24 results on '"Hilbe M"'
Search Results
2. Was ist Ihre Diagnose?
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Stephan, R., Ramsauer, A. Sophie, Thür, B., Schlatter, A., and Hilbe, M.
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- 2024
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3. A combined approach for detection of small ruminant retrovirus co-infections
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Rosato, G., primary, Abril, C., additional, Hilbe, M., additional, and Seehusen, F., additional
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- 2023
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4. Virus discovery in dogs with non-suppurative encephalitis reveals a high incidence of tick-borne encephalitis virus infections in Switzerland.
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Dawson, K. L. D., Wildi, N., Koch, M. C., Oevermann, A., Rosato, G., Grest, P., Hilbe, M., and Seuberlich, T.
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- 2023
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5. Ex vivo validation of delayed gadolinium-enhanced magnetic resonance imaging (MRI) of cartilage (dGEMRIC) and T2 mapping for quantifying cartilage thickness in normal and naturally occurred osteoarthritic distal interphalangeal joints using a high-field MRI
- Author
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Bischofberger, A S, primary, Fürst, R, additional, Fürst, A, additional, Hilbe, M, additional, Torgerson, P R, additional, and Kircher, P, additional
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- 2023
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6. Small intestinal incarceration caused by external herniation can be diagnosed clinically in cattle, but laparotomy is required to confirm internal incarceration.
- Author
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Braun U, Gerspach C, Bennien E, Hilbe M, and Nuss K
- Abstract
Objective: To describe the clinical, laboratory and ultrasonographic findings, treatment, and outcome of cattle with small intestinal incarceration (SII) through internal and external hernias., Methods: The medical records of 85 cattle with SII admitted between January 1, 1987, and December 31, 2019, were retrospectively reviewed. The long-term outcome was determined 2 years after discharge., Results: 85 cattle had herniation of the small intestine through congenital or acquired openings in mesentery or omentum (internal herniation; n = 60) or the abdominal wall (external herniation; 25). The most common findings were little or no feces in the rectum (77 of 85 [90.6%]), reduced or absent intestinal motility (76 of 85 [89.4%]), and hypocalcemia (36 of 44 [81.8%]). Thirteen (15.3%) cattle died or were euthanized without surgery. Of the remaining 72 (84.7%) cattle that underwent surgery, 42 survived the procedure. Overall, 52 of 85 cattle (61.2%; 95% CI, 50% to 72%) did not survive to hospital discharge and 33 (38.8%; 95% CI, 28% to 50%) were discharged alive. Of these, 11 (33.3%; 6 with and 5 without hernias closed completely) were still productive in their respective herds 2 years later., Conclusions: The diagnosis of an incarcerated external hernia is usually straightforward, whereas internal SII necessitates laparotomy or postmortem examination for a definitive diagnosis., Clinical Relevance: Internal herniation should be part of the differential diagnosis in cattle with signs of ileus. Immediate surgical treatment is paramount in cattle with SII.
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- 2024
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7. Quantifying Tendon Degeneration Using Magic Angle Insensitive Ultra-Short Echo Time Magnetization Transfer: A Phantom Study in Bovine Tendons.
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Feuerriegel GC, Marth AA, Goller SS, Hilbe M, Sommer S, and Sutter R
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- Animals, Cattle, Imaging, Three-Dimensional methods, Sensitivity and Specificity, Reproducibility of Results, Image Interpretation, Computer-Assisted methods, Phantoms, Imaging, Magnetic Resonance Imaging methods, Tendons diagnostic imaging, Tendons pathology
- Abstract
Objectives: The aim of this study was to qualitatively and quantitatively assess changes in bovine flexor tendons before and after collagen degradation and at different angles in relation to the static B 0 field using 3-dimensional ultra-short echo time (UTE) magnetization transfer (MT) imaging within a clinically feasible acquisition time., Materials and Methods: Eight bovine flexor tendons were examined at 3 T magnetic resonance imaging including 3-dimensional UTE MT and UTE T2* research application sequences (acquired within 4:04 and 6:38 minutes, respectively) before and after enzyme-induced degradation. The tendons were divided into 2 groups: group 1 (controls) treated with phosphate-buffered saline and group 2 treated with collagenase I to induce collagen degeneration. Magnetic resonance imaging was repeated at 0, 27, 55, and 90 degrees to the B 0 field. To calculate quantitative tissue properties, all tendons were semiautomatically segmented, and changes in quantitative UTE T2* and UTE MT ratios (MTRs) were compared at different angles and between groups. In addition to descriptive statistics, the coefficient of variation was calculated to compare UTE MT and UTE T2* imaging., Results: Ultra-short echo time MTR showed a significantly lower coefficient of variation compared with UTE T2* values, indicating a more robust imaging method (UTE MTR 9.64%-11.25%, UTE T2* 18.81%-24.06%, P < 0.001). Both methods showed good performance in detecting degenerated tendons using histopathology as reference standard, with UTE MT imaging having a better area under the curve than UTE T2* mapping (0.918 vs 0.865). Falsely high UTE T2* values were detected at the 55 degrees acquisition angle, whereas UTE MTR values were robust, that is, insensitive to the MAE., Conclusions: Ultra-short echo time MT imaging is a reliable method for quantifying tendon degeneration that is robust to the MAE and can be acquired in a clinically reasonable time., Competing Interests: Conflicts of interest and sources of funding: Balgrist University Hospital has an academic research agreement with Siemens Healthineers., (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.)
