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1. First application of a liquid argon time projection chamber for the search for intranuclear neutron-antineutron transitions and annihilation in $^{40}$Ar using the MicroBooNE detector

Author

MicroBooNE collaboration, Abratenko, P., Alterkait, O., Aldana, D. Andrade, Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barr, G., Barrow, D., Barrow, J., Basque, V., Rodrigues, O. Benevides, Berkman, S., Bhanderi, A., Bhat, A., Bhattacharya, M., Bishai, M., Blake, A., Bogart, B., Bolton, T., Book, J. Y., Camilleri, L., Cao, Y., Caratelli, D., Terrazas, I. Caro, Cavanna, F., Cerati, G., Chen, Y., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadon, J. I., Cross, R., Del Tutto, M., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Djurcic, Z., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Englezos, P., Ereditato, A., Evans, J. J., Fine, R., Finnerud, O. G., Fleming, B. T., Foppiani, N., Foreman, W., Franco, D., Furmanski, A. P., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Goodwin, O., Gramellini, E., Green, P., Greenlee, H., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hicks, R., Hilgenberg, C., Horton-Smith, G. A., Imani, Z., Irwin, B., Itay, R., James, C., Ji, X., Jiang, L., Jo, J. H., Johnson, R. A., Jwa, Y. J., Kalra, D., Kamp, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Lepetic, I., Li, J. -Y., Li, K., Li, Y., Lin, K., Littlejohn, B. R., Liu, H., Louis, W. C., Luo, X., Mariani, C., Marsden, D., Marshall, J., Martinez, N., Caicedo, D. A. Martinez, Martynenko, S., Mastbaum, A., McConkey, N., Meddage, V., Micallef, J., Miller, K., Mistry, K., Mohayai, T., Mogan, A., Mooney, M., Moor, A. F., Moore, C. D., Lepin, L. Mora, Moudgalya, M. M., Babu, S. Mulleria, Naples, D., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Nowak, J., Oza, N., Palamara, O., Pallat, N., Paolone, V., Papadopoulou, A., Papavassiliou, V., Parkinson, H., Pate, S. F., Patel, N., Pavlovic, Z., Piasetzky, E., Ponce-Pinto, I., Pophale, I., Qian, X., Raaf, J. L., Radeka, V., Rafique, A., Reggiani-Guzzo, M., Ren, L., Rochester, L., Rondon, J. Rodriguez, Rosenberg, M., Ross-Lonergan, M., von Rohr, C. Rudolph, Safa, I., Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Snider, E. L., Soderberg, M., Soldner-Rembold, S., Spitz, J., Stancari, M., John, J. St., Strauss, T., Szelc, A. M., Tang, W., Taniuchi, N., Terao, K., Thorpe, C., Torbunov, D., Totani, D., Toups, M., Tsai, Y. -T., Tyler, J., Uchida, M. A., Usher, T., Viren, B., Weber, M., Wei, H., White, A. J., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wright, N., Wu, W., Yandel, E., Yang, T., Yates, L. E., Yu, H. W., Zeller, G. P., Zennamo, J., and Zhang, C.

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

We present a novel methodology to search for intranuclear neutron-antineutron transition ($n\rightarrow\bar{n}$) followed by $\bar{n}$-nucleon annihilation within an $^{40}$Ar nucleus, using the MicroBooNE liquid argon time projection chamber (LArTPC) detector. A discovery of $n\rightarrow\bar{n}$ transition or a new best limit on the lifetime of this process would either constitute physics beyond the Standard Model or greatly constrain theories of baryogenesis, respectively. The approach presented in this paper makes use of deep learning methods to select $n\rightarrow\bar{n}$ events based on their unique features and differentiate them from cosmogenic backgrounds. The achieved signal and background efficiencies are (70.22$\pm$6.04)\% and (0.0020$\pm$0.0003)\%, respectively. A demonstration of a search is performed with a data set corresponding to an exposure of $3.32 \times10^{26}\,$neutron-years, and where the background rate is constrained through direct measurement, assuming the presence of a negligible signal. With this approach, no excess of events over the background prediction is observed, setting a demonstrative lower bound on the $n\rightarrow\bar{n}$ lifetime in $^{40}$Ar of $\tau_{\textrm{m}} \gtrsim 1.1\times10^{26}\,$years, and on the free $n\rightarrow\bar{n}$ transition time of $\tau_{\textrm{\nnbar}} \gtrsim 2.6\times10^{5}\,$s, each at the $90\%$ confidence level. This analysis represents a first-ever proof-of-principle demonstration of the ability to search for this rare process in LArTPCs with high efficiency and low background., Comment: 22 pages, 7 figures, 6 tables

Published
2023

2. Measurement of three-dimensional inclusive muon-neutrino charged-current cross sections on argon with the MicroBooNE detector

Author

MicroBooNE Collaboration, Abratenko, P., Alterkait, O., Aldana, D. Andrade, Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barr, G., Barrow, D., Barrow, J., Basque, V., Rodrigues, O. Benevides, Berkman, S., Bhanderi, A., Bhat, A., Bhattacharya, M., Bishai, M., Blake, A., Bogart, B., Bolton, T., Book, J. Y., Camilleri, L., Cao, Y., Caratelli, D., Terrazas, I. Caro, Cavanna, F., Cerati, G., Chen, Y., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadon, J. I., Del Tutto, M., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Djurcic, Z., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Englezos, P., Ereditato, A., Evans, J. J., Fine, R., Finnerud, O. G., Fleming, B. T., Foppiani, N., Foreman, W., Franco, D., Furmanski, A. P., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Goodwin, O., Gramellini, E., Green, P., Greenlee, H., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hicks, R., Hilgenberg, C., Horton-Smith, G. A., Imani, Z., Irwin, B., Itay, R., James, C., Ji, X., Jiang, L., Jo, J. H., Johnson, R. A., Jwa, Y. J., Kalra, D., Kamp, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Leibovitch, M. B., Lepetic, I., Li, J. -Y., Li, K., Li, Y., Lin, K., Littlejohn, B. R., Liu, H., Louis, W. C., Luo, X., Mariani, C., Marsden, D., Marshall, J., Martinez, N., Caicedo, D. A. Martinez, Mastbaum, A., McConkey, N., Meddage, V., Micallef, J., Miller, K., Mistry, K., Mohayai, T., Mogan, A., Mooney, M., Moor, A. F., Moore, C. D., Lepin, L. Mora, Moudgalya, M., Babu, S. Mulleria, Naples, D., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Nowak, J., Oza, N., Palamara, O., Pallat, N., Paolone, V., Papadopoulou, A., Papavassiliou, V., Parkinson, H., Pate, S. F., Patel, N., Pavlovic, Z., Piasetzky, E., Ponce-Pinto, I., Pophale, I., Prince, S., Qian, X., Raaf, J. L., Radeka, V., Rafique, A., Reggiani-Guzzo, M., Ren, L., Rochester, L., Rondon, J. Rodriguez, Rosenberg, M., Ross-Lonergan, M., von Rohr, C. Rudolph, Safa, I., Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Snider, E. L., Soderberg, M., Soldner-Rembold, S., Spitz, J., Stancari, M., John, J. St., Strauss, T., Szelc, A. M., Tang, W., Taniuchi, N., Terao, K., Thorpe, C., Torbunov, D., Totani, D., Toups, M., Tsai, Y. -T., Tyler, J., Uchida, M. A., Usher, T., Viren, B., Weber, M., Wei, H., White, A. J., Williams, Z., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wright, N., Wu, W., Yandel, E., Yang, T., Yates, L. E., Yu, H. W., Zeller, G. P., Zennamo, J., and Zhang, C.

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

We report the measurement of the differential cross section $d^{2}\sigma (E_{\nu})/ d\cos(\theta_{\mu}) dP_{\mu}$ for inclusive muon-neutrino charged-current scattering on argon. This measurement utilizes data from 6.4$\times10^{20}$ protons on target of exposure collected using the MicroBooNE liquid argon time projection chamber located along the Fermilab Booster Neutrino Beam with a mean neutrino energy of approximately 0.8~GeV. The mapping from reconstructed kinematics to truth quantities, particularly from reconstructed to true neutrino energy, is validated within uncertainties by comparing the distribution of reconstructed hadronic energy in data to that of the model prediction in different muon scattering angle bins after applying a conditional constraint from the muon momentum distribution in data. The success of this validation gives confidence that the missing energy in the MicroBooNE detector is well-modeled within uncertainties in simulation, enabling the unfolding to a three-dimensional measurement over muon momentum, muon scattering angle, and neutrino energy. The unfolded measurement covers an extensive phase space, providing a wealth of information useful for future liquid argon time projection chamber experiments measuring neutrino oscillations. Comparisons against a number of commonly used model predictions are included and their performance in different parts of the available phase-space is discussed.

Published
2023

3. Measurement of ambient radon progeny decay rates and energy spectra in liquid argon using the MicroBooNE detector

Author

MicroBooNE collaboration, Abratenko, P., Alterkait, O., Aldana, D. Andrade, Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barr, G., Barrow, D., Barrow, J., Basque, V., Rodrigues, O. Benevides, Berkman, S., Bhanderi, A., Bhat, A., Bhattacharya, M., Bishai, M., Blake, A., Bogart, B., Bolton, T., Book, J. Y., Camilleri, L., Cao, Y., Caratelli, D., Terrazas, I. Caro, Cavanna, F., Cerati, G., Chen, Y., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadon, J. I., Cross, R., Del Tutto, M., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Djurcic, Z., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Englezos, P., Ereditato, A., Evans, J. J., Fine, R., Finnerud, O. G., Fleming, B. T., Foppiani, N., Foreman, W., Franco, D., Furmanski, A. P., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Goodwin, O., Gramellini, E., Green, P., Greenlee, H., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hicks, R., Hilgenberg, C., Horton-Smith, G. A., Imani, Z., Irwin, B., Itay, R., James, C., Ji, X., Jiang, L., Jo, J. H., Johnson, R. A., Jwa, Y. J., Kalra, D., Kamp, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Leibovitch, M. B., Lepetic, I., Li, J. -Y., Li, K., Li, Y., Lin, K., Littlejohn, B. R., Liu, H., Louis, W. C., Luo, X., Mariani, C., Marsden, D., Marshall, J., Martinez, N., Caicedo, D. A. Martinez, Martynenko, S., Mastbaum, A., McConkey, N., Meddage, V., Micallef, J., Miller, K., Mistry, K., Mohayai, T., Mogan, A., Mooney, M., Moor, A. F., Moore, C. D., Lepin, L. Mora, Moudgalya, M., Babu, S. Mulleria, Naples, D., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Nowak, J., Oza, N., Palamara, O., Pallat, N., Paolone, V., Papadopoulou, A., Papavassiliou, V., Parkinson, H., Pate, S. F., Patel, N., Pavlovic, Z., Piasetzky, E., Ponce-Pinto, I., Pophale, I., Qian, X., Raaf, J. L., Radeka, V., Rafique, A., Reggiani-Guzzo, M., Ren, L., Rochester, L., Rondon, J. Rodriguez, Rosenberg, M., Ross-Lonergan, M., von Rohr, C. Rudolph, Safa, I., Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Snider, E. L., Soderberg, M., Soldner-Rembold, S., Spitz, J., Stancari, M., John, J. St., Strauss, T., Szelc, A. M., Tang, W., Taniuchi, N., Terao, K., Thorpe, C., Torbunov, D., Totani, D., Toups, M., Tsai, Y. -T., Tyler, J., Uchida, M. A., Usher, T., Viren, B., Weber, M., Wei, H., White, A. J., Williams, Z., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wright, N., Wu, W., Yandel, E., Yang, T., Yates, L. E., Yu, H. W., Zeller, G. P., Zennamo, J., and Zhang, C.

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

We report measurements of radon progeny in liquid argon within the MicroBooNE time projection chamber (LArTPC). The presence of specific radon daughters in MicroBooNE's 85 metric tons of active liquid argon bulk is probed with newly developed charge-based low-energy reconstruction tools and analysis techniques to detect correlated $^{214}$Bi-$^{214}$Po radioactive decays. Special datasets taken during periods of active radon doping enable new demonstrations of the calorimetric capabilities of single-phase neutrino LArTPCs for $\beta$ and $\alpha$ particles with electron-equivalent energies ranging from 0.1 to 3.0 MeV. By applying $^{214}$Bi-$^{214}$Po detection algorithms to data recorded over a 46-day period, no statistically significant presence of radioactive $^{214}$Bi is detected, and a limit on the activity is placed at $<0.35$ mBq/kg at the 95% confidence level. This bulk $^{214}$Bi radiopurity limit -- the first ever reported for a liquid argon detector incorporating liquid-phase purification -- is then further discussed in relation to the targeted upper limit of 1 mBq/kg on bulk $^{222}$Rn activity for the DUNE neutrino detector.

