1. Acromegaly: an endocrine pathology with serious consequences
- Author
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Horchani A, Bayar I, Ben Amor B, Hellara I, Abdelali M, Neffati F, Khochtali I, and Najjar MF
- Subjects
- Aged, Delayed Diagnosis adverse effects, Humans, Male, Acromegaly complications, Acromegaly diagnosis, Pituitary Neoplasms complications, Pituitary Neoplasms diagnosis, Pituitary Neoplasms pathology
- Abstract
Acromegaly is a rare endocrine disorder leading to an acquired physical disfigurement and multisystem damage. It is caused in over 95% of cases by a secreting pituitary adenoma. Latency period between disease onset and diagnosis is mainly 10 years due to progressive chronic evolution and exposure to high levels of GH and IGF-1. Here we present a case of acromegaly with over 25 years of diagnostic delay in 69-years-old male with typical features and recurrent urolithiasis. Biochemical diagnosis was confirmed by high levels of IGF-1and lack of suppression of GH during an oral glucose load. Imaging and histological study revealed a co-secreting GH/ prolactine macroadenoma. After three months of complete transphenoidal surgical resection, biochemical remission was not obtained and the patient was treated by a somatostatin receptor ligand. Based on this severe case with atypical manifestations, the diagnosis of acromegaly should be always considered.
- Published
- 2022
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