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- 2024
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8. Skeletal malformation in growing milk sheep.
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Gimmel A, Hochstrasser R, Hilbe M, Nuss K, and Liesegang A
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- Animals, Female, Sheep, Bone Density, Diet veterinary, Sheep Diseases pathology
- Abstract
Introduction: Two six-month old female Lacaune lambs with severe skeletal malformations of both front limbs were presented to the Department of Farm Animals, University of Zurich. The clinical examination showed alert animals with a high body weight and body condition score as well as a valgus deformation without pain or swelling. Radiographic examination showed severe irregularities in the epiphysial plate of the metacarpal bones in both lambs. Delayed growth in the lateral aspects of the physis was evident and resulted in valgus deformation. Nutritional causes were considered as the main reason for this presentation and a nutritional consultation was performed by the Institute of Animal Nutrition and Dietetics, University of Zurich. The estimated energy intake of these lambs was 65 % higher than the recommended maximum for growing sheep and the estimated vitamin D content of the diet was 71 % below the recommended allowance. Both animals were euthanized, and peripheral quantitative computed tomography (pQCT) was performed postmortem to measure total bone mineral density (BMD), trabecular bone mineral density (tBMD) and cortical bone mineral density (cBMD) of the left and right metatarsal bone of both animals. The BMD and the tBMD at 10 % of bone length were below the reference values and the BMD at 50 % was above the reference values. In addition, postmortem examination revealed a Salter-Harris-Typ-1 facture in the right caput humeri of one lamb. Histological evaluation showed defects in the articular cartilage with an eburnation in the metacarpal region and a disrupted area of columnar cartilage. This case report supports the fact that a high dietary energy intake leads to damage to the cartilage and the epiphyseal zone in sheep. In addition, insufficient dietary vitamin D intake contributed to the incomplete bone mineralization, as well as delayed growth and skeletal malformation.
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- 2024
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9. Exudative glomerulonephritis associated with acute leptospirosis in dogs.
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Hilbe M, Posthaus H, Paternoster G, Schuller S, Imlau M, and Jahns H
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- Animals, Dogs, Retrospective Studies, Male, Female, Switzerland, Immunohistochemistry veterinary, Leptospira interrogans isolation & purification, Acute Disease, Polymerase Chain Reaction veterinary, Antibodies, Bacterial blood, Leptospirosis veterinary, Leptospirosis pathology, Leptospirosis diagnosis, Leptospirosis microbiology, Dog Diseases pathology, Dog Diseases microbiology, Dog Diseases diagnosis, Glomerulonephritis veterinary, Glomerulonephritis pathology, Glomerulonephritis microbiology
- Abstract
In the past 20 years in Switzerland, dogs with suspect acute leptospirosis frequently showed severe glomerular changes that had not been previously reported. These features were characterized by abundant extravasated erythrocytes and fewer neutrophils accompanied by marked fibrin exudation into the urinary space that was interpreted as an exudative glomerulonephritis (GN). This retrospective study describes this significant glomerular pathological change and investigates the association with leptospirosis. Tissues from 50 dogs with exudative GN, retrieved from 2 pathology archives in Switzerland were reviewed using hematoxylin and eosin, periodic acid-Schiff, phosphotungstic acid-hematoxylin, and Warthin and Starry stains. Clinical and postmortem data were collected for each case. Immunohistochemistry (IHC) and/or polymerase chain reactions were used as confirmatory tests for leptospirosis. While all 50 cases had clinical and pathological features supporting a diagnosis of leptospirosis, 37 cases were confirmed for the disease. Using a LipL32 antibody in addition to the OMV2177 antibody raised against the lipopolysaccharide of Leptospira interrogans serovar Copenhageni increased the detection rate of Leptospira by IHC in exudative GN from 24% to 62%. Signalment, seasonality, clinical signs, blood results, and pathological changes in dogs with exudative GN were similar to those reported for dogs without GN and confirmed infection by Leptospira spp.. Exudative GN was common among Swiss dogs with leptospirosis where it caused acute severe disease. Leptospirosis should be considered as a cause of this new pathologic feature by the pathologist. The pathogenesis remains unclear, but involvement of a geographic-specific serovar with unique virulence factors is suspected and warrants further investigation., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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- 2024
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10. Torsion of the spiral colon in cattle- a retrospective analysis of 58 cases.