Published
2023
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4. First measurement of $\eta$ production in neutrino interactions on argon with MicroBooNE

Author

MicroBooNE collaboration, Abratenko, P., Alterkait, O., Aldana, D. Andrade, Anthony, J., Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barr, G., Barrow, J., Basque, V., Rodrigues, O. Benevides, Berkman, S., Bhanderi, A., Bhat, A., Bhattacharya, M., Bishai, M., Blake, A., Bogart, B., Bolton, T., Book, J. Y., Camilleri, L., Cao, Y., Caratelli, D., Terrazas, I. Caro, Cavanna, F., Cerati, G., Chen, Y., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadon, J. I., Del Tutto, M., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Djurcic, Z., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Englezos, P., Ereditato, A., Evans, J. J., Fine, R., Finnerud, O. G., Fleming, B. T., Foppiani, N., Foreman, W., Franco, D., Furmanski, A. P., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Goodwin, O., Gramellini, E., Green, P., Greenlee, H., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hicks, R., Hilgenberg, C., Horton-Smith, G. A., Imani, Z., Irwin, B., Itay, R., James, C., Ji, X., Jiang, L., Jo, J. H., Johnson, R. A., Jwa, Y. J., Kalra, D., Kamp, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Leibovitch, M. B., Lepetic, I., Li, J. -Y., Li, K., Li, Y., Lin, K., Littlejohn, B. R., Louis, W. C., Luo, X., Mariani, C., Marsden, D., Marshall, J., Martinez, N., Caicedo, D. A. Martinez, Mason, K., Mastbaum, A., McConkey, N., Meddage, V., Miller, K., Mills, J., Mistry, K., Mohayai, T., Mogan, A., Mooney, M., Moor, A. F., Moore, C. D., Lepin, L. Mora, Babu, S. Mulleria, Naples, D., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Nowak, J., Oza, N., Palamara, O., Pallat, N., Paolone, V., Papadopoulou, A., Papavassiliou, V., Parkinson, H., Pate, S. F., Patel, N., Pavlovic, Z., Piasetzky, E., Ponce-Pinto, I., Pophale, I., Prince, S., Qian, X., Raaf, J. L., Radeka, V., Rafique, A., Reggiani-Guzzo, M., Ren, L., Rochester, L., Rondon, J. Rodriguez, Rosenberg, M., Ross-Lonergan, M., von Rohr, C. Rudolph, Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Snider, E. L., Soderberg, M., Soldner-Rembold, S., Spitz, J., Stancari, M., John, J. St., Strauss, T., Sword-Fehlberg, S., Szelc, A. M., Tang, W., Taniuchi, N., Terao, K., Thorpe, C., Torbunov, D., Totani, D., Toups, M., Tsai, Y. -T., Tyler, J., Uchida, M. A., Usher, T., Viren, B., Weber, M., Wei, H., White, A. J., Williams, Z., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wright, N., Wu, W., Yandel, E., Yang, T., Yates, L. E., Yu, H. W., Zeller, G. P., Zennamo, J., and Zhang, C.

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

We present a measurement of $\eta$ production from neutrino interactions on argon with the MicroBooNE detector. The modeling of resonant neutrino interactions on argon is a critical aspect of the neutrino oscillation physics program being carried out by the DUNE and Short Baseline Neutrino programs. $\eta$ production in neutrino interactions provides a powerful new probe of resonant interactions, complementary to pion channels, and is particularly suited to the study of higher-order resonances beyond the $\Delta(1232)$. We measure a flux-integrated cross section for neutrino-induced $\eta$ production on argon of $3.22 \pm 0.84 \; \textrm{(stat.)} \pm 0.86 \; \textrm{(syst.)}$ $10^{-41}{\textrm{cm}}^{2}$/nucleon. By demonstrating the successful reconstruction of the two photons resulting from $\eta$ production, this analysis enables a novel calibration technique for electromagnetic showers in GeV accelerator neutrino experiments.

Published
2023
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5. First demonstration of $\mathcal{O}(1\,\text{ns})$ timing resolution in the MicroBooNE liquid argon time projection chamber

Author

MicroBooNE collaboration, Abratenko, P., Alterkait, O., Aldana, D. Andrade, Anthony, J., Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barr, G., Barrow, J., Basque, V., Rodrigues, O. Benevides, Berkman, S., Bhanderi, A., Bhattacharya, M., Bishai, M., Blake, A., Bogart, B., Bolton, T., Book, J. Y., Camilleri, L., Cao, Y., Caratelli, D., Terrazas, I. Caro, Cavanna, F., Cerati, G., Chen, Y., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadon, J. I., Del Tutto, M., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Djurcic, Z., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Ereditato, A., Evans, J. J., Fine, R., Finnerud, O. G., Fleming, B. T., Foppiani, N., Foreman, W., Franco, D., Furmanski, A. P., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Goodwin, O., Gramellini, E., Green, P., Greenlee, H., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hicks, R., Hilgenberg, C., Horton-Smith, G. A., Imani, Z., Irwin, B., Itay, R., James, C., Ji, X., Jiang, L., Jo, J. H., Johnson, R. A., Jwa, Y. J., Kalra, D., Kamp, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Leibovitch, M. B., Lepetic, I., Li, J. -Y., Li, K., Li, Y., Lin, K., Littlejohn, B. R., Louis, W. C., Luo, X., Mariani, C., Marsden, D., Marshall, J., Martinez, N., Caicedo, D. A. Martinez, Mason, K., Mastbaum, A., McConkey, N., Meddage, V., Miller, K., Mills, J., Mistry, K., Mohayai, T., Mogan, A., Mooney, M., Moor, A. F., Moore, C. D., Lepin, L. Mora, Mousseau, J., Babu, S. Mulleria, Naples, D., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Nowak, J., Oza, N., Palamara, O., Pallat, N., Paolone, V., Papadopoulou, A., Papavassiliou, V., Parkinson, H., Pate, S. F., Patel, N., Pavlovic, Z., Piasetzky, E., Ponce-Pinto, I., Pophale, I., Prince, S., Qian, X., Raaf, J. L., Radeka, V., Rafique, A., Reggiani-Guzzo, M., Ren, L., Rochester, L., Rondon, J. Rodriguez, Rosenberg, M., Ross-Lonergan, M., von Rohr, C. Rudolph, Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Snider, E. L., Soderberg, M., Soldner-Rembold, S., Spitz, J., Stancari, M., John, J. St., Strauss, T., Sword-Fehlberg, S., Szelc, A. M., Tang, W., Taniuchi, N., Terao, K., Thorpe, C., Torbunov, D., Totani, D., Toups, M., Tsai, Y. -T., Tyler, J., Uchida, M. A., Usher, T., Viren, B., Weber, M., Wei, H., White, A. J., Williams, Z., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wright, N., Wu, W., Yandel, E., Yang, T., Yates, L. E., Yu, H. W., Zeller, G. P., Zennamo, J., and Zhang, C.

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

MicroBooNE is a neutrino experiment located in the Booster Neutrino Beamline (BNB) at Fermilab, which collected data from 2015 to 2021. MicroBooNE's liquid argon time projection chamber (LArTPC) is accompanied by a photon detection system consisting of 32 photomultiplier tubes used to measure the argon scintillation light and determine the timing of neutrino interactions. Analysis techniques combining light signals and reconstructed tracks are applied to achieve a neutrino interaction time resolution of $\mathcal{O}(1\,\text{ns})$. The result obtained allows MicroBooNE to access the ns neutrino pulse structure of the BNB for the first time. The timing resolution achieved will enable significant enhancement of cosmic background rejection for all neutrino analyses. Furthermore, the ns timing resolution opens new avenues to search for long-lived-particles such as heavy neutral leptons in MicroBooNE, as well as in future large LArTPC experiments, namely the SBN program and DUNE.

Published
2023

6. First measurement of quasi-elastic $\Lambda$ baryon production in muon anti-neutrino interactions in the MicroBooNE detector

Author

MicroBooNE collaboration, Abratenko, P., Aldana, D. Andrade, Anthony, J., Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barr, G., Barrow, J., Basque, V., Rodrigues, O. Benevides, Berkman, S., Bhanderi, A., Bhattacharya, M., Bishai, M., Blake, A., Bogart, B., Bolton, T., Book, J. Y., Camilleri, L., Caratelli, D., Terrazas, I. Caro, Cavanna, F., Cerati, G., Chen, Y., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadon, J. I., Del Tutto, M., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Djurcic, Z., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Ereditato, A., Evans, J. J., Fine, R., Finnerud, O. G., Fleming, B. T., Foppiani, N., Foreman, W., Franco, D., Furmanski, A. P., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Goodwin, O., Gramellini, E., Green, P., Greenlee, H., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hicks, R., Hilgenberg, C., Horton-Smith, G. A., Irwin, B., Itay, R., James, C., Ji, X., Jiang, L., Jo, J. H., Johnson, R. A., Jwa, Y. J., Kalra, D., Kamp, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Leibovitch, M. B., Lepetic, I., Li, J. -Y., Li, K., Li, Y., Lin, K., Littlejohn, B. R., Louis, W. C., Luo, X., Mariani, C., Marsden, D., Marshall, J., Martinez, N., Caicedo, D. A. Martinez, Mason, K., Mastbaum, A., McConkey, N., Meddage, V., Miller, K., Mills, J., Mistry, K., Mohayai, T., Mogan, A., Mooney, M., Moor, A. F., Moore, C. D., Lepin, L. Mora, Mousseau, J., Babu, S. Mulleria, Naples, D., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Nowak, J., Nunes, M., Oza, N., Palamara, O., Pallat, N., Paolone, V., Papadopoulou, A., Papavassiliou, V., Parkinson, H., Pate, S. F., Patel, N., Pavlovic, Z., Piasetzky, E., Ponce-Pinto, I., Pophale, I., Prince, S., Qian, X., Raaf, J. L., Radeka, V., Rafique, A., Reggiani-Guzzo, M., Ren, L., Rochester, L., Rondon, J. Rodriguez, Rosenberg, M., Ross-Lonergan, M., von Rohr, C. Rudolph, Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Snider, E. L., Soderberg, M., Soldner-Rembold, S., Spitz, J., Stancari, M., John, J. St., Strauss, T., Sword-Fehlberg, S., Szelc, A. M., Tang, W., Taniuchi, N., Terao, K., Thorpe, C., Torbunov, D., Totani, D., Toups, M., Tsai, Y. -T., Tyler, J., Uchida, M. A., Usher, T., Viren, B., Weber, M., Wei, H., White, A. J., Williams, Z., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wright, N., Wu, W., Yandel, E., Yang, T., Yates, L. E., Yu, H. W., Zeller, G. P., Zennamo, J., and Zhang, C.

Subjects
High Energy Physics - Experiment
Abstract

We present the first measurement of the cross section of Cabibbo-suppressed $\Lambda$ baryon production, using data collected with the MicroBooNE detector when exposed to the neutrinos from the Main Injector beam at the Fermi National Accelerator Laboratory. The data analyzed correspond to $2.2 \times 10^{20}$ protons on target of neutrino mode running and $4.9 \times 10^{20}$ protons on target of anti-neutrino mode running. An automated selection is combined with hand scanning, with the former identifying five candidate $\Lambda$ production events when the signal was unblinded, consistent with the GENIE prediction of $5.3 \pm 1.1$ events. Several scanners were employed, selecting between three and five events, compared with a prediction from a blinded Monte Carlo simulation study of $3.7 \pm 1.0$ events. Restricting the phase space to only include $\Lambda$ baryons that decay above MicroBooNE's detection thresholds, we obtain a flux averaged cross section of $2.0^{+2.2}_{-1.7} \times 10^{-40}$ cm$^2/$Ar, where statistical and systematic uncertainties are combined.

Published
2022

7. First Measurement of Differential Cross Sections for Muon Neutrino Charged Current Interactions on Argon with a Two-proton Final State in the MicroBooNE Detector

Author

MicroBooNE collaboration, Abratenko, P., Aldana, D. Andrade, Anthony, J., Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barr, G., Barrow, J., Basque, V., Bathe-Peters, L., Rodrigues, O. Benevides, Berkman, S., Bhanderi, A., Bhattacharya, M., Bishai, M., Blake, A., Bogart, B., Bolton, T., Book, J. Y., Camilleri, L., Caratelli, D., Terrazas, I. Caro, Cavanna, F., Cerati, G., Chen, Y., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadon, J. I., Del Tutto, M., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Ereditato, A., Evans, J. J., Fine, R., Finnerud, O. G., Fleming, B. T., Foppiani, N., Foreman, W., Franco, D., Furmanski, A. P., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Goodwin, O., Gramellini, E., Green, P., Greenlee, H., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hicks, R., Hilgenberg, C., Horton-Smith, G. A., Irwin, B., Itay, R., James, C., Ji, X., Jiang, L., Jo, J. H., Johnson, R. A., Jwa, Y. J., Kalra, D., Kamp, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Leibovitch, M. B., Lepetic, I., Li, J. -Y., Li, K., Li, Y., Lin, K., Littlejohn, B. R., Louis, W. C., Luo, X., Manivannan, K., Mariani, C., Marsden, D., Marshall, J., Caicedo, D. A. Martinez, Mason, K., Mastbaum, A., McConkey, N., Meddage, V., Miller, K., Mills, J., Mistry, K., Mohayai, T., Mogan, A., Mooney, M., Moor, A. F., Moore, C. D., Lepin, L. Mora, Mousseau, J., Babu, S. Mulleria, Naples, D., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Nowak, J., Nunes, M., Oza, N., Palamara, O., Pallat, N., Paolone, V., Papadopoulou, A., Papavassiliou, V., Parkinson, H., Pate, S. F., Patel, N., Pavlovic, Z., Piasetzky, E., Ponce-Pinto, I., Pophale, I., Prince, S., Qian, X., Raaf, J. L., Radeka, V., Reggiani-Guzzo, M., Ren, L., Rochester, L., Rondon, J. Rodriguez, Rosenberg, M., Ross-Lonergan, M., von Rohr, C. Rudolph, Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Smith, A., Snider, E. L., Soderberg, M., Soldner-Rembold, S., Spitz, J., Stancari, M., John, J. St., Strauss, T., Sword-Fehlberg, S., Szelc, A. M., Tang, W., Taniuchi, N., Terao, K., Thorpe, C., Torbunov, D., Totani, D., Toups, M., Tsai, Y. -T., Tyler, J., Uchida, M. A., Usher, T., Viren, B., Weber, M., Wei, H., White, A. J., Williams, Z., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wright, N., Wu, W., Yandel, E., Yang, T., Yates, L. E., Yu, H. W., Zeller, G. P., Zennamo, J., and Zhang, C.

