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4 results on '"Huber, Gabriela"'

2. Helena’s Many Daughters: More Mitogenome Diversity behind the Most Common West Eurasian mtDNA Control Region Haplotype in an Extended Italian Population Sample

Author

Bodner, Martin; https://orcid.org/0000-0002-3870-9862, Amory, Christina, Olivieri, Anna; https://orcid.org/0000-0002-3941-8098, Gandini, Francesca, Cardinali, Irene; https://orcid.org/0000-0003-0632-9993, Lancioni, Hovirag; https://orcid.org/0000-0001-5514-1853, Huber, Gabriela, Xavier, Catarina; https://orcid.org/0000-0003-3522-1631, Pala, Maria, Fichera, Alessandro, Schnaller, Lisa, Gysi, Mario; https://orcid.org/0000-0002-4649-534X, Sarno, Stefania, Pettener, Davide, Luiselli, Donata; https://orcid.org/0000-0003-2105-2478, Richards, Martin B; https://orcid.org/0000-0003-3118-0967, Semino, Ornella; https://orcid.org/0000-0002-9675-9403, Achilli, Alessandro; https://orcid.org/0000-0001-6871-3451, Torroni, Antonio, Parson, Walther; https://orcid.org/0000-0002-5692-2392, Bodner, Martin; https://orcid.org/0000-0002-3870-9862, Amory, Christina, Olivieri, Anna; https://orcid.org/0000-0002-3941-8098, Gandini, Francesca, Cardinali, Irene; https://orcid.org/0000-0003-0632-9993, Lancioni, Hovirag; https://orcid.org/0000-0001-5514-1853, Huber, Gabriela, Xavier, Catarina; https://orcid.org/0000-0003-3522-1631, Pala, Maria, Fichera, Alessandro, Schnaller, Lisa, Gysi, Mario; https://orcid.org/0000-0002-4649-534X, Sarno, Stefania, Pettener, Davide, Luiselli, Donata; https://orcid.org/0000-0003-2105-2478, Richards, Martin B; https://orcid.org/0000-0003-3118-0967, Semino, Ornella; https://orcid.org/0000-0002-9675-9403, Achilli, Alessandro; https://orcid.org/0000-0001-6871-3451, Torroni, Antonio, and Parson, Walther; https://orcid.org/0000-0002-5692-2392

Abstract

The high number of matching haplotypes of the most common mitochondrial (mt)DNA lineages are considered to be the greatest limitation for forensic applications. This study investigates the potential to solve this constraint by massively parallel sequencing a large number of mitogenomes that share the most common West Eurasian mtDNA control region (CR) haplotype motif (263G 315.1C 16519C). We augmented a pilot study on 29 to a total of 216 Italian mitogenomes that represents the largest set of the most common CR haplotype compiled from a single country. The extended population sample confirmed and extended the huge coding region diversity behind the most common CR motif. Complete mitogenome sequencing allowed for the detection of 163 distinct haplotypes, raising the power of discrimination from 0 (CR) to 99.6% (mitogenome). The mtDNAs were clustered into 61 named clades of haplogroup H and did not reveal phylogeographic trends within Italy. Rapid individualization approaches for investigative purposes are limited to the most frequent H clades of the dataset, viz. H1, H3, and H7.

Published
2022

3. Helena’s Many Daughters: More Mitogenome Diversity behind the Most Common West Eurasian mtDNA Control Region Haplotype in an Extended Italian Population Sample

Author

Bodner, Martin, primary, Amory, Christina, additional, Olivieri, Anna, additional, Gandini, Francesca, additional, Cardinali, Irene, additional, Lancioni, Hovirag, additional, Huber, Gabriela, additional, Xavier, Catarina, additional, Pala, Maria, additional, Fichera, Alessandro, additional, Schnaller, Lisa, additional, Gysi, Mario, additional, Sarno, Stefania, additional, Pettener, Davide, additional, Luiselli, Donata, additional, Richards, Martin B., additional, Semino, Ornella, additional, Achilli, Alessandro, additional, Torroni, Antonio, additional, and Parson, Walther, additional

Published
2022
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4. Helena's Many Daughters: More Mitogenome Diversity behind the Most Common West Eurasian mtDNA Control Region Haplotype in an Extended Italian Population Sample

Author

Martin Bodner, Christina Amory, Anna Olivieri, Francesca Gandini, Irene Cardinali, Hovirag Lancioni, Gabriela Huber, Catarina Xavier, Maria Pala, Alessandro Fichera, Lisa Schnaller, Mario Gysi, Stefania Sarno, Davide Pettener, Donata Luiselli, Martin B. Richards, Ornella Semino, Alessandro Achilli, Antonio Torroni, Walther Parson, Bodner, Martin, Amory, Christina, Olivieri, Anna, Gandini, Francesca, Cardinali, Irene, Lancioni, Hovirag, Huber, Gabriela, Xavier, Catarina, Pala, Maria, Fichera, Alessandro, Schnaller, Lisa, Gysi, Mario, Sarno, Stefania, Pettener, Davide, Luiselli, Donata, Richards, Martin B, Semino, Ornella, Achilli, Alessandro, Torroni, Antonio, Parson, Walther, and University of Zurich

Subjects
1503 Catalysis, mtDNA haplogroup, 340 Law, 1607 Spectroscopy, mtDNA haplogroup H, 610 Medicine & health, Pilot Projects, DNA, Mitochondrial, Catalysis, Nuclear Family, Inorganic Chemistry, 1312 Molecular Biology, 1706 Computer Science Applications, power of discrimination, Physical and Theoretical Chemistry, Molecular Biology, Spectroscopy, massively parallel sequencing, next-generation sequencing, forensics, most common haplotype, random match probability, 1604 Inorganic Chemistry, Organic Chemistry, General Medicine, Sequence Analysis, DNA, forensic, 10218 Institute of Legal Medicine, Computer Science Applications, Genetics, Population, Haplotypes, Genome, Mitochondrial, 1606 Physical and Theoretical Chemistry, 1605 Organic Chemistry
Abstract

The high number of matching haplotypes of the most common mitochondrial (mt)DNA lineages are considered to be the greatest limitation for forensic applications. This study investigates the potential to solve this constraint by massively parallel sequencing a large number of mitogenomes that share the most common West Eurasian mtDNA control region (CR) haplotype motif (263G 315.1C 16519C). We augmented a pilot study on 29 to a total of 216 Italian mitogenomes that represents the largest set of the most common CR haplotype compiled from a single country. The extended population sample confirmed and extended the huge coding region diversity behind the most common CR motif. Complete mitogenome sequencing allowed for the detection of 163 distinct haplotypes, raising the power of discrimination from 0 (CR) to 99.6% (mitogenome). The mtDNAs were clustered into 61 named clades of haplogroup H and did not reveal phylogeographic trends within Italy. Rapid individualization approaches for investigative purposes are limited to the most frequent H clades of the dataset, viz. H1, H3, and H7.

Published
2022

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