- Author
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Braun U, Gerspach C, Volz C, Hilbe M, and Nuss K
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- Cattle, Animals, Female, Pregnancy, Retrospective Studies, Colon, Cattle Diseases diagnosis, Ileus veterinary
- Abstract
Background: Torsion of the spiral colon (TSC) describes twisting of the spiral colon around its mesentery. The present study reviewed the medical records of 58 cows and heifers with TSC and described the findings, treatment and outcome., Results: All cases had an abnormal general condition, and the main vital sign abnormalities were tachycardia (72.4%), tachypnoea (67.2%) and decreased rectal temperature (51.8%). Signs of colic were seen in 62.1% of the cows. The most common intestinal abnormalities were an empty or almost empty rectum (96.6%), reduced or absent rumen motility (93.2%), positive ballottement and/or percussion and simultaneous auscultation on the right side of the abdomen (87.9%), reduced or absent intestinal motility (84.5%) and dilatation of the large intestines (spiral colon and/or caecum, 70.7%) diagnosed by transrectal palpation. The main biochemical changes were hypermagnesaemia (70.8%), hypocalcaemia (70.8%), and acidosis (66.7%). Haemoconcentration was found in 63.8%. The main ultrasonographic findings were reduced to absent small intestinal motility (83.3%), dilated small intestines (69.6%) and ascites (66.7%). The spiral colon was dilated in 44.0% of the cows and the caecum in 24.0%. The actual site of torsion could not be visualised. Based on the clinical findings, TSC was diagnosed in 22.4% and caecal dilatation in 50.0% of the cows. A tentative diagnosis of small intestinal ileus was made in another 10.3% of the cows, and a definitive diagnosis of small intestinal ileus in 17.3%. Fifty-three cows underwent right flank laparotomy, and the TSC could be reduced in 26. Twenty-six of the 58 (44.8%) cows were discharged and 32 (55.2%) were euthanased before, during or after surgery., Conclusions: Acute illness, a sparse amount of faeces in the rectum and dilated spiral colon and caecum are characteristic findings of TSC. The final diagnosis often relies on the surgical or postmortem findings. Cattle with TSC should be treated surgically without delay. The prognosis is guarded with a survival rate of 44.8%., (© 2024. The Author(s).)
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- 2024
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11. Small intestinal volvulus in 47 cows.
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Braun U, Gerspach C, Volz C, Hilbe M, and Nuss K
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- Humans, Female, Cattle, Animals, Pregnancy, Retrospective Studies, Intestine, Small, Rectum, Feces, Magnesium, Intestinal Volvulus diagnosis, Intestinal Volvulus surgery, Intestinal Volvulus veterinary, Cattle Diseases diagnosis
- Abstract
Objective: To describe the findings, treatment, and outcome of small intestinal volvulus (SIV) in 47 cows., Animals and Procedure: Retrospective analysis of medical records. Comparison of the findings for 18 surviving and 29 non-surviving cows., Results: The most common abnormal vital signs were tachycardia (68.0%), tachypnea (59.6%), and decreased rectal temperature (51.1%). Signs of colic occurred in 66.0% of cows in the study. Rumen motility was reduced or absent in 93.6% of cows, and intestinal motility in 76.6%. Clinical signs on ballottement and/or percussion and simultaneous auscultation were positive on the right side in 78.7% of cows. Transrectal examination showed dilated small intestines in 48.9% of cows. The rectum contained little or no feces in 93.6% of cows. The principal laboratory abnormalities were hypocalcemia (74.1%), hypokalemia (73.8%), azotemia (62.8%), hypermagnesemia (61.6%), and hemoconcentration (60.0%). The principal ultrasonographic findings were dilated small intestines (87.1%) and reduced or absent small intestinal motility (85.2%). Forty-one of the 47 cows underwent right flank laparotomy and the SIV was reduced in 21 cows. When comparing the clinical and laboratory findings of 18 surviving and 29 non-surviving cows, the groups differed significantly with respect to severely abnormal general condition (16.7 versus 37.9%), rumen stasis (22.2 versus 79.3%), intestinal atony (16.7 versus 48.3%), serum urea concentration (6.5 versus 9.8 mmol/L), and serum magnesium concentration (0.98 versus 1.30 mmol/L). In summary, 38.3% of the cows were discharged and 61.7% were euthanized before, during, or after surgery., Conclusion and Clinical Relevance: An acute course of disease, little or no feces in the rectum, and dilated small intestines were characteristic of SIV in this study population., (Copyright and/or publishing rights held by the Canadian Veterinary Medical Association.)