Subjects
High Energy Physics - Experiment, Nuclear Experiment
Abstract

We present the first measurement of differential cross sections for charged-current muon neutrino interactions on argon with one muon, two protons, and no pions in the final state. Such interactions leave the target nucleus in a two-particle two-hole state; these states are of great interest, but currently there is limited information about their production in neutrino-nucleus interactions. Detailed investigations of the production of two-particle two-hole states are vital to support upcoming experiments exploring the nature of the neutrino, and the development of the liquid-argon time-projection-chamber has made possible the isolation of such final states. The opening angle between the two protons, the angle between the total proton momentum and the muon, and the total transverse momentum of the final state system are sensitive to the underlying physics processes as embodied in a variety of models. Realistic initial-state momentum distributions are shown to be important in reproducing the data., Comment: Resubmitted to PRL in response to reviewer comments

Published
2022

8. First constraints on light sterile neutrino oscillations from combined appearance and disappearance searches with the MicroBooNE detector

Author

MicroBooNE collaboration, Abratenko, P., Aldana, D. Andrade, Anthony, J., Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barr, G., Barrow, J., Basque, V., Bathe-Peters, L., Rodrigues, O. Benevides, Berkman, S., Bhanderi, A., Bhattacharya, M., Bishai, M., Blake, A., Bogart, B., Bolton, T., Book, J. Y., Camilleri, L., Caratelli, D., Terrazas, I. Caro, Cavanna, F., Cerati, G., Chen, Y., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadon, J. I., Del Tutto, M., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Ereditato, A., Evans, J. J., Fine, R., Finnerud, O. G., Fleming, B. T., Foppiani, N., Foreman, W., Franco, D., Furmanski, A. P., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Goodwin, O., Gramellini, E., Green, P., Greenlee, H., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hicks, R., Hilgenberg, C., Horton-Smith, G. A., Irwin, B., Itay, R., James, C., Ji, X., Jiang, L., Jo, J. H., Johnson, R. A., Jwa, Y. J., Kalra, D., Kamp, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Leibovitch, M. B., Lepetic, I., Li, J. -Y., Li, K., Li, Y., Lin, K., Littlejohn, B. R., Louis, W. C., Luo, X., Manivannan, K., Mariani, C., Marsden, D., Marshall, J., Martinez, N., Caicedo, D. A. Martinez, Mason, K., Mastbaum, A., McConkey, N., Meddage, V., Miller, K., Mills, J., Mistry, K., Mohayai, T., Mogan, A., Mooney, M., Moor, A. F., Moore, C. D., Lepin, L. Mora, Mousseau, J., Babu, S. Mulleria, Naples, D., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Nowak, J., Nunes, M., Oza, N., Palamara, O., Pallat, N., Paolone, V., Papadopoulou, A., Papavassiliou, V., Parkinson, H., Pate, S. F., Patel, N., Pavlovic, Z., Piasetzky, E., Ponce-Pinto, I., Pophale, I., Prince, S., Qian, X., Raaf, J. L., Radeka, V., Reggiani-Guzzo, M., Ren, L., Rochester, L., Rondon, J. Rodriguez, Rosenberg, M., Ross-Lonergan, M., von Rohr, C. Rudolph, Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Smith, A., Snider, E. L., Soderberg, M., Soldner-Rembold, S., Spitz, J., Stancari, M., John, J. St., Strauss, T., Sword-Fehlberg, S., Szelc, A. M., Tang, W., Taniuchi, N., Terao, K., Thorpe, C., Torbunov, D., Totani, D., Toups, M., Tsai, Y. -T., Tyler, J., Uchida, M. A., Usher, T., Viren, B., Weber, M., Wei, H., White, A. J., Williams, Z., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wright, N., Wu, W., Yandel, E., Yang, T., Yates, L. E., Yu, H. W., Zeller, G. P., Zennamo, J., and Zhang, C.

Subjects
High Energy Physics - Experiment
Abstract

We present a search for eV-scale sterile neutrino oscillations in the MicroBooNE liquid argon detector, simultaneously considering all possible appearance and disappearance effects within the $3+1$ active-to-sterile neutrino oscillation framework. We analyze the neutrino candidate events for the recent measurements of charged-current $\nu_e$ and $\nu_{\mu}$ interactions in the MicroBooNE detector, using data corresponding to an exposure of 6.37$\times$10$^{20}$ protons on target from the Fermilab booster neutrino beam. We observe no evidence of light sterile neutrino oscillations and derive exclusion contours at the $95\%$ confidence level in the plane of the mass-squared splitting $\Delta m^2_{41}$ and the sterile neutrino mixing angles $\theta_{\mu e}$ and $\theta_{ee}$, excluding part of the parameter space allowed by experimental anomalies. Cancellation of $\nu_e$ appearance and $\nu_e$ disappearance effects due to the full $3+1$ treatment of the analysis leads to a degeneracy when determining the oscillation parameters, which is discussed in this paper and will be addressed by future analyses., Comment: 9 pages, 4 figures; supplemental: 6 pages, 8 figures

Published
2022
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9. Differential cross section measurement of charged current $\nu_{e}$ interactions without final-state pions in MicroBooNE

Author

MicroBooNE collaboration, Abratenko, P., Anthony, J., Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barnes, C., Barr, G., Barrow, J., Basque, V., Bathe-Peters, L., Rodrigues, O. Benevides, Berkman, S., Bhanderi, A., Bhattacharya, M., Bishai, M., Blake, A., Bogart, B., Bolton, T., Book, J. Y., Camilleri, L., Caratelli, D., Terrazas, I. Caro, Cavanna, F., Cerati, G., Chen, Y., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadon, J. I., Del Tutto, M., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Ereditato, A., Evans, J. J., Fine, R., Finnerud, O. G., Fleming, B. T., Foppiani, N., Foreman, W., Franco, D., Furmanski, A. P., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Goodwin, O., Gramellini, E., Green, P., Greenlee, H., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hicks, R., Hilgenberg, C., Horton-Smith, G. A., Irwin, B., Itay, R., James, C., Ji, X., Jiang, L., Jo, J. H., Johnson, R. A., Jwa, Y. J., Kalra, D., Kamp, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Leibovitch, M. B., Lepetic, I., Li, J. -Y., Li, K., Li, Y., Lin, K., Littlejohn, B. R., Louis, W. C., Luo, X., Manivannan, K., Mariani, C., Marsden, D., Marshall, J., Caicedo, D. A. Martinez, Mason, K., Mastbaum, A., McConkey, N., Meddage, V., Miller, K., Mills, J., Mistry, K., Mohayai, T., Mogan, A., Mooney, M., Moor, A. F., Moore, C. D., Lepin, L. Mora, Mousseau, J., Babu, S. Mulleria, Naples, D., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Newmark, D. A., Nowak, J., Nunes, M., Oza, N., Palamara, O., Pallat, N., Paolone, V., Papadopoulou, A., Papavassiliou, V., Parkinson, H., Pate, S. F., Patel, N., Pavlovic, Z., Piasetzky, E., Ponce-Pinto, I., Prince, S., Qian, X., Raaf, J. L., Radeka, V., Reggiani-Guzzo, M., Ren, L., Rochester, L., Rondon, J. Rodriguez, Rosenberg, M., Ross-Lonergan, M., von Rohr, C. Rudolph, Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Smith, A., Snider, E. L., Soderberg, M., Soldner-Rembold, S., Spitz, J., Stancari, M., John, J. St., Strauss, T., Sword-Fehlberg, S., Szelc, A. M., Tang, W., Taniuchi, N., Terao, K., Thorpe, C., Torbunov, D., Totani, D., Toups, M., Tsai, Y. -T., Tyler, J., Uchida, M. A., Usher, T., Viren, B., Weber, M., Wei, H., White, A. J., Williams, Z., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wright, N., Wu, W., Yandel, E., Yang, T., Yates, L. E., Yu, H. W., Zeller, G. P., Zennamo, J., and Zhang, C.

Subjects
High Energy Physics - Experiment
Abstract

In this letter we present the first measurements of an exclusive electron neutrino cross section with the MicroBooNE experiment using data from the Booster Neutrino Beamline at Fermilab. These measurements are made for a selection of charged-current electron neutrinos without final-state pions. Differential cross sections are extracted in energy and angle with respect to the beam for the electron and the leading proton. The differential cross section as a function of proton energy is measured using events with protons both above and below the visibility threshold. This is done by including a separate selection of electron neutrino events without reconstructed proton candidates in addition to those with proton candidates. Results are compared to the predictions from several modern generators, and we find the data agrees well with these models. The data shows best agreement, as quantified by $p$-value, with the generators that predict a lower overall cross section, such as GENIE v3 and NuWro.

Published
2022

10. Search for long-lived heavy neutral leptons and Higgs portal scalars decaying in the MicroBooNE detector

Author

MicroBooNE collaboration, Abratenko, P., Anthony, J., Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barnes, C., Barr, G., Barrow, J., Basque, V., Bathe-Peters, L., Rodrigues, O. Benevides, Berkman, S., Bhanderi, A., Bhattacharya, M., Bishai, M., Blake, A., Bogart, B., Bolton, T., Book, J. Y., Camilleri, L., Caratelli, D., Terrazas, I. Caro, Cavanna, F., Cerati, G., Chen, Y., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadon, J. I., Del Tutto, M., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Ereditato, A., Evans, J. J., Fine, R., Finnerud, O. G., Fleming, B. T., Foppiani, N., Foreman, W., Franco, D., Furmanski, A. P., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Goodwin, O., Gramellini, E., Green, P., Greenlee, H., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hicks, R., Hilgenberg, C., Horton-Smith, G. A., Itay, R., James, C., Ji, X., Jiang, L., Jo, J. H., Johnson, R. A., Jwa, Y. J., Kalra, D., Kamp, N., Kaneshige, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Leibovitch, M. B., Lepetic, I., Li, J. -Y., Li, K., Li, Y., Lin, K., Littlejohn, B. R., Louis, W. C., Luo, X., Manivannan, K., Mariani, C., Marsden, D., Marshall, J., Caicedo, D. A. Martinez, Mason, K., Mastbaum, A., McConkey, N., Meddage, V., Miller, K., Mills, J., Mistry, K., Mohayai, T., Mogan, A., Mooney, M., Moor, A. F., Moore, C. D., Lepin, L. Mora, Mousseau, J., Babu, S. Mulleria, Naples, D., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Newmark, D. A., Nowak, J., Nunes, M., Oza, N., Palamara, O., Pallat, N., Paolone, V., Papadopoulou, A., Papavassiliou, V., Parkinson, H., Pate, S. F., Patel, N., Pavlovic, Z., Piasetzky, E., Ponce-Pinto, I., Prince, S., Qian, X., Raaf, J. L., Radeka, V., Rafique, A., Reggiani-Guzzo, M., Ren, L., Rice, L. C. J., Rochester, L., Rondon, J. Rodriguez, Rosenberg, M., Ross-Lonergan, M., von Rohr, C. Rudolph, Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Smith, A., Snider, E. L., Soderberg, M., Soldner-Rembold, S., Spitz, J., Stancari, M., John, J. St., Strauss, T., Sword-Fehlberg, S., Szelc, A. M., Tang, W., Taniuchi, N., Terao, K., Thorpe, C., Torbunov, D., Totani, D., Toups, M., Tsai, Y. -T., Tyler, J., Uchida, M. A., Usher, T., Viren, B., Weber, M., Wei, H., White, A. J., Williams, Z., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wright, N., Wu, W., Yandel, E., Yang, T., Yates, L. E., Yu, H. W., Zeller, G. P., Zennamo, J., and Zhang, C.

Subjects
High Energy Physics - Experiment
Abstract

We present a search for long-lived Higgs portal scalars (HPS) and heavy neutral leptons (HNL) decaying in the MicroBooNE liquid-argon time projection chamber. The measurement is performed using data collected synchronously with the NuMI neutrino beam from Fermilab's Main Injector with a total exposure corresponding to $7.01 \times 10^{20}$ protons on target. We set upper limits at the $90\%$ confidence level on the mixing parameter $\lvert U_{\mu 4}\rvert^2$ ranging from $\lvert U_{\mu 4}\rvert^2<12.9\times 10^{-8}$ for Majorana HNLs with a mass of $m_{\rm HNL}=246$ MeV to $\lvert U_{\mu 4}\rvert^2<0.92 \times 10^{-8}$ for $m_{\rm HNL}=385$ MeV, assuming $\lvert U_{e 4}\rvert^2 = \lvert U_{\tau 4}\rvert^2 = 0$ and HNL decays into $\mu^\pm\pi^\mp$ pairs. These limits on $\lvert U_{\mu 4}\rvert^2$ represent an order of magnitude improvement in sensitivity compared to the previous MicroBooNE result. We also constrain the scalar-Higgs mixing angle $\theta$ by searching for HPS decays into $\mu^+\mu^-$ final states, excluding a contour in the parameter space with lower bounds of $\theta^2<31.3 \times 10^{-9}$ for $m_{\rm HPS}=212$ GeV and $\theta^2<1.09 \times 10^{-9}$ for $m_{\rm HPS}=275$ GeV. These are the first constraints on the scalar-Higgs mixing angle $\theta$ from a dedicated experimental search in this mass range., Comment: This paper is dedicated to the memory of Salvatore Davide Porzio. This is the journal accepted version with only minor presentational changes compared to preprint

Published
2022
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11. Measurement of neutral current single $\pi^0$ production on argon with the MicroBooNE detector

Author

MicroBooNE collaboration, Abratenko, P., Anthony, J., Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barnes, C., Barr, G., Barrow, J., Basque, V., Bathe-Peters, L., Rodrigues, O. Benevides, Berkman, S., Bhanderi, A., Bhat, A., Bhattacharya, M., Bishai, M., Blake, A., Bolton, T., Book, J. Y., Camilleri, L., Caratelli, D., Terrazas, I. Caro, Cavanna, F., Cerati, G., Chen, Y., Cianci, D., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadon, J. I., Del Tutto, M., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Ereditato, A., Evans, J. J., Fine, R., Finnerud, O. G., Aguirre, G. A. Fiorentini, Fitzpatrick, R. S., Fleming, B. T., Foppiani, N., Franco, D., Furmanski, A. P., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Goodwin, O., Gramellini, E., Green, P., Greenlee, H., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hicks, R., Hilgenberg, C., Horton-Smith, G. A., Itay, R., James, C., Ji, X., Jiang, L., Jo, J. H., Johnson, R. A., Jwa, Y. J., Kalra, D., Kamp, N., Kaneshige, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Leibovitch, M. B., Lepetic, I., Li, J. -Y., Li, K., Li, Y., Lin, K., Littlejohn, B. R., Louis, W. C., Luo, X., Manivannan, K., Mariani, C., Marsden, D., Marshall, J., Caicedo, D. A. Martinez, Mason, K., Mastbaum, A., McConkey, N., Meddage, V., Mettler, T., Miller, K., Mills, J., Mistry, K., Mohayai, T., Mogan, A., Mooney, M., Moor, A. F., Moore, C. D., Lepin, L. Mora, Mousseau, J., Babu, S. Mulleria, Naples, D., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Neely, R. K., Newmark, D. A., Nowak, J., Nunes, M., Oza, N., Palamara, O., Paolone, V., Papadopoulou, A., Papavassiliou, V., Parkinson, H., Pate, S. F., Patel, N., Paudel, A., Pavlovic, Z., Piasetzky, E., Ponce-Pinto, I., Prince, S., Qian, X., Raaf, J. L., Radeka, V., Rafique, A., Reggiani-Guzzo, M., Ren, L., Rice, L. C. J., Rochester, L., Rondon, J. Rodriguez, Rosenberg, M., Ross-Lonergan, M., von Rohr, C. Rudolph, Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Sinclair, J., Smith, A., Snider, E. L., Soderberg, M., Soldner-Rembold, S., Spentzouris, P., Spitz, J., Stancari, M., John, J. St., Strauss, T., Sutton, K., Sword-Fehlberg, S., Szelc, A. M., Tang, W., Taniuchi, N., Terao, K., Thorpe, C., Torbunov, D., Totani, D., Toups, M., Tsai, Y. -T., Uchida, M. A., Usher, T., Viren, B., Weber, M., Wei, H., White, A. J., Williams, Z., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wright, N., Wu, W., Yandel, E., Yang, T., Yarbrough, G., Yates, L. E., Yu, H. W., Zeller, G. P., Zennamo, J., and Zhang, C.

