used to identify 20 eligible adult participants with UC. Concept elicitation data were analyzed using thematic analysis, and a deductive approach was used to analyze cognitive debriefing data. Thematic analysis was also applied to meaningful change-related data.Results: Twenty participants were interviewed (average age = 42.6 years old, 50% male); 14 with moderately active (70.0%) and 6 with severely active UC (30.0%). Disease remission was not consistently defined by participants and description varied in terms of definition (absence vs not complete absence of symptoms), duration (months vs days) and key symptoms to consider. Urgency was a prominent symptom for all participants, with 8 (40.0%) identifying it as the most bothersome aspect of UC. No issues were identified with the Urgency NRS. Participants were able to define different levels of urgency severity, describe how they relate to daily life impacts, and score them differently on the Urgency NRS. Participants were also able to reflect urgency improvement on the NRS and discuss how small changes in numeric ratings of urgency can reflect meaningful change in the symptom burden of their UC.Conclusion: The Urgency NRS is a content valid and interpretable measure to assess bowel urgency severity.Keywords: ulcerative colitis, qualitative, bowel urgency, content validity

We present deep, sub-arcsecond (⁠|$\sim$| 2000 au) resolution ALMA 0.82-mm observations of the former high-mass prestellar core candidate G11.92–0.61 MM2, recently shown to be an |$\sim$| 500 au-separation protobinary. Our observations show that G11.92–0.61 MM2, located in the G11.92–0.61 protocluster, lies on a filamentary structure traced by 0.82-mm continuum and N |$_2$| H |$^+$| (4-3) emission. The N |$_2$| H |$^+$| (4-3) spectra are multipeaked, indicative of multiple velocity components along the line of sight. To analyse the gas kinematics, we performed pixel-by-pixel Gaussian decomposition of the N |$_2$| H |$^+$| spectra using scousepy and hierarchical clustering of the extracted velocity components using acorns. Seventy velocity- and position-coherent clusters (called 'trees') are identified in the N |$_2$| H |$^+$| -emitting gas, with the eight largest trees accounting for |$\gt $| 60 per cent of the fitted velocity components. The primary tree, with |$\sim$| 20 per cent of the fitted velocity components, displays a roughly north–south velocity gradient along the filamentary structure traced by the 0.82-mm continuum. Analysing an |$\sim$| 0.17 pc-long substructure, we interpret its velocity gradient of |$\sim$| 10.5 km s |$^{-1}$|  pc |$^{-1}$| as tracing filamentary accretion towards MM2 and estimate a mass inflow rate of |$\sim 1.8\times 10^{-4}$| to 1.2 |$\times 10^{-3}$|  M |$_\odot$| yr |$^{-1}$|⁠. Based on the recent detection of a bipolar molecular outflow associated with MM2, accretion on to the protobinary is ongoing, likely fed by the larger scale filamentary accretion flows. If 50 per cent of the filamentary inflow reaches the protostars, each member of the protobinary would attain a mass of 8 M |$_\odot$| within |$\sim 1.6\times 10^5$| yr, comparable to the combined time-scale of the 70- μ m- and mid-infrared-weak phases derived for ATLASGAL-TOP100 massive clumps using chemical clocks. [ABSTRACT FROM AUTHOR]

Abstract Noncompliance is a central challenge for conservation, but in settings with limited access to behavioral data, it can be difficult to evaluate what drives compliance. Conservationists can measure and evaluate resource users' attitudes, and in so doing, leverage a complementary, nonbehavioral measure for evaluating compliance. In Greenland, wild Atlantic salmon (Salmo salar) fishers are under increasing regulatory pressure to report salmon catch because the majority of North Atlantic salmon stocks are classified as suffering. The objective of this study is to measure salmon catch reporting compliance, reporting behavior, and attitudes toward Greenland's salmon management. We surveyed Greenland's licensed salmon fishers, used an unmatched count technique to estimate the incidence of underreporting salmon catch, and linked salmon fishers' actual catch reports to their survey responses. In 2019, more than 84% of salmon fishers reported their catch and demonstrating high levels of compliance. We also found that salmon fishers did not indicate strong instrumental motivations for reporting, but exhibited moral obligations and normative, legitimacy‐based motivations to report catch. Salmon fishers found regulations to be fair, and that regulatory authorities were professional and acted honestly. Catch underreporting was also remarkably low, with 90–94% of respondents stating that they report all their catch. Joining together individuals' attitudinal and behavioral responses to conservation rules illustrates the benefits and limitations of expanding actor‐based theories of compliance. This case of already high levels of compliance offers empirical evidence for further improving fisheries compliance, and it also illustrates the limitations that fishery managers face when conserving a highly migratory species.