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- 2024
12. Intracoronary delivery of extracellular vesicles from human cardiac progenitor cells reduces infarct size in porcine acute myocardial infarction.
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Emmert MY, Burrello J, Wolint P, Hilbe M, Andriolo G, Balbi C, Provasi E, Turchetto L, Radrizzani M, Nazari-Shafti TZ, Cesarovic N, Neuber S, Falk V, Hoerstrup SP, Hemetsberger R, Gyöngyösi M, Barile L, and Vassalli G
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- Humans, Swine, Animals, Coronary Vessels, Stem Cells, Myocardial Infarction therapy, Extracellular Vesicles
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- 2024
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13. [Food hygiene and safety - What is your diagnosis?]
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Stephan R, Ramsauer AS, Thür B, Schlatter A, and Hilbe M
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- Animals, Female, Lymph Nodes pathology, Meat, Sus scrofa, Swine, Switzerland, Papilloma pathology, Papilloma veterinary, Swine Diseases diagnosis, Swine Diseases prevention & control, Food Safety
- Abstract
Introduction: A healthy, 1,5 year old female wild boar (Sus scrofa) was shoot in a hunting district in Switzerland on June 22, 2023. The meat inspection revealed noticeable skin changes on all four distal extremities which were described histologically as multifocal epidermal hyperplasia and moderate orthokeratotic hyperkeratosis. The rest of the animal body, the organs and the lymph nodes were without any obvious lesions. The diagnosis of papilloma virus-associated exophytically growing papillomas was made. The venison was approved as fit for human consumption.
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- 2024
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14. Isolation of Mycobacterium avium ssp. paratuberculosis and other non-tuberculous mycobacteria from head lymph nodes of wild ruminants and badgers in Switzerland.
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Lienhard J, Friedel U, Paganini C, Hilbe M, Scherrer S, and Schmitt S
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Introduction: The family Mycobacteriaceae contains over 188 species, most of which are saprophytic non-tuberculous mycobacteria (NTM). In wildlife, a variety of different NTM can be found, with different reports about their pathogenic potential. A pathogenic member of NTM is Mycobacterium avium ssp. paratuberculosis (MAP), which can infect farmed and wild ruminants. It causes paratuberculosis which is an economically important chronic disease. Infected farm animals are considered to be the source of infection in wild animals. Wildlife, on the other hand, is thought to be a reservoir for certain members of the Mycobacterium tuberculosis complex (MTBC), such as M. caprae , which causes tuberculosis in cattle and red deer., Methods: Switzerland implemented a surveillance program for tuberculosis in wild animals in 2014. Here, we describe the results from the mycobacterial culture of lymph node samples collected from red deer, roe deer, chamois, ibex, and badgers collected within this surveillance program from 2020 to 2022. Overall, samples from 548 animals were checked macroscopically for tuberculosis-like lesions., Results: In total, 88 animals (16.1%), which either had lesions in their lymph nodes or were male and aged older than 5 years, were investigated using mycobacterial culture. In total, 25 animals (28.4%) were positive for NTM, while no MTBC was detected. The most often identified NTM was M. vaccae , followed by M. avium . Most animals positive for NTM did not show any macroscopic lesions. Furthermore, MAP was isolated from the head lymph nodes of two male red deer. Neither of the two MAP-positive animals had any macroscopic lesions in their head lymph nodes or any other signs of disease., Discussion: The shooting sites of the two MAP-positive animals were located in Alpine pastures used for grazing of cattle during summer, which confirms that species transmission can occur when contaminated pastures are used by different species. In agreement with other studies, the occurrence of MAP in red deer was quite low. However, so far, MAP was mostly isolated from feces and intestinal lymph nodes of wild animals. This is the first detection of MAP in the head lymph nodes of red deer in Switzerland., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Lienhard, Friedel, Paganini, Hilbe, Scherrer and Schmitt.)
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- 2024
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15. Small intestinal strangulation in 60 cattle - clinical, laboratory and ultrasonographic findings, treatment and outcome.