Subjects
High Energy Physics - Experiment
Abstract

We report the first measurement of $\pi^0$ production in neutral current (NC) interactions on argon with average neutrino energy of $\lesssim1$~GeV. We use data from the MicroBooNE detector's 85-tonne active volume liquid argon time projection chamber situated in Fermilab's Booster Neutrino Beam and exposed to $5.89\times10^{20}$ protons on target for this measurement. Measurements of NC $\pi^0$ events are reported for two exclusive event topologies without charged pions. Those include a topology with two photons from the decay of the $\pi^0$ and one proton and a topology with two photons and zero protons. Flux-averaged cross-sections for each exclusive topology and for their semi-inclusive combination are extracted (efficiency-correcting for two-plus proton final states), and the results are compared to predictions from the \textsc{genie}, \textsc{neut}, and \textsc{NuWro} neutrino event generators. We measure cross sections of $1.243\pm0.185$ (syst) $\pm0.076$ (stat), $0.444\pm0.098\pm0.047$, and $0.624\pm0.131\pm0.075$ $[10^{-38}\textrm{cm}^2/\textrm{Ar}]$ for the semi-inclusive NC$\pi^0$, exclusive NC$\pi^0$+1p, and exclusive NC$\pi^0$+0p processes, respectively., Comment: 16 pages, 14 figures, 2 tables

Published
2022

16. Sirius I: prototype of a prime-power source for future 1 - 10 GJ fusion-yield experiments

Author

LeChien, K, primary, Stygar, W, additional, Anderson, M, additional, Max, D, additional, Anaya, R, additional, Beatty, C, additional, White, A, additional, Trueblood, J, additional, Benson, A, additional, Beverly, R, additional, Chaffee, R, additional, Cortes, J, additional, Drews, W, additional, Hicks, R, additional, Howland, F, additional, Norton, D, additional, Speer, R, additional, and Watson, J, additional

Published
2023
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21. Measurement of triple-differential inclusive muon-neutrino charged-current cross section on argon with the MicroBooNE detector

Author

Abratenko, P., Alterkait, O., Aldana, D. Andrade, Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barr, G., Barrow, D., Barrow, J., Basque, V., Rodrigues, O. Benevides, Berkman, S., Bhanderi, A., Bhat, A., Bhattacharya, M., Bishai, M., Blake, A., Bogart, B., Bolton, T., Book, J. Y., Camilleri, L., Cao, Y., Caratelli, D., Terrazas, I. Caro, Cavanna, F., Cerati, G., Chen, Y., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadon, J. I., Del Tutto, M., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Djurcic, Z., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Englezos, P., Ereditato, A., Evans, J. J., Fine, R., Finnerud, O. G., Fleming, B. T., Foppiani, N., Foreman, W., Franco, D., Furmanski, A. P., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Goodwin, O., Gramellini, E., Green, P., Greenlee, H., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hicks, R., Hilgenberg, C., Horton-Smith, G. A., Imani, Z., Irwin, B., Itay, R., James, C., Ji, X., Jiang, L., Jo, J. H., Johnson, R. A., Jwa, Y. J., Kalra, D., Kamp, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Leibovitch, M. B., Lepetic, I., Li, J. -Y., Li, K., Li, Y., Lin, K., Littlejohn, B. R., Liu, H., Louis, W. C., Luo, X., Mariani, C., Marsden, D., Marshall, J., Martinez, N., Caicedo, D. A. Martinez, Mastbaum, A., McConkey, N., Meddage, V., Micallef, J., Miller, K., Mistry, K., Mohayai, T., Mogan, A., Mooney, M., Moor, A. F., Moore, C. D., Lepin, L. Mora, Moudgalya, M., Babu, S. Mulleria, Naples, D., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Nowak, J., Oza, N., Palamara, O., Pallat, N., Paolone, V., Papadopoulou, A., Papavassiliou, V., Parkinson, H., Pate, S. F., Patel, N., Pavlovic, Z., Piasetzky, E., Ponce-Pinto, I., Pophale, I., Prince, S., Qian, X., Raaf, J. L., Radeka, V., Rafique, A., Reggiani-Guzzo, M., Ren, L., Rochester, L., Rondon, J. Rodriguez, Rosenberg, M., Ross-Lonergan, M., von Rohr, C. Rudolph, Safa, I., Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Snider, E. L., Soderberg, M., Soldner-Rembold, S., Spitz, J., Stancari, M., John, J. St., Strauss, T., Szelc, A. M., Tang, W., Taniuchi, N., Terao, K., Thorpe, C., Torbunov, D., Totani, D., Toups, M., Tsai, Y. -T., Tyler, J., Uchida, M. A., Usher, T., Viren, B., Weber, M., Wei, H., White, A. J., Williams, Z., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wright, N., Wu, W., Yandel, E., Yang, T., Yates, L. E., Yu, H. W., Zeller, G. P., Zennamo, J., and Zhang, C.

Subjects
High Energy Physics - Experiment (hep-ex), Physics - Instrumentation and Detectors, FOS: Physical sciences, Instrumentation and Detectors (physics.ins-det), High Energy Physics - Experiment
Abstract

We report the first measurement of the differential cross section $d^{2}\sigma (E_{\nu})/ d\cos(\theta_{\mu}) dP_{\mu}$ for inclusive muon-neutrino charged-current scattering on argon. This measurement utilizes data from 6.4$\times10^{20}$ protons on target of exposure collected using the MicroBooNE liquid argon time projection chamber located along the Fermilab Booster Neutrino Beam with a mean neutrino energy of approximately 0.8~GeV. The mapping from reconstructed kinematics to truth quantities, particularly from reconstructed to true neutrino energy, is validated by comparing the distribution of reconstructed hadronic energy in data to that of the model prediction in different muon scattering angle bins after conditional constraint from the muon momentum distribution in data. The success of this validation gives confidence that the missing energy in the MicroBooNE detector is well-modeled in simulation, enabling the unfolding to a triple-differential measurement over muon momentum, muon scattering angle, and neutrino energy. The unfolded measurement covers an extensive phase space, providing a wealth of information useful for future liquid argon time projection chamber experiments measuring neutrino oscillations. Comparisons against a number of commonly used model predictions are included and their performance in different parts of the available phase-space is discussed.

Published
2023

22. First Measurement of Quasielastic <math><mi>Λ</mi></math> Baryon Production in Muon Antineutrino Interactions in the MicroBooNE Detector

Author

Abratenko, P., Andrade Aldana, D., Anthony, J., Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barr, G., Barrow, J., Basque, V., Benevides Rodrigues, O., Berkman, S., Bhanderi, A., Bhattacharya, M., Bishai, M., Blake, A., Bogart, B., Bolton, T., Book, J. Y., Camilleri, L., Caratelli, D., Caro Terrazas, I., Cavanna, F., Cerati, G., Chen, Y., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadón, J. I., Del Tutto, M., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Djurcic, Z., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Ereditato, A., Evans, J. J., Fine, R., Finnerud, O. G., Foreman, W., Fleming, B. T., Foppiani, N., Franco, D., Furmanski, A. P., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Goodwin, O., Gramellini, E., Green, P., Greenlee, H., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hicks, R., Hilgenberg, C., Horton-Smith, G. A., Irwin, B., Itay, R., James, C., Ji, X., Jiang, L., Jo, J. H., Johnson, R. A., Jwa, Y.J., Kalra, D., Kamp, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Leibovitch, M. B., Lepetic, I., Li, J.Y., Li, K., Li, Y., Lin, K., Littlejohn, B. R., Louis, W. C., Luo, X., Mariani, C., Marsden, D., Marshall, J., Martinez, N., Martinez Caicedo, D. A., Mason, K., Mastbaum, A., McConkey, N., Meddage, V., Miller, K., Mills, J., Mogan, A., Mohayai, T., Mooney, M., Moor, A. F., Moore, C. D., Mora Lepin, L., Mousseau, J., Mulleriababu, S., Naples, D., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Nowak, J., Nunes, M., Oza, N., Palamara, O., Pallat, N., Paolone, V., Papadopoulou, A., Papavassiliou, V., Parkinson, H. B., Pate, S. F., Patel, N., Pavlovic, Z., Piasetzky, E., Ponce-Pinto, I. D., Pophale, I., Prince, S., Qian, X., Raaf, J. L., Radeka, V., Rafique, A., Reggiani-Guzzo, M., Ren, L., Rochester, L., Rodriguez Rondon, J., Rosenberg, M., Ross-Lonergan, M., Rudolf von Rohr, C., Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Snider, E. L., Soderberg, M., Söldner-Rembold, S., Spitz, J., Stancari, M., John, J. St., Strauss, T., Sword-Fehlberg, S., Szelc, A. M., Tang, W., Taniuchi, N., Terao, K., Thorpe, C., Torbunov, D., Totani, D., Toups, M., Tsai, Y.T., Tyler, J., Uchida, M. A., Usher, T., Viren, B., Weber, M., Wei, H., White, A. J., Williams, Z., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wright, N., Wu, W., Yandel, E., Yang, T., Yates, L. E., Yu, H. W., Zeller, G. P., Zennamo, J., and Zhang, C.

Abstract

We present the first measurement of the cross section of Cabibbo-suppressed Λ baryon production, using data collected with the MicroBooNE detector when exposed to the neutrinos from the main injector beam at the Fermi National Accelerator Laboratory. The data analyzed correspond to 2.2×1020 protons on target running in neutrino mode, and 4.9×1020 protons on target running in anti-neutrino mode. An automated selection is combined with hand scanning, with the former identifying five candidate Λ production events when the signal was unblinded, consistent with the GENIE prediction of 5.3±1.1 events. Several scanners were employed, selecting between three and five events, compared with a prediction from a blinded Monte Carlo simulation study of 3.7±1.0 events. Restricting the phase space to only include Λ baryons that decay above MicroBooNE’s detection thresholds, we obtain a flux averaged cross section of 2.0−1.7+2.2×10−40 cm2/Ar, where statistical and systematic uncertainties are combined.

Published
2023

23. Active readout-error mitigation

Author

Hicks, R, Hicks, R, Kobrin, B, Bauer, CW, Nachman, B, Hicks, R, Hicks, R, Kobrin, B, Bauer, CW, and Nachman, B

Abstract

Mitigating errors is a significant challenge for near-term quantum computers. One of the most important sources of errors is related to the readout of the quantum state into a classical bit stream. A variety of techniques have been proposed to mitigate these errors with post-hoc corrections. We propose a complementary scheme to actively reduce readout errors on a shot-by-shot basis by encoding single qubits, immediately prior to readout, into multiqubit states. The computational resources of our technique are independent of the circuit depth and are compatible with the error rates and connectivity of many current devices. We analyze the potential of our approach using two types of error-correcting codes, and, as a proof of principle, we demonstrate an 80% improvement in readout error on the IBMQ Mumbai quantum computer.

