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Cation-disordered rock-salt cathode material is a promising material for next-generation lithium-ion batteries due to their extra-high capacities. However, the drawbacks of large first-cycle irreversible capacity loss, severe capacity decay, and lower discharge voltage have undoubtedly hindered their application in commercial systems. In this study, cation doping (Mo4+) and atomic layer deposition (ALD) techniques were used to synthetically modify the Li1.2Ti0.4Mn0.4O2 (LTMO) material to improve the cycling stability. First, the optimal Mo-doped sample (Mo01) with the best electrochemical performance among the different doping amounts was selected for further study. Second, the selected sample was subsequently coated with an Al2O3 layer by the ALD technique to further optimize its electrochemical performance. Results show that the LTMMO/24Al2O3 sample, under optimal conditions, could obtain a specific discharge capacity of up to 228.4 mAh g−1 after 30 cycles, which is much higher than that of the unmodified LTMO cathode material. Our work has provided a new possible solution to address some of the capacity fading issues related to the cation-disordered rock-salt cathode materials. [ABSTRACT FROM AUTHOR]

This work aimed to find the association of mixed-type histology and prognosis of T2/T3 GC patients. Eligible T2/T3 gastric cancer patients at our institution were identified. The histological types and risk factors affecting OS were examined. Survival differences were assessed by log-rank tests and Kaplan–Meier curves. The study identified 972 T2/T3 gastric cancer patients, including 283 differentiated-type patients, 544 undifferentiated-type patients and 145 mixed type. Mixed-type histology was associated with shorter 5-year OS (DT vs UDT vs MT:57.5% vs 44.9% vs 39.6%, P = 0.002). MT histology can be predictive for prognosis of T2/T3 GC patients (HR for OS: 1.386, 95% CI: 1.028–1.868, P = 0.032), and its malignant potential is not inferior to UDT. In the subgroup analysis, MT can potentially be independent risk factor for non-distal GC patients (P = 0.010). This study reported that mixed histology could be regarded as a potential prognostic factor for T2/T3 gastric cancer patients, especially for those with non-distal cancer. MT patients have higher incidence of metastasis and recurrence and had poorer prognosis than those with pure histological type. It is necessary for MT patients to have preoperative pathological examination for accurate histologic classification, so as to make the comprehensive treatment strategies.. [ABSTRACT FROM AUTHOR]

Long noncoding RNAs (lncRNAs) are a type of regulatory molecule with potential roles in the development of several different malignancies. However, the underlying mechanisms of lncRNAs in colorectal cancer (CRC) are incompletely understood. The present study investigated the molecular mechanism of LINC02038 in CRC. LINC02038 expression was decreased in CRC tissues compared to the para‑cancerous tissues and LINC02038 overexpression markedly reduced the proliferation, vitality, migration and invasive ability and greatly accelerated apoptosis of colorectal cancer cells. Bioinformatics examination indicated that LINC02038 may have targeted microRNA (miR)‑552‑5p. RNA immunoprecipitation and luciferase reporter assays showed that LINC02038 served as a sponge for miR‑552‑5p, hindering target gene FAM172A of miR‑552‑5p degradation. Moreover, methylated RNA immunoprecipitation (MeRIP)‑qualitative PCR assays revealed that YTHDF2 could identify and regulate the METTL3‑mediated LINC02038 N6‑methyladenosine (m 6 A) modification and increase its degradation, thereby promoting CRC progression via the PI3K/AKT pathway. Based on the CRC clinical specimens, it was shown that LINC02038 was negatively associated with lymphatic metastasis and distant metastasis. These results revealed that m 6 A/LINC02038/miR‑552‑5p/FAM172A may be a novel anti‑tumor axis and LINC02038 may serve as a biomarker and treatment option for colorectal cancer.