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7. Contributors

Author

Martin R. Adams, Lilia Ahrné, Veslemøy Andersen, Diána Bánáti, Shai Barbut, Christopher H. Bell, Sarah Blanchard, Dijana Blazekovic-Dimovska, Arnaud Bouxin, Wolfram M. Brück, Pablo A. Carrión, Suchart Chaven, Daniele Chieffi, Stella Cochrane, René Crevel, Carlos de la Cruz García, Ana Maria de Roda Husman, Tibor Deak, Patricia Desmarchelier, Arnold F. Dijkstra, Pedro Elez-Martínez, Francesca Fanelli, Vincenzina Fusco, Wentzel C.A. Gelderblom, Alireza Ghiasi, Christopher J. Griffith, Lara Hanna-Wakim, Marta Hernandez-Jover, John Holah, Serge Imboden, Aline Issa, Tim Jackson, Christian James, Stephen J. James, Tibor Janči, Jelena Jovicic-Petrovic, Jacques Kastelein, Igor S. Kljujev, Gisela Kopper, Blazo T. Lalevic, Huub Lelieveld, Cheng Liu, Friedrich-Karl Lücke, Nikos Manouselis, A. Robert Marsellés-Fontanet, Olga Martín-Belloso, Slavko Mirecki, Ned Mitenius, Frank Moerman, Csilla Mohácsi-Farkas, Gloria Sánchez Moragas, Sara Mortimore, Yasmine Motarjemi, Gerald G. Moy, David Nordqvist, Mikko Nuutinen, Thomas Ohlsson, Abenaa A. Okyere, Peter Overbosch, Marjana Peterman, Vlasta Piližota, Vera B. Raicevic, John P. Rheeder, Timothy Rugh, Robert Ryther, Shridhar K. Sathe, Gerhard Schleining, F. Tracy Schonrock, Gordon S. Shephard, Alexandrina Sîrbu, Robert Soliva-Fortuny, Gerrit J.A. Speijers, Marijntje H.M. Speijers-Lafferty, Giannis Stoitsis, Stojmir Stojanovski, Rick Stokes, John Y.H. Tang, Remy Tenud, Gry Carl Terrell, Marianne Thomsen, Ewen C.D. Todd, Jennifer van de Ligt, Gerrit van Duijn, Nina Veflen, Humberto Vega-Mercado, Sanja Vidaček Filipec, Iuliana Vintilă, Carol A. Wallace, Benjamin R. Warren, Anett Winkler, Marc Bou Zeidan, and Tanja Pajk Žontar

Published
2023
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8. Handbook of Cell and Gene Therapy : From Proof-of-Concept Through Manufacturing to Commercialization

Author

Hazel Aranha, Humberto Vega-Mercado, Hazel Aranha, and Humberto Vega-Mercado

Subjects
Cellular therapy--Research--Handbooks, manuals, etc, Gene therapy--Research--Handbooks, manuals, etc, Cellular therapy--Handbooks, manuals, etc, Gene therapy--Handbooks, manuals, etc
Abstract

This handbook provides an in-depth review of information across the developmental spectrum of gene and cell therapy products. From introductory information to state-of-the-art technologies and concepts, the book provides insights into upstream processes such as vector design and construction, purification, formulation and fill/finish, as well as delivery options. Planning steps for compliance with current good manufacturing practice (cGMP) to readiness for chemistry, manufacturing and controls (CMC) are also discussed. This book wraps up with examples of successes and pitfalls addressed by experts who have navigated the multiple challenges that are part of any innovative endeavor.Features Provides the most up-to-date information on the development of gene therapy, from the technology involved to gene correction and genome editing Discusses siRNA, mRNA, and plasmid manufacturing Describes the importance of supplier-sponsor synergies on the path to commercialization Written for a diverse audience with a large number of individuals in the core technologies and supportive practices It is intended as a one-stop resource for the availability of state-of-the-art information related to cell and gene therapy products for researchers, scientists, management and other academic and research institutions.

Published
2023

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