Published
2022

29. First demonstration for a LArTPC-based search for intranuclear neutron-antineutron transitions and annihilation in $^{40}$Ar using the MicroBooNE detector

Author

MicroBooNE collaboration, Abratenko, P., Alterkait, O., Aldana, D. Andrade, Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barr, G., Barrow, D., Barrow, J., Basque, V., Rodrigues, O. Benevides, Berkman, S., Bhanderi, A., Bhat, A., Bhattacharya, M., Bishai, M., Blake, A., Bogart, B., Bolton, T., Book, J. Y., Camilleri, L., Cao, Y., Caratelli, D., Terrazas, I. Caro, Cavanna, F., Cerati, G., Chen, Y., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadon, J. I., Cross, R., Del Tutto, M., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Djurcic, Z., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Englezos, P., Ereditato, A., Evans, J. J., Fine, R., Finnerud, O. G., Fleming, B. T., Foppiani, N., Foreman, W., Franco, D., Furmanski, A. P., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Goodwin, O., Gramellini, E., Green, P., Greenlee, H., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hicks, R., Hilgenberg, C., Horton-Smith, G. A., Imani, Z., Irwin, B., Itay, R., James, C., Ji, X., Jiang, L., Jo, J. H., Johnson, R. A., Jwa, Y. J., Kalra, D., Kamp, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Leibovitch, M. B., Lepetic, I., Li, J. -Y., Li, K., Li, Y., Lin, K., Littlejohn, B. R., Liu, H., Louis, W. C., Luo, X., Mariani, C., Marsden, D., Marshall, J., Martinez, N., Caicedo, D. A. Martinez, Martynenko, S., Mastbaum, A., McConkey, N., Meddage, V., Micallef, J., Miller, K., Mistry, K., Mohayai, T., Mogan, A., Mooney, M., Moor, A. F., Moore, C. D., Lepin, L. Mora, Moudgalya, M. M., Babu, S. Mulleria, Naples, D., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Nowak, J., Oza, N., Palamara, O., Pallat, N., Paolone, V., Papadopoulou, A., Papavassiliou, V., Parkinson, H., Pate, S. F., Patel, N., Pavlovic, Z., Piasetzky, E., Ponce-Pinto, I., Pophale, I., Qian, X., Raaf, J. L., Radeka, V., Rafique, A., Reggiani-Guzzo, M., Ren, L., Rochester, L., Rondon, J. Rodriguez, Rosenberg, M., Ross-Lonergan, M., von Rohr, C. Rudolph, Safa, I., Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Snider, E. L., Soderberg, M., Soldner-Rembold, S., Spitz, J., Stancari, M., John, J. St., Strauss, T., Szelc, A. M., Tang, W., Taniuchi, N., Terao, K., Thorpe, C., Torbunov, D., Totani, D., Toups, M., Tsai, Y. -T., Tyler, J., Uchida, M. A., Usher, T., Viren, B., Weber, M., Wei, H., White, A. J., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wright, N., Wu, W., Yandel, E., Yang, T., Yates, L. E., Yu, H. W., Zeller, G. P., Zennamo, J., Zhang, C., MicroBooNE collaboration, Abratenko, P., Alterkait, O., Aldana, D. Andrade, Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barr, G., Barrow, D., Barrow, J., Basque, V., Rodrigues, O. Benevides, Berkman, S., Bhanderi, A., Bhat, A., Bhattacharya, M., Bishai, M., Blake, A., Bogart, B., Bolton, T., Book, J. Y., Camilleri, L., Cao, Y., Caratelli, D., Terrazas, I. Caro, Cavanna, F., Cerati, G., Chen, Y., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadon, J. I., Cross, R., Del Tutto, M., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Djurcic, Z., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Englezos, P., Ereditato, A., Evans, J. J., Fine, R., Finnerud, O. G., Fleming, B. T., Foppiani, N., Foreman, W., Franco, D., Furmanski, A. P., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Goodwin, O., Gramellini, E., Green, P., Greenlee, H., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hicks, R., Hilgenberg, C., Horton-Smith, G. A., Imani, Z., Irwin, B., Itay, R., James, C., Ji, X., Jiang, L., Jo, J. H., Johnson, R. A., Jwa, Y. J., Kalra, D., Kamp, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Leibovitch, M. B., Lepetic, I., Li, J. -Y., Li, K., Li, Y., Lin, K., Littlejohn, B. R., Liu, H., Louis, W. C., Luo, X., Mariani, C., Marsden, D., Marshall, J., Martinez, N., Caicedo, D. A. Martinez, Martynenko, S., Mastbaum, A., McConkey, N., Meddage, V., Micallef, J., Miller, K., Mistry, K., Mohayai, T., Mogan, A., Mooney, M., Moor, A. F., Moore, C. D., Lepin, L. Mora, Moudgalya, M. M., Babu, S. Mulleria, Naples, D., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Nowak, J., Oza, N., Palamara, O., Pallat, N., Paolone, V., Papadopoulou, A., Papavassiliou, V., Parkinson, H., Pate, S. F., Patel, N., Pavlovic, Z., Piasetzky, E., Ponce-Pinto, I., Pophale, I., Qian, X., Raaf, J. L., Radeka, V., Rafique, A., Reggiani-Guzzo, M., Ren, L., Rochester, L., Rondon, J. Rodriguez, Rosenberg, M., Ross-Lonergan, M., von Rohr, C. Rudolph, Safa, I., Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Snider, E. L., Soderberg, M., Soldner-Rembold, S., Spitz, J., Stancari, M., John, J. St., Strauss, T., Szelc, A. M., Tang, W., Taniuchi, N., Terao, K., Thorpe, C., Torbunov, D., Totani, D., Toups, M., Tsai, Y. -T., Tyler, J., Uchida, M. A., Usher, T., Viren, B., Weber, M., Wei, H., White, A. J., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wright, N., Wu, W., Yandel, E., Yang, T., Yates, L. E., Yu, H. W., Zeller, G. P., Zennamo, J., and Zhang, C.

Abstract

In this paper, we present a novel methodology to search for intranuclear neutron-antineutron transition ($n\rightarrow\bar{n}$) followed by annihilation within an $^{40}$Ar nucleus, using the MicroBooNE liquid argon time projection chamber (LArTPC) detector. A discovery of $n\rightarrow\bar{n}$ transition or increased lower limit on the lifetime of this process would either constitute physics beyond the Standard Model or greatly constrain theories of baryogenesis, respectively. The approach presented in this paper makes use of deep learning methods to select $n\rightarrow\bar{n}$ events based on their unique features and differentiate them from cosmogenic backgrounds. The achieved signal and background efficiencies are (70$\pm$6)\% and (0.0020$\pm$0.0003)\%, respectively. A demonstration of a search is performed with a data set corresponding to an exposure of $3.32 \times10^{26}\,$neutron-years, and where the background rate is constrained through direct measurement, assuming the presence of a negligible signal. With this approach, no excess of events over the background prediction is observed, setting a demonstrative lower bound on the $n\rightarrow\bar{n}$ lifetime in $^{40}$Ar of $\tau_{\textrm m} > 1.1\times10^{26}\,$years, and on the free $n\rightarrow\bar{n}$ transition time of $\tau_{\textrm n-\bar{n}} > 2.6\times10^{5}\,$s, each at the $90\%$ confidence level. This analysis represents a first-ever proof-of-principle demonstration of the ability to search for this rare process in LArTPCs with high efficiency and low background., Comment: 11 pages, 6 figures, 6 tables

Published
2023

30. First demonstration of a liquid argon time projection chamber based search for intranuclear neutron-antineutron transitions and annihilation in $^{40}$Ar using the MicroBooNE detector

Author

MicroBooNE collaboration, Abratenko, P., Alterkait, O., Aldana, D. Andrade, Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barr, G., Barrow, D., Barrow, J., Basque, V., Rodrigues, O. Benevides, Berkman, S., Bhanderi, A., Bhat, A., Bhattacharya, M., Bishai, M., Blake, A., Bogart, B., Bolton, T., Book, J. Y., Camilleri, L., Cao, Y., Caratelli, D., Terrazas, I. Caro, Cavanna, F., Cerati, G., Chen, Y., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadon, J. I., Cross, R., Del Tutto, M., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Djurcic, Z., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Englezos, P., Ereditato, A., Evans, J. J., Fine, R., Finnerud, O. G., Fleming, B. T., Foppiani, N., Foreman, W., Franco, D., Furmanski, A. P., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Goodwin, O., Gramellini, E., Green, P., Greenlee, H., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hicks, R., Hilgenberg, C., Horton-Smith, G. A., Imani, Z., Irwin, B., Itay, R., James, C., Ji, X., Jiang, L., Jo, J. H., Johnson, R. A., Jwa, Y. J., Kalra, D., Kamp, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Lepetic, I., Li, J. -Y., Li, K., Li, Y., Lin, K., Littlejohn, B. R., Liu, H., Louis, W. C., Luo, X., Mariani, C., Marsden, D., Marshall, J., Martinez, N., Caicedo, D. A. Martinez, Martynenko, S., Mastbaum, A., McConkey, N., Meddage, V., Micallef, J., Miller, K., Mistry, K., Mohayai, T., Mogan, A., Mooney, M., Moor, A. F., Moore, C. D., Lepin, L. Mora, Moudgalya, M. M., Babu, S. Mulleria, Naples, D., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Nowak, J., Oza, N., Palamara, O., Pallat, N., Paolone, V., Papadopoulou, A., Papavassiliou, V., Parkinson, H., Pate, S. F., Patel, N., Pavlovic, Z., Piasetzky, E., Ponce-Pinto, I., Pophale, I., Qian, X., Raaf, J. L., Radeka, V., Rafique, A., Reggiani-Guzzo, M., Ren, L., Rochester, L., Rondon, J. Rodriguez, Rosenberg, M., Ross-Lonergan, M., von Rohr, C. Rudolph, Safa, I., Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Snider, E. L., Soderberg, M., Soldner-Rembold, S., Spitz, J., Stancari, M., John, J. St., Strauss, T., Szelc, A. M., Tang, W., Taniuchi, N., Terao, K., Thorpe, C., Torbunov, D., Totani, D., Toups, M., Tsai, Y. -T., Tyler, J., Uchida, M. A., Usher, T., Viren, B., Weber, M., Wei, H., White, A. J., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wright, N., Wu, W., Yandel, E., Yang, T., Yates, L. E., Yu, H. W., Zeller, G. P., Zennamo, J., Zhang, C., MicroBooNE collaboration, Abratenko, P., Alterkait, O., Aldana, D. Andrade, Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barr, G., Barrow, D., Barrow, J., Basque, V., Rodrigues, O. Benevides, Berkman, S., Bhanderi, A., Bhat, A., Bhattacharya, M., Bishai, M., Blake, A., Bogart, B., Bolton, T., Book, J. Y., Camilleri, L., Cao, Y., Caratelli, D., Terrazas, I. Caro, Cavanna, F., Cerati, G., Chen, Y., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadon, J. I., Cross, R., Del Tutto, M., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Djurcic, Z., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Englezos, P., Ereditato, A., Evans, J. J., Fine, R., Finnerud, O. G., Fleming, B. T., Foppiani, N., Foreman, W., Franco, D., Furmanski, A. P., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Goodwin, O., Gramellini, E., Green, P., Greenlee, H., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hicks, R., Hilgenberg, C., Horton-Smith, G. A., Imani, Z., Irwin, B., Itay, R., James, C., Ji, X., Jiang, L., Jo, J. H., Johnson, R. A., Jwa, Y. J., Kalra, D., Kamp, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Lepetic, I., Li, J. -Y., Li, K., Li, Y., Lin, K., Littlejohn, B. R., Liu, H., Louis, W. C., Luo, X., Mariani, C., Marsden, D., Marshall, J., Martinez, N., Caicedo, D. A. Martinez, Martynenko, S., Mastbaum, A., McConkey, N., Meddage, V., Micallef, J., Miller, K., Mistry, K., Mohayai, T., Mogan, A., Mooney, M., Moor, A. F., Moore, C. D., Lepin, L. Mora, Moudgalya, M. M., Babu, S. Mulleria, Naples, D., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Nowak, J., Oza, N., Palamara, O., Pallat, N., Paolone, V., Papadopoulou, A., Papavassiliou, V., Parkinson, H., Pate, S. F., Patel, N., Pavlovic, Z., Piasetzky, E., Ponce-Pinto, I., Pophale, I., Qian, X., Raaf, J. L., Radeka, V., Rafique, A., Reggiani-Guzzo, M., Ren, L., Rochester, L., Rondon, J. Rodriguez, Rosenberg, M., Ross-Lonergan, M., von Rohr, C. Rudolph, Safa, I., Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Snider, E. L., Soderberg, M., Soldner-Rembold, S., Spitz, J., Stancari, M., John, J. St., Strauss, T., Szelc, A. M., Tang, W., Taniuchi, N., Terao, K., Thorpe, C., Torbunov, D., Totani, D., Toups, M., Tsai, Y. -T., Tyler, J., Uchida, M. A., Usher, T., Viren, B., Weber, M., Wei, H., White, A. J., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wright, N., Wu, W., Yandel, E., Yang, T., Yates, L. E., Yu, H. W., Zeller, G. P., Zennamo, J., and Zhang, C.

Abstract

We present a novel methodology to search for intranuclear neutron-antineutron transition ($n\rightarrow\bar{n}$) followed by $\bar{n}$-nucleon annihilation within an $^{40}$Ar nucleus, using the MicroBooNE liquid argon time projection chamber (LArTPC) detector. A discovery of $n\rightarrow\bar{n}$ transition or a new best limit on the lifetime of this process would either constitute physics beyond the Standard Model or greatly constrain theories of baryogenesis, respectively. The approach presented in this paper makes use of deep learning methods to select $n\rightarrow\bar{n}$ events based on their unique features and differentiate them from cosmogenic backgrounds. The achieved signal and background efficiencies are (70.22$\pm$6.04)\% and (0.0020$\pm$0.0003)\%, respectively. A demonstration of a search is performed with a data set corresponding to an exposure of $3.32 \times10^{26}\,$neutron-years, and where the background rate is constrained through direct measurement, assuming the presence of a negligible signal. With this approach, no excess of events over the background prediction is observed, setting a demonstrative lower bound on the $n\rightarrow\bar{n}$ lifetime in $^{40}$Ar of $\tau_{\textrm{m}} \gtrsim 1.1\times10^{26}\,$years, and on the free $n\rightarrow\bar{n}$ transition time of $\tau_{\textrm{\nnbar}} \gtrsim 2.6\times10^{5}\,$s, each at the $90\%$ confidence level. This analysis represents a first-ever proof-of-principle demonstration of the ability to search for this rare process in LArTPCs with high efficiency and low background., Comment: 22 pages, 7 figures, 6 tables

Published
2023

31. The Impact of 18-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography on the Staging and Management of Primary Rectal Cancer

Author

Davey, K., Heriot, A., Mackay, J., Drummond, E., Hogg, A., Ngan, S., Milner, A., and Hicks, R.

Abstract

Abstract: Purpose: 18-fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET-CT) has a role in recurrent colorectal cancer. This study was designed to assess the impact of PET-CT on management of primary rectal cancer. Methods: Eighty-three patients with rectal cancer underwent PET-CT scan between 2002 and 2005. Referring physicians prospectively recorded stage and management plan after conventional imaging before PET-CT scan, which were compared to subsequent stage and management after PET-CT. Results: Staging PET-CT caused a change in stage from conventional imaging in 26 patients (31 percent). Twelve (14 percent) were upstaged (7 change in N stage; 4 change in M stage; 1 change in N and M stage), and 14 (17 percent) were downstaged (10 change in N stage; 3 change in M stage; 1 change in N and M stage). PET-CT scan altered management intent in seven patients (8 percent) (curative to palliative 6 patients; palliative to curative 1 patient). Management was altered in ten patients (12 percent). There was no difference in impact with respect to tumor height. Conclusions: PET-CT scan impacts the management of patients with primary rectal cancer and influences staging/therapy in a third of patients and should be a component of rectal cancer workup.