This paper proposes a novel origami-inspired adult diaper design that improves discretion by reducing sag and increasing wicking across the entire diaper pad. While other diapers rely on supporting elastics to reduce the sag of the diaper as a whole, this paper proposes an absorbent core that uses liquid activated shaping to take a specified shape. Origami-based folds are also incorporated into the diaper design to increase wicking performance. The paper introduces a disposable compliant mechanism waistband used to deploy the diaper, making it easier to put onto one’s body.

Waste PCBs the core of e‐waste is rich in copper, tin, zinc, iron, and nickel. Leaching base metals from PCB used to be done in toxic, corrosive acidic/alkali mediums. In this work, an environmentally friendly method for leaching metals from thermally treated PCBs (TPCBs) of mobile phones was proposed using choline chloride based deep eutectic solvents (DES). DES selectivity and solubility of metals from metal oxides were the main screening criteria. FA−ChCl had the maximum solubility of Cu, Fe, and Ni, while Urea−ChCl had high Zn selectivity and solubility. Oxalic acid has high selectivity for Sn. FA−ChCl extracted Cu and Fe best at 16 h, 100 °C, and 1/30 g/mL. Urea−ChCl extracted Zn (90.4±2.9 %) from TPCBs at 100 °C, 21 h, 1/20 g/mL, and 400 rpm. Oxalic acid (1 M) removed 92.3±2.1 % Sn from TPCBs in 1 h at 80 °C and 1/20 g/mL. The shrinking core model‐based kinetic investigation of FA−ChCl for Cu extraction showed a diffusion‐controlled process. The proposed method is greener than mineral acids utilized for metal extraction. [ABSTRACT FROM AUTHOR]

Novel metal oxide nanoparticle (NP) contrast agents may offer safety and functionality advantages over conventional gadolinium-based contrast agents (GBCAs) for cancer diagnosis by magnetic resonance imaging. However, little is known about the behavior of metal oxide NPs, or of their effect, upon coming into contact with the innate immune system. As neutrophils are the body’s first line of defense, we sought to understand how manganese oxide and iron oxide NPs impact leukocyte functionality. Specifically, we evaluated whether contrast agents caused neutrophils to release web-like fibers of DNA known as neutrophil extracellular traps (NETs), which are known to enhance metastasis and thrombosis in cancer patients. Murine neutrophils were treated with GBCA, bare manganese oxide or iron oxide NPs, or poly(lactic-co-glycolic acid) (PLGA)-coated metal oxide NPs with different incorporated levels of poly(ethylene glycol) (PEG). Manganese oxide NPs elicited the highest NETosis rates and had enhanced neutrophil uptake properties compared to iron oxide NPs. Interestingly, NPs with low levels of PEGylation produced more NETs than those with higher PEGylation. Despite generating a low rate of NETosis, GBCA altered neutrophil cytokine expression more than NP treatments. This study is the first to investigate whether manganese oxide NPs and GBCAs modulate NETosis and reveals that contrast agents may have unintended off-target effects which warrant further investigation.

Electronic cigarettes are frequently viewed as a safer alternative to conventional cigarettes; however, evidence to support this perspective has not materialized. Indeed, the current literature reports that electronic cigarette use is associated with both acute lung injury and subclinical dysfunction to the lung and vasculature that may result in pathology following chronic use. E-cigarettes can alter vascular dynamics, polarize innate immune populations towards a proinflammatory state, compromise barrier function in the pulmonary endothelium and epithelium, and promote pre-oncogenic phenomena. This review will summarize the variety of e-cigarette products available to users, discuss current challenges in e-cigarette study design, outline the range of pathologies occurring in cases of e-cigarette associated acute lung injury, highlight disease supporting tissue- and cellular-level changes resulting from e-cigarette exposure, and briefly examine how these changes may promote tumorigenesis. Continued research of the mechanisms by which e-cigarettes induce pathology benefit users and clinicians by resulting in increased regulation of vaping devices, informing treatments for emerging diseases e-cigarettes produce, and increasing public awareness to reduce e-cigarette use and the onset of preventable disease.