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Braun U, Gerspach C, Loss S, Hilbe M, and Nuss K
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- Female, Cattle, Animals, Pregnancy, Retrospective Studies, Intestine, Small, Pain veterinary, Treatment Outcome, Intestinal Obstruction diagnostic imaging, Intestinal Obstruction veterinary, Cattle Diseases diagnostic imaging, Cattle Diseases surgery
- Abstract
Background: Intestinal strangulation is constriction of the intestine by a band of tissue, ligament or blood vessel causing partial or complete intestinal obstruction. This retrospective study describes the clinical, laboratory and ultrasonographic findings, treatment and outcome of 60 cows with intestinal strangulation., Results: The general condition was abnormal in all cows (60/60), 23.3% (14/60) had nonspecific signs of pain, 40.0% (24/60) had signs of colic and 48.3% (29/60) had signs of somatic (parietal) pain. The most common digestive tract abnormalities were, in decreasing frequency, reduced or absent intestinal motility (100%, 60/60), reduced or absent faecal output (98.3%, 59/60), reduced or absent rumen motility (93.4%, 56/60), dilated small intestines on transrectal palpation (63.3%, 38/60), positive ballottement and swinging auscultation (BSA) and/or percussion and simultaneous auscultation (PSA) on the right side of the abdomen (58.3%, 35/60) and at least one positive foreign body test, most commonly the back grip, in 33.9% (20/59) of the cows. Other common findings were reduced skin surface temperature (67.8%, 40/59), reduced skin turgor (51.7%, 31/60), prolonged capillary refill time (49.2%, 29/59), enophthalmus (48.3%, 29/60) and moderate to severe scleral injection (46.6%, 27/58). The most common laboratory findings were hypokalaemia (58.3%, 35/60), haemoconcentration (57.6%, 34/59), base excess (51.1%, 24/47), hyperproteinaemia (45.8%, 27/59), hyperbilirubinaemia (43.3%, 26/60), acidosis (42.6%, 20/47) and azotaemia (38.3%, 23/60). The principal ultrasonographic findings were subjectively reduced or absent small intestinal motility and dilated small intestines, but the strangulation could not be visualised by ultrasonography. With one exception, all cows underwent a right flank laparotomy to resolve the strangulation by transection or resection of the impinging tissue. Forty-nine (81.7%) cows were discharged and 11 (18.3%) were euthanized before, during or after surgery., Conclusions: Without laparotomy, intestinal strangulation could be clinically (transrectally) diagnosed in only 10% of the cows. A laparotomy is therefore essential for the correct diagnosis. The prognosis is good with prompt surgical treatment., (© 2023. The Author(s).)
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- 2023
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16. Dilated small and large intestines combined with a severely abnormal demeanor are characteristic of mesenteric torsion in cattle.
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Braun U, Gerspach C, Volz C, Hilbe M, and Nuss K
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- Female, Cattle, Animals, Pregnancy, Retrospective Studies, Intestine, Small surgery, Cecum, Colon, Intestine, Large, Cattle Diseases diagnosis, Cattle Diseases surgery
- Abstract
Objective: To describe the clinical, laboratory, and ultrasonographic findings; treatment; and outcome of cattle with mesenteric torsion (MT)., Animals: 61 cattle with MT between November 1, 1986, and December 31, 2019., Methods: Medical records were retrospectively reviewed. Results were compared for cattle that survived versus did not survive to hospital discharge., Results: All cattle had abnormal demeanor. The most common clinical signs were tachycardia (80.3% [49/61]), tachypnea (65.0% [39/60]), and lower rectal temperature (59.3% [35/59]). Signs of colic occurred in 65.6% (40/61). The most common gastrointestinal findings were an empty or almost empty rectum (100% [59/59]), reduced or absent motility of the small intestines (96.6% [57/59]) or rumen (93.2% [55/59]), positive ballottement and/or percussion and simultaneous auscultation on the right side (91.7% [55/60]), and dilated small (49.2% [29/59]) and large intestines (spiral colon and/or cecum, 44.1% [26/59]) detected during transrectal examination. The most common laboratory findings were acidosis (82.6%, [38/46]) hypermagnesemia (74.5% [35/47]). Ultrasonographic findings included reduced or absent small intestinal motility (86.7% [26/30]) and dilated small intestines (83.8% [31/37]). The spiral colon was dilated in 32.4% (12/37) of the cattle. Eighty-two percent (50/61) of the cattle underwent right flank laparotomy and the MT could be reduced in 34.4% (21/61). Twenty-three percent (14/61) of the cattle survived to hospital discharge, and 77.0% (47/61) were euthanized before hospital discharge., Clinical Relevance: Dilated small and large intestines (spiral colon, cecum) combined with a severely abnormal demeanor and tachycardia are characteristic findings in cows with MT. Immediate surgical treatment is paramount.
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- 2023
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17. Hypertensive nonobstructive hydrocephalus as main magnetic resonance imaging feature in a dog with disseminated choroid plexus carcinomatosis.