Published
2024
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34. Measurement of neutral current single <math><msup><mi>π</mi><mn>0</mn></msup></math> production on argon with the MicroBooNE detector

Author

Abratenko, P., Anthony, J., Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barnes, C., Barr, G., Barrow, J., Basque, V., Bathe-Peters, L., Benevides Rodrigues, O., Berkman, S., Bhanderi, A., Bhat, A., Bhattacharya, M., Bishai, M., Blake, A., Bolton, T., Book, J. Y., Camilleri, L., Caratelli, D., Caro Terrazas, I., Cavanna, F., Cerati, G., Chen, Y., Cianci, D., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadón, J. I., Del Tutto, M., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Ereditato, A., Evans, J. J., Fine, R., Finnerud, O. G., Fiorentini Aguirre, G. A., Fitzpatrick, R. S., Fleming, B. T., Foppiani, N., Franco, D., Furmanski, A. P., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Goodwin, O., Gramellini, E., Green, P., Greenlee, H., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hicks, R., Hilgenberg, C., Horton-Smith, G. A., Itay, R., James, C., Ji, X., Jiang, L., Jo, J. H., Johnson, R. A., Jwa, Y.J., Kalra, D., Kamp, N., Kaneshige, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Leibovitch, M. B., Lepetic, I., Li, J.Y., Li, K., Li, Y., Lin, K., Littlejohn, B. R., Louis, W. C., Luo, X., Manivannan, K., Mariani, C., Marsden, D., Marshall, J., Martinez Caicedo, D. A., Mason, K., Mastbaum, A., McConkey, N., Meddage, V., Mettler, T., Miller, K., Mills, J., Mistry, K., Mogan, A., Mohayai, T., Mooney, M., Moor, A. F., Moore, C. D., Mora Lepin, L., Mousseau, J., Mulleriababu, S., Naples, D., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Neely, R. K., Newmark, D. A., Nowak, J., Nunes, M., Oza, N., Palamara, O., Paolone, V., Papadopoulou, A., Papavassiliou, V., Parkinson, H. B., Pate, S. F., Patel, N., Paudel, A., Pavlovic, Z., Piasetzky, E., Ponce-Pinto, I. D., Prince, S., Qian, X., Raaf, J. L., Radeka, V., Rafique, A., Reggiani-Guzzo, M., Ren, L., Rice, L. C. J., Rochester, L., Rodriguez Rondon, J., Rosenberg, M., Ross-Lonergan, M., Rudolf von Rohr, C., Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Sinclair, J., Smith, A., Snider, E. L., Soderberg, M., Söldner-Rembold, S., Spentzouris, P., Spitz, J., Stancari, M., John, J. St., Strauss, T., Sutton, K., Sword-Fehlberg, S., Szelc, A. M., Tang, W., Taniuchi, N., Terao, K., Thorpe, C., Torbunov, D., Totani, D., Toups, M., Tsai, Y.T., Uchida, M. A., Usher, T., Viren, B., Weber, M., Wei, H., White, A. J., Williams, Z., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wright, N., Wu, W., Yandel, E., Yang, T., Yarbrough, G., Yates, L. E., Yu, H. W., Zeller, G. P., Zennamo, J., and Zhang, C.

Abstract

We report the first measurement of π0 production in neutral current (NC) interactions on argon with average neutrino energy of ≲1 GeV. We use data from the MicroBooNE detector’s 85 metric tons active volume liquid argon time projection chamber situated in Fermilab’s Booster Neutrino Beam and exposed to 5.89×1020 protons on target for this measurement. Measurements of NC π0 events are reported for two exclusive event topologies without charged pions. Those include a topology with two photons from the decay of the π0 and one proton and a topology with two photons and zero protons. Flux-averaged cross sections for each exclusive topology and for their semi-inclusive combination are extracted (efficiency correcting for two-plus proton final states), and the results are compared to predictions from the genie, neut, and nuwro neutrino event generators. We measure cross sections of 1.243±0.185(syst)±0.076(stat), 0.444±0.098±0.047, and 0.624±0.131±0.075 [10−38 cm2/Ar] for the semi-inclusive NCπ0, exclusive NCπ0+1p, and exclusive NCπ0+0p processes, respectively.

Published
2023

35. First constraints on light sterile neutrino oscillations from combined appearance and disappearance searches with the MicroBooNE detector

Author

MicroBooNE collaboration, Abratenko, P., Aldana, D. Andrade, Anthony, J., Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barr, G., Barrow, J., Basque, V., Bathe-Peters, L., Rodrigues, O. Benevides, Berkman, S., Bhanderi, A., Bhattacharya, M., Bishai, M., Blake, A., Bogart, B., Bolton, T., Book, J. Y., Camilleri, L., Caratelli, D., Terrazas, I. Caro, Cavanna, F., Cerati, G., Chen, Y., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadon, J. I., Del Tutto, M., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Ereditato, A., Evans, J. J., Fine, R., Finnerud, O. G., Fleming, B. T., Foppiani, N., Foreman, W., Franco, D., Furmanski, A. P., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Goodwin, O., Gramellini, E., Green, P., Greenlee, H., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hicks, R., Hilgenberg, C., Horton-Smith, G. A., Irwin, B., Itay, R., James, C., Ji, X., Jiang, L., Jo, J. H., Johnson, R. A., Jwa, Y. J., Kalra, D., Kamp, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Leibovitch, M. B., Lepetic, I., Li, J. -Y., Li, K., Li, Y., Lin, K., Littlejohn, B. R., Louis, W. C., Luo, X., Manivannan, K., Mariani, C., Marsden, D., Marshall, J., Martinez, N., Caicedo, D. A. Martinez, Mason, K., Mastbaum, A., McConkey, N., Meddage, V., Miller, K., Mills, J., Mistry, K., Mohayai, T., Mogan, A., Mooney, M., Moor, A. F., Moore, C. D., Lepin, L. Mora, Mousseau, J., Babu, S. Mulleria, Naples, D., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Nowak, J., Nunes, M., Oza, N., Palamara, O., Pallat, N., Paolone, V., Papadopoulou, A., Papavassiliou, V., Parkinson, H., Pate, S. F., Patel, N., Pavlovic, Z., Piasetzky, E., Ponce-Pinto, I., Pophale, I., Prince, S., Qian, X., Raaf, J. L., Radeka, V., Reggiani-Guzzo, M., Ren, L., Rochester, L., Rondon, J. Rodriguez, Rosenberg, M., Ross-Lonergan, M., von Rohr, C. Rudolph, Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Smith, A., Snider, E. L., Soderberg, M., Soldner-Rembold, S., Spitz, J., Stancari, M., John, J. St., Strauss, T., Sword-Fehlberg, S., Szelc, A. M., Tang, W., Taniuchi, N., Terao, K., Thorpe, C., Torbunov, D., Totani, D., Toups, M., Tsai, Y. -T., Tyler, J., Uchida, M. A., Usher, T., Viren, B., Weber, M., Wei, H., White, A. J., Williams, Z., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wright, N., Wu, W., Yandel, E., Yang, T., Yates, L. E., Yu, H. W., Zeller, G. P., Zennamo, J., and Zhang, C.

Subjects
High Energy Physics - Experiment (hep-ex), General Physics and Astronomy, FOS: Physical sciences, High Energy Physics - Experiment
Abstract

This document was prepared by the MicroBooNE Collaboration using the resources of the Fermi National Accelerator Laboratory (Fermilab), a U.S. Department of Energy, Office of Science, HEP User Facility. Fermilab is managed by Fermi Research Alliance, LLC (FRA), acting under Contract No. DE-AC02-07CH11359. MicroBooNE is supported by the following: the U.S. Department of Energy, Office of Science, Offices of High Energy Physics and Nuclear Physics; the U.S. National Science Foundation; the Swiss National Science Foundation; the Science and Technology Facilities Council (STFC), part of the United Kingdom Research and Innovation; the Royal Society (United Kingdom); and the UK Research and Innovation (UKRI) Future Leaders Fellowship. Additional support for the laser calibration system and cosmic ray tagger was provided by the Albert Einstein Center for Fundamental Physics, Bern, Switzerland. We also acknowledge the contributions of technical and scientific staff to the design, construction, and operation of the MicroBooNE detector as well as the contributions of past collaborators to the development of MicroBooNE analyses, without whom this Letter would not have been possible. For the purpose of open access, the authors have applied a Creative Commons Attribution (CC BY) public copyright license to any author accepted manuscript version arising from this submission., We present a search for eV-scale sterile neutrino oscillations in the MicroBooNE liquid argon detector, simultaneously considering all possible appearance and disappearance effects within the 3+1 active-to-sterile neutrino oscillation framework. We analyze the neutrino candidate events for the recent measurements of charged-current νe and νμ interactions in the MicroBooNE detector, using data corresponding to an exposure of 6.37×1020 protons on target from the Fermilab booster neutrino beam. We observe no evidence of light sterile neutrino oscillations and derive exclusion contours at the 95% confidence level in the plane of the mass-squared splitting Δm241 and the sterile neutrino mixing angles θμe and θee, excluding part of the parameter space allowed by experimental anomalies. Cancellation of νe appearance and νe disappearance effects due to the full 3+1 treatment of the analysis leads to a degeneracy when determining the oscillation parameters, which is discussed in this Letter and will be addressed by future analyses., Fermi Research Alliance, LLC DE-AC02-07CH11359, High Energy Physics and Nuclear Physics, United Kingdom Research and Innovation, National Science Foundation, U.S. Department of Energy, Office of Science, UK Research and Innovation, Science and Technology Facilities Council, Royal Society, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Published
2023

36. Measurement of ambient radon daughter decay rates and energy spectra in liquid argon using the MicroBooNE detector

Author

MicroBooNE collaboration, Abratenko, P., Alterkait, O., Aldana, D. Andrade, Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barr, G., Barrow, D., Barrow, J., Basque, V., Rodrigues, O. Benevides, Berkman, S., Bhanderi, A., Bhat, A., Bhattacharya, M., Bishai, M., Blake, A., Bogart, B., Bolton, T., Book, J. Y., Camilleri, L., Cao, Y., Caratelli, D., Terrazas, I. Caro, Cavanna, F., Cerati, G., Chen, Y., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadon, J. I., Cross, R., Del Tutto, M., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Djurcic, Z., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Englezos, P., Ereditato, A., Evans, J. J., Fine, R., Finnerud, O. G., Fleming, B. T., Foppiani, N., Foreman, W., Franco, D., Furmanski, A. P., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Goodwin, O., Gramellini, E., Green, P., Greenlee, H., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hicks, R., Hilgenberg, C., Horton-Smith, G. A., Imani, Z., Irwin, B., Itay, R., James, C., Ji, X., Jiang, L., Jo, J. H., Johnson, R. A., Jwa, Y. J., Kalra, D., Kamp, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Leibovitch, M. B., Lepetic, I., Li, J. -Y., Li, K., Li, Y., Lin, K., Littlejohn, B. R., Liu, H., Louis, W. C., Luo, X., Mariani, C., Marsden, D., Marshall, J., Martinez, N., Caicedo, D. A. Martinez, Martynenko, S., Mastbaum, A., McConkey, N., Meddage, V., Micallef, J., Miller, K., Mistry, K., Mohayai, T., Mogan, A., Mooney, M., Moor, A. F., Moore, C. D., Lepin, L. Mora, Moudgalya, M., Babu, S. Mulleria, Naples, D., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Nowak, J., Oza, N., Palamara, O., Pallat, N., Paolone, V., Papadopoulou, A., Papavassiliou, V., Parkinson, H., Pate, S. F., Patel, N., Pavlovic, Z., Piasetzky, E., Ponce-Pinto, I., Pophale, I., Qian, X., Raaf, J. L., Radeka, V., Rafique, A., Reggiani-Guzzo, M., Ren, L., Rochester, L., Rondon, J. Rodriguez, Rosenberg, M., Ross-Lonergan, M., von Rohr, C. Rudolph, Safa, I., Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Snider, E. L., Soderberg, M., Soldner-Rembold, S., Spitz, J., Stancari, M., John, J. St., Strauss, T., Szelc, A. M., Tang, W., Taniuchi, N., Terao, K., Thorpe, C., Torbunov, D., Totani, D., Toups, M., Tsai, Y. -T., Tyler, J., Uchida, M. A., Usher, T., Viren, B., Weber, M., Wei, H., White, A. J., Williams, Z., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wright, N., Wu, W., Yandel, E., Yang, T., Yates, L. E., Yu, H. W., Zeller, G. P., Zennamo, J., and Zhang, C.

