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This study addresses the critical need for high signal-to-noise ratio in optical detection methods for biological sample discrimination under low-photon-flux conditions to ensure accuracy without compromising sample integrity. We explore polarization-based probing, which often excels over intensity modulation when assessing a specimen's morphology. Leveraging non-classical light sources, our approach capitalizes on sub-Poissonian photon statistics and quantum correlation-based measurements. We present a novel, highly sensitive method for probing single-layer cell cultures using entangled photon pairs. Our approach demonstrates capability in monolayer cell analysis, distinguishing between two types of monolayer cells and their host medium. The experimental results highlight our method's sensitivity, showcasing its potential for biological sample detection using quantum techniques, and paving the way for advanced diagnostic methodologies.