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Carisch L, Golini L, Schurna L, Bergamino C, Beckmann KM, Hilbe M, Asawapattanakul T, Baumgärtner W, Puff C, and Wang-Leandro A
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- Dogs, Animals, Choroid Plexus diagnostic imaging, Choroid Plexus pathology, Magnetic Resonance Imaging veterinary, Hydrocephalus diagnostic imaging, Hydrocephalus veterinary, Choroid Plexus Neoplasms complications, Choroid Plexus Neoplasms diagnostic imaging, Choroid Plexus Neoplasms veterinary, Carcinoma complications, Carcinoma diagnostic imaging, Carcinoma veterinary, Dog Diseases diagnosis
- Abstract
Obstructive or nonobstructive hypertensive hydrocephalus is reported in choroid plexus tumors. Choroid plexus tumors typically present as T2-weighted hyperintense intraventricular masses with occasional cerebrospinal fluid-drop metastasis. Acquired neoplastic nonobstructive hydrocephalus without visible mass lesion in magnetic resonance imaging is not reported in dogs. A 4.5-year-old Rhodesian Ridgeback presented with reduced mental status, unilaterally absent pupillary light reflex, and neck pain. Magnetic resonance imaging revealed a nonobstructive hydrocephalus and widened lumbar subarachnoid space with no evidence of a primary mass lesion. Postmortem examination confirmed a disseminated choroid plexus tumor affecting the ependyma and choroid plexi of all ventricles and the cerebral and lumbar subarachnoid space. Disseminated choroid plexus carcinomatosis should be considered as a possible cause of hypertensive hydrocephalus even in absence of a primary mass., (© 2023 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC. on behalf of the American College of Veterinary Internal Medicine.)
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- 2023
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18. A retrospective review of small intestinal intussusception in 126 cattle in Switzerland.
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Braun U, Gerspach C, Volz C, Boesiger M, Hilbe M, and Nuss K
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Background: Intussusception is a form of ileus of the intestines in which an oral intestinal segment slides into the adjacent aboral intestinal segment, causing obstruction of the bowel., Methods: We analysed the medical records of 126 cattle with intussusception of the small intestine., Results: Demeanour and appetite were abnormal in 123 cattle. Non-specific signs of pain occurred in 26.2%, signs of visceral pain in 46.8% and signs of parietal pain in 56.4%. Intestinal motility was decreased or absent in 93.7% of the cattle. The most common findings of transrectal palpation were rumen dilation (37.3%) and dilated small intestines (24.6%). In 96% of the cattle, the rectum was empty or contained little faeces. The principal laboratory findings were hypokalaemia (89.6%), hypocalcaemia (76.5%), base excess (72.9%), hypochloraemia (71.8%), azotaemia (62.1%) and haemoconcentration (61.1%). The main ultrasonographic findings were reduced or absent intestinal motility (98.2%) and dilated small intestines (96.0%). A diagnosis of ileus was made in 87.8% and a diagnosis of ileus attributable to intussusception was made in another 9.8%. Right-flank laparotomy was carried out in 114 cattle. Fifty-six (44.4%) cows were discharged., Conclusions: Clinical findings of intussusception in cattle are often non-specific. Ultrasonography may be required to diagnose ileus., Competing Interests: The authors declare they have no conflicts of interest., (© 2023 The Authors. Veterinary Record Open published by John Wiley & Sons Ltd on behalf of British Veterinary Association.)
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- 2023
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19. A Combined Approach for Detection of Ovine Small Ruminant Retrovirus Co-Infections.
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Rosato G, Abril C, Hilbe M, and Seehusen F
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- Sheep, Animals, Retroviridae, Ruminants, Antibodies, Real-Time Polymerase Chain Reaction, Coinfection veterinary, Retroviridae Infections, Arthritis-Encephalitis Virus, Caprine, Jaagsiekte sheep retrovirus
- Abstract
Jaagsiekte retrovirus (JSRV)-induced ovine pulmonary adenocarcinoma (OPA) is an important ovine respiratory disease in Switzerland. Furthermore, ovine lungs with OPA frequently exhibited lesions suggestive of maedi-visna virus (MVV) or caprine arthritis encephalitis virus (CAEV) infection, indicating that co-morbidities might occur. Lungs and pulmonary lymph nodes were sampled from suspected OPA cases, inflammatory lung lesions and control lungs (total of 110 cases). Tissues were (a) processed for histology and immunohistochemistry (IHC), and (b) underwent DNA extraction and real-time PCR for JSRV, MVV and CAEV. Peptide sequences were used to generate virus-specific customized polyclonal antibodies. PCR-positive OPA cases and formalin-fixed and paraffin-embedded MVV- and CAEV-infected synovial cell pellets served as positive controls. Fifty-two lungs were histologically diagnosed with OPA. Histological evidence of MVV/CAEV infection was detected in 25 lungs. JSRV was detected by PCR in 84% of the suspected OPA cases; six were co-infected with MVV and one with CAEV. MVV was detected by PCR in 14 cases, and four lungs were positive for CAEV. Three lungs had MVV/CAEV co-infection. In IHC, JSRV was detected in 91% of the PCR-positive cases, whereas MVV and CAEV immunoreactivity was seen in all PCR-positive lungs. Although PCR showed a higher sensitivity compared to IHC, the combined approach allows for investigations on viral cell tropism and pathogenic processes in co-morbidities, including their potential interdependency. Furthermore, an immunohistochemical tool for specific differentiation of MVV and/or CAEV infection was implemented.