Subjects
High Energy Physics - Experiment (hep-ex), Physics - Instrumentation and Detectors, FOS: Physical sciences, Instrumentation and Detectors (physics.ins-det), High Energy Physics - Experiment
Abstract

We report measurements of radon daughters in liquid argon within the MicroBooNE time projection chamber (LArTPC). The presence of radon in MicroBooNE's 85 metric tons of active liquid argon bulk is probed with newly developed charge-based low-energy reconstruction tools and analysis techniques to detect correlated $^{214}$Bi-$^{214}$Po radioactive decays. Special datasets taken during periods of active radon doping enable new demonstrations of the calorimetric capabilities of single-phase neutrino LArTPCs for $\beta$ and $\alpha$ particles with electron-equivalent energies ranging from 0.1 to 3.0 MeV. By applying $^{214}$Bi-$^{214}$Po detection algorithms to beam-external physics data recorded over a 46-day period, no statistically significant presence of radon is detected, corresponding to a limit of $

Published
2023
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37. Differential cross section measurement of charged current <math><msub><mi>ν</mi><mi>e</mi></msub></math> interactions without final-state pions in MicroBooNE

Author

Abratenko, P., Anthony, J., Arellano, L., Asaadi, J., Ashkenazi, A., Balasubramanian, S., Baller, B., Barnes, C., Barr, G., Barrow, J., Basque, V., Bathe-Peters, L., Benevides Rodrigues, O., Berkman, S., Bhanderi, A., Bhattacharya, M., Bishai, M., Blake, A., Bogart, B., Bolton, T., Book, J. Y., Camilleri, L., Caratelli, D., Caro Terrazas, I., Cavanna, F., Cerati, G., Chen, Y., Conrad, J. M., Convery, M., Cooper-Troendle, L., Crespo-Anadón, J. I., Del Tutto, M., Dennis, S. R., Detje, P., Devitt, A., Diurba, R., Dorrill, R., Duffy, K., Dytman, S., Eberly, B., Ereditato, A., Evans, J. J., Fine, R., Finnerud, O. G., Foreman, W., Fleming, B. T., Foppiani, N., Franco, D., Furmanski, A. P., Garcia-Gamez, D., Gardiner, S., Ge, G., Gollapinni, S., Goodwin, O., Gramellini, E., Green, P., Greenlee, H., Gu, W., Guenette, R., Guzowski, P., Hagaman, L., Hen, O., Hicks, R., Hilgenberg, C., Horton-Smith, G. A., Irwin, B., Itay, R., James, C., Ji, X., Jiang, L., Jo, J. H., Johnson, R. A., Jwa, Y.J., Kalra, D., Kamp, N., Karagiorgi, G., Ketchum, W., Kirby, M., Kobilarcik, T., Kreslo, I., Leibovitch, M. B., Lepetic, I., Li, J.Y., Li, K., Li, Y., Lin, K., Littlejohn, B. R., Louis, W. C., Luo, X., Manivannan, K., Mariani, C., Marsden, D., Marshall, J., Martinez Caicedo, D. A., Mason, K., Mastbaum, A., McConkey, N., Meddage, V., Miller, K., Mills, J., Mogan, A., Mohayai, T., Mooney, M., Moor, A. F., Moore, C. D., Mora Lepin, L., Mousseau, J., Mulleriababu, S., Naples, D., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Newmark, D. A., Nowak, J., Nunes, M., Oza, N., Palamara, O., Pallat, N., Paolone, V., Papadopoulou, A., Papavassiliou, V., Parkinson, H. B., Pate, S. F., Patel, N., Pavlovic, Z., Piasetzky, E., Ponce-Pinto, I. D., Prince, S., Qian, X., Raaf, J. L., Radeka, V., Reggiani-Guzzo, M., Ren, L., Rochester, L., Rodriguez Rondon, J., Rosenberg, M., Ross-Lonergan, M., Rudolf von Rohr, C., Scanavini, G., Schmitz, D. W., Schukraft, A., Seligman, W., Shaevitz, M. H., Sharankova, R., Shi, J., Smith, A., Snider, E. L., Soderberg, M., Söldner-Rembold, S., Spitz, J., Stancari, M., St. John, J., Strauss, T., Sword-Fehlberg, S., Szelc, A. M., Tang, W., Taniuchi, N., Terao, K., Thorpe, C., Torbunov, D., Totani, D., Toups, M., Tsai, Y.T., Tyler, J., Uchida, M. A., Usher, T., Viren, B., Weber, M., Wei, H., White, A. J., Williams, Z., Wolbers, S., Wongjirad, T., Wospakrik, M., Wresilo, K., Wright, N., Wu, W., Yandel, E., Yang, T., Yates, L. E., Yu, H. W., Zeller, G. P., Zennamo, J., and Zhang, C.

Abstract

In this paper we present the first measurements of an exclusive electron neutrino cross section with the MicroBooNE experiment using data from the Booster neutrino beamline at Fermilab. These measurements are made for a selection of charged-current electron neutrinos without final-state pions. Differential cross sections are extracted in energy and angle with respect to the beam for the electron and the leading proton. The differential cross section as a function of proton energy is measured using events with protons both above and below the visibility threshold. This is done by including a separate selection of electron neutrino events without reconstructed proton candidates in addition to those with proton candidates. Results are compared to the predictions from several modern generators, and we find the data agrees well with these models. The data shows best agreement, as quantified by the p-value, with the generators that predict a lower overall cross section, such as GENIE v3 and NuWro.

Published
2022

39. 1616P Circulating tumour DNA (ctDNA) measurements and PET-imaging to evaluate response in a phase Ib trial of metastatic castration-resistant prostate cancer (mCRPC) treated with Lutetium-177-PSMA-617 (LuPSMA) plus pembrolizumab (PRINCE)

Author

Tolmeijer, S.H., Kwan, E.M., Ng, S.W.S., Joshua, A., Emmett, L., Crumbaker, M., Hamid, A.A., Anton, A., Horvath, L.G., Chan, J., Bressel, M., Buteau, J.P., Dhiantravan, N., Ayati, N., Keerthikumar, S., Goode, D., Hicks, R., Hofman, M.S., Wyatt, A.W., and Sandhu, S.K.

Published
2024
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40. The relationship between tumour dosimetry, response, and overall survival in patients with unresectable Neuroendocrine Neoplasms (NEN) treated with 177Lu DOTATATE (LuTate).

Author

Alipour, R., Jackson, P., Bressel, M., Hogg, A., Callahan, J., Hicks, R. J., and Kong, G.

Subjects
NEUROENDOCRINE tumors, MEDICAL dosimetry, OVERALL survival, PROGNOSIS, PEPTIDE receptors, CHILD patients, DOSE-response relationship (Radiation)
Abstract

Peptide Receptor Radionuclide Therapy (PRRT) delivers targeted radiation to Somatostatin Receptor (SSR) expressing Neuroendocrine Neoplasms (NEN). We sought to assess the predictive and prognostic implications of tumour dosimetry with respect to response by 68 Ga DOTATATE (GaTate) PET/CT molecular imaging tumour volume of SSR (MITVSSR) change and RECIST 1.1, and overall survival (OS). Methods: Patients with gastro-entero-pancreatic (GEP) NEN who received LuTate followed by quantitative SPECT/CT (Q-SPECT/CT) the next day (Jul 2010 to Jan 2019) were retrospectively reviewed. Single time-point (STP) lesional dosimetry was performed for each cycle using population-based pharmacokinetic modelling. MITVSSR and RECIST 1.1 were measured at 3-months post PRRT. Results: Median of 4 PRRT cycles were administered to 90 patients (range 2–5 cycles; mean 27.4 GBq cumulative activity; mean 7.6 GBq per cycle). 68% received at least one cycle with radiosensitising chemotherapy (RSC). RECIST 1.1 partial response was 24%, with 70% stable and 7% progressive disease. Cycle 1 radiation dose in measurable lesions was associated with local response (odds ratio 1.5 per 50 Gy [95% CI: 1.1–2.0], p = 0.002) when adjusted by tumour grade and RSC. Median change in MITVSSR was -63% (interquartile range -84 to -29), with no correlation with radiation dose to the most avid lesion on univariable or multivariant analyses (5.6 per 10 Gy [95% CI: -1.6, 12.8], p = 0.133). OS at 5-years was 68% (95% CI: 56–78%). Neither baseline MITVSSR (hazard ratio 1.1 [95% CI: 1.0, 1.2], p = 0.128) nor change in baseline MITVSSR (hazard ratio 1.0 [95% CI: 1.0, 1.1], p = 0.223) were associated with OS when adjusted by tumour grade and RSC but RSC was (95% CI: 0.2, 0.8, p = 0.012). Conclusion: Radiation dose to tumour during PRRT was predictive of radiologic response but not survival. Survival outcomes may relate to other biological factors. There was no evidence that MITVSSR change was associated with OS, but a larger study is needed. [ABSTRACT FROM AUTHOR]

Published
2023
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41. ENETS standardized (synoptic) reporting for endoscopy in neuroendocrine tumors

Author

Borbath, I., Pape, U. -F., Deprez, P. H., Bartsch, D. K., Caplin, M., Falconi, M., Garcia-Carbonero, R., Grozinsky-Glasberg, S., Jensen, R. T., Arnold, R., Ruszniewski, P., Toumpanakis, C., Valle, J. W., O'Toole, D., Belli, S. H., Castano, J. P., Chen, J., Costa, F. P., Couvelard, A., de Herder, W. W., Deroose, C. M., Dromain, C., Faggiano, A., Falkerby, J., Fazio, N., Frilling, A., Grande, E., Hand, P., Hicks, R. J., Horsch, D., Howe, J. R., Kloppel, G., Kolarova, T., Kos-Kudla, B., Koumarianou, A., Krejs, G. J., Krenning, E. P., Krishna, B. A., Leyden, S., Masui, T., Niederle, B., Nieveen van Dijkum, E. J., Oberg, K., Pavel, M., Perren, A., Prasad, V., Ramage, J. K., Reed, N. S., Rindi, G., Gemelli, A., Rinke, A., Rothmund, M., Singh, S., Sundin, A., Velthuysen, M. F. V., Verslype, C., Vullierme, M. P., Welin, S., Wiedenmann, B., Zhao, H., Graduate School, Surgery, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, UCL - (SLuc) Centre du cancer, UCL - (SLuc) Service de gastro-entérologie, and UCL - (SLuc) Unité d'oncologie médicale

Subjects
Cellular and Molecular Neuroscience, Neuroendocrine Tumors, Endocrinology, neuroendocrine neoplasms, Endocrine and Autonomic Systems, Endocrinology, Diabetes and Metabolism, Humans, Endoscopy, endoscopy, standardised reporting
Abstract

Despite efforts from various endoscopy societies, reporting in the field of endoscopy remains extremely heterogeneous. Harmonisation of clinical practice in endoscopy has been highlighted by application of many clinical practice guidelines and standards pertaining to the endoscopic procedures and reporting are underlined. The aim of the proposed "standardised reporting" is to (1) facilitate recognition of gastrointestinal neuroendocrine neoplasms (NEN) on initial endoscopy, (2) to enable interdisciplinary decision making for treatment by a multidisciplinary team, (3) to provide a basis for a standardised endoscopic follow-up which allows detection of recurrence or progression reliably, (4) to make endoscopic reports on NEN comparable between different units, and (5) to allow research collaboration between NEN centres in terms of consistency of their endoscopic data. The ultimate goal is to improve disease management, patient outcome and reduce the diagnostic burden on the side of the patient by ensuring the highest possible diagnostic accuracy and validity of endoscopic exams and possibly interventions.

Published
2022

42. The Effect of Attitudes Towards Individuals with Sexual Convictions on Professional and Student Risk Judgments

Author

Craig A. Harper and Hicks R

Subjects
Psychiatry and Mental health, Judgment, Attitude, Sexual Behavior, education, Sex Offenses, Humans, Psychology, Students, Social psychology, General Psychology, humanities
Abstract

Attitudes towards individuals with sexual convictions is an area with growing research interest, but the effects of such attitudes on professional judgments is largely unexplored. What is known from the existing literature is that attitudes guide the interpretation of sexual crime related information, which cascade into potential biased or heuristically driven judgments. In this study we recruited samples of both students ( n = 341) and forensic professionals ( n = 186) to explore whether attitudes towards individuals with sexual convictions predicted risk judgments of hypothetical sexual offense scenarios, and whether this relationship is moderated by professional status or perpetrator characteristics. Forensic professionals expressed more positive attitudes overall, but the significant effect of attitudes on risk judgments was consistent between participant groups and was not moderated by perpetrator age or sex. We suggest that relying on attitudes as a basis for risk judgments opens the door to incorrect (and potentially dangerous) decision-making and discuss our data in terms of their potential clinical implications. An open-access preprint of this work is available at https://psyarxiv.com/rjt5h/ .

Published
2022

44. Joint EANM/SNMMI/ANZSNM practice guidelines/procedure standards on recommended use of [F]FDG PET/CT imaging during immunomodulatory treatments in patients with solid tumors version 1.0.

Author

UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Centre du cancer, UCL - (SLuc) Service de médecine nucléaire, Lopci, E, Hicks, R J, Dimitrakopoulou-Strauss, A, Dercle, L, Iravani, A, Seban, R D, Sachpekidis, C, Humbert, O, Gheysens, O, Glaudemans, A W J M, Weber, W, Wahl, R L, Scott, A M, Pandit-Taskar, N, Aide, N, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Centre du cancer, UCL - (SLuc) Service de médecine nucléaire, Lopci, E, Hicks, R J, Dimitrakopoulou-Strauss, A, Dercle, L, Iravani, A, Seban, R D, Sachpekidis, C, Humbert, O, Gheysens, O, Glaudemans, A W J M, Weber, W, Wahl, R L, Scott, A M, Pandit-Taskar, N, and Aide, N

Abstract

The goal of this guideline/procedure standard is to assist nuclear medicine physicians, other nuclear medicine professionals, oncologists or other medical specialists for recommended use of [F]FDG PET/CT in oncological patients undergoing immunotherapy, with special focus on response assessment in solid tumors. In a cooperative effort between the EANM, the SNMMI and the ANZSNM, clinical indications, recommended imaging procedures and reporting standards have been agreed upon and summarized in this joint guideline/procedure standard. The field of immuno-oncology is rapidly evolving, and this guideline/procedure standard should not be seen as definitive, but rather as a guidance document standardizing the use and interpretation of [F]FDG PET/CT during immunotherapy. Local variations to this guideline should be taken into consideration. The European Association of Nuclear Medicine (EANM) is a professional non-profit medical association founded in 1985 to facilitate worldwide communication among individuals pursuing clinical and academic excellence in nuclear medicine. The Society of Nuclear Medicine and Molecular Imaging (SNMMI) is an international scientific and professional organization founded in 1954 to promote science, technology and practical application of nuclear medicine. The Australian and New Zealand Society of Nuclear Medicine (ANZSNM), founded in 1969, represents the major professional society fostering the technical and professional development of nuclear medicine practice across Australia and New Zealand. It promotes excellence in the nuclear medicine profession through education, research and a commitment to the highest professional standards. EANM, SNMMI and ANZSNM members are physicians, technologists, physicists and scientists specialized in the research and clinical practice of nuclear medicine. All three societies will periodically put forth new standards/guidelines for nuclear medicine practice to help advance the science of nuclear medicine and i

Published
2022

45. [18F]FDG-PET-CT compared with CT for persistent or recurrent neutropenic fever in high-risk patients (PIPPIN): a multicentre, open-label, phase 3, randomised, controlled trial

Author

Douglas, A, Thursky, K, Spelman, T, Szer, J, Bajel, A, Harrison, S, Tio, SY, Bupha-Intr, O, Tew, M, Worth, L, Teh, B, Chee, L, Ng, A, Carney, D, Khot, A, Haeusler, G, Yong, M, Trubiano, J, Chen, S, Hicks, R, Ritchie, D, Slavin, M, Douglas, A, Thursky, K, Spelman, T, Szer, J, Bajel, A, Harrison, S, Tio, SY, Bupha-Intr, O, Tew, M, Worth, L, Teh, B, Chee, L, Ng, A, Carney, D, Khot, A, Haeusler, G, Yong, M, Trubiano, J, Chen, S, Hicks, R, Ritchie, D, and Slavin, M

