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Abstract The methods of QCD sum rules and light-cone sum rules within the framework of heavy quark effective theory have been widely applied to study the singly heavy baryons, and especially, we have applied these methods to predict not only the mass and width of the $$\varXi _b(6087)^0$$ Ξ b ( 6087 ) 0 recently discovered by LHCb, but also its observation channel and its mass difference from the $$\varXi _b(6100)^-$$ Ξ b ( 6100 ) - . We apply the same approach to perform a complete study on the P-wave bottom baryons of the SU(3) flavor $${\bar{\textbf{3}}}_F$$ 3 ¯ F and investigate their fine structure. Besides the $$\varLambda _b(5912)^0$$ Λ b ( 5912 ) 0 , $$\varLambda _b(5920)^0$$ Λ b ( 5920 ) 0 , $$\varXi _b(6087)^0$$ Ξ b ( 6087 ) 0 , and $$\varXi _b(6100)^-$$ Ξ b ( 6100 ) - , our results suggest the existence of the other two $$\varLambda _b$$ Λ b and two $$\varXi _b$$ Ξ b baryons, whose widths are limited. They are the $$\varLambda _b(J^P = 3/2^-)$$ Λ b ( J P = 3 / 2 - ) with the mass and width about $$(5.93^{+0.13}_{-0.13}~\textrm{GeV},\,0.0^{+12.0}_{-~0.0}~\textrm{MeV})$$ ( 5 . 93 - 0.13 + 0.13 GeV , 0 . 0 - 0.0 + 12.0 MeV ) , the $$\varLambda _b(5/2^-)$$ Λ b ( 5 / 2 - ) with $$(5.94^{+0.13}_{-0.13}~\textrm{GeV},\,\approx 0~\textrm{MeV})$$ ( 5 . 94 - 0.13 + 0.13 GeV , ≈ 0 MeV ) , the $$\varXi _b(3/2^-)$$ Ξ b ( 3 / 2 - ) with $$(6.10^{+0.15}_{-0.10}~\textrm{GeV},\, 1.4{^{+11.6}_{-~1.4}}~\textrm{MeV})$$ ( 6 . 10 - 0.10 + 0.15 GeV , 1.4 - 1.4 + 11.6 MeV ) , and the $$\varXi _b(5/2^-)$$ Ξ b ( 5 / 2 - ) with $$(6.11^{+0.15}_{-0.10}~\textrm{GeV},\,1.0{^{+7.4}_{-1.0}}~\textrm{MeV})$$ ( 6 . 11 - 0.10 + 0.15 GeV , 1.0 - 1.0 + 7.4 MeV ) . Their mass splittings are calculated to be $$M_{\varLambda _b(5/2^-)} - M_{\varLambda _b(3/2^-)} = 17\pm 7~\textrm{MeV}$$ M Λ b ( 5 / 2 - ) - M Λ b ( 3 / 2 - ) = 17 ± 7 MeV and $$M_{\varXi _b(5/2^-)} - M_{\varXi _b(3/2^-)} = 14\pm 7~\textrm{MeV}$$ M Ξ b ( 5 / 2 - ) - M Ξ b ( 3 / 2 - ) = 14 ± 7 MeV . All these baryons are explained as the P-wave bottom baryons of the $$\rho $$ ρ -mode, where the orbital excitation is between the two light quarks. However, the existence of this mode is still controversial, so their experimental searches can verify both our approach and the existence of the $$\rho $$ ρ -mode, which can significantly improve our understanding on the internal structure of hadrons.

Abstract Background Williams syndrome is an autosomal dominant multisystem disorder caused by a 1.5–1.8 Mb deletion on chromosome 7q11.23. It is characterized by facial deformations, cardiovascular abnormalities, developmental delays, gastrointestinal manifestations, and endocrine disorders. Case description A 1‐year‐old child presenting with developmental delays, special facial features, gastrointestinal bleeding, renal calcium deposition, and hypotonia was admitted to the hospital for “hypercalcemia and gastrointestinal bleeding.” Genetic testing showed a deletion mutation in the 7q11.23 region. Currently, the child receiving treatment to promote calcium excretion and rehabilitation training, but hypercalcemia has recurred. Conclusion The clinical phenotype of Williams syndrome is complex, and different severities, characterized by developmental delays, facial deformities, cardiovascular abnormalities, gastrointestinal symptoms and endocrine disorders, should be considered in children. The syndrome may require thorough genetic testing for diagnosis and early intervention treatment to improve patient quality of life.