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- 2023
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20. Left and right displaced abomasum and abomasal volvulus: comparison of clinical, laboratory and ultrasonographic findings in 1982 dairy cows.
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Braun U, Nuss K, Reif S, Hilbe M, and Gerspach C
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- Female, Cattle, Animals, Pregnancy, Abomasum diagnostic imaging, Rumen, Intestinal Volvulus veterinary, Stomach Diseases diagnostic imaging, Stomach Diseases veterinary, Cattle Diseases diagnostic imaging
- Abstract
Background: Although left and right displacement of the abomasum and abomasal volvulus are well-known disorders of cattle, a comparative evaluation of the clinical, laboratory and ultrasonographic findings of these types of abomasal displacements has not been undertaken. Therefore, the objective of this study was to compare these conditions in a large population of cows. The medical records of 1982 dairy cows with left displaced abomasum (LDA, n = 1341), right displaced absomasum (RDA, n = 338) and abomasal volvulus (AV, n = 303) were searched for the results of clinical, laboratory and ultrasonographic evaluations., Results: The main clinical findings were an abnormal demeanour in 48.2% of the cows, reduced rumen motility in 89.7% and decreased intestinal motility in 61.1%. Ballottement and simultaneous auscultation and percussion and simultaneous auscultation were positive on the left side in 96.9% of the cows with LDA and on the right in 98.5% of the cows with RDA and in 99.3% of the cows with AV. Ultrasonography was useful for diagnosing LDA in 97.9% of the cows and RDA/AV in 90.2% of the cows. The laboratory findings characteristic of abomasal reflux syndrome varied in severity; 83% of the cows had hypokalaemia, 67% had increased rumen chloride concentration, 67% had an increased base excess and 50% had haemoconcentration. Based on the clinical signs, a definitive diagnosis was made in 75.0% of the cows with LDA and in 22.5% of the cows with RDA/AV. Ultrasonography was required for a definitive diagnosis in another 22.0% of the cows with LDA and in 53.0% of the cows with RDA/AV. Laparotomy or postmortem examination was required for reliable differentiation of RDA and AV., Conclusions: LDA, RDA and AV differ with respect to the severity and the frequency of several abnormal clinical, laboratory and ultrasonographic findings as well as the methods required for a diagnosis., (© 2022. The Author(s).)
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- 2022
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21. Validation of seismic hazard curves using a calibrated 14 ka lacustrine record in the Eastern Alps, Austria.
- Author
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Daxer C, Huang JS, Weginger S, Hilbe M, Strasser M, and Moernaut J
- Abstract
Seismic hazard maps are crucial for earthquake mitigation and mostly rely on probabilistic seismic hazard analysis (PSHA). However, the practise and value of PSHA are under debate because objective testing procedures for seismic hazard maps are scarce. We present a lacustrine turbidite record revealing 44 earthquakes over the last ~ 14 ka and use it to test seismic hazard curves in southern Austria. We derive local seismic intensities for paleo-earthquakes by applying scaling relationships between the sedimentary imprint and seismic intensity of well-documented historical earthquakes. The last ~ 2.8 ka of the record agree with a Poissonian recurrence behaviour and therefore a constant hazard rate, which is the modelling choice for standard PSHA. The lacustrine data are consistent with the intensity-frequency relationship of the local seismic hazard curve, confirming the current PSHA approach for this part of Austria. On longer timescales, distinct phases of enhanced regional seismicity occurred, indicating a potential increase of seismic hazard after large earthquakes-a factor hitherto disregarded in the PSHA of the Eastern Alps. Our new method forms an independent procedure to test hazard maps in any setting where suitable lake systems are available., (© 2022. The Author(s).)
- Published
- 2022
- Full Text
- View/download PDF
22. Frequent Occurrence of Simultaneous Infection with Multiple Rotaviruses in Swiss Pigs.
- Author
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Baumann S, Sydler T, Rosato G, Hilbe M, Kümmerlen D, Sidler X, and Bachofen C
- Subjects
- Animals, Cross-Sectional Studies, Diarrhea epidemiology, Diarrhea veterinary, Longitudinal Studies, Swine, Coinfection epidemiology, Coinfection veterinary, Rotavirus genetics, Rotavirus Infections epidemiology, Rotavirus Infections veterinary, Swine Diseases epidemiology
- Abstract
Rotavirus (RV) infections are the most important viral cause of diarrhea in piglets in Switzerland and are thought to cause substantial economic losses to the pig industry. However, no data are available on the occurrence and dynamics of the main porcine RV species, namely RVA, RVB, and RVC, and the diversity of the circulating strains. We therefore tested fecal samples from a cross-sectional ( n = 95) and a longitudinal ( n = 48) study for RVA, RVB, and RVC by real-time RT-PCR and compared the results of the cross-sectional study to postmortem findings. In addition, eight samples were fully genotyped by using next-generation sequencing. In the cross-sectional study, triple RV infections significantly correlated with diarrhea and wasting and were most frequent in the weaned age group. In the longitudinal study, the shedding of RV peaked one week after weaning and decreased thereafter. Here, mainly double infections were seen, and only a few animals showed diarrhea. The full-genome sequencing revealed a genotype pattern similar to other European countries and, importantly, co-infection by up to four RVA strains. Our results imply that the weaning of piglets may trigger not only RV shedding but facilitate co-infection of multiple RV species and strains in the same host.