Abstract

BACKGROUND: Management of neutropenic fever in high-risk haematology patients is challenging; there are often few localising clinical features, and diagnostic tests have poor sensitivity and specificity. We aimed to compare how [18F]flurodeoxyglucose ([18F]FDG)-PET-CT scans and conventional CT scans affected the guidance of antimicrobial management and the outcomes of patients with persistent or recurrent neutropenic fever. METHODS: We did a multicentre, open-label, phase 3, randomised, controlled trial in two tertiary referral hospitals in Australia. We recruited adults aged 18 years or older who were receiving conditioning chemotherapy for haematopoietic stem-cell transplantation or chemotherapy for acute leukaemia and had persistent (>72 h) or recurrent (new fever beyond 72 h of initial onset interspersed with >48 h defervescence) neutropenic fever. Exclusion criteria were pregnancy, allergy to iodinated contrast, or estimated glomerular filtration rate of less than 30 mL/min. Patients were randomly assigned by computer-generated randomisation chart (1:1) to [18F]FDG-PET-CT or conventional CT. Masking was not possible because of the nature of the investigation. Scans were done within 3 days of random assignment. The primary endpoint was a composite of starting, stopping, or changing the spectrum (broadening or narrowing) of antimicrobial therapy-referred to here as antimicrobial rationalisation-within 96 h of the assigned scan, analysed per protocol. This trial is registered with clinicaltrials.gov, NCT03429387, and is complete. FINDINGS: Between Jan 8, 2018, and July 23, 2020, we assessed 316 patients for eligibility. 169 patients were excluded and 147 patients were randomly assigned to either [18F]FDG-PET-CT (n=73) or CT (n=74). Nine patients did not receive a scan per protocol, and two participants in each group were excluded for repeat entry into the study. 65 patients received [18F]FDG-PET-CT (38 [58%] male; 53 [82%] White) and 69 patients received CT (50 [7

Published
2022

46. ImmunoPET: IMaging of cancer imMUNOtherapy targets with positron Emission Tomography: a phase 0/1 study characterising PD-L1 with 89Zr-durvalumab (MEDI4736) PET/CT in stage III NSCLC patients receiving chemoradiation study protocol.

Author

Hegi-Johnson, F, Rudd, SE, Wichmann, C, Akhurst, T, Roselt, P, Trinh, J, John, T, Devereux, L, Donnelly, PS, Hicks, R, Scott, AM, Steinfort, D, Fox, S, Blyth, B, Parakh, S, Hanna, GG, Callahan, J, Burbury, K, MacManus, M, Hegi-Johnson, F, Rudd, SE, Wichmann, C, Akhurst, T, Roselt, P, Trinh, J, John, T, Devereux, L, Donnelly, PS, Hicks, R, Scott, AM, Steinfort, D, Fox, S, Blyth, B, Parakh, S, Hanna, GG, Callahan, J, Burbury, K, and MacManus, M

Abstract

BACKGROUND: ImmunoPET is a multicentre, single arm, phase 0-1 study that aims to establish if 89Zr-durvalumab PET/CT can be used to interrogate the expression of PD-L1 in larger, multicentre clinical trials. METHODS: The phase 0 study recruited 5 PD-L1+ patients with metastatic non-small cell lung cancer (NSCLC). Patients received 60MBq/70 kg 89Zr-durva up to a maximum of 74 MBq, with scan acquisition at days 0, 1, 3 or 5±1 day. Data on (1) Percentage of injected 89Zr-durva dose found in organs of interest (2) Absorbed organ doses (µSv/MBq of administered 89Zr-durva) and (3) whole-body dose expressed as mSv/100MBq of administered dose was collected to characterise biodistribution.The phase 1 study will recruit 20 patients undergoing concurrent chemoradiotherapy for stage III NSCLC. Patients will have 89Zr-durva and FDG-PET/CT before, during and after chemoradiation. In order to establish the feasibility of 89Zr-durva PET/CT for larger multicentre trials, we will collect both imaging and toxicity data. Feasibility will be deemed to have been met if more than 80% of patients are able complete all trial requirements with no significant toxicity. ETHICS AND DISSEMINATION: This phase 0 study has ethics approval (HREC/65450/PMCC 20/100) and is registered on the Australian Clinical Trials Network (ACTRN12621000171819). The protocol, technical and clinical data will be disseminated by conference presentations and publications. Any modifications to the protocol will be formally documented by administrative letters and must be submitted to the approving HREC for review and approval. TRIAL REGISTRATION NUMBER: Australian Clinical Trials Network ACTRN12621000171819.

Published
2022

47. Perspective paper about the joint EANM/SNMMI/ESTRO practice recommendations for the use of 2-[18F]FDG-PET/CT external beam radiation treatment planning in lung cancer

Author

Vaz, S., Adam, J., Bolton Delgado, R., Vera, P., Elmpt, W., Herrmann, K., Hicks, R., Lievens, Y., Santos, A., Schöder, H., Dubray, B., Visvikis, D., (0000-0001-9550-9050) Troost, E. G. C., Geus-Oei, L., Vaz, S., Adam, J., Bolton Delgado, R., Vera, P., Elmpt, W., Herrmann, K., Hicks, R., Lievens, Y., Santos, A., Schöder, H., Dubray, B., Visvikis, D., (0000-0001-9550-9050) Troost, E. G. C., and Geus-Oei, L.

Abstract

In ‘‘Joint EANM/SNMMI/ESTRO Practice Recommendations for the Use of 2-[18F]FDG-PET/CT External Beam Radiation Treatment Planning in Lung Cancer V1.0” clinical indications for PET-CT in (non-)small cell lung cancer are highlighted and selective nodal irradiation is discussed. Additionally, concepts about target definition, target delineation and treatment evaluation are reviewed.

Published
2022

48. Joint EANM/SNMMI/ESTRO practice recommendations for the use of 2‑[18F]FDG PET/CT external beam radiation treatment planning in lung cancer V1.0

Author

Vaz, S., Adam, J., Delgado Bolton, R., Vera, P., Elmpt, W., Herrmann, K., Hicks, R., Lievens, Y., Santos, A., Schöder, H., Dubray, B., Visvikis, D., (0000-0001-9550-9050) Troost, E. G. C., Geus-Oei, L., Vaz, S., Adam, J., Delgado Bolton, R., Vera, P., Elmpt, W., Herrmann, K., Hicks, R., Lievens, Y., Santos, A., Schöder, H., Dubray, B., Visvikis, D., (0000-0001-9550-9050) Troost, E. G. C., and Geus-Oei, L.

Abstract

Purpose 2-[18F]FDGPET/CT is of utmost importance for radiation treatment (RT) planning and response monitoring in lung cancer patients, in both non-small and small cell lung cancer (NSCLC and SCLC). This topic has been addressed in guidelines composed by experts within the feld of radiation oncology. However, up to present, there is no procedural guideline on this subject, with involvement of the nuclear medicine societies. Methods A literature review was performed, followed by a discussion between a multidisciplinary team of experts in the different fields involved in the RT planning of lung cancer, in order to guide clinical management. The project was led by experts of the two nuclear medicine societies (EANM and SNMMI) and radiation oncology (ESTRO). Results and conclusion This guideline results from a joint and dynamic collaboration between the relevant disciplines for this topic. It provides a worldwide, state of the art, and multidisciplinary guide to 2-[18F]FDG PET/CT RT planning in NSCLC and SCLC. These practical recommendations describe applicable updates for existing clinical practices, highlight potential faws, and provide solutions to overcome these as well. Finally, the recent developments considered for future application are also reviewed.

Published
2022

49. ENETS standardized (synoptic) reporting for molecular imaging studies in neuroendocrine tumours

Author

Hicks, R. J., Dromain, C., de Herder, W. W., Costa, F. P., Deroose, C. M., Frilling, A., Koumarianou, A., Krenning, E. P., Raymond, E., Bodei, L., Sorbye, H., Welin, S., Wiedenmann, B., Wild, D., Howe, J. R., Yao, J., O’Toole, D., Sundin, A., Prasad, V., Hicks, R. J., Dromain, C., de Herder, W. W., Costa, F. P., Deroose, C. M., Frilling, A., Koumarianou, A., Krenning, E. P., Raymond, E., Bodei, L., Sorbye, H., Welin, S., Wiedenmann, B., Wild, D., Howe, J. R., Yao, J., O’Toole, D., Sundin, A., and Prasad, V.

Abstract

The European Neuroendocrine Tumor Society (ENETS) promotes practices and procedures that aim to improve the standard of care delivered to patients diagnosed with or suspected of having neuroendocrine neoplasia (NEN). At its annual Scientific Advisory Board Meeting in 2018, experts in imaging, pathology and clinical care of patients with NEN drafted guidance for the standardised reporting of diagnostic studies critical to the diagnosis, grading, staging and treatment of NEN. These included pathology, radiology, endoscopy and molecular imaging procedures. In an iterative process, a synoptic reporting template for molecular imaging procedures was developed to guide personalised therapies. Following pilot implementation and refinement within the ENETS Center of Excellence network, harmonisation with specialist imaging societies including the Society of Nuclear Medicine, European Association of Nuclear Medicine and the International Cancer Imaging Society will be pursued.

Published
2022

50. Joint EANM/SNMMI/ANZSNM practice guidelines/procedure standards on recommended use of [F]FDG PET/CT imaging during immunomodulatory treatments in patients with solid tumors version 1.0

Author

Lopci, E, Hicks, R J, Dimitrakopoulou-Strauss, A, Dercle, L, Iravani, A, Seban, R D, Sachpekidis, C, Humbert, O, Gheysens, O, Glaudemans, A W J M, Weber, W, Wahl, R L, Scott, A M, Pandit-Taskar, N, Aide, N, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Centre du cancer, and UCL - (SLuc) Service de médecine nucléaire

Subjects
Positron emission tomography, PET/CT, Australia, treatment response, Molecular Imaging, Fluorodeoxyglucose F18, Neoplasms, Positron Emission Tomography Computed Tomography, Humans, immunotherapy, Nuclear Medicine, [18F]FDG, Societies, guideline, malignant tumors
Abstract

The goal of this guideline/procedure standard is to assist nuclear medicine physicians, other nuclear medicine professionals, oncologists or other medical specialists for recommended use of [F]FDG PET/CT in oncological patients undergoing immunotherapy, with special focus on response assessment in solid tumors. In a cooperative effort between the EANM, the SNMMI and the ANZSNM, clinical indications, recommended imaging procedures and reporting standards have been agreed upon and summarized in this joint guideline/procedure standard. The field of immuno-oncology is rapidly evolving, and this guideline/procedure standard should not be seen as definitive, but rather as a guidance document standardizing the use and interpretation of [F]FDG PET/CT during immunotherapy. Local variations to this guideline should be taken into consideration. The European Association of Nuclear Medicine (EANM) is a professional non-profit medical association founded in 1985 to facilitate worldwide communication among individuals pursuing clinical and academic excellence in nuclear medicine. The Society of Nuclear Medicine and Molecular Imaging (SNMMI) is an international scientific and professional organization founded in 1954 to promote science, technology and practical application of nuclear medicine. The Australian and New Zealand Society of Nuclear Medicine (ANZSNM), founded in 1969, represents the major professional society fostering the technical and professional development of nuclear medicine practice across Australia and New Zealand. It promotes excellence in the nuclear medicine profession through education, research and a commitment to the highest professional standards. EANM, SNMMI and ANZSNM members are physicians, technologists, physicists and scientists specialized in the research and clinical practice of nuclear medicine. All three societies will periodically put forth new standards/guidelines for nuclear medicine practice to help advance the science of nuclear medicine and improve service to patients. Existing standards/guidelines will be reviewed for revision or renewal, as appropriate, on their fifth anniversary or sooner, if indicated. Each standard/guideline, representing a policy statement by the EANM/SNMMI/ANZSNM, has undergone a thorough consensus process, entailing extensive review. These societies recognize that the safe and effective use of diagnostic nuclear medicine imaging requires particular training and skills, as described in each document. These standards/guidelines are educational tools designed to assist practitioners in providing appropriate and effective nuclear medicine care for patients. These guidelines are consensus documents based on current knowledge. They are not intended to be inflexible rules or requirements of practice, nor should they be used to establish a legal standard of care. For these reasons and those set forth below, the EANM, SNMMI and ANZSNM caution against the use of these standards/guidelines in litigation in which the clinical decisions of a practitioner are called into question. The ultimate judgment regarding the propriety of any specific procedure or course of action must be made by medical professionals considering the unique circumstances of each case. Thus, there is no implication that an action differing from what is laid out in the guidelines/procedure standards, standing alone, is below standard of care. To the contrary, a conscientious practitioner may responsibly adopt a course of action different from that set forth in the standards/guidelines when, in the reasonable judgment of the practitioner, such course of action is indicated by the condition of the patient, limitations of available resources or advances in knowledge or technology subsequent to publication of the guidelines/procedure standards. The practice of medicine involves not only the science, but also the art of dealing with the prevention, diagnosis, alleviation and treatment of disease. The variety and complexity of human conditions make it impossible for general guidelines to consistently allow for an accurate diagnosis to be reached or a particular treatment response to be predicted. Therefore, it should be recognized that adherence to these standards/ guidelines will not ensure a successful outcome. All that should be expected is that practitioners follow a reasonable course of action, based on their level of training, current knowledge, clinical practice guidelines, available resources and the needs/context of the patient being treated. The sole purpose of these guidelines is to assist practitioners in achieving this objective. The present guideline/procedure standard was developed collaboratively by the EANM, the SNMMI and the ANZSNM, with the support of international experts in the field. They summarize also the views of the Oncology and Theranostics and the Inflammation and Infection Committees of the EANM, as well as the procedure standards committee of the SNMMI, and reflect recommendations for which the EANM and SNMMI cannot be held responsible. The recommendations should be taken into the context of good practice of nuclear medicine and do not substitute for national and international legal or regulatory provisions.

Published
2022

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