BackgroundRecurrence is considered a vital problem for assessing the prognosis of Henoch–Schonlein purpura (HSP). The objective of this study was to evaluate factors affecting the recurrence in children with HSP.MethodsWe retrospectively reviewed records of 368 patients under the age of 16 years diagnosed with HSP from October 2019 to December 2020 in Beijing Children's Hospital. Patients were divided into a non-recurrence group and a recurrence group according to whether there was a recurrence. Incidence of manifestation, possible cause, age, and treatment were retrospectively analyzed. Univariate and multivariate logistic regression analyses were used to determine the risk factors of recurrence in HSP.ResultsPercentages of patients were 65.2% for the non-recurrence group and 34.8% for the recurrence group. The percentage of patients with renal involvement was significantly higher in the recurrence group (40.6%) than in the non-recurrence group (26.3%). Respiratory tract infection was the most frequent trigger: 67.5% in the non-recurrence group and 66.4% in the recurrence group. Recurrence was more likely to occur in patients aged >6 years (53.3% vs. 71.9%). Logistic regression analysis revealed that hematuria plus proteinuria was an independent risk factor for the recurrence of HSP. Conversely, animal protein, exercise restriction, and age ≤6 years were independent favorable factors for the non-recurrence of HSP.ConclusionThese results suggest that organ involvement, exercise, and diet management during the initial episode of HSP should be strictly monitored for children with HSP. Adequate clinical intervention for these risk factors may limit or prevent HSP recurrence. Moreover, renal involvement is associated with the long-term prognosis of HSP.

Studies have shown that teachers’ wellbeing has a positive effect on teachers’ learning quality and learners’ performance. Nevertheless, teaching is a stressful and exhausting profession at all academic level with special difficulties about the nature of language education. Tension and fear are still classic challenges in learning, though the concepts such as hope and optimism are core issues in assisting teachers to feel happy during instruction and work longer. The present review makes efforts to provide the most current confirmation on the interface of hope and optimism with educational issues since they are progressively documented as significant emotional capitals for educational success, job growth, and presentation. It is worth mentioning that the current review of research can benefit educational administrations, and other stakeholders and officials in the educational community to contemplate the functions of constructive emotions in the process of learning to decrease and even diminish stress and apprehension that consequently lead to flourishing.

Background and Aim: Patients suspected of Alpha 1-Antitrypsin (A1AT) abnormality based on low serum concentration are routinely confirmed through polymerase chain reaction (PCR) testing of peripheral blood. Genotyping formalin- fixed paraffin-embedded (FFPE) tissue is a novel approach that could aid in detecting variant A1AT. We performed qPCR on FFPE liver explants with Periodic Acid Schiff after Diastase (PASD)- and A1AT-positive globules to confirm and estimate the frequency of A1AT deficiency in transplant cases. Materials and Methods: Eighteen (12.68%) of 142 patients with end-stage liver disease showed PASD/A1AT positive globules. FFPE of the explants was tested through qPCR to detect S and Z alleles. A second age- and sex-matched control group consisting of five liver transplant patients with negative globules was included in the study. Results: qPCR assay was successful with all the samples meeting QC parameters. All patients included in the study elucidated Z allele variants; 2 homozygous (11.1%) and 16 heterozygous (88.9%). The control group demonstrated normal wild-type MM allele. Conclusion: Screening for A1AT deficiency using serum levels is not sufficiently sensitive to detect deficiency, especially in carriers. If A1AT testing was not performed preoperatively and the risk is high based on the PASD/ A1AT-positive globules in the explants, then molecular testing of FFPE tissue can be a viable method for confirming the diagnosis. [ABSTRACT FROM AUTHOR]