- Published
- 2022
- Full Text
- View/download PDF
23. Efficacy and safety of P 11 -4 for the treatment of periodontal defects in dogs.
- Author
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Bommer C, Waller T, Hilbe M, Wiedemeier D, Meyer N, Mathes S, and Jung R
- Subjects
- Alveolar Bone Loss diagnostic imaging, Alveolar Bone Loss pathology, Alveolar Bone Loss surgery, Animals, Bone Regeneration, Dental Cementum, Dogs, Mandible surgery, Tooth Root surgery, X-Ray Microtomography, Guided Tissue Regeneration, Periodontal veterinary, Oligopeptides adverse effects, Periodontal Ligament pathology
- Abstract
Objectives: This study's aim was to investigate the safety and performance of a self-assembling peptide matrix (SAPM) P
11 -4 for the treatment of periodontal disease in a controlled pre-clinical study., Materials and Methods: Acute buccal bony dehiscence defects (LxW: 5 × 3 mm) were surgically created on the distal root of four teeth on one mandible side of 7 beagle dogs followed by another identical surgery 8 weeks later on the contralateral side. SAPM P11 -4 (with and without root conditioning with 24% EDTA (T1, T2)), Emdogain® (C) and a sham intervention (S) were randomly applied on the four defects at each time point. Four weeks after the second surgery and treatment, the animals were sacrificed, the mandibles measured by micro-computed tomography (µ-CT) and sections of the tissue were stained and evaluated histologically., Results: Clinically and histologically, no safety concerns or pathological issues due to the treatments were observed in any of the study groups at any time point. All groups showed overall similar results after 4 and 12 weeks of healing regarding new cementum, functionality of newly formed periodontal ligament and recovery of height and volume of the new alveolar bone and mineral density., Conclusion: A controlled clinical study in humans should be performed in a next step as no adverse effects or safety issues, which might affect clinical usage of the product, were observed., Clinical Relevance: The synthetic SAPM P11 -4 may offer an alternative to the animal-derived product Emdogain® in the future., (© 2022. The Author(s).)- Published
- 2022
- Full Text
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24. New World camelids are sentinels for the presence of Borna disease virus.
- Author
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Malbon AJ, Dürrwald R, Kolodziejek J, Nowotny N, Kobera R, Pöhle D, Muluneh A, Dervas E, Cebra C, Steffen F, Paternoster G, Gerspach C, and Hilbe M
- Subjects
- Animals, Borna Disease epidemiology, Borna Disease pathology, Borna disease virus genetics, Camelids, New World, Encephalitis veterinary
- Abstract
Borna disease (BD), a frequently fatal neurologic disorder caused by Borna disease virus 1 (BoDV-1), has been observed for decades in horses, sheep, and other mammals in certain regions of Europe. The bicoloured white-toothed shrew (Crocidura leucodon) was identified as a persistently infected species involved in virus transmission. Recently, BoDV-1 attracted attention as a cause of fatal encephalitis in humans. Here, we report investigations on BoDV-1-infected llamas from a farm in a BD endemic area of Switzerland, and alpacas from holdings in a region of Germany where BD was last seen in the 1960s but not thereafter. All New World camelids showed apathy and abnormal behaviour, necessitating euthanasia. Histologically, severe non-suppurative meningoencephalitis with neuronal Joest-Degen inclusion bodies was observed. BoDV-1 was confirmed by immunohistology, RT-qPCR, and sequencing in selected animals. Analysis of the llama herd over 20 years showed that losses due to clinically suspected BD increased within the last decade. BoDV-1 whole-genome sequences from one Swiss llama and one German alpaca and-for comparison-from one Swiss horse and one German shrew were established. They represent the first published whole-genome sequences of BoDV-1 clusters 1B and 3, respectively. Our analysis suggests that New World camelids may have a role as a sentinel species for BoDV-1 infection, even when symptomatic cases are lacking in other animal species., (© 2021 The Authors. Transboundary and Emerging Diseases published by Wiley-VCH GmbH.)
- Published
- 2022
- Full Text
- View